926 completed, 224 unknown, 201 recruiting, 111 terminated. 523 Not applicable, 312 Phase 2, 183 Phase 3, 141 Phase 1, 115 Phase 4.
Follow Dyskinesias: new trials by email Literature Review of Dyskinesias trials Research Report on Dyskinesias
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Mindfulness in Nonflaccid Facial Paralysis Mindfulness Sessions, No Mindfulness Sessions - Facial Paralysis | Not applicable | Not yet recruiting | Wake Forest University Health Sciences | 24 | 2027-04-01 | 2026-09-30 |
| A Clinical Trial of Iron Supplementation for Youth With ADHD and Restless Sleep Ferrous Sulfate, Placebo - ADHD, Sleep Problems | Phase 1 / Phase 2 | Not yet recruiting | Hugo W. Moser Research Institute at Kennedy Krieger, Inc. | 70 | 2027-03-01 | 2026-05-04 |
| A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus) Glycerol Tributyrate - MELAS Syndrome, Lebers Hereditory Optic Neuropathy With Extra Ocular Symptoms (LHON-Plus) | Phase 1 / Phase 2 | Not yet recruiting | George Washington University | 24 | 2027-03-01 | 2026-10-05 |
| Multi-Modal Digital Monitoring of Disease Symptoms Huntington's Disease Huntington Disease | Not yet recruiting | BioSensics | 75 | 2027-01-31 | 2026-10-13 | |
| Can Acute Photobiomodulation Improve Balance and Cognition in Individuals With Ataxia: a Pilot Feasibility Placebo Randomized Controlled Trial. Photobiomodulation, Sham photobiomodulation - Ataxia | Not applicable | Not yet recruiting | University of Central Lancashire | 20 | 2027-01-01 | 2026-09-22 |
| Umbilical Cord Mesenchymal Stem Cells Therapy (19#iSCLife®-SA) for Patients With Spinocerebellar Ataxia Intravenous infusion, Intrathecal injection, umbilical cord mesenchymal stem cell - Spinocerebellar Ataxia Type 1, Spinocerebellar Ataxia Type 2 | Phase 2 | Not yet recruiting | Sclnow Biotechnology Co., Ltd. | 45 | 2026-12-31 | 2026-04-23 |
| Multi-Modal Digital Monitoring of Disease Symptoms in Spinocerebellar Ataxia Spinocerebellar Ataxia (SCA) | Not yet recruiting | BioSensics | 25 | 2026-12-15 | 2026-10-01 | |
| Virtual Reality to Advance Dementia Care and Quality of Life Supervised Virtual Reality Sessions - Dementia, Agitation | Not applicable | Not yet recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 10 | 2026-12-01 | 2026-10-26 |
| Inhibition of Aggressive Behavior in Participants With Fragile X Syndrome SRX246, Placebo - Aggressive Behavior in Fragile X Syndome | Phase 2 | Not yet recruiting | Azevan Pharmaceuticals | 80 | 2026-12-01 | 2026-10-30 |
| Safety and Tolerability of Single and Repeated Dose of IMM02-KORA in PD-associated Dyskinesia IMM02-KORA - Dyskinesia, Medication-induced, Dyskinesia, Drug-Induced | Phase 1 | Not yet recruiting | Immunis, Inc. | 15 | 2026-11-30 | 2026-10-30 |
| Distinguishing Tics and Functional Tics Using Clinical Neurophysiological Techniques Tics, Functional Tics | Recruiting | National Institute of Neurological Disorders and Stroke (NINDS) | 75 | 2026-11-09 | 2026-11-04 | |
| Wearable for Assessing Tremor and Continuous Health in Parkinson's Disease and Essential Tremor Device exposure: Wearable inertial sensor monitoring - PARKINSON DISEASE (Disorder) | Recruiting | Heriot-Watt University | 60 | 2026-11-01 | 2026-10-09 | |
| Creatine and Beta-Hydroxy-Beta-Methylbutyrate (HMB) Supplementation Plus Home-Based Exercise for Sarcopenia in Huntington's Disease Creatine monohydrate, Beta-hydroxy-beta-methylbutyrate (HMB), Placebo (microcrystalline cellulose) - Huntington Disease, Sarcopenia | Not applicable | Not yet recruiting | Universidad de Burgos | 88 | 2026-11-01 | 2026-10-28 |
| Evaluating and Promoting Resilience in Adolescents With Tourette Syndrome PRISM Intervention, Usual care intervention - Tourette Syndrome, Tic Disorders | Not applicable | Not yet recruiting | Wake Forest University Health Sciences | 95 | 2026-11-01 | 2026-10-30 |
| Aprepitant for the Treatment of CLIFAHDD Aprepitant Powder for Oral Suspension - CLIFAHDD, Congenital Contractures of the Limbs and Face, Hypotonia, and Developmental Delay | Early Phase 1 | Recruiting | The University of Texas Health Science Center at San Antonio | 5 | 2026-10-31 | 2026-10-05 |
| Assessment of Cervical Range of Motion Restrictions in Infants With Arthrogenic Torticollis - A Feasibility Study Mobilisation of the upper cervical spine (but the effectiveness of the investigation is not part of the study evaluation) - Torticollis (Arthrogenic) | Not yet recruiting | Balgrist University Hospital | 10 | 2026-10-07 | 2026-10-08 | |
