167 completed, 28 unknown, 20 recruiting, 19 terminated. 64 Not applicable, 60 Phase 4, 55 Phase 2, 46 Phase 3, 24 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation of Fluoxetine for Refractory Constipation With Somatic Symptom Disorder Features Fluoxetine, Placebo - Refractory Constipation, Somatic Symptom Disorder (DSM-5) | Phase 2 | Not yet recruiting | Zhifeng Zhao, PhD | 194 | 2026-09-01 | 2026-09-02 |
| Clinical Trials to Evaluate Metformin to Treat Depression in People Living With HIV Metformin, Placebo, Fluoxetine - Depression, Hiv | Phase 2 | Withdrawn | University of Minnesota | 2026-07-01 | 2026-07-10 | |
| Deprescription of Antidepressants in Primary Care (DAPriCare) Deprescription of Antidepressants (fluoxetine, citalopram, sertraline, paroxetine, and escitalopram) - Deprescription, Antidepressants | Early Phase 1 | Not yet recruiting | University of Huelva | 325 | 2026-06-01 | 2026-05-04 |
| Fluoxetine and Understanding Social Experiences Fluoxetine, Placebo - Depression in Adolescence, Antidepressant Activity in Healthy Volunteers | Not applicable | Not yet recruiting | University of Oxford | 80 | 2026-03-01 | 2026-03-06 |
| Dapagliflozin in Depression Fluoxetine, Dapagliflozin - Depression | Phase 1 / Phase 2 | Recruiting | Tanta University | 60 | 2025-11-01 | 2025-11-25 |
| Fluoxetine on Emotional Experience (FLEX) Study Fluoxetine, Placebo - Depression - Major Depressive Disorder, Irritability | Not applicable | Recruiting | University of Oxford | 80 | 2025-10-01 | 2026-02-20 |
| SSRI Antidepressant Fluoxetine Improving Immunotherapy Efficacy in Advanced Hepatobiliary Malignancy Patients With Depression and Anxiety Fluoxetine (drug), Placebo - Hepatobiliary Malignancy, Fluoxetine | Phase 2 | Recruiting | First Affiliated Hospital of Wenzhou Medical University | 240 | 2025-10-01 | 2026-03-24 |
| Disposition Kinetics of Dolutegravir Among People Living With HIV With Major Depression in Nigeria Fluoxetine, Cognitive-behavioral therapy - Depression, HIV | Phase 4 | Not yet recruiting | University of Ibadan | 168 | 2025-08-14 | 2025-08-08 |
| Magnesium Supplementation With Fluoxetine for Cognitive Function in Depression Fluoxetine (drug), Magnesium - Major Depressive Disorder (MDD) | Not applicable | Completed | Hasanuddin University | 40 | 2025-07-01 | 2026-04-09 |
| The Friendship Bench Plus Trial Fluoxetine, Sertraline Pill, Friendship Bench Intervention- Problem Solving Therapy - Major Depressive Disorder, Severe Depressive Episode Without Psychotic Symptoms | Not applicable | Recruiting | University of Bern | 296 | 2025-06-26 | 2025-11-20 |
| Identifying and Treating Depression in the Orthopaedic Trauma Population Fluoxetine 20 MG, Duloxetine 30 MG, Observation - Depression | Phase 4 | Recruiting | Wake Forest University Health Sciences | 100 | 2025-06-25 | 2026-05-22 |
| Effect of Exercise on Tapering Antipsychotics in Patients With Psycho-cardiological Disease(EXTRA-study) Moderate-intensity continuous movement and Antipsychotics intervention, Antipsychotics intervention(sertraline, escitalopram, fluoxetine, duloxetine, paroxetine, venlafaxine, and fluvoxamine) - Cardiovascular Diseases (CVD), Depression Anxiety Disorder | Not applicable | Recruiting | Guangdong Provincial People's Hospital | 106 | 2025-04-22 | 2025-06-17 |
| TDM-Guided Treatment With SSRIs in Hospitalized Adults and Children Fluoxetine, Escitalopram, Sertralin - Depression - Major Depressive Disorder, Depressive Episodes | Phase 4 | Recruiting | Poznan University of Medical Sciences | 180 | 2025-04-03 | 2026-03-18 |
