110 completed, 25 terminated, 14 unknown, 13 recruiting. 65 Phase 4, 33 Phase 2, 32 Phase 3, 27 Not applicable, 14 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Methadone as an Alternative Treatment for Children Underdoing HSCT PCA plus methadone (Experimental), PCA Alone (SOC) - Leukemia, Aplastic Anemia | Phase 3 | Suspended | University of Texas Southwestern Medical Center | 60 | 2028-01-01 | 2025-10-23 |
| Mechanistic Evaluation of Polypharmacy Effects for Pain Within-subject test of blinded study medications (Placebo, Hydromorphone, Gabapentin) - Chronic Lower Back Pain (CLBP) | Phase 1 / Phase 2 | Not yet recruiting | University of Maryland, Baltimore | 110 | 2027-01-15 | 2026-09-29 |
| An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service TPS-Select, Pharmacologic Pain Management, Interventional Pain Procedures - Postsurgical Pain Management, Postsurgical Pain, Chronic | Phase 3 | Not yet recruiting | University of California, San Francisco | 474 | 2026-10-01 | 2026-10-09 |
| Epidural Analgesia Versus Opioid-sparing Analgesia for Open Ventral Hernia Repair With Transversus Abdominis Release Bupivicaine, Fentanyl, Thoracic epidural analgesia - Ventral Hernia, Ventral Hernia Repair | Phase 4 | Recruiting | Northwestern University | 40 | 2026-09-25 | 2026-10-07 |
| Buprenorphine for Analgesia in Older Adults With Acute Fractures in the Emergency Department Buprenorphine 0.15 MG, Hydromorphone 0.25 mg IV - Fracture | Phase 1 / Phase 2 | Recruiting | The Cooper Health System | 48 | 2026-05-07 | 2026-06-29 |
| Clinical Practice of Hydromorphone in Multimodal Analgesia for Enhanced Recovery After Surgery (ERAS) in Knee Arthroplasty Hydromorphone, Ropivacaine - VAS Score, Quadriceps Strength | Not applicable | Completed | China-Japan Friendship Hospital | 90 | 2026-03-10 | 2026-07-27 |
| Intrathecal Hydromorphone vs Intrathecal Morphine to Treat Post Cesarean Pain in Patients With Opioid Use Disorder Taking Buprenorphine Morphine, Bupivacaine, Fentanyl - Opioid Use Disorder | Phase 4 | Withdrawn | University of North Carolina, Chapel Hill | 2026-02-01 | 2026-03-09 | |
| Fentanyl Versus Hydromorphone in Patients on Mechanical Ventilation fentanyl, Hydromorphone - Mechanical Ventilation, Sedation and Analgesia | Phase 2 | Completed | Beth Israel Deaconess Medical Center | 319 | 2025-11-03 | 2026-07-14 |
| Reducing Pain With Methadone and Ketamine in Liver Transplant Methadone, ketamine, Hydromorphone - Liver Transplantation | Phase 4 | Completed | Lahey Clinic | 50 | 2025-06-30 | 2026-08-11 |
| Optimizing Perioperative Analgesia to Lower Pain Following Cleft Palate Surgery Methadone hydrochloride, Fentanyl/Hydromorphone - Cleft Palate, Pain | Phase 4 | Recruiting | Duke University | 60 | 2025-06-04 | 2026-04-14 |
| Hydromorphone Hydrochloride Epidural Preemptive Analgesia for Postoperative Pain After Cesarean Section Hydromorphone hydrochloride low dose, Hydromorphone hydrochloride high dose, 0.9% sodium chloride - Post-surgical Pain | Phase 4 | Completed | Liquan Liang | 105 | 2025-03-03 | 2025-09-05 |
| Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial NSAID, Opioid, Acetaminophen - Surgery, Pain, Post Operative | Phase 4 | Recruiting | University of Michigan | 900 | 2025-01-10 | 2026-10-20 |
| Intravenous Hydromorphone for the Treatment of Acute Pain Hydromorphone - Acute Chest Pain | Phase 1 / Phase 2 | Recruiting | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 30 | 2025-01-01 | 2025-11-17 |
| Optimization of Pediatric Tonsillectomy to IMprove AnaLgesia Methadone, Fentanyl/Hydromorphone - Pain, Postoperative, Tonsillar Hypertrophy | Phase 4 | Recruiting | Duke University | 440 | 2024-11-21 | 2025-12-05 |
| Personalized Post-Operative Pain Management PGx guided personalized post-operative pain management, Oxycodone, Hydromorphone - Persistent Post Operative Opioid Use, Post-surgical Pain | Phase 4 | Active not recruiting | University of Tennessee Graduate School of Medicine | 208 | 2024-09-25 | 2024-11-01 |
