33 completed, 9 unknown, 4 terminated, 3 recruiting. 52 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 52 | Completed 33, Unknown 9, Terminated 4, Recruiting 3, Not yet recruiting 2, Withdrawn 1 |
Follow Sedation: new trials by email Literature Review of Sedation trials Research Report on Sedation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of IV Lidocaine on Duodenal Peristalsis and Sedation in ERCP Lidocaine Hydrochloride 2%, 0.9 % Normal Saline - Duodenal Spasm, ERCP | Phase 4 | Completed | Ankara City Hospital Bilkent | 120 | 2026-02-11 | 2026-04-08 |
| Safety Exploration and Evaluation of Dexmedetomidine Hydrochloride Nasal Spray for Pre-anesthesia Sedation in Low-Monitoring Settings Dexmedetomidine hydrochloride nasal spray, Placebo - Dexmedetomidine, Sedation | Phase 4 | Not yet recruiting | Sichuan Provincial People's Hospital | 564 | 2026-01-10 | 2025-12-23 |
| The Effect of Reversal of Remimazolam Sedation With Flumazenil on Cognitive Function in Patients Undergoing Hip Arthroplasty Under Spinal Anesthesia remimazolam sedation reversal with flumazenil, placebo - Postoperative Delirium, Sedation | Phase 4 | Not yet recruiting | Medical University of Gdansk | 150 | 2026-01-01 | 2026-01-06 |
| Inhaled Sedation in Critically Ill Patients Isoflurane, Propofol - Sedation, Airway Extubation | Phase 4 | Recruiting | Instituto de Investigación Hospital Universitario La Paz | 620 | 2025-12-15 | 2026-06-29 |
| Oral vs IV Sedation for Cataract Surgery in Older Adults Alprazolam, Midazolam - Cataract Surgery, Sedation | Phase 4 | Completed | University of California, San Francisco | 20 | 2025-08-12 | 2026-04-27 |
| Efficacy and Safety of Remimazolam Besylate for Sedation in Post-Non-Cardiac Surgery Patients Requiring Mechanical Ventilation Remimazolam Besylate, Dexmedetomidine Hydrochloride - Effect of Drug, Adverse Drug Event | Phase 4 | Recruiting | Beijing Shijitan Hospital, Capital Medical University | 306 | 2025-01-20 | 2026-06-16 |
| Sedation in ICU Patients With Mechanical Ventilation Ciprofol, Sedation with Propofol - Sedation, Mechanical Ventilation | Phase 4 | Completed | Zhongda Hospital | 366 | 2024-08-01 | 2026-06-30 |
| Nebulized Dexmedetomidine Combined With Ketamine Versus Nebulized Dexmedetomidine for Cleft Palate Nebulization of dexmedetomidine and ketamine, Nebulization of dexmedetomidine - Sedation, Emergence Delirium | Phase 4 | Recruiting | Assiut University | 60 | 2024-04-10 | 2025-10-03 |
| Effect of Esketamine on 95% Induction Dose of Remimazolam Remimazolam besylate and low-dose Esketamine, Remimazolam besylate and Medium dose Esketamine - Pediatric, Gastroscopy | Phase 4 | Completed | Second Affiliated Hospital of Wenzhou Medical University | 80 | 2024-04-01 | 2025-02-06 |
| The ED95 of Single Intravenous Bolus Remimazolam Besylate in Pediatric Patients During General Anesthesia Induction Remimazolam besylate - Pediatric, ED95 | Phase 4 | Completed | Second Affiliated Hospital of Wenzhou Medical University | 120 | 2023-10-06 | 2025-02-07 |
| Dexmedetomidine-Propofol Versus Ketamine-Propofol for Sedation of CT Guided Bone Biopsy Dexmedetomidine-propofol, Ketamine-Propofol - Sedation | Phase 4 | Completed | National Cancer Institute, Egypt | 60 | 2023-03-04 | 2023-09-28 |
| Ketamine Versus Propofol as ICU Sedation Ketamine, Propofol - Ketamine, Propofol | Phase 4 | Completed | Menoufia University | 100 | 2022-10-01 | 2024-02-06 |
| RemImazolam Besylate for ICU-sedation in Patients With Mechanical Ventilation After Oral and Maxillofacial Surgery Remimazolam Besylate, Propofol, Midazolam - Sedation, ICU | Phase 4 | Terminated | Nanfang Hospital, Southern Medical University | 117 | 2022-03-16 | 2026-07-02 |
| Endoscopic Hemostatic and Sedative Treatment of Esophageal and Gastric Variceal Bleeding Propofol, Remimazolam besylate - Endoscopic Hemostasis, Sedation | Phase 4 | Unknown | Renmin Hospital of Wuhan University | 60 | 2022-02-10 | 2022-11-10 |
