13 completed, 2 withdrawn, 1 not yet recruiting, 1 terminated. 9 Not applicable, 3 Phase 2, 3 Phase 3, 3 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 9 | Completed 7, Not yet recruiting 1, Unknown 1 |
| Phase 2 | 3 | Withdrawn 2, Completed 1 |
| Phase 3 | 3 | Completed 2, Terminated 1 |
| Phase 4 | 3 | Completed 3 |
Follow Chloral Hydrate: new trials by email Literature Review of Chloral Hydrate trials Research Report on Chloral Hydrate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intranasal Dexmedetomidine vs. Oral Chloral Hydrate for Pediatric Orthopedic Procedural Sedation Dexmedetomidine, Chloral Hydrate, Intranasal Saline Placebo - Pediatric Procedural Sedation | Not applicable | Not yet recruiting | Seoul National University Childrens Hospital | 44 | 2026-09-01 | 2026-08-17 |
| A Comparison Between Oral Melatonin With Nasal Sevoflurane Versus Oral Chloral Hydrate With Nasal Sevoflurane in Sedation of Children Undergoing Brain MRI Melatonin 3 MG, Chloral Hydrate, Sevoflurane - Sedation for Children Undergoing MRI | Not applicable | Completed | Ain Shams University | 60 | 2024-09-20 | 2025-11-20 |
| WASPE Sleep Adjustment for Children Aged 0-4 Years Undergoing Radiation Therapy WASPE Sleep Adjustment Protocol, Chloral Hydrate - Pediatric Cancer | Not applicable | Completed | Shandong Cancer Hospital and Institute | 48 | 2024-06-01 | 2026-01-02 |
| An Open-label Trial to Evaluate the Safety and Efficacy of Chloral Hydrate in Patients with Severe Insomnia Chloral Hydrate - Insomnia, Insomnia Chronic | Phase 4 | Completed | Pharmanovia | 100 | 2023-09-01 | 2024-11-07 |
| Buccal Midazolam Versus Intranasal Dexmedetomidine Plus Oral Chloral Hydrate in Inguinal Hernia Repair buccal midazolam +oral placebo syrup, oral chloral hydrate,intranasal dexmedetomidine and buccal normal saline - Inguinal Hernia Repair | Not applicable | Completed | Benha University | 80 | 2023-03-26 | 2024-05-17 |
| Comparison of Oral Chloral Hydrate and Combination of Intranasal Dexmedetomidine and Ketamine for Rescue After Failed Pediatric Procedural Sedation Intranasal dexmedetomidine and ketamine, Oral chloral hydrate - Sedation | Not applicable | Unknown | Seoul National University Hospital | 70 | 2022-09-22 | 2023-11-24 |
| Comparison of Oral Chloral Hydrate and Combination of Intranasal Dexmedetomidine and Ketamine for Procedural Sedation in Children Intranasal dexmedetomidine and ketamine, Oral chloral hydrate - Sedation | Not applicable | Completed | Seoul National University Hospital | 136 | 2021-10-29 | 2024-10-09 |
| Sedation and Nursing Management in EEG Recording in Children Sedation and Nursing Management in EEG Recording in Children, Chloral Hydrate, Hydroxyzine - Electroencephalography, Melatonin | Not applicable | Completed | Suleyman Demirel University | 180 | 2021-01-01 | 2022-08-09 |
| Comparison Between Oral and Enema of Chloral Hydrate oral chloral hydrate, enema chloral hydrate - Congenital Cataract | Not applicable | Completed | Sun Yat-sen University | 120 | 2017-01-01 | 2017-08-08 |
| Pharmacovigilance in Gerontopsychiatric Patients Phenobarbital, Phenytoin, Carbamazepine - Dementia, Depression | Phase 3 | Terminated | Hannover Medical School | 407 | 2015-01-01 | 2018-02-28 |
