106 completed, 26 unknown, 25 terminated, 16 recruiting. 62 Phase 3, 47 Phase 2, 31 Phase 4, 21 Not applicable, 14 Phase 1.
Follow this drug Literature Review of Tissue Plasminogen Activator trials Research Report on Tissue Plasminogen Activator
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Augmented Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for PE Ultrasound-facilitated, catheter-directed lower-dose fibrinolysis, Tissue Plasminogen Activator - Pulmonary Embolism, Right Ventricular Dysfunction | Suspended | Brigham and Women's Hospital | 60 | 2027-01-01 | 2026-01-21 | |
| Reduced-Dose Versus Full-Dose Alteplase for High-Risk Pulmonary Embolism Reduced-dose alteplase, Full-dose alteplase - Pulmonary Embolism Acute | Phase 4 | Not yet recruiting | Sahlgrenska University Hospital | 400 | 2026-12-01 | 2026-09-17 |
| Efficacy and Safety of Intrapleural Fibrinolytic Therapy in Tuberculous Pleural Effusion Versus Non-Tuberculous Pleural Infection Intrapleural Fibrinolytic Therapy (IPFT) - Tuberculous Pleural Effusion | Not yet recruiting | National University of Malaysia | 160 | 2026-09-20 | 2026-09-16 | |
| Intra-arterial Thrombolysis For Acute Ischemic Stroke With Medium Vessel Occlusion Recombinant Tissue Plasminogen Activator (rt-PA), Intra-arterial Thrombolysis, Best Medical Management - Medium Vessel Occlusion, Ischemic Stroke, Acute | Phase 3 | Recruiting | The First Affiliated Hospital with Nanjing Medical University | 372 | 2026-09-19 | 2026-09-23 |
| ACT-GLOBAL IA Thrombolysis(ACT-REACT-004)Domain Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632 Tenecteplase or Alteplase- depending upon availability at each treating centre, Control - Stroke, Acute Ischemic, Endovascular Thrombectomy | Phase 3 | Recruiting | University of Calgary | 1500 | 2026-08-11 | 2026-10-21 |
| TeleStroke-Guided Thrombolysis for Acute Ischemic Stroke in Oman alteplase or tenecteplase - Ischemic Stroke, Acute, Ischemic Stroke | Phase 4 | Not yet recruiting | Oman Ministry of Health | 200 | 2026-08-01 | 2026-07-22 |
| INtra-arterial AltEplase folloWing successfuL reperfusIoN After mEchanical Thrombectomy Alteplase, Endovascular thrombectomy - Stroke, Acute Ischemic, Large Vessel Occlusion | Phase 3 | Recruiting | 115 People's Hospital | 416 | 2026-08-01 | 2026-09-25 |
| CleaRRAflow: Isotonic Solution vs. TPA for IVH Clearance Tissue Plasminogen Activator (tPA), Isotonic solution - Tissue Plasminogen Activator, Intraventricular Brain Hemorrhage | Phase 4 | Enrolling by invitation | David Dornbos | 80 | 2026-07-31 | 2026-08-06 |
| Flush, Lyse, Operate Intrapleural Saline with possible escalation to intraplerual alteplase and dornase. - Complicated Parapneumonic Effusion, Empyema, Pleural | Phase 4 | Not yet recruiting | Dartmouth-Hitchcock Medical Center | 30 | 2026-04-01 | 2026-05-18 |
| Intrapleural Alteplase-Tyloxapol vs Intrapleural Alteplase-DNase in Pleural Infection Intrapleural t-PA/Dnase arm, t-PA (Alteplase) 5-10mg and Tyloxapol 200mg - Pleural Infection | Recruiting | National University of Malaysia | 80 | 2026-04-01 | 2026-06-30 | |
| Efficacy and Safety of Tenecteplase Bridging Mechanical Thrombectomy for Acute Large Vessel Occlusion Stroke Tenecteplase, Alteplase - Stroke, Ischemic, Stroke, Acute | Phase 3 | Recruiting | Xuanwu Hospital, Beijing | 850 | 2025-12-25 | 2026-04-09 |
| Reperfusion Treatment in Acute Pulmonary Embolism Catheter directed intervention, any device, Alteplase - Pulmonary Embolism | Recruiting | Sahlgrenska University Hospital | 220 | 2025-04-01 | 2026-01-21 | |
| Thrombolysis in Factor Xa-inhibitors Trial thrombolysis therapy - Stroke, Stroke (in Patients With Atrial Fibrillation) | Phase 3 | Recruiting | Guri Hagberg | 300 | 2025-03-14 | 2026-09-23 |
| Safety and Efficacy of Intravenous Thrombolysis in Patients With Ischemic Stroke and Direct Oral Anticoagulants Intake Tenecteplase or Alteplase - Ischemic Stroke | Phase 4 | Recruiting | Insel Gruppe AG, University Hospital Bern | 906 | 2025-03-14 | 2026-09-30 |
