37 completed, 9 unknown, 4 withdrawn, 3 terminated. 24 Phase 4, 10 Not applicable, 9 Phase 2, 8 Phase 3, 3 Phase 1.
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| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Optimized Predictive Treatment In Medications for Unipolar Major Depression (OPTIMUM-D) Escitalopram, Brexpiprazole - Major Depressive Disorder | Phase 4 | Recruiting | Nova Scotia Health Authority | 400 | 2023-01-20 | 2026-06-11 |
| Reward-specific Changes of the Chemical Messenger Dopamine in the Brain of Healthy and Depressed People WELLBUTRIN SR (Bupropion HCI) Sustained-Release Tablets, 150 mg; GlaxoSmithKline, Cipralex (escitalopram) - Major Depressive Disorder (MDD) | Phase 4 | Recruiting | Medical University of Vienna | 120 | 2022-12-01 | 2024-11-05 |
| Drug Concentrations in Breast Milk and Prediction of Blood Levels of the Breastfed Infants either of Atenolol, Bupropion, Brivaracetam, Escitalopram, Fluconazole, Lacosamide, Lamotrigine, Levetiracetam, Methotrexate or Ezetimibe - Breast Feeding | Completed | The Hospital for Sick Children | 39 | 2022-03-09 | 2024-04-10 | |
| Canadian Biomarker Integration Network for Depression (CAN-BIND) - Validation Study Escitalopram, Brexpiprazole - Major Depressive Disorder | Phase 3 | Completed | University Health Network, Toronto | 1 | 2019-12-23 | 2023-03-02 |
| Effect of Attention Training or SSRIs on Symptoms and Neural Activation in Social Anxiety Gaze Contingent Music Reward Therapy, Escitalopram, Waitlist - Social Anxiety Disorder | Not applicable | Completed | Tel Aviv University | 105 | 2018-07-20 | 2022-02-01 |
| PF-04995274 and Emotional Processing in Un-medicated Depression PF-04995274, Citalopram, Placebo Oral Tablet - Depression, Unipolar | Phase 1 | Completed | University of Oxford | 90 | 2018-05-16 | 2022-11-03 |
| Cortical Ischemic Stroke and Serotonin Serotonin Uptake Inhibitors, Placebo - Stroke | Phase 2 | Unknown | Insel Gruppe AG, University Hospital Bern | 90 | 2016-08-01 | 2020-03-06 |
| The Effect of Escitalopram on Mood, Quality of Life and Cognitive Functioning in Glioblastoma Patients Escitalopram, placebo - GBM, Depression | Phase 2 / Phase 3 | Unknown | Tel-Aviv Sourasky Medical Center | 100 | 2015-12-01 | 2015-12-07 |
| Patient Stratification and Treatment Response Prediction in Neuropharmacotherapy Using Hybrid Positron Emmission Tomography/Magnetic Resconance Imaging (PET/MR) PET/MR [11C]DASB, Citalopram, Escitalopram (Mirtazapine/Duloxetine/Venlafaxine) - Major Depressive Disorder | Phase 4 | Unknown | Medical University of Vienna | 80 | 2015-05-01 | 2019-09-03 |
| Efficacy of Exposure and Response Prevention(ERP) and SSRIs in Chinese OCD Patients Fluoxetine, Sertraline, Paroxetine - Obsessive-Compulsive Disorder, Anxiety Disorders | Phase 4 | Completed | Shanghai Mental Health Center | 78 | 2014-01-01 | 2022-09-09 |
| The Efficacy of Citalopram Treatment in Acute Stroke Citalopram, Placebo - Stroke, Ischemic | Phase 2 | Completed | University of Aarhus | 642 | 2013-09-01 | 2017-02-24 |
| The Effect of Cipralex on Quality of Life, Adrenal Activity Glucose Metabolism, Physical and Mental Health in PCOS Cipralex, Placebo - Polycystic Ovary Syndrome | Phase 4 | Completed | Odense University Hospital | 42 | 2013-06-01 | 2016-05-09 |
| The Effects of Vilazodone on Glutamate in the Anterior Cingulate Cortex in Anxious Unipolar Depressives Vilazodone, Citalopram - Major Depressive Disorder, Anxiety | Phase 4 | Withdrawn | Massachusetts General Hospital | 2013-04-01 | 2016-11-08 | |
