21 completed, 2 suspended, 2 unknown, 1 active not recruiting. 28 Phase 3, 5 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 28 | Completed 21, Suspended 2, Unknown 2, Active not recruiting 1, Recruiting 1, Terminated 1 |
| Phase 2 | 5 | Completed 3, Suspended 2 |
Follow Sedation: new trials by email Literature Review of Sedation trials Research Report on Sedation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sedation During Endoscopy Using Remimazolam: Efficacy in a Novel Exploration Remimazolam, Propofol - Anesthesia, Sedation | Phase 3 | Completed | Massachusetts General Hospital | 100 | 2026-03-03 | 2026-09-14 |
| Effect of Remimazolam Sedation on Outcomes of Mechanically Ventilated Patients in the ICU Remimazolam, propofol - Remimazolam Besylate, Mechanically Ventilated ICU Patients | Phase 3 | Recruiting | Southeast University, China | 80 | 2025-04-01 | 2026-05-19 |
| The Effect of Music on the Sedation Quality Among Children in the Emergency Department. Music intervention - Sedation | Phase 3 | Completed | Tehran University of Medical Sciences | 88 | 2025-03-31 | 2025-12-08 |
| Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensive Care Unit Adult Patients (INSPiRE-ICU2) Isoflurane, Propofol - Sedation | Phase 3 | Completed | Sedana Medical | 282 | 2022-06-30 | 2026-03-24 |
| Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensive Care Unit Adult Patients (INSPiRE-ICU1) Isoflurane, Propofol, Isoflurane (run-ins) - Sedation | Phase 3 | Completed | Sedana Medical | 277 | 2022-04-28 | 2026-03-24 |
| A Pooled Analysis of Long-Term Outcomes After Inhaled Isoflurane Via the Sedaconda ACD-S Compared to Intravenous Propofol Inhaled isoflurane administered by Sedaconda ACD-S, Intravenous infusion of propofol - Post-Intensive Care Syndrome, Sedation | Phase 3 | Active not recruiting | Sedana Medical | 312 | 2022-04-22 | 2025-02-05 |
| Adjuvant Continuous Infusion of Nefopam Versus Standard of Care in Mechanically Ventilated Critically Ill Patients: Randomized Double-blind Controlled Study Nefopam, Standard of care in the ICU for assessment and management of pain, sedation, and delirium. - Analgesia, Critical Illness | Phase 3 | Completed | Cairo University | 60 | 2021-10-01 | 2025-12-19 |
| Risk Prediction of Dexmedetomidine-associated Hemodynamic Instability DEX 0.2 μg/kg/h. - Sedation | Phase 2 / Phase 3 | Suspended | Assiut University | 250 | 2021-06-01 | 2021-01-14 |
| Effect & Safety of Inhaled Isoflurane vs IV Midazolam for Sedation in Mechanically Ventilated Children 3-17 Years Old Midazolam, Isoflurane - Sedation | Phase 3 | Completed | Sedana Medical | 94 | 2021-01-14 | 2025-05-25 |
| Propranolol as an Anxiolytic to Reduce the Use of Sedatives From Critically-ill Adults Receiving Mechanical Ventilation Propranolol Hydrochloride - Mechanical Ventilation, Sedation | Phase 3 | Completed | Ottawa Hospital Research Institute | 72 | 2021-01-08 | 2022-12-05 |
| A Clinical Study of Remimazolam Tosilate in Patients Undergoing Bronchoscopy Remimazolam Tosilate, Propofol - Sedation | Phase 3 | Completed | Jiangsu HengRui Medicine Co., Ltd. | 330 | 2020-06-15 | 2022-08-22 |
| The Use of Ketamine and Dexmedetomidine in Intensive Care Sedation Dexmedetomidine, Ketamine - ICU Patients, Sedation | Phase 3 | Unknown | Lebanese American University Medical Center | 394 | 2019-09-16 | 2020-02-20 |
| Analgosedative adjuncT keTAmine Infusion iN Mechanically vENTilated ICU Patients Ketamine - Critical Illness, Sedation | Phase 3 | Completed | King Faisal Specialist Hospital & Research Center | 84 | 2019-08-28 | 2021-05-07 |
| Intranasal Dexmedetomidine for Procedural Pain Management in Elderly Adults in Palliative Care Opioids, Dexmedetomidine, Placebo - Analgesia, Sedation | Phase 3 | Terminated | Walid HABRE | 33 | 2018-11-14 | 2021-07-28 |