| Dexmedetomidine in Children Having Transthoracic Echocardiography Chloral Hydrate, Dexmedetomidine, Placebo - Heart Disease | Phase 4 | Completed | Children's Hospital Medical Center, Cincinnati | 279 | 2014-09-01 | 2017-07-31 |
| The Role of Melatonin in the Effective Attainment of Sleep Electroencephalograms (EEG) in Children Melatonin, Chloral Hydrate - Epilepsy, Electroencephalogram | Phase 3 | Completed | University of Cape Town | 194 | 2014-04-01 | 2017-11-30 |
| A Trial Of Oral Chloral Hydrate Versus Intranasal Dexmedetomidine For Sedated Abr Exams Chloral Hydrate, Dexmedetomidine, Oral placebo - Sedation | Phase 4 | Completed | Baylor College of Medicine | 90 | 2011-08-01 | 2016-05-16 |
| Evaluation of Pediatric Procedural Sedation With Rectal Chloral Hydrate or Intranasal Midazolam Midazolam, Chloral Hydrate - Traumatic Brain Injury, Computed Tomography | Phase 2 | Withdrawn | University of Sao Paulo | 2011-08-01 | 2013-06-20 | |
| Effects of Chloral Hydrate on Induction, Maintenance, and Recovery From Sevoflurane Anesthesia in Day-case Pediatric Surgery chloral hydrate - Pediatric | Not applicable | Completed | Yonsei University | 100 | 2010-05-01 | 2011-06-10 |
| Sedation to Electroencephalography With Dexmedetomidine or Chloral Hydrate Dexmedetomidine, Chloral Hydrate - Other Conditions of Brain | Phase 3 | Completed | Federal University of Minas Gerais | 25 | 2009-12-01 | 2013-10-25 |
| Dexmedetomidine Versus Chloral Hydrate for Pediatric Sedation During EEG Dexmedetomidine, Chloral hydrate - Procedural Sedation | Phase 2 | Withdrawn | Wesley Medical Center | 2009-08-01 | 2016-11-03 | |
| Chloral Hydrate to Perform Auditory Brainstem Response (ABR) Chloral Hydrate - Auditory Brainstem Response in Children, Sedation With Chloral Hydrate | Phase 2 | Completed | Pontificia Universidade Catolica de Sao Paulo | 41 | 2007-10-01 | 2009-07-31 |
Anxiety Disorders (1) · Brain Injuries, Traumatic (1) · Dementia (1) · Depression (1) · Emergencies (1) · Epilepsy (1) · Heart Diseases (1) · Neoplasms (1) · Psychophysiologic Disorders (1) · Schizophrenia (1) · Sleep Deprivation (1) · Sleep Initiation and Maintenance Disorders (1)
Seoul National University Hospital (2) · Ain Shams University (1) · Baylor College of Medicine (1) · Benha University (1) · Children's Hospital Medical Center, Cincinnati (1) · Federal University of Minas Gerais (1) · Hannover Medical School (1) · Pharmanovia (1) · Pontificia Universidade Catolica de Sao Paulo (1) · Seoul National University Childrens Hospital (1) · Shandong Cancer Hospital and Institute (1) · Suleyman Demirel University (1) · Sun Yat-sen University (1) · University of Cape Town (1) · University of Sao Paulo (1)
South Korea (4) · Brazil (3) · China (2) · Egypt (2) · United States (2) · Germany (1) · South Africa (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Eduardo Mekitarian Filho, MSc (1) · Gomez Renato (1) · Haotian Lin, M.D,Ph.D (1) · Helge Frieling, Prof., MD (1) · Jeffrey Miller, MD (1) · Jinbo Yue, Dorcter (1) · Lindall E Smith, MD (1) · Magda Fernandes (1) · Mi Hyun Song (1) · Ramy Saleh, MD (1)
PMID 11932914, PMID 18522761, PMID 19293705, PMID 20124985, PMID 23273995, PMID 25889312, PMID 30614477, PMID 30700212, PMID 31439084, PMID 32111187, PMID 34397100, PMID 35079644, PMID 36154677, PMID 36494032, PMID 36597163, PMID 37001762, PMID 42199304, PMID 42526653