81 completed, 13 unknown, 12 terminated, 7 recruiting. 45 Phase 4, 26 Phase 3, 19 Phase 2, 16 Not applicable, 16 Phase 1.
Follow Lithium: new trials by email Literature Review of Lithium trials Research Report on Lithium
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Assess the Long-term Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-3) KarXT, Lithium, Valproate - Bipolar Disorder Type I With Mania | Phase 3 | Recruiting | Bristol-Myers Squibb | 450 | 2025-07-18 | 2026-09-14 |
| Real-world Lithium Intake Lithium (LI) based on clinical indication - Bipolar Disorder (BD) | Recruiting | University of Aarhus | 50 | 2025-07-05 | 2025-09-11 | |
| Τhe Combination of Pharmacotherapy With RECOVERYTRSGR and RECOVERYTRSBDGR. Group A: (Clozapine, quietiapine, olanzapine, aripiprazole, zyprasidone, risperidone, asenapine, paliperidone, clopixol,anxiolytics: clonazepam, stedon, tavor antidepressants: seropram),, Group B (Pharmacotherapy and TAU) (Clozapine, quietiapine, olanzapine, aripiprazole, zyprasidone, risperidone, asenapine, paliperidone, clopixol, clonazepam, stedon, tavor, antidepressants,, Group C (Pharmacotherapy and Psychotherapy) Clozapine, quietiapine, olanzapine, aripiprazole, zyprasidone, risperidone, asenapine, paliperidone, clopixol, clonazepam, stedon, tavor, lithium, depakine - Treatment Resistant Schizophrenia, Treatment Resistant Bipolar Disorder | Phase 4 | Active not recruiting | Dr. Stavroula Rakitzi | 84 | 2025-06-04 | 2026-05-01 |
| Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression After a First-time Treatment Failure Clozapine, Esketamine Nasal Product, Escitalopram - Schizophrenia and Related Disorders, Major Depressive Disorder | Phase 3 | Recruiting | Dr. Inge Winter | 1254 | 2025-04-27 | 2026-01-22 |
| The Effect of a Six Week Intensified Pharmacological Treatment for Bipolar Depression Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment. Escitalopram, Sertraline, Venlafaxine - Bipolar Depression | Phase 3 | Recruiting | Dr. Inge Winter | 418 | 2025-02-11 | 2025-09-26 |
| A Study of Lithium and Enlicitide in Healthy Adult Participants (MK-0616-034) lithium carbonate, enlicitide - Healthy | Phase 1 | Completed | Merck Sharp & Dohme LLC | 16 | 2025-01-02 | 2025-02-17 |
| A Study to Evaluate the Effects of Lithium, Valproic Acid, and Lamotrigine on the Pharmacokinetics of KarXT and Effects of KarXT on the Pharmacokinetics of Lithium, Valproic Acid, and Lamotrigine in Healthy Participants Xanomeline/Trospium Chloride, Lithium, Valproic Acid - Healthy Volunteers | Phase 1 | Completed | Karuna Therapeutics, Inc., a Bristol Myers Squibb company | 133 | 2024-12-26 | 2026-02-24 |
| Repurposing Lithium for Parkinson's Disease: a RCT Lithium, Placebo - Parkinson Disease | Phase 1 / Phase 2 | Active not recruiting | State University of New York at Buffalo | 20 | 2024-07-03 | 2026-06-16 |
| Lithium Treatment to Prevent Cognitive Impairment After Brain Radiotherapy Lithium, Placebo - Cognitive Impairment, Cognitive Decline | Phase 2 | Recruiting | Region Stockholm | 84 | 2024-02-16 | 2024-04-12 |
| Lithium Long COVID Dose-finding Study Lithium - Long COVID | Phase 1 | Completed | State University of New York at Buffalo | 5 | 2023-10-12 | 2024-10-22 |
| Electroconvulsive Therapy and Concomitant Lithium in Depressive Disorder: A Pilot Study Lithium - Depressive Disorder | Early Phase 1 | Unknown | Melbourne Health | 20 | 2023-06-01 | 2023-08-01 |
| Lithium Versus Cariprazine in the Acute Phase Treatment of Bipolar Depression (DUAG9) Lithium, Cariprazine - Depression, Bipolar | Phase 4 | Recruiting | Aalborg University Hospital | 122 | 2022-12-13 | 2026-01-21 |
| Effect of Lithium Therapy on Long COVID Symptoms Lithium, Placebo - Long COVID | Phase 2 | Completed | State University of New York at Buffalo | 52 | 2022-11-28 | 2025-03-05 |