| Fluoxetine for the Modification of Colorectal Tumor Immune Cells Before Surgery in Patients With Colorectal Cancer Fluoxetine - Colorectal Adenocarcinoma | Phase 1 | Recruiting | Jonsson Comprehensive Cancer Center | 10 | 2025-03-20 | 2026-08-20 |
| Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients Fluoxetine, Roflumilast, Placebo - Depressive Disorder, Major | Phase 3 | Recruiting | Tanta University | 60 | 2025-03-01 | 2026-05-04 |
| Neurobiological and Genomic Predictors of Relapse in Depression Antidepressant Medications - Healthy, Major Depressive Disorder (MDD) | Recruiting | Mehmet Kemal Arikan | 204 | 2025-01-01 | 2026-01-09 | |
| Psilocybe Cubensis Mushrooms With or Without Fluoxetine for Refractory Depression Psilocybin and Psilocyn, Placebo, Psychotherapy-assisted session - Depressive Disorder | Phase 1 / Phase 2 | Recruiting | Federal University of Latin American Integration | 24 | 2024-09-05 | 2026-03-27 |
| Precision Psychiatry for Depression: Immune Response and Affective Symptoms as Predictors of Response to Antidepressants SSRI - Depression, Inflammation | Completed | Germans Trias i Pujol Hospital | 50 | 2024-04-01 | 2026-09-14 | |
| Improving Outcomes in Depression in Primary Care in a Low Resource Setting Healthy Activity Program (HAP), Antidepressant medication (fluoxetine) - Depression, Depressive Disorder | Phase 3 | Active not recruiting | Harvard Medical School (HMS and HSDM) | 1500 | 2024-03-18 | 2026-05-22 |
| Can Immediate Post-injury Fluoxetine Improve the Recovery Trajectories of Victims in Bodily Trauma? Fluoxetine, Placebo - Musculoskeletal Injury | Phase 4 | Recruiting | University of Florida | 200 | 2024-03-01 | 2026-04-13 |
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Eli Lilly and Company (12) · New York State Psychiatric Institute (10) · University of Pittsburgh (7) · Shanghai Mental Health Center (6) · University of Texas Southwestern Medical Center (6) · Massachusetts General Hospital (5) · National Institute of Mental Health (NIMH) (4) · University of California, Los Angeles (4) · University of Minnesota (4) · University of Oxford (4) · University of Pennsylvania (4) · Cairo University (3) · Emory University (3) · Forest Laboratories (3) · Sandoz (3)
United States (126) · China (21) · France (13) · Canada (12) · Mexico (10) · Egypt (9) · Brazil (8) · Germany (7) · Spain (6) · India (5) · Poland (5) · Russia (5) · South Africa (5) · South Korea (5) · Taiwan (5)
Beth D. Kennard, PsyD (2) · Cynthia N Epperson, MD (2) · Dr. James John, MBBS, MD (2) · Eric Hollander, MD (2) · Graham J. Emslie, MD (2) · James D Carlson, Pharm.D. (2) · Linmarie Sikich, MD (2) · Meredith Gunlicks-Stoessel, PhD (2) · Qingchuan Zhao, Prof. (2) · Roderick Malone, M.D. (2) · Zhang-Jin Zhang, MMed, PhD (2) · Ahmed Abdelhalem (1) · Ahmed Elsayem, MD (1)
PMID 37811711, PMID 19578654, PMID 20973714, PMID 21095016, PMID 24643964, PMID 25978741, PMID 33884617, PMID 38700708, PMID 10990547, PMID 11063978, PMID 11723286, PMID 11806859, PMID 12244081, PMID 12649628, PMID 12874492, PMID 12949224, PMID 1438661, PMID 14627997, PMID 14639062, PMID 14677403, PMID 15147306, PMID 15315995, PMID 15351385, PMID 15365580, PMID 15602505, PMID 15608541, PMID 15729083, PMID 15910213, PMID 15987799, PMID 16002441, PMID 16086624, PMID 16585452, PMID 16772623, PMID 16794566, PMID 16946178, PMID 17014022, PMID 17135984, PMID 17135985, PMID 17135986, PMID 17135987, PMID 17135988, PMID 17135989, PMID 17295567, PMID 17335320, PMID 17414235, PMID 17450048, PMID 17475735, PMID 17591596, PMID 17657327, PMID 17907854
2008 (4), R01MH039188 (2), R01MH061017 (2), 2005 (1), 2015 (1), 2016 (1), 2018 (1), K24MH121571 (1), K43TW011995 (1), P01GM032165 (1), P20AA015630 (1), R01AA013370 (1), R01AA015173 (1), R01AR045416 (1), R01DA006234 (1)