| Ketamine for Sedation in Severe Traumatic Brain Injury Ketamine with propofol, Standard of Care propofol, fentanyl, dexmedetomidine, morphine, hydromorphone, midazolam, or lorazepam - Severe Traumatic Brain Injury, Intracranial Hypertension | Phase 4 | Suspended | Henry M. Jackson Foundation for the Advancement of Military Medicine | 50 | 2024-09-23 | 2025-07-14 |
| Methadone Versus Intrathecal Hydromorphone for Postoperative Pain Relief in Gynecologic Cancer Undergoing Surgery Hydromorphone, Methadone, Questionnaire Administration - Malignant Female Reproductive System Neoplasm | Phase 4 | Recruiting | Mayo Clinic | 140 | 2024-09-03 | 2026-03-04 |
| Enhanced Recovery After Surgery-Based Multimodal Preemptive Analgesia for Perioperative Management in Transarterial Chemoembolization of Intermediate-to-Advanced Hepatocellular Carcinoma hydrochloride hydromorphone + flurbiprofen axetil, conventional analgesia - Enhanced Recovery After Surgery, Multimodal Analgesia | Phase 4 | Completed | First Affiliated Hospital, Sun Yat-Sen University | 129 | 2024-08-01 | 2026-01-02 |
| Drug-Drug Interaction and Safety of AZD4041 Study (Part 1) and Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of AZD4041 Study in Opioid Use Disorder (Part 2). AZD4041, Itraconazole, Buprenorphine - Opioid Use Disorder | Phase 1 | Terminated | AstraZeneca | 15 | 2024-05-13 | 2025-03-26 |
| Rectus Sheath Block With Liposomal Bupivacaine Versus Thoracic Epidural Analgesia for Pain Control Following Pancreatoduodenectomy Bupivacaine, Hydromorphone, Iopamidol - Duodenal Neoplasm, Pancreatic Neoplasm | Phase 2 | Recruiting | Masonic Cancer Center, University of Minnesota | 78 | 2023-11-10 | 2026-02-03 |
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Pain (45) · Pain, Postoperative (32) · Agnosia (23) · Acute Pain (17) · Emergencies (16) · Opioid-Related Disorders (16) · Labor Pain (5) · Neoplasms (5) · Cancer Pain (4) · Chronic Pain (4) · Nausea (4) · Respiratory Insufficiency (4) · Anemia, Sickle Cell (3) · Heroin Dependence (3) · Postoperative Nausea and Vomiting (3)
Montefiore Medical Center (15) · Duke University (8) · Mayo Clinic (8) · M.D. Anderson Cancer Center (5) · Endeavor Health (3) · Johns Hopkins University (3) · National Institute on Drug Abuse (NIDA) (3) · Northwestern University (3) · University of British Columbia (3) · University of California, San Francisco (3) · University of Erlangen-Nürnberg Medical School (3) · Albert Einstein College of Medicine (2) · Brigham and Women's Hospital (2) · Columbia University (2) · Emory University (2)
United States (120) · Canada (20) · China (19) · Germany (3) · South Korea (2) · Austria (1) · Italy (1) · Poland (1) · Spain (1) · Switzerland (1) · Taiwan (1)
Andrew K Chang, MD (4) · Glenn S Murphy, MD (3) · Andrew Chang, M.D. (2) · Grant C Lynde, MD (2) · Mark Greenwald, PhD (2) · Min Yan, Doctor (2) · Na Li, MD (2) · Yar Yeap, MD (2) · Adam Jacob, MD (1) · Adam W Amundson, MD (1) · Adrienne Birnbaum, MD (1) · Akhila S Reddy (1) · Alex Grunfeld, MD (1) · Alina Beaton, MD (1)
PMID 22339949, PMID 25630964, PMID 25911999, PMID 10928310, PMID 15151094, PMID 15791113, PMID 18806056, PMID 19135997, PMID 19209273, PMID 19331993, PMID 19338859, PMID 19535182, PMID 20173643, PMID 20588151, PMID 20890791, PMID 21102969, PMID 21467190, PMID 21562420, PMID 22008309, PMID 22079773, PMID 22357901, PMID 22524979, PMID 23221859, PMID 23379573, PMID 23406078, PMID 23846749, PMID 24519631, PMID 24937669, PMID 25077099, PMID 25619263, PMID 26079353, PMID 26286816, PMID 26650971, PMID 26797808, PMID 26827847, PMID 26897453, PMID 27049826, PMID 27529160, PMID 27547910, PMID 27555162, PMID 28002229, PMID 28526048, PMID 28648803, PMID 29046364, PMID 29605036, PMID 29687077, PMID 29934395, PMID 30119941, PMID 30290794, PMID 30344172
K23DA029609 (2), K23AG033100 (1), P30CA077598 (1), R01DA002812 (1), R01DA015462 (1), R01DA018125 (1), R01DA042985 (1), R01DA052937 (1), R01DA061796 (1), R01HD114678 (1), R33DA049130 (1), U24HL137907 (1), UL1TR002345 (1)