370 completed. 370 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 370 | Completed 370 |
Follow Behavioral Symptoms: new trials by email Literature Review of Behavioral Symptoms trials Research Report on Behavioral Symptoms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Treatment of Psoriasis With Depression and/or Anxiety With Methotrexate vs Combined Methotrexate and Antidepressant Combination of methotrexate and escitalopram in treatment of psoriasis patients with depression and/or anxiety, Methotrexate - Depression, Anxiety | Phase 4 | Completed | Cairo University | 40 | 2026-02-01 | 2026-10-05 |
| Efficacy of Bacillus Coagulans in Alleviating Anxiety and Depression in Patients With Functional Dyspepsia Bacillus coagulans, placebo - Functional Dyspepsia, Probiotics | Phase 4 | Completed | Xijing Hospital of Digestive Diseases | 181 | 2025-09-18 | 2026-10-13 |
| Brimonidine 0.33% for Rosacea-Related Facial Erythema Brimonidine 0.33% gel, Placebo gel - Rosacea, Rosacea Subtype 1 (Erythematotelangiectatic) | Phase 4 | Completed | Istanbul Training and Research Hospital | 45 | 2025-05-01 | 2026-02-24 |
| Impact of Astaxanthin on Cognition in Recreationally Active Females Astaxanthin, Placebo - Mental Fatigue | Phase 4 | Completed | University of North Alabama | 26 | 2024-08-01 | 2026-05-26 |
| Detoxification From the Lipid Tract electroencephalogram biofeedback, electrical brain stimulation, ultra-low frequency transcranial magnetic stimulation - COVID-19 Vaccine Adverse Reaction | Phase 4 | Completed | Pachankis, Yang I., M.D. | 1 | 2024-02-26 | 2024-04-10 |
| Impact of Ketamine On Depressive Symptoms In Patients Undergoing Lumbo-peritoneal Shunt Insertion normal Saline, Ketamine - Depression, Anxiety | Phase 4 | Completed | Benha University | 110 | 2023-10-29 | 2026-01-08 |
| Tachyphylaxis, Tolerance, & Withdrawal Post Treatment With Igalmi for Agitation in Schizophrenia or Bipolar Disorder Sublingual film containing Igalmi - Bipolar Disorder, Schizophrenia | Phase 4 | Completed | BioXcel Therapeutics Inc | 29 | 2023-10-02 | 2026-08-11 |
| Efficacy and Safety of Toluedesvenlafaxine Hydrochloride Extended-release Tablets in Somatic Symptoms of Depression toludesvenlafaxine hydrochloride sustained-release tablets - Somatic Symptom | Phase 4 | Completed | Shanghai Mental Health Center | 60 | 2023-05-12 | 2025-05-31 |
| Affective Effects of Pre-surgery Opioids: a Randomized, Doubleblind Placebo-controlled Trial Placebo, Morphine 2.5 mg i.v., Morphine 5 mg i.v. - Opioid Use, Affective Symptoms | Phase 4 | Completed | Oslo University Hospital | 1014 | 2022-12-13 | 2026-09-24 |
| Oral Aspirin + Ketamine as Adjunct to Oral Antidepressant Therapy for Depression VTS-K - Treatment Resistant Depression, Major Depressive Disorder | Phase 4 | Completed | Theresa Jacob, PhD, MPH | 15 | 2022-12-06 | 2026-04-21 |
| Fluoxetine Treatment of Depression in Down Syndrome Fluoxetine - Down Syndrome, Depression | Phase 4 | Completed | Massachusetts General Hospital | 4 | 2022-12-05 | 2025-03-30 |
| Bisoprolol Versus Cognitive Behavioral Therapy for Stress in Patients on Peritoneal Dialysis Cognitive behavioral therapy, Bisoprolol - Kidney Failure, Chronic, Peritoneal Dialysis, Continuous Ambulatory | Phase 4 | Completed | Universitas Sebelas Maret | 20 | 2022-11-10 | 2026-10-27 |
| Comparison of Esketamine/Propofol and Methohexital Anesthesia for ECT Methohexital, Ketofol - ECT, Depression | Phase 4 | Completed | Medical University of Vienna | 56 | 2022-11-01 | 2026-10-07 |
| Brain and Stress Study Minocycline, Placebo - Stress, Psychological, Motivation | Phase 4 | Completed | University of North Carolina, Chapel Hill | 10 | 2022-09-12 | 2024-12-18 |
| Anhedonia, Development, and Emotions: Phenotyping and Therapeutics Continuous theta burst stimulation (cTBS), Positive Affect Training, Ketamine Injectable Solution - Depression, Anhedonia | Phase 4 | Completed | Erika Forbes | 123 | 2022-07-22 | 2026-03-17 |
| Efficacy of the Therapy With BRAINMAX® Using fMRI for the Treatment of Patients With Asthenia After COVID-19 Structural and functional MRI, Ethyl methyl hydroxypyridine succinate + Meldonium, Placebo - Asthenia, COVID-19 | Phase 4 | Completed | Promomed, LLC | 30 | 2022-05-18 | 2023-07-13 |