| Study of Remimazolam Tosilate in Patients Undergoing Colonoscopy Remimazolam Tosilate, Propofol - Sedation | Phase 3 | Completed | Jiangsu HengRui Medicine Co., Ltd. | 388 | 2018-06-28 | 2018-12-19 |
| Sedation MRI - Propofol Versus Propofol-Ketamin in Children Propofol, Ketamine-Propofol - Sedation | Phase 3 | Completed | Achim Schmitz | 347 | 2018-02-09 | 2024-12-20 |
| Cerebral Vascular Effects of Dexmedetomidine Versus Propofol Sedation in Intubated Mechanically Ventilated ICU Patients 0.2-0.7 mcg/kg/h dexmedetomedine infusion., 10-70 mcg/kg/h propofol infusion. - Sedation | Phase 2 / Phase 3 | Suspended | Assiut University | 60 | 2017-09-14 | 2020-07-14 |
| Study of Remimazolam Tosilate in Patients Undergoing Diagnostic Upper GI Endoscopy Remimazolam Tosilate, Propofol - Sedation | Phase 3 | Completed | Jiangsu HengRui Medicine Co., Ltd. | 378 | 2017-09-01 | 2018-02-12 |
| Pharmacokinetics and Pharmacodynamics of Oral Transmucosal Dexmedetomidine. OTM Dexmedetomidine 1µg/ kg., OTM Dexmedetomidine 0.75µg/ kg., OTM Dexmedetomidine 0.5µg/ kg. - Sedation | Phase 2 / Phase 3 | Completed | Assiut University | 36 | 2017-04-05 | 2019-08-01 |
| Safety And Efficacy Of Dexmedetomidine Sedation In Intubated Mechanically Ventilated Infants With Respiratory Failure Dexmedetomidine 0.35µg/kg /h, Dexmedetomidine 0.5µg/kg /h - Sedation | Phase 2 / Phase 3 | Completed | Assiut University | 40 | 2016-12-01 | 2018-07-03 |
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Critical Illness (3) · Agnosia (2) · Delirium (2) · Epilepsy (1) · Motor Activity (1) · Pain (1) · Stress Disorders, Post-Traumatic (1) · postintensive care syndrome (1)
Pathological Conditions, Signs and Symptoms (5) · Nervous System Diseases (4) · Neurologic Manifestations (4) · Signs and Symptoms (4) · Disease Attributes (3) · Mental Disorders (3) · Neurobehavioral Manifestations (3) · Pathologic Processes (3) · Confusion (2) · Neurocognitive Disorders (2) · Perceptual Disorders (2) · Behavior (1) · Brain Diseases (1) · Central Nervous System Diseases (1) · Stress Disorders, Traumatic (1)
Dexmedetomidine (11) · Propofol (8) · Midazolam (4) · Isoflurane (3) · Fentanyl (2) · Ketamine (2) · Morphine (2) · remimazolam (2) · Analgesics, Opioid (1) · Chloral Hydrate (1) · Melatonin (1) · Nefopam (1) · Propranolol (1) · Restraint, Physical (1) · Saline Solution (1)
Assiut University (4) · Hospira, now a wholly owned subsidiary of Pfizer (4) · Sedana Medical (4) · Jiangsu HengRui Medicine Co., Ltd. (3) · Achim Schmitz (1) · Cairo University (1) · King Faisal Specialist Hospital & Research Center (1) · Lebanese American University Medical Center (1) · Massachusetts General Hospital (1) · Ottawa Hospital Research Institute (1) · Pfizer (1) · Southeast University, China (1) · Tehran University of Medical Sciences (1) · The University of Hong Kong (1) · Ullevaal University Hospital (1)
United States (6) · Egypt (5) · China (4) · Japan (3) · Canada (2) · Switzerland (2) · France (1) · Germany (1) · Guatemala (1) · Hong Kong (1) · Iran (1) · Lebanon (1) · Norway (1) · Saudi Arabia (1) · South Africa (1)
Hala S Abdelghaffar, MD (2) · Peter Sackey, MD, PhD (2) · Achim J Schmitz, MD (1) · Hadi Mirfazaelian, MD (1) · Hala S Abdel-Ghaffar, MD (1) · James Downar, MDCM (1) · Jeremy Beitler, M.D. (1) · Kimberly Rengel, M.D. (1) · Misa Kawai (1) · Mohammed Gamal Abdelraouf Amer, Pharm D (1) · Oluwaseun Johnson-Akeju, MD (1) · Robert Bilkovski, MD (1) · Saher A Mohamed, MD (1)
PMID 24238862, PMID 32197636, PMID 32889844, PMID 34462007, PMID 35221757, PMID 35221758, PMID 37170043, PMID 38767196, PMID 39461861, PMID 39982178, PMID 40165305, PMID 40250620, PMID 40680761