| Lithium Versus Anticonvulsants and the Risk of Physical Disorders Lithium - Bipolar Disorder | Completed | Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital | 169285 | 2022-06-01 | 2023-08-22 | |
| Dose Escalation Study of Lithium With Oxaliplatin and Capecitabine in Advanced Oesophago-Gastric or Colorectal Cancer Lithium, Oxaliplatin, Capecitabine - Colorectal Neoplasms, Stomach Neoplasm | Phase 1 | Terminated | Cancer Trials Ireland | 2 | 2022-01-13 | 2025-07-08 |
| Indirect Evaluation of Lithium Level in Blood Using Non-invasive Sweat Biosensors Smartwatch with integrated Li+ sensor (provided by Spectrophon LTD) - Lithium Level Detection in Sweat | Unknown | Tirat Carmel Mental Health Center | 75 | 2020-01-01 | 2020-10-08 | |
| Effects of Lithium Therapy on Blood-based Therapeutic Targets in Parkinson's Disease. Lithium - Parkinson Disease | Phase 1 | Completed | State University of New York at Buffalo | 19 | 2019-10-17 | 2023-08-15 |
| Preventing Relapse After Successful Electroconvulsive Therapy for Depression Lithium - Major Depressive Disorder (MDD) | Not applicable | Completed | Universiteit Antwerpen | 96 | 2019-07-26 | 2026-05-05 |
| Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder Lithium - Bipolar Disorder, Bipolar I Depression | Completed | Brigham and Women's Hospital | 81 | 2017-12-07 | 2026-07-16 | |
| Effect of Lithium Versus Placebo in Adults With Treatment-Resistant Depression Who Are Receiving Ketamine Lithium, Placebo, Ketamine - Treatment Resistant Depression | Phase 2 | Withdrawn | William V. Bobo, M.D. | 2017-11-30 | 2018-08-16 |
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Bipolar Disorder (64) · Depression (23) · Depressive Disorder, Major (13) · Mania (13) · Depressive Disorder (7) · Depressive Disorder, Treatment-Resistant (5) · Psychotic Disorders (5) · Schizophrenia (4) · Mood Disorders (3) · Aggression (2) · Alzheimer Disease (2) · Brain Neoplasms (2) · Conduct Disorder (2) · Congenital Abnormalities (2) · Leukemia, Myeloid, Acute (2)
AstraZeneca (7) · New York State Psychiatric Institute (5) · National Institute of Mental Health (NIMH) (4) · Roxane Laboratories (4) · State University of New York at Buffalo (4) · University Hospitals Cleveland Medical Center (4) · Shanghai Mental Health Center (3) · University of Cincinnati (3) · University of Sao Paulo (3) · Dr. Inge Winter (2) · Federal University of Rio Grande do Sul (2) · Icahn School of Medicine at Mount Sinai (2) · Indiana University (2) · Melbourne Health (2) · National Institute of Neurological Disorders and Stroke (NINDS) (2)
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Keming Gao, MD, PhD (4) · Amit Anand, MD (3) · James W Murrough, MD (2) · Jerry Herron, MD (2) · Marcelo Fleck, PhD (2) · Trisha Suppes, MD, PhD (2) · A Elias (1) · A. John Rush, MD (1) · Alan G. Mallinger, M.D. (1) · Andree Daigneault, Dr. (1) · Andrew A Nierenberg, MD (1) · Anothony Cleare (1)
PMID 18588360, PMID 23761037, PMID 28832750, PMID 34523118, PMID 35585125, PMID 39356507, PMID 41401709, PMID 11765093, PMID 15005752, PMID 15110730, PMID 15330403, PMID 15349007, PMID 15465989, PMID 15541061, PMID 15569893, PMID 15677618, PMID 15723025, PMID 15898966, PMID 15950022, PMID 15960566, PMID 16023735, PMID 16168792, PMID 16176440, PMID 16197928, PMID 16338761, PMID 16339615, PMID 16339616, PMID 16390886, PMID 16426088, PMID 16426099, PMID 16448626, PMID 16449473, PMID 16449474, PMID 16457894, PMID 16551710, PMID 16552982, PMID 16554525, PMID 16554526, PMID 16566612, PMID 16566627, PMID 16566901, PMID 16595351, PMID 16635643, PMID 16636629, PMID 16642436, PMID 16675760, PMID 16677228, PMID 16690084, PMID 16754414, PMID 16816220
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