| Efficacy and Safety of Sertraline in the Treatment of Maintenance Hemodialysis Patients With Depression Sertraline - Efficacy, Team, Adverse Reaction to Drug | Phase 4 | Completed | First Affiliated Hospital of Chongqing Medical University | 125 | 2022-01-10 | 2023-11-09 |
| Integrating a Stepped Care Model of Screening and Treatment for Depression Into Malawi's National HIV Care Delivery Platform Problem Management Plus, Antidepressant Therapy - Depressive Disorder | Phase 4 | Completed | RAND | 487 | 2021-09-01 | 2026-06-09 |
| Effectiveness of Ketamine Treatment for Three Consecutive Days in Depression Ketamine Hydrochloride, Midazolam - Depression | Phase 4 | Completed | Mahidol University | 24 | 2021-09-01 | 2024-03-15 |
| Perceived Changes in Anxiety Symptom Burden During Treatment With Bryophyllum Pinnatum and Tolerability Bryophyllum 50 % Chewing Tablets - Anxiety Symptoms | Phase 4 | Completed | Markus Schlemmer | 51 | 2021-08-31 | 2024-06-21 |
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Depression (299) · Depressive Disorder, Major (88) · Psychomotor Agitation (33) · Bipolar Disorder (32) · Depressive Disorder (31) · Anxiety Disorders (29) · Psychotic Disorders (13) · Aggression (12) · Schizophrenia (12) · Suicidal Ideation (12) · Suicide (11) · Alzheimer Disease (10) · Mood Disorders (10) · Dementia (9) · Dysthymic Disorder (9)
Behavior (366) · Mental Disorders (228) · Mood Disorders (135) · Pathological Conditions, Signs and Symptoms (97) · Depressive Disorder (89) · Signs and Symptoms (86) · Nervous System Diseases (82) · Neurologic Manifestations (69) · Neurobehavioral Manifestations (54) · Aberrant Motor Behavior in Dementia (41) · Dyskinesias (33) · Psychomotor Disorders (33) · Bipolar and Related Disorders (32) · Neurocognitive Disorders (25)
Escitalopram (50) · Sertraline (32) · Venlafaxine Hydrochloride (20) · Duloxetine Hydrochloride (18) · Sugars (16) · Ketamine (15) · Citalopram (14) · Fluoxetine (13) · Bupropion (12) · Paroxetine (12) · Quetiapine Fumarate (12) · Lithium (9) · Risperidone (8) · Saline Solution (8) · Dexetimide (7)
New York State Psychiatric Institute (24) · Massachusetts General Hospital (16) · Emory University (13) · University of California, Los Angeles (13) · University of Pittsburgh (13) · Indiana University (10) · Eli Lilly and Company (7) · National Institute of Mental Health (NIMH) (7) · University of Pennsylvania (7) · University of Texas Southwestern Medical Center (6) · University of North Carolina, Chapel Hill (5) · Wyeth is now a wholly owned subsidiary of Pfizer (5) · Forest Laboratories (4) · Sunnybrook Health Sciences Centre (4) · Weill Medical College of Cornell University (4)
United States (231) · Canada (26) · Germany (11) · China (10) · Italy (10) · Denmark (8) · Netherlands (8) · South Korea (8) · France (7) · Spain (6) · Switzerland (6) · Russia (5) · Turkey (Türkiye) (5) · Austria (4) · Belgium (4)
Amit Anand, MD (7) · David J. Hellerstein, MD (4) · Helen Lavretsky, M.D. (3) · Warren D Taylor, MD, MHSc (3) · Carl Gommoll, MS (2) · Charles Bowden, MD (2) · Dan Iosifescu, MD (2) · Davangere Devanand, M.D. (2)
PMID 33884617, PMID 25080392, PMID 24144505, PMID 26803397, PMID 29608461, PMID 30358242, PMID 36999619, PMID 37952772, PMID 40728007, PMID 11442853, PMID 14996777, PMID 15800144, PMID 15956269, PMID 16009352, PMID 16166403, PMID 16168037, PMID 16390886, PMID 16426099, PMID 16457894, PMID 16540613, PMID 16551710, PMID 16554525, PMID 16554526, PMID 16566612, PMID 16566901, PMID 16636629, PMID 16642436, PMID 16690084, PMID 16754414, PMID 16772623, PMID 16816220, PMID 16824617, PMID 16946176, PMID 16946177, PMID 16974189, PMID 17074942, PMID 17091129, PMID 17195602, PMID 17229469, PMID 17302619, PMID 17303771, PMID 17431740, PMID 17685736, PMID 17727882, PMID 17854250, PMID 17917554, PMID 18039992, PMID 18070841, PMID 18162025, PMID 18251622
2005 (2), 2009 (2), R01MH060353 (2), R01MH061017 (2), R01MH072383 (2), 2008 (1), 2016 (1), 2018 (1), 5UL1TR001420-03 (1), K01MH095920 (1), K12HD001441 (1), K23AA017666 (1), K23DA020681 (1), K23MH001828 (1), K23MH064196 (1)