135 completed, 36 unknown, 24 not yet recruiting, 22 recruiting. 172 Not applicable, 20 Phase 4, 19 Phase 3, 7 Phase 2, 2 Early Phase 1.
Follow Pain, Procedural: new trials by email Literature Review of Pain, Procedural trials Research Report on Pain, Procedural
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| VR-PAT and fNIRS to Identify CNS Biomarkers of Pain VR-PAT - Acute Pain, Pediatric ALL | Not applicable | Not yet recruiting | Nationwide Children's Hospital | 4 | 2027-07-01 | 2026-09-09 |
| E-MOHS Trial of TENS and Vibration During Local Anesthesia Active Vibration:TENS, Sham TENS - Pain, Procedural Pain | Not applicable | Not yet recruiting | University of Minnesota | 90 | 2027-01-01 | 2026-10-06 |
| Pain Control During Hysterosalpingography: A Three-Arm Randomized Trial Indomethacin 100Mg Suppository, Lidocaine %2 ampoule - Hysterosalpingography-Related Pain | Phase 4 | Not yet recruiting | Balikesir University | 180 | 2026-11-01 | 2026-10-15 |
| LI4 Acupuncture for Pain During Intrauterine Device Insertion LI4 Acupuncture, Sham Acupuncture - Pain Associated With Intrauterine Device Insertion | Not applicable | Not yet recruiting | Nigde Omer Halisdemir University | 150 | 2026-10-15 | 2026-10-02 |
| Natural Sound Therapy on Procedural Pain and Anxiety During Negative Pressure Wound Therapy Dressing Changes Personalized Natural Sound Therapy, Standardized Natural Sound Therapy - Pain, Anxiety | Not applicable | Not yet recruiting | University of Basrah | 150 | 2026-10-11 | 2026-10-02 |
| Virtual Reality (VR) Audiovisual Distraction to Reduce Pain and Anxiety for Prone Pain Procedures Virtual Reality (VR) Audiovisual Distraction - Procedural Pain, Procedural Anxiety | Not applicable | Not yet recruiting | University of California, Davis | 230 | 2026-10-01 | 2026-08-21 |
| Crochet Octopus in Reducing Procedural Pain During Heel Lance in Preterm Neonates Crochet Octopus - Preterm Neonates, Heel Lance Procedures | Not applicable | Not yet recruiting | Mansoura University | 98 | 2026-10-01 | 2026-09-23 |
| Stress-Ball Distraction for Pain and Anxiety During Painful Procedures in Critically Ill Patients Stress-Ball Distraction, Standard care - Procedural Pain | Not applicable | Not yet recruiting | Alexandria University | 104 | 2026-09-30 | 2026-09-23 |
| Virtual Reality for Pain and Anxiety During HyFoSy virtual reality, rest - Infertility | Not applicable | Not yet recruiting | HaEmek Medical Center, Israel | 68 | 2026-09-15 | 2026-09-11 |
| Cold Spray and Helfer Skin Tap for Pain During Infant Vaccination Cold spray, Helfer Skin Tap Technique - Procedural Pain, Vaccination Pain | Not applicable | Not yet recruiting | Hitit University | 120 | 2026-09-15 | 2026-08-21 |
| The Effect of Using a Stress Ball on Pain, Anxiety, and Vital Signs During Breast Biopsy Using a Stress Ball - Breast Biopsy, Procedural Pain | Not applicable | Recruiting | TC Erciyes University | 53 | 2026-09-11 | 2026-09-28 |
| Fentanyl Intranasal for Retinopathy of Prematurity Screening in Preterm Infants Fentanyl Citrate (Intranasal), Normal Saline (Placebo, Intranasal) - Neonatal Pain, Retinopathy of Prematurity (ROP) | Phase 1 / Phase 2 | Not yet recruiting | Marsha Campbell-Yeo | 58 | 2026-09-09 | 2026-06-30 |
| Non-Wearable Audiovisual Distraction for Children's Medical Anxiety in the ED Non-Wearable Audiovisual Distraction, Routine ED Care - Pediatric Anxiety | Not applicable | Not yet recruiting | National Taiwan University Hospital | 90 | 2026-09-01 | 2026-08-12 |
| TEAS for Sedation During ERCP: A Multicenter Trial With Mechanistic Substudy TEAS + Conscious Sedation, Sham TEAS + Conscious Sedation - Endoscopic Retrograde Cholangiopancreatography, Conscious Sedation Adverse Event | Not applicable | Not yet recruiting | Beijing 302 Hospital | 130 | 2026-09-01 | 2026-06-16 |
| TENS During Transperineal Prostate Biopsy Transcutaneous Electrical Nerve Stimulation (TENS), Sham Transcutaneous Electrical Nerve Stimulation - Prostate Cancer (Diagnosis), Prostate Biopsy | Not applicable | Recruiting | Medical University of Gdansk | 140 | 2026-08-12 | 2026-08-13 |