| Dexmedetomidine Versus Ketofol for Moderate Sedation in Endoscopic Retrograde Cholangiopancreatography Dexmedetomidine, Ketofole - Sedation | Phase 4 | Completed | Sindh Institute of Urology and Transplantation | 62 | 2021-12-01 | 2024-01-18 |
| Dexmedetomidine Versus Ketamine Loading for Dexmedetomidine Sedation During Elective Cesarean Section Under Spinal Anesthesia Dexmedetomidine, Ketamine - Cesarean Birth, Spinal Anesthesia | Phase 4 | Completed | Haseki Training and Research Hospital | 80 | 2021-06-01 | 2026-06-30 |
| A Randomized Single-blind Clinical Trial of the Efficacy and Safety of Remimazolam in Painless Bronchoscopy Remimazolam, Dexmedetomidine - Bronchoscopy, Sedation | Phase 4 | Unknown | Second Affiliated Hospital, Zhejiang University, School of Medicine | 364 | 2021-04-23 | 2021-06-09 |
| Remimazolam for Sedation in ICU Patients Undergoing Mechanical Ventilation Remimazolam, Dexmedetomidine - Sedation | Phase 4 | Unknown | Tianjin Nankai Hospital | 488 | 2021-04-01 | 2021-03-24 |
| Dexmedetomidine Versus Propofol for Sedation During Awake Endotracheal Intubation dexmedetomidine combined with midazolam and remifentanil., propofol combined with midazolam and remifentanil. - Sedation, Intubation | Phase 4 | Completed | Sixth Affiliated Hospital, Sun Yat-sen University | 100 | 2021-03-05 | 2022-11-30 |
| Intravenous Infusion of Lidocaine in Gastroscopy placebo, Lidocaine - Sedation | Phase 4 | Unknown | Shandong University | 130 | 2020-07-01 | 2020-06-19 |
Showing 20 of 52. Sign in to see all of them.
Personal Satisfaction (3) · Agnosia (2) · Delirium (2) · Emergence Delirium (2) · Aortic Aneurysm, Thoracoabdominal (1) · Atrial Fibrillation (1) · Cleft Palate (1) · Critical Illness (1) · Drug-Related Side Effects and Adverse Reactions (1) · Glaucoma (1) · Hypoxia (1) · Inflammatory Bowel Diseases (1) · Mouth Neoplasms (1) · Patient Satisfaction (1) · Pulmonary Disease, Chronic Obstructive (1)
Pathological Conditions, Signs and Symptoms (10) · Pathologic Processes (6) · Signs and Symptoms (6) · Nervous System Diseases (5) · Neurobehavioral Manifestations (5) · Neurologic Manifestations (5) · Behavior (4) · Confusion (4) · Mental Disorders (4) · Neurocognitive Disorders (4) · Cardiovascular Diseases (2) · Delirium (2) · Disease Attributes (2) · Mouth Diseases (2) · Perceptual Disorders (2)
Dexmedetomidine (18) · Propofol (16) · Midazolam (15) · Remifentanil (6) · Fentanyl (5) · Ketamine (5) · Lidocaine (5) · Sodium Chloride (4) · Saline Solution (3) · Alfentanil (2) · remimazolam (2) · (2-(1R)-1-cyclopropyl)ethyl-6-isopropyl-phenol (1) · Alprazolam (1) · Calorimetry (1) · Calorimetry, Indirect (1)
Hennepin Healthcare Research Institute (3) · Shandong University (3) · Copenhagen University Hospital at Herlev (2) · GlaxoSmithKline (2) · Helsinki University Central Hospital (2) · Second Affiliated Hospital of Wenzhou Medical University (2) · Ankara City Hospital Bilkent (1) · Assiut University (1) · Avera McKennan Hospital & University Health Center (1) · Baylor College of Medicine (1) · Beijing Shijitan Hospital, Capital Medical University (1) · Boston Medical Center (1) · Cairo University (1) · Dayton VA Medical Center (1) · Eisai Inc. (1)
United States (14) · China (11) · Egypt (4) · Denmark (2) · Finland (2) · Turkey (Türkiye) (2) · Brazil (1) · Czechia (1) · France (1) · Germany (1) · Italy (1) · Lebanon (1) · Netherlands (1) · Pakistan (1) · South Korea (1)
Huacheng Liu (2) · James R Miner, MD (2) · Yuhang Cai (2) · Catherine L Chen, MD, MPH (1) · Corey A Amlong, MD (1) · Halil C Canatan (1) · Harri Mustonen, PhD (1) · Helge Servatius, MD (1) · James R. Miner, MD (1) · Jarno Jokelainen, M.D. (1)
PMID 15920188, PMID 18465717, PMID 20624140, PMID 21040558, PMID 22190555, PMID 23607840, PMID 23701339, PMID 25840875, PMID 31112380, PMID 31993819, PMID 32156544, PMID 33371995, PMID 34397100, PMID 39085782, PMID 40107902
2009 (1), 2018 (1)