370 completed, 60 unknown, 47 terminated, 31 recruiting. 552 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 552 | Completed 370, Unknown 60, Terminated 47, Recruiting 31, Withdrawn 24, Not yet recruiting 11, Active not recruiting 7, Enrolling by invitation 1, Suspended 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Managing Hepatitis B (Hep. B) and Human Papilloma Virus (HPV) Related Cancers and Mental Health. Gardasil 9 vaccine, Hepatitis B Virus Vaccine(HBV), Cognitive Behavioral Therapy - Hepatitis B, Human Papilloma Virus | Phase 4 | Not yet recruiting | Eunice Dube | 2140 | 2027-01-30 | 2026-07-30 |
| Broadband Near Infrared Spectroscopy to Understand the Role of Brain Cytochrome C Oxidase in Bipolar Disorder Lurasidone (Latuda) - Bipolar Disorder Depression | Phase 4 | Not yet recruiting | Martin Lan | 60 | 2026-11-01 | 2026-09-08 |
| Safety and Efficacy of Esketamine - Dexmedetomidine Combination Versus Dexmedetomidine Monotherapy for Hyperactive Delirium in ICU Patients on Non-Invasive Respiratory Support (SEED-NIRS Trial): Study Protocol of a Randomized Controlled Trial Esketamine combined with dexmedetomidine, Dexmedetomidine - Dexmedetomidine, Ketamine | Phase 4 | Not yet recruiting | The First Affiliated Hospital with Nanjing Medical University | 356 | 2026-09-28 | 2026-09-03 |
| The Effects of Lumateperone on Obesity and Physiologic Aging and Their Association With Antidepressant Response in Bipolar Depression Lumateperone 42 mg - Bipolar Depression Depressed Phase, Obesity & Overweight | Phase 4 | Recruiting | Massachusetts General Hospital | 25 | 2026-09-09 | 2026-09-11 |
| Dexmedetomidine-Esketamine Combination on Depression and Anxiety After Laparoscopic Ureteral Reconstruction Combined dexmedetomidine-esketamine administration, Placebo administration - Ureteral Stricture, Dexmedetomidine | Phase 4 | Not yet recruiting | Peking University First Hospital | 658 | 2026-08-01 | 2026-08-14 |
| Deutetrabenazine Treatment for Tardive Dyskinesia in Intellectual/Developmental Disabilities Deutetrabenazine Oral Capsule - Tardive Dyskinesia, Intellectual Disability | Phase 4 | Recruiting | University Hospitals Cleveland Medical Center | 25 | 2026-06-22 | 2026-07-06 |
| Esketamine Versus Crisis Response Planning Versus Enhanced Treatment as Usual for Suicide Prevention: A Pragmatic Randomized Trial in a Brazilian Municipality (SAVE) Intravenous Esketamine, Crisis Response Planning (CRP), Enhanced Treatment as Usual (eTAU) - Suicide Prevention, Ketamine | Phase 4 | Recruiting | University of Sao Paulo | 478 | 2026-06-01 | 2026-09-16 |
| Intranasal Esketamine-dexmedetomidine Combination and Postpartum Depression Esketamine-dexmedetomidine combination, Placebo - Parturients, Depressive Symptoms | Phase 4 | Not yet recruiting | Peking University First Hospital | 164 | 2026-06-01 | 2026-06-15 |
| Comprehensive Toileting Program Glycerin Suppository, Behavioral strategies - Encopresis, ASD | Phase 4 | Recruiting | Emory University | 150 | 2026-06-01 | 2026-06-18 |
| Self-hangIng Patient and Hyperbaric Oxygen Therapy _ SIPHON Study OXYGENE MEDICINAL LIQUIDE AIR PRODUCTS MEDICAL - Suicide | Phase 4 | Not yet recruiting | University Hospital, Lille | 50 | 2026-06-01 | 2026-05-22 |
| The Improvement of Low-dose Esketamine on Postoperative Depression in Patients Undergoing Bariatric Surgery With Preoperative Depression Esketamine, Dexmedetomidine - Depressed, Bariatric Surgery | Phase 4 | Active not recruiting | The First Hospital of Jilin University | 40 | 2026-05-01 | 2026-05-08 |
| Comparing Acupuncture With Medication to Reduce Depression, Anxiety and Comorbid Sleep Disorders in China Psychotropic Drugs, Acupuncture - Anxiety Depression, Sleep | Phase 4 | Recruiting | Duke Kunshan University | 180 | 2026-04-01 | 2026-07-29 |
| Efficacy of Clostridium Butyricum in Alleviating Anxiety and Depression in Patients With Functional Dyspepsia Clostridium butyricum, placebo - Functional Dyspepsia, Probiotics | Phase 4 | Recruiting | Xijing Hospital of Digestive Diseases | 180 | 2026-03-26 | 2026-10-13 |
| Predictors of Improvements in Irritability and Aggression in Children With ADHD Treated With CNS Stimulants CNS Stimulant, Placebo, CNS Stimulant open label first phase - ADHD - Attention Deficit Disorder With Hyperactivity, Irritability | Phase 4 | Recruiting | Milton S. Hershey Medical Center | 136 | 2026-03-05 | 2026-04-20 |
| Discontination of Antidepressants in Remitted Depression Hyperbolic tapering, Linear tapering - Depression - Major Depressive Disorder | Phase 4 | Not yet recruiting | Universita di Verona | 150 | 2026-02-01 | 2026-02-06 |
