45 completed, 28 recruiting, 12 not yet recruiting, 12 terminated. 64 Phase 3, 25 Phase 2, 11 Phase 4, 3 Not applicable, 2 Phase 1.
Follow Tenecteplase: new trials by email Literature Review of Tenecteplase trials Research Report on Tenecteplase
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Tenecteplase in Acute Ischemic Stroke Under Different Transfer Models tenecteplase - Acute Ischemic Stroke | Not yet recruiting | Fujian Medical University Union Hospital | 2000 | 2027-04-01 | 2026-10-27 | |
| Tenecteplase Bridging Thrombolysis Prior to Inter-hospital Transfer for Endovascular Therapy in Anterior Circulation Large Vessel Occlusion Stroke Within 4.5-24 Hours Tenecteplase (rhTNK-tPA) (0.25 mg/kg, to maximum of 25mg) - Acute Ischemic Stroke, Large Vessel Occlusion | Phase 3 | Not yet recruiting | Fujian Medical University Union Hospital | 1266 | 2027-04-01 | 2026-11-03 |
| INTRA-ARTERIAL MeVO TREATMENT (IMP-ACT) Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632 Mechanical Endovascular Thrombectomy, Intravenous Thrombolysis, Tenecteplase/Alteplase- depending upon availability at each treating centre - Stroke, Acute Ischemic, Medium Vessel Occlusion | Phase 3 | Not yet recruiting | University of Calgary | 800 | 2026-12-15 | 2026-10-30 |
| Tenecteplase or Reteplase as Bridging Thrombolysis Before Thrombectomy in Acute Ischemic Cerebrovascular Events rhTNK-tPA (0.25mg/kg), Reteplase 10 Units (U) plus a second dose of reteplase 10 U, No thrombolysis (thrombectomy alone) - Acute Ischemic Stroke, Large Vessel Occlusion | Phase 3 | Recruiting | Yongjun Wang | 1440 | 2026-10-16 | 2026-10-22 |
| Unknown Time of Onset Stroke RePerfusIon Without Advanced Imaging Tenecteplase (TNK) (0.25 mg/kg, to maximum of 25mg), Standard medical treatment - Acute Ischemic Stroke, Tenecteplase | Phase 3 | Recruiting | First Affiliated Hospital of Guangxi Medical University | 352 | 2026-09-24 | 2026-09-30 |
| Intra-arterial Thrombolysis For Acute Ischemic Stroke With Medium Vessel Occlusion Recombinant Tissue Plasminogen Activator (rt-PA), Intra-arterial Thrombolysis, Best Medical Management - Medium Vessel Occlusion, Ischemic Stroke, Acute | Phase 3 | Recruiting | The First Affiliated Hospital with Nanjing Medical University | 372 | 2026-09-19 | 2026-09-23 |
| ACT-GLOBAL IA Thrombolysis(ACT-REACT-004)Domain Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632 Tenecteplase or Alteplase- depending upon availability at each treating centre, Control - Stroke, Acute Ischemic, Endovascular Thrombectomy | Phase 3 | Recruiting | University of Calgary | 1500 | 2026-08-11 | 2026-10-21 |
| rhTNK-tPA for Acute Ischemic Stroke Under Simplified Imaging in the Extended Time Window Tenecteplase (rhTNK-tPA) (0.25 mg/kg, to maximum of 25mg), Standard medical treatment - Acute Ischemic Stroke | Phase 3 | Recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 750 | 2026-08-01 | 2026-06-15 |
| TeleStroke-Guided Thrombolysis for Acute Ischemic Stroke in Oman alteplase or tenecteplase - Ischemic Stroke, Acute, Ischemic Stroke | Phase 4 | Not yet recruiting | Oman Ministry of Health | 200 | 2026-08-01 | 2026-07-22 |
| STRATEGY-PE: Real-World Treatment Strategies for Intermediate-High Risk Pulmonary Embolism Anticoagulants, Thrombolytic Agents, Mechanical Thrombectomy Devices - Pulmonary Embolism, Venous Thromboembolism | Not yet recruiting | Nanjing First Hospital, Nanjing Medical University | 1300 | 2026-06-01 | 2026-05-22 | |
| Extended Time Window Intravenous Tenecteplase Thrombolysis Registry for Acute Ischemic Stroke Tenecteplase - Stroke, Acute Ischemic Stroke | Not yet recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 3000 | 2026-04-01 | 2026-04-17 | |
| Neuronavigation-assisted Stereotactic Minimally Invasive Puncture With Tenecteplase for Acute Lobar Intracerebral Hemorrhage Neuronavigation-assisted Stereotactic Minimally Invasive Puncture Combined with Tenecteplase, Standard medical treatment - Intracerebral Hemorrhage Lobar | Phase 3 | Not yet recruiting | Beijing Tiantan Hospital | 636 | 2026-03-31 | 2026-03-25 |
| Repeated Intravenous Thrombolysis for Ischemic Stroke Within 3.0 Hours of Onset With Tenecteplase (RITIS-TNK) Tenecteplase - Ischemic Stroke | Phase 2 | Recruiting | General Hospital of Shenyang Military Region | 120 | 2026-03-25 | 2026-04-01 |