| Virtual Reality for Pain and Fear in Children With Burns Virtual Reality (VR) Distraction, Standard Burn Dressing Care - Burns, Pain, Procedural | Not applicable | Not yet recruiting | Mansoura University | 80 | 2026-08-01 | 2026-08-03 |
| Pretibial TENS for Pain and Anxiety During Intravesical OnabotulinumtoxinA Injection Active Pretibial TENS, Sham Pretibial TENS - Overactive Bladder (OAB), Botulinum Toxin Injection | Not applicable | Not yet recruiting | Başakşehir Çam & Sakura City Hospital | 68 | 2026-07-20 | 2026-07-16 |
| Effect of 4-7-8 Breathing on AV Fistula Needle Pain in Dialysis Patients Breathing technique - Chronic Kidney Diseases, Pain, Procedural | Not applicable | Not yet recruiting | Izmir Kavram Vocational School | 80 | 2026-07-20 | 2026-07-15 |
| Effects of Robotic Pet and Video-Based Distraction on Pain, Fear, and Anxiety in Children During Venipuncture Robotic Pet-Based Distraction, Video-Based Distraction - Procedural Pain, Anxiety | Not applicable | Completed | Akdeniz University | 90 | 2026-07-13 | 2026-08-19 |
| Use of VR for Diagnostic Hysteroscopy Immersive Virtual Reality Distraction (IVR), Hypno-Virtual Reality Distraction (HVR), Usual Care Group - Hysteroscopy, Anxiety | Not applicable | Recruiting | St. Justine's Hospital | 45 | 2026-07-08 | 2026-09-21 |
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Pain (63) · Anxiety Disorders (43) · Agnosia (30) · Acute Pain (26) · Burns (10) · Neoplasms (6) · Pain, Postoperative (6) · Patient Satisfaction (6) · Deafness, Autosomal Recessive 1A (5) · Arteriovenous Fistula (4) · Emergencies (4) · Premature Birth (4) · Iatrophobia (3) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (3)
Neurologic Manifestations (229) · Pathological Conditions, Signs and Symptoms (229) · Signs and Symptoms (229) · Pain (166) · Mental Disorders (46) · Nervous System Diseases (34) · Neurobehavioral Manifestations (33) · Perceptual Disorders (30) · Pathologic Processes (22) · Wounds and Injuries (14) · Behavior (13) · Urogenital Diseases (12) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (11) · Disease Attributes (9) · Female Urogenital Diseases and Pregnancy Complications (9)
Lidocaine (8) · Music Therapy (6) · Fentanyl (5) · Ketamine (4) · Standard of Care (4) · Sucrose (4) · Epinephrine (3) · Kangaroo-Mother Care Method (3) · Ropivacaine (3) · Saline Solution (3) · Transcutaneous Electric Nerve Stimulation (3) · Acupressure (2) · Control Groups (2) · Cryotherapy (2) · Dexmedetomidine (2)
St. Justine's Hospital (9) · IRCCS Burlo Garofolo (7) · Istanbul Medeniyet University (5) · Akdeniz University (4) · Kaohsiung Medical University Chung-Ho Memorial Hospital (4) · Marmara University (4) · Mersin University (4) · Nationwide Children's Hospital (4) · University Hospital, Clermont-Ferrand (4) · AlgoRx Pharmaceuticals (3) · Erzincan Binali Yildirim Universitesi (3) · Hakkari Universitesi (3) · Istanbul University (3) · Aynur Aytekin Ozdemir (2) · Bandırma Onyedi Eylül University (2)
Turkey (Türkiye) (72) · United States (40) · Canada (16) · France (10) · Italy (10) · Egypt (6) · Taiwan (6) · Spain (5) · China (4) · Switzerland (4) · Denmark (3) · Pakistan (3) · Sweden (3) · Greece (2) · India (2)
Egidio Barbi, MD (5) · Sylvie Le May, PhD (4) · Franca Crevatin, RN (2) · Giorgio Cozzi, MD (2) · Henry Xiang, MD, MPH, PhD, MBA (2) · Lisa M Einhorn, MD (2) · Sylvie Le May, RN, PhD (2) · William Zempsky, MD (2) · Zeynep Erkut, PhD (2) · Abhishek Sharma, BPT (1) · Agostino Guarino, RN (1)
PMID 33485746, PMID 10915627, PMID 11994056, PMID 15278085, PMID 16330518, PMID 16428010, PMID 16580851, PMID 16925535, PMID 18245406, PMID 18299545, PMID 18385262, PMID 18387963, PMID 18450903, PMID 19482767, PMID 19505775, PMID 20003351, PMID 20137814, PMID 21806301, PMID 22374882, PMID 22926182, PMID 23057434, PMID 23957021, PMID 24108531, PMID 24262016, PMID 24300226, PMID 24696691, PMID 24918475, PMID 25504956, PMID 25551218, PMID 25555856, PMID 25998310, PMID 26164784, PMID 26401633, PMID 26630545, PMID 26755209, PMID 27112434, PMID 27409593, PMID 28285862, PMID 28368368, PMID 28779961, PMID 28890146, PMID 29290273, PMID 29547610, PMID 29559294, PMID 30153126, PMID 30205934, PMID 30486427, PMID 30555754, PMID 30782698, PMID 30971304
2014 (1), 2016 (1), 2019 (1), R44HD056647 (1)