| Intravenous Thrombolytic Therapy for Acute Ischemic Stroke Patients with Low NIHSS and Non-disabling Deficits Intravenous thrombolysis (alteplase and other guideline-recommended thrombolytic agents) - Thrombosis, Acute Ischemic Stroke (AIS) | Phase 4 | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 390 | 2025-03-01 | 2025-03-06 |
| Endovascular Treatment or Standard Medical Care for Cerebral Venous Sinus Thrombosis(ESCORT) Heparin, Endovascular treatment - Cerebral Venous Sinus Thrombosis | Not applicable | Active not recruiting | Beijing Tiantan Hospital | 224 | 2024-12-24 | 2026-08-21 |
| Trial of Reduced Alteplase Dose for Parapneumonic Effusion (TRAPPE) Tissue Plasminogen Activator - Pleural Infection | Phase 2 / Phase 3 | Recruiting | Chinese University of Hong Kong | 30 | 2024-11-01 | 2026-01-05 |
| To Compare the Efficacy & Safety of Ultra-Slow (24 hr) Low Dose (25 mg) Infusion of Alteplase Over Slow (24hr) Infusion of Streptokinase in Mechanical Prosthetic Valve Thrombosis Alteplase, streptokinase - Thrombolysed | Not applicable | Completed | U. N. Mehta Institute of Cardiology and Research Center | 100 | 2024-11-01 | 2026-01-26 |
| A Real-world Study of Tenecteplase Versus Alteplase for Thrombolysis in Patients Within 4.5 H of Onset of Ischemic Stroke Tenecteplase, Alteplase - Stroke Acute, Tenecteplase | Unknown | Tianjin Huanhu Hospital | 6000 | 2024-10-26 | 2024-10-29 | |
| Intravenous Thrombolytic Therapy in Acute Ischemic Stroke Patients on DOAC alteplase or tenecteplase - CVA (Cerebrovascular Accident) | Not applicable | Recruiting | Chinese University of Hong Kong | 260 | 2024-04-15 | 2026-02-24 |
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Ischemic Stroke (58) · Stroke (55) · Pulmonary Embolism (17) · Thrombosis (14) · Myocardial Infarction (10) · Brain Ischemia (5) · Ischemia (4) · ST Elevation Myocardial Infarction (4) · Subarachnoid Hemorrhage (4) · Venous Thrombosis (4) · Ventricular Dysfunction, Right (4) · Bites and Stings (3) · Cardiovascular Diseases (3) · Cerebral Hemorrhage (3) · Cerebral Infarction (3)
Boehringer Ingelheim (12) · Assiut University (5) · Johns Hopkins University (5) · Beijing Tiantan Hospital (4) · NHS Greater Glasgow and Clyde (4) · Second Affiliated Hospital, Zhejiang University, School of Medicine (4) · Angde Biotech Pharmaceutical Co., Ltd. (3) · Boston Scientific Corporation (3) · Centre Hospitalier Sud Francilien (3) · General Hospital of Shenyang Military Region (3) · Kafrelsheikh University (3) · National University of Malaysia (3) · Neuroscience Trials Australia (3) · University of Calgary (3) · University of Cincinnati (3)
United States (54) · China (38) · Canada (21) · France (14) · Germany (13) · Spain (12) · United Kingdom (12) · Australia (9) · Belgium (9) · Egypt (8) · Denmark (7) · Netherlands (7) · Sweden (7) · Switzerland (7) · Austria (6)
Bijoy K Menon, MD (2) · Daniel F. Hanley, MD (2) · Geoffrey Donnan, MD FRACP (2) · Joseph P. Broderick, MD (2) · Kenneth Mann (2) · Sergey S Markin, MD, PhD (2) · Shuya Li (2) · Stephen Davis, MD FRACP (2) · Thomas A. Tomsick, MD (2) · Thomas Meinel, MD, PhD (2) · Yamei Tang (2) · Aaron S Weinberg, MD (1) · Ahmed Hamdy, Ass.Prof (1)
PMID 12221155, PMID 16731270, PMID 22435369, PMID 29694815, PMID 31067369, PMID 34515113, PMID 20185783, PMID 21830966, PMID 23489534, PMID 25726502, PMID 26387127, PMID 28780236, PMID 29766770, PMID 30523735, PMID 34786868, PMID 36446950, PMID 37830342, PMID 39500603, PMID 10591382, PMID 11546885, PMID 12639166, PMID 12917889, PMID 16574919, PMID 16763187, PMID 18701066, PMID 18705914, PMID 18815396, PMID 19233036, PMID 19277904, PMID 19741062, PMID 20047905, PMID 20075341, PMID 20651267, PMID 21030700, PMID 21664144, PMID 21737309, PMID 21940973, PMID 22015331, PMID 22340437, PMID 22382155, PMID 22398159, PMID 22474059, PMID 22683421, PMID 23264523, PMID 23273695, PMID 23370203, PMID 23390923, PMID 23418571, PMID 23463422, PMID 23493340
2018 (2), 2019 (2), 2023 (2), P50NS044148 (2), 2016 (1), R01HL038454 (1), R01HL042311 (1), R01HL042428 (1), R01NS037666 (1), R01NS045170 (1), U01HL088476 (1), U01NS052220 (1), U01NS054630 (1), U01NS062851 (1), U01NS080824 (1)