| Repeated Intravenous Thrombolysis for Ischemic Stroke With Medium to Large Vessel Occlusion Presenting Within 4.5 Hours of Onset With Tenecteplase (RITIS-TNK2) Tenecteplase - Ischemic Stroke | Phase 2 | Recruiting | General Hospital of Shenyang Military Region | 198 | 2026-03-25 | 2026-04-01 |
| Intravenous Tenecteplase in Very Old Patients With Acute Ischemic Stroke Tenecteplase (TNK) (0.25 mg/kg, to maximum of 25mg), Standard medical care - Acute Ischemic Stroke, Tenecteplase | Recruiting | First Affiliated Hospital of Guangxi Medical University | 392 | 2026-03-22 | 2026-08-31 | |
| Reperfusion Completion Via Local Arterial Infusion of Tenecteplase After Incomplete Mechanical Thrombectomy Tenecteplase (0.0938mg/kg), Placebo - Stroke | Phase 3 | Not yet recruiting | Chuansheng Zhao | 344 | 2026-03-01 | 2026-03-13 |
| Precision Reperfusion Therapy for Disabling Minor Stroke With Large Vessel Occlusion Beyond Time Window Tenecteplase (0.25mg/kg), Standard Medical Management - Stroke | Phase 3 | Not yet recruiting | First Hospital of China Medical University | 864 | 2026-03-01 | 2026-03-17 |
| A Study to Test if Tenecteplase Helps People to Recover From an Acute Stroke When Given More Than 4.5 Hours After the Person Was Last Seen Well Tenecteplase, Standard of care treatment - Acute Ischemic Stroke | Phase 3 | Recruiting | Boehringer Ingelheim | 1325 | 2026-02-17 | 2026-10-27 |
| Tenecteplase Before Interhospital Transfer for EVT in Acute Anterior Circulation LVO at 4.5-24 Hours Tenecteplase (TNK) (0.25 mg/kg, to maximum of 25mg) - Acute Ischemic Stroke, Large Vessel Occlusion | Phase 3 | Recruiting | Xuanwu Hospital, Beijing | 572 | 2026-01-06 | 2026-08-19 |
| Efficacy and Safety of Tenecteplase Bridging Mechanical Thrombectomy for Acute Large Vessel Occlusion Stroke Tenecteplase, Alteplase - Stroke, Ischemic, Stroke, Acute | Phase 3 | Recruiting | Xuanwu Hospital, Beijing | 850 | 2025-12-25 | 2026-04-09 |
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Ischemic Stroke (59) · Stroke (34) · Myocardial Infarction (11) · ST Elevation Myocardial Infarction (6) · Pulmonary Embolism (5) · Cerebral Infarction (3) · Cerebrovascular Disorders (3) · Ischemia (3) · Nervous System Diseases (3) · Brain Diseases (2) · Brain Infarction (2) · Brain Ischemia (2) · Cardiovascular Diseases (2) · Central Nervous System Diseases (2) · Hemorrhage (2)
Beijing Tiantan Hospital (10) · Boehringer Ingelheim (8) · General Hospital of Shenyang Military Region (7) · University of Calgary (6) · Genentech, Inc. (5) · The First Affiliated Hospital of University of Science and Technology of China (4) · Centre Hospitalier Sud Francilien (3) · Huashan Hospital (3) · Insel Gruppe AG, University Hospital Bern (3) · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University (3) · First Affiliated Hospital of Guangxi Medical University (2) · First Hospital of China Medical University (2) · Fujian Medical University Union Hospital (2) · Hospital Moinhos de Vento (2) · NHS Greater Glasgow and Clyde (2)
China (45) · Canada (14) · United States (13) · Australia (11) · France (11) · Norway (11) · Spain (10) · Austria (8) · Belgium (8) · Germany (8) · Brazil (7) · Greece (6) · Italy (6) · United Kingdom (6) · Finland (5)
Bijoy K Menon, MD (3) · Raul G Nogueira, MD (3) · Barbara Gillespie, M.D., FASN (2) · Craig Anderson, MD (2) · Dongdong Sun, M.D.,Ph.D. (2) · Sheila CO Martins, MD, PhD (2) · Shuya Li (2) · Thomas Meinel, MD, PhD (2) · Wei Hu, MD (2) · Yamei Tang (2) · Yong Cao (2) · Yuan Wu, MD, PhD (2) · Andy Yong, MBBS (1) · Anthony Keech, MBBS (1)
PMID 20185783, PMID 25726502, PMID 26387127, PMID 28780236, PMID 22435369, PMID 29694815, PMID 30602354, PMID 33408145, PMID 33857326, PMID 34906976, PMID 35017305, PMID 36289001, PMID 36878701, PMID 37830342, PMID 38502892, PMID 39689189, PMID 39952376, PMID 40497495, PMID 41446320, PMID 41619999, PMID 15262836, PMID 16488800, PMID 16574919, PMID 18815396, PMID 19092151, PMID 19233036, PMID 19833379, PMID 20133491, PMID 20562693, PMID 20598969, PMID 20651267, PMID 20971744, PMID 21111365, PMID 21315210, PMID 21545942, PMID 22172434, PMID 23418571, PMID 23473396, PMID 24716681, PMID 24916050, PMID 25161043, PMID 25212800, PMID 25433511, PMID 25677596, PMID 25691510, PMID 26304934, PMID 26514192, PMID 26763281, PMID 26783237, PMID 27965285
2018 (2), 2023 (2), 2014 (1), 2025 (1), R01NS037666 (1), R01NS045170 (1)