| Canadian Biomarker Integration Network for Depression Study escitalopram, aripiprazole - Major Depressive Disorder | Phase 3 | Completed | University Health Network, Toronto | 211 | 2012-04-23 | 2018-05-11 |
| Antidepressants and Bone Mineral Density sertraline, citalopram, venlafaxine - Bone Mineral Density Quantitative Trait Locus 7 | Phase 3 | Completed | Guiyang Medical University | 203 | 2012-03-01 | 2014-07-01 |
| Serotonergic System and Violent Video Games cipralex - Healthy Volunteers | Not applicable | Completed | RWTH Aachen University | 47 | 2012-02-01 | 2015-09-29 |
| Analgesic Effect of Escitalopram in Total Knee Arthroplasty (TKA) Escitalopram, Placebo - Postoperative Pain | Phase 4 | Completed | Hvidovre University Hospital | 120 | 2011-09-01 | 2013-06-05 |
| Neural, Genetic, and Peripheral Correlates of SSRI Pharmaco-Response Escitalopram - Depression | Phase 4 | Completed | Medical University of Vienna | 26 | 2011-08-01 | 2016-10-31 |
| Exploring Biomarkers for Depression Escitalopram, Healthy Control - Major Depressive Disorder | Completed | Wyss Institute at Harvard University | 51 | 2011-08-01 | 2018-05-01 | |
| Predictors of Antidepressant Response Placebo, identified as placebo to participants, Celexa or other antidepressant as clinically indicated, Placebo, identifed to participants as "Active medication" - Depression | Phase 4 | Completed | University of Michigan | 44 | 2011-01-01 | 2017-12-05 |
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Depressive Disorder, Major (17) · Depression (16) · Anxiety Disorders (5) · Depressive Disorder (4) · Obsessive-Compulsive Disorder (4) · Phobia, Social (4) · Stroke (3) · Generalized Anxiety Disorder (2) · Psychotic Disorders (2) · Alcoholism (1) · Alzheimer Disease (1) · Angina, Unstable (1) · Anxiety, Separation (1) · Bipolar Disorder (1) · Breast Feeding (1)
H. Lundbeck A/S (3) · Medical University of Vienna (3) · Abarbanel Mental Health Center (2) · Eli Lilly and Company (2) · Hadassah Medical Organization (2) · Massachusetts General Hospital (2) · Tel-Aviv Sourasky Medical Center (2) · University Health Network, Toronto (2) · University of Aarhus (2) · University of Copenhagen (2) · University of Ottawa (2) · Centre for Addiction and Mental Health (1) · Chonnam National University Hospital (1) · Espace Hogan (1) · Finnish Institute for Health and Welfare (1)
Canada (12) · United States (9) · Denmark (7) · Israel (7) · Austria (3) · Switzerland (3) · Germany (2) · Romania (2) · Russia (2) · Spain (2) · United Kingdom (2) · Brazil (1) · China (1) · Estonia (1) · Finland (1)
A. Daigneault, Dr. (1) · A. Ravindran, Dr. (1) · A. Schaffer, Dr. (1) · A.V. Mysore, Dr. (1) · Alyn H Morice, Professor (1) · Andrew A. Nierenberg, M.D. (1) · Andrew Nierenberg, MD (1) · Aviv M Weinstein, Ph.D (1) · B. Frey, Dr. (1) · Birte Glenthoj, MD, DMSc. (1) · Boris Modrau, M.D. (1)
PMID 10534584, PMID 11110112, PMID 16009352, PMID 17559755, PMID 18348597, PMID 18834506, PMID 19578654, PMID 19671139, PMID 21034680, PMID 21738622, PMID 21811192, PMID 21907540, PMID 22393376, PMID 22722513, PMID 22841131, PMID 23948637, PMID 25375836, PMID 25412614, PMID 25581916, PMID 26313133, PMID 26421634, PMID 26709390, PMID 30043065, PMID 30079814, PMID 30355209, PMID 30840787, PMID 31471185, PMID 31907104, PMID 32241310, PMID 32349119, PMID 32558407, PMID 32836109, PMID 33032615, PMID 33296696, PMID 33520402, PMID 33667309, PMID 33683582, PMID 33814546, PMID 33860922, PMID 34008342, PMID 34229186, PMID 34416758, PMID 35023065, PMID 35459929, PMID 35546043, PMID 36945823, PMID 36997260, PMID 37530824, PMID 37796764, PMID 37967350
2004 (1), 2016 (1), 2019 (1), R01MH061394 (1), R01MH061757 (1), R01MH061758 (1), R01MH084900 (1), R34MH070753 (1)