134 completed, 37 unknown, 15 recruiting, 14 not yet recruiting. 71 Not applicable, 52 Phase 4, 28 Phase 3, 20 Phase 1, 18 Phase 2.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Prospective Multicenter Registry Study of Sedation and Analgesia in Critically Ill Patients Not applicable- observational study - Sedation, Analgesia Assessment | Enrolling by invitation | Beijing Chao Yang Hospital | 2000 | 2027-01-01 | 2026-10-21 | |
| The Impact of Long-term High-risk Drinking on the Effective Dose of Osselidin long-term high-risk drinking, non-drinking - Sedation | Not applicable | Not yet recruiting | Affiliated Hospital of Jiaxing University | 110 | 2026-10-15 | 2026-10-19 |
| Efficacy and Safety of Nasopharyngeal Tube During Sedation nasopharyngeal tube, regular cannula - Sedation in Non-intubated Diagnostic and Therapeutic Procedures, Sedation | Not applicable | Not yet recruiting | International Peace Maternity and Child Health Hospital | 160 | 2026-10-08 | 2026-10-19 |
| Dexametedomidine Ketamine Infusion Versus Dexametedomidine Propofol Infusion in Non-compliant Agitated Patients on Continuous Positive Airway Pressure (CPAP) Mask Ventilation in the Intensive Care Unit Group DK will receive dexmedetomidine (0.2-1.4 μg/kg/hour) and ketamine (0.5 mg/kg/hr)., Group KP will receive dexmedetomidine (0.2-1.4 μg/kg/hour) and propofol (2-4 mg/kg/hr).( - CPAP Ventilation, Sedation | Not applicable | Not yet recruiting | Ain Shams University | 100 | 2026-10-01 | 2026-10-22 |
| Effects of Low-Dose Ketamine Added to Propofol Sedation During Colonoscopy Propofol group, Propofol + Ketamine - Colonoscopy Procedures, Sedation | Not applicable | Not yet recruiting | Ankara Etlik City Hospital | 100 | 2026-09-14 | 2026-09-09 |
| High-Flow Nasal Oxygyen Therapy During Sedated Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration(EBUS-TBNA) High-Flow Nasal Oxygen Therapy, Conventional Oxygen Therapy - High Flow Oxygen Therapy, ENDOBRONCHIAL ULTRASOUND - TRANSBRONCHIAL NEEDLE ASPIRATION | Completed | Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital | 120 | 2026-08-20 | 2026-10-28 | |
| Effect of Maternal Voice on Pain, Sedation, and Physiological Parameters in Mechanically Ventilated Children Recorded Maternal Voice - Pain, Sedation | Not applicable | Not yet recruiting | TC Erciyes University | 28 | 2026-08-15 | 2026-08-10 |
| The Use of Remimazolam Versus Dexmedetomidine for Patients Receiving Drug-Induced Sleep Endoscopy Remimazolam, Dexmedetomidine - OSAS (Obstructive Sleep Apneas Syndrome), DISE | Not applicable | Not yet recruiting | Fu Jen Catholic University Hospital | 60 | 2026-08-05 | 2026-08-12 |
| Remimazolam Combined With Oliceridine for Sedation in Elderly Patients Undergoing Gastrointestinal Endoscopy Remimazolam Tosilate for Injection, Oliceridine Fumarate - Sedation, Gastrointestinal Endoscopy | Not applicable | Completed | Baoshan Branch, Renji Hospital, Shanghai Jiao Tong University School of Medicine | 240 | 2026-07-17 | 2026-11-03 |
| Prospective Multicentre Observational Registry of Peri-procedural Anaesthesia, Sedation and Related Medication Exposure in Patients With Brugada Syndrome Brugada Syndrome (BrS), Ventricular Arrhythmia | Recruiting | Hospital Clinic of Barcelona | 200 | 2026-07-15 | 2026-09-08 | |
| Neonatal Neurological Observation With Video AI Continuous bedside video monitoring with AI anatomic landmark tracking for neurologic monitoring - Neonatal Encephalopathy, Hypoxic-Ischemic Encephalopathy | Recruiting | Artemis AI Labs | 200 | 2026-07-13 | 2026-07-15 | |
| Opioid-Free Versus Opioid-Based Sedation for Endoscopic Procedures Dexmedetomidine, Remifentanil - Sedation, Endoscopy | Not applicable | Not yet recruiting | Bakirkoy Dr. Sadi Konuk Research and Training Hospital | 80 | 2026-06-01 | 2026-06-16 |
| Sedation Safety Assessment Using IPI Monitoring in Pediatric Hematologic Procedures Deep Sedation with IPI and BIS Monitoring - Sedation, Pediatric | Completed | Ankara City Hospital Bilkent | 80 | 2026-04-01 | 2026-07-29 | |
| EEG Signal Correlates During Anesthesia and Sedation in Adults and Children Anesthesia, Sedation | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 330 | 2026-03-15 | 2026-03-10 | |
| Sedation During Endoscopy Using Remimazolam: Efficacy in a Novel Exploration Remimazolam, Propofol - Anesthesia, Sedation | Phase 3 | Completed | Massachusetts General Hospital | 100 | 2026-03-03 | 2026-09-14 |