| Esketamine With or Without Integration Therapy for Treatment-Resistant Depression Esketamine hydrochloride (intranasal), Integration Therapy - Treatment-resistant Depression (TRD) | Phase 4 | Recruiting | University of Puerto Rico | 20 | 2026-02-01 | 2026-01-27 |
| Treatment of Psoriasis With Depression and/or Anxiety With Methotrexate vs Combined Methotrexate and Antidepressant Combination of methotrexate and escitalopram in treatment of psoriasis patients with depression and/or anxiety, Methotrexate - Depression, Anxiety | Phase 4 | Completed | Cairo University | 40 | 2026-02-01 | 2026-10-05 |
| Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients Ketamine, standard general anesthesia - Orthopedic Trauma Surgery Patients, Postoperative Pain | Phase 4 | Recruiting | Texas Tech University Health Sciences Center | 90 | 2025-11-06 | 2026-03-24 |
| Clinical Study of Compound Ciwujia Granules in the Treatment of Depression Compound Ciwujia Granules, placebo - Depression - Major Depressive Disorder, Depression Disorders | Phase 4 | Active not recruiting | Shanghai Mental Health Center | 60 | 2025-10-01 | 2026-04-23 |
| Efficacy of Metformin as an Adjunct to Standard Antidepressant Therapy in Treating Depression Among Obese Patients Metformin Hydrochloride - Depression | Phase 4 | Recruiting | Fazaia Ruth Pfau Medical College | 140 | 2025-10-01 | 2025-09-19 |
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Depression (437) · Depressive Disorder, Major (125) · Psychomotor Agitation (48) · Bipolar Disorder (45) · Anxiety Disorders (42) · Depressive Disorder (38) · Psychotic Disorders (19) · Aggression (17) · Suicidal Ideation (17) · Mood Disorders (16) · Schizophrenia (16) · Suicide (15) · Cognitive Dysfunction (13) · Alzheimer Disease (12) · Depressive Disorder, Treatment-Resistant (12)
Behavior (548) · Mental Disorders (331) · Mood Disorders (185) · Pathological Conditions, Signs and Symptoms (149) · Signs and Symptoms (130) · Depressive Disorder (128) · Nervous System Diseases (128) · Neurologic Manifestations (102) · Neurobehavioral Manifestations (78) · Aberrant Motor Behavior in Dementia (61) · Dyskinesias (50) · Psychomotor Disorders (48) · Bipolar and Related Disorders (45) · Central Nervous System Diseases (42)
Escitalopram (71) · Sertraline (44) · Ketamine (29) · Duloxetine Hydrochloride (28) · Venlafaxine Hydrochloride (26) · Fluoxetine (22) · Citalopram (21) · Bupropion (20) · Sugars (19) · Paroxetine (18) · Saline Solution (18) · Quetiapine Fumarate (16) · Dexmedetomidine (15) · Lithium (12) · Risperidone (12)
New York State Psychiatric Institute (33) · Massachusetts General Hospital (24) · Emory University (16) · University of Pittsburgh (15) · University of California, Los Angeles (14) · Indiana University (11) · University of North Carolina, Chapel Hill (8) · Eli Lilly and Company (7) · National Institute of Mental Health (NIMH) (7) · University of Pennsylvania (7) · University of Texas Southwestern Medical Center (7) · Stanford University (5) · Sunnybrook Health Sciences Centre (5) · University of Cincinnati (5) · Weill Medical College of Cornell University (5)
United States (316) · Canada (38) · China (28) · Germany (16) · Denmark (13) · South Korea (13) · Italy (12) · Israel (11) · France (10) · Netherlands (9) · Australia (8) · Egypt (8) · Spain (7) · Switzerland (7) · Brazil (6)
Amit Anand, MD (8) · David J. Hellerstein, MD (4) · Warren D Taylor, MD, MHSc (4) · Helen Lavretsky, M.D. (3) · Jennifer Felger, PhD (3) · Michael E Henry, MD (3) · Bret Rutherford, MD (2) · Carl Gommoll, MS (2) · Charles Bowden, MD (2)
PMID 33884617, PMID 25080392, PMID 24144505, PMID 26803397, PMID 29608461, PMID 30358242, PMID 30524702, PMID 36999619, PMID 37952772, PMID 40728007, PMID 10074879, PMID 10534584, PMID 11110112, PMID 11442853, PMID 12377400, PMID 12874492, PMID 1438661, PMID 14639062, PMID 14996777, PMID 15800144, PMID 15910213, PMID 15956269, PMID 16009352, PMID 16166403, PMID 16168037, PMID 16247923, PMID 16390886, PMID 16426099, PMID 16457894, PMID 16540613, PMID 16551710, PMID 16554525, PMID 16554526, PMID 16566612, PMID 16566901, PMID 16636629, PMID 16642436, PMID 16690084, PMID 16754414, PMID 16772623, PMID 16816220, PMID 16824617, PMID 16946176, PMID 16946177, PMID 16974189, PMID 17017829, PMID 17074942, PMID 17091129, PMID 17195602, PMID 17229469
2005 (3), 2009 (2), 2018 (2), 5UL1TR001420-03 (2), K23MH067710 (2), K23MH076049 (2), R01MH060353 (2), R01MH061017 (2), R01MH072383 (2), 1KL2RR025015-01 (1), 2008 (1), 2016 (1), 2019 (1), 2023 (1), K01MH095920 (1)