| Digital Patient Engagement in Technology-Supported Neurorehabilitation Stroke, Parkinson Disease (PD) | Not yet recruiting | Catholic University, Italy | 129 | 2026-10-01 | 2026-09-15 | |
| Sensor-Based Optimization of Therapy for Parkinson's Disease Patients With Motor Fluctuations wearable-based adjustment therapy - Parkinson Disease (PD) | Not applicable | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 218 | 2026-10-01 | 2026-09-02 |
| Rare Disease Registry Database for Movement Disorders in Southern Anhui Province Motor Neuron Diseases, Spinocerebellar Ataxias | Recruiting | First Affiliated Hospital of Wannan Medical College | 180 | 2026-09-30 | 2026-10-23 | |
| Safety and Efficacy of Esketamine - Dexmedetomidine Combination Versus Dexmedetomidine Monotherapy for Hyperactive Delirium in ICU Patients on Non-Invasive Respiratory Support (SEED-NIRS Trial): Study Protocol of a Randomized Controlled Trial Esketamine combined with dexmedetomidine, Dexmedetomidine - Dexmedetomidine, Ketamine | Phase 4 | Not yet recruiting | The First Affiliated Hospital with Nanjing Medical University | 356 | 2026-09-28 | 2026-09-03 |
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Huntington Disease (292) · Psychomotor Agitation (281) · Parkinson Disease (274) · Dystonia (206) · Tremor (150) · Ataxia (140) · Torticollis (119) · Alzheimer Disease (96) · Movement Disorders (95) · Spinocerebellar Ataxias (92) · Dementia (82) · Essential Tremor (81) · Cerebellar Ataxia (69) · Tics (65)
Nervous System Diseases (1513) · Neurologic Manifestations (1380) · Pathological Conditions, Signs and Symptoms (1304) · Signs and Symptoms (1278) · Central Nervous System Diseases (1156) · Brain Diseases (971) · Neurodegenerative Diseases (784) · Movement Disorders (733) · Mental Disorders (616) · Basal Ganglia Diseases (611) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (550) · Genetic Diseases, Inborn (531) · Heredodegenerative Disorders, Nervous System (490) · Neurocognitive Disorders (448)
Botulinum Toxins, Type A (45) · Dexmedetomidine (40) · Deep Brain Stimulation (33) · Transcranial Magnetic Stimulation (24) · Haloperidol (20) · valbenazine (19) · abobotulinumtoxinA (18) · Saline Solution (17) · Olanzapine (14) · Blood Specimen Collection (13) · Levodopa (13) · Risperidone (13) · Amantadine (12) · Midazolam (12) · Sodium Chloride (12)
National Institute of Neurological Disorders and Stroke (NINDS) (76) · Assistance Publique - Hôpitaux de Paris (27) · University of Florida (26) · Neurocrine Biosciences (18) · Institut National de la Santé Et de la Recherche Médicale, France (17) · Johns Hopkins University (17) · Oregon Health and Science University (13) · BioXcel Therapeutics Inc (12) · Ipsen (12) · Novartis Pharmaceuticals (12) · Otsuka Pharmaceutical Development & Commercialization, Inc. (12) · Pfizer (12) · University Health Network, Toronto (12) · CHDI Foundation, Inc. (11) · Great Lakes NeuroTechnologies Inc. (11)
United States (778) · France (198) · Canada (156) · Germany (145) · United Kingdom (126) · Spain (104) · Italy (95) · China (62) · Australia (59) · Poland (56) · Netherlands (45) · Turkey (Türkiye) (45) · Austria (39) · Israel (38) · Belgium (35)
Mark Hallett, M.D. (12) · BioXcel MM, MD (8) · Kristina Simonyan, MD, PhD (7) · Dustin A Heldman, PhD (6) · Mandar Jog, MD (5)
PMID 36463457, PMID 31356217, PMID 38489195, PMID 38557959, PMID 29480210, PMID 31381524, PMID 31617235, PMID 32250312, PMID 40681915, PMID 41533472, PMID 41961243, PMID 25962554, PMID 30776019, PMID 36811812, PMID 39108660, PMID 40739200, PMID 41591746, PMID 10816186, PMID 12112073, PMID 1444775, PMID 15137564, PMID 15313841, PMID 15365159, PMID 16193476, PMID 19026963, PMID 19126811, PMID 19191832, PMID 20359934, PMID 20519680, PMID 21211990, PMID 21484867, PMID 23245705, PMID 23422376, PMID 23667214, PMID 24035670, PMID 24361112, PMID 24780882, PMID 25037310, PMID 25185211, PMID 25324317, PMID 25568297, PMID 26666500, PMID 26679193, PMID 26714284, PMID 27214258, PMID 27939583, PMID 28265459, PMID 28404690, PMID 28674168, PMID 29163985
2014 (8), 2025 (7), 2015 (5), 2016 (5), 2023 (5), 2005 (4), 2017 (4), 2018 (4), 2008 (3), 2009 (3), U54NS065701 (3), R01HD040289 (2), U01NS055903 (2), U54TR001456 (2), UL1TR002345 (2)