| Effect of IV Lidocaine on Duodenal Peristalsis and Sedation in ERCP Lidocaine Hydrochloride 2%, 0.9 % Normal Saline - Duodenal Spasm, ERCP | Phase 4 | Completed | Ankara City Hospital Bilkent | 120 | 2026-02-11 | 2026-04-08 |
| Safety Exploration and Evaluation of Dexmedetomidine Hydrochloride Nasal Spray for Pre-anesthesia Sedation in Low-Monitoring Settings Dexmedetomidine hydrochloride nasal spray, Placebo - Dexmedetomidine, Sedation | Phase 4 | Not yet recruiting | Sichuan Provincial People's Hospital | 564 | 2026-01-10 | 2025-12-23 |
| End-of-life Care in Mechanically Ventilated Patients: Impact of a Comprehensive Palliative Care Protocol in the Intensive Care Setting Protocol for palliative care and life-support withdrawal - Palliative Care, Withdrawal of Life Support | Not applicable | Not yet recruiting | Nantes University Hospital | 720 | 2026-01-10 | 2026-01-26 |
| Children of Age 2-6years Undergoing Elective Surgery Will be Divided Into Two Groups Randomly. This Study Aims to Evaluate if Intranasal Dexmedetomidine is Better Than Intranasal Ketamine in Producing Sedation and Reducing Parent Separation Anxiety Before Surgery. Intranasal dexmedetomidine, Intranasal ketamine - Sedation, Preoperative Anxiety Experienced by the Pediatric Patient | Phase 1 / Phase 2 | Not yet recruiting | Liaquat National Hospital & Medical College | 60 | 2026-01-01 | 2025-09-18 |
| The Effect of Reversal of Remimazolam Sedation With Flumazenil on Cognitive Function in Patients Undergoing Hip Arthroplasty Under Spinal Anesthesia remimazolam sedation reversal with flumazenil, placebo - Postoperative Delirium, Sedation | Phase 4 | Not yet recruiting | Medical University of Gdansk | 150 | 2026-01-01 | 2026-01-06 |
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Agnosia (13) · Pain (12) · Anxiety Disorders (9) · Delirium (9) · Critical Illness (7) · Hypoxia (5) · Personal Satisfaction (4) · Respiratory Aspiration (3) · Respiratory Insufficiency (3) · Arrhythmias, Cardiac (2) · Bradycardia (2) · Burns (2) · COVID-19 (2) · Cataract (2) · Emergence Delirium (2)
Pathological Conditions, Signs and Symptoms (49) · Signs and Symptoms (38) · Neurologic Manifestations (29) · Nervous System Diseases (25) · Mental Disorders (22) · Neurobehavioral Manifestations (21) · Pathologic Processes (20) · Respiratory Tract Diseases (14) · Perceptual Disorders (13) · Confusion (11) · Neurocognitive Disorders (11) · Behavior (10) · Disease Attributes (10) · Respiration Disorders (9) · Cardiovascular Diseases (7)
Dexmedetomidine (58) · Propofol (48) · Midazolam (35) · Ketamine (19) · Fentanyl (16) · Remifentanil (14) · HSK3486 (9) · remimazolam (9) · Lidocaine (8) · Sodium Chloride (6) · Isoflurane (5) · (2-(1R)-1-cyclopropyl)ethyl-6-isopropyl-phenol (4) · Chloral Hydrate (4) · Saline Solution (4) · Alfentanil (3)
Sichuan Haisco Pharmaceutical Group Co., Ltd (11) · Ankara City Hospital Bilkent (8) · Assiut University (6) · Changhai Hospital (5) · Hospira, now a wholly owned subsidiary of Pfizer (5) · Jiangsu HengRui Medicine Co., Ltd. (5) · Sedana Medical (5) · Massachusetts General Hospital (4) · Pfizer (4) · University of Wisconsin, Madison (4) · Cairo University (3) · Helsinki University Central Hospital (3) · Hennepin Healthcare Research Institute (3) · Seoul National University Hospital (3) · Shandong University (3)
United States (48) · China (41) · Turkey (Türkiye) (23) · Egypt (15) · France (11) · South Korea (8) · Spain (8) · Canada (6) · Finland (6) · Germany (6) · Japan (5) · Switzerland (5) · Italy (4) · Israel (3) · Lebanon (3)
Hala S Abdelghaffar, MD (2) · Huacheng Liu (2) · James R Miner, MD (2) · Peter Sackey, MD, PhD (2) · Susan J Dempsey, PhD(c) (2) · Yuhang Cai (2) · Achim J Schmitz, MD (1) · Amr Gaber (1) · Amy R Deipolyi, M.D., Ph.D. (1)
PMID 27671621, PMID 10360845, PMID 11719318, PMID 11797025, PMID 12421743, PMID 15460178, PMID 15920188, PMID 16387935, PMID 16573781, PMID 16694380, PMID 17102966, PMID 18465717, PMID 18492267, PMID 19003534, PMID 19869306, PMID 20225074, PMID 20586747, PMID 20624140, PMID 21040558, PMID 2105779, PMID 21233500, PMID 21304242, PMID 21318594, PMID 21926576, PMID 21965374, PMID 22030215, PMID 22190555, PMID 22964265, PMID 23223772, PMID 23263584, PMID 23607840, PMID 23701339, PMID 24199628, PMID 24238862, PMID 24614374, PMID 24893689, PMID 24935517, PMID 24949994, PMID 25460022, PMID 25493968, PMID 25840875, PMID 26039810, PMID 26363333, PMID 26420017, PMID 2689263, PMID 26926644, PMID 27210780, PMID 27522443, PMID 27626706, PMID 28137820
2009 (1), 2018 (1), 2019 (1), K23GM068842 (1)