Arrhythmias, Cardiac: Clinical Trials

2780 completed, 1123 unknown, 704 recruiting, 365 terminated. 2444 Not applicable, 498 Phase 4, 340 Phase 3, 255 Phase 2, 99 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	2444	Completed 1113, Unknown 430, Recruiting 346, Not yet recruiting 171, Terminated 165, Active not recruiting 109, Withdrawn 78, Enrolling by invitation 28, Suspended 4
Phase 4	498	Completed 256, Unknown 105, Terminated 44, Recruiting 37, Not yet recruiting 21, Withdrawn 17, Active not recruiting 14, Enrolling by invitation 2, Suspended 2
Phase 3	340	Completed 187, Terminated 44, Unknown 44, Recruiting 32, Not yet recruiting 13, Withdrawn 13, Active not recruiting 5, Enrolling by invitation 1, Suspended 1
Phase 2	255	Completed 134, Unknown 36, Recruiting 28, Terminated 27, Withdrawn 15, Active not recruiting 7, Not yet recruiting 7, Enrolling by invitation 1
Phase 1	99	Completed 61, Unknown 14, Terminated 10, Withdrawn 6, Recruiting 5, Not yet recruiting 2, Active not recruiting 1
Early Phase 1	18	Completed 5, Terminated 4, Recruiting 3, Unknown 2, Withdrawn 2, Active not recruiting 1, Not yet recruiting 1

Follow this condition Literature Review of Arrhythmias, Cardiac trials Research Report on Arrhythmias, Cardiac

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Standalone Thoracoscopic Left Atrial Appendage Closure Versus Medical Therapy in Atrial Fibrillation Video-assisted thoracoscopic closure of the left atrial appendage using a closure device and discontinuation of treatment if the patient is treated with OAC - ATRIAL APPENDAGE CLOSURE for ATRIAL FIBRILLATION, Oral Anticoagulation	Not applicable	Not yet recruiting	Region Skane	936	2028-01-01	2026-07-15
Study to Evaluate the effIcacy and Safety of Abelacimab in High-risk Patients With Atrial Fibrillation Who Have Been Deemed Unsuitable for Oral Anticoagulation Abelacimab - Atrial Fibrillation (AF)	Phase 3	Not yet recruiting	Novartis Pharmaceuticals	2500	2027-12-30	2026-07-31
Conscious Sedation Study CLAAS® System - Atrial Fibrillation	Not applicable	Not yet recruiting	Conformal Medical, Inc	300	2027-08-01	2026-03-20
Registry on Luma Vision's VERAFEYE System (ENLIgHT) VERAFEYE System - Atrial Fibrillation, Left Atrial Appendage Closure		Not yet recruiting	LUMA Vision Ltd.	50	2027-05-15	2026-09-15
The Effectiveness of Patch-Based Screening for Pre-Symptomatic Atrial Fibrillation to Improve Patient Outcome Zio XT® Patch - Atrial Fibrillation	Not applicable	Not yet recruiting	VA Office of Research and Development	24060	2027-03-08	2026-06-30
OPTIA-AF Trial: Rhythm-Guided Antithrombotic Strategy After AF Ablation Oral anticoagulation, Single antiplatelet therapy - Atrial Fibrillation (AF), Coronary Artery Disease	Phase 4	Not yet recruiting	Ewha Womans University Mokdong Hospital	2	2027-03-01	2026-03-27
WSO BEAT STROKE Initiative Educational and implementation Neurocardiology tool, No educational or implementation tool will be provided - Stroke, PFO - Patent Foramen Ovale	Not applicable	Not yet recruiting	Luciano A. Sposato	2400	2027-03-01	2026-09-18
Lattice vs Pentaspline Comparative Evaluation in Persistent AF Pulmonary vein isolation - Persistent Atrial Fibrillation	Not applicable	Not yet recruiting	Mitera Hospital	250	2027-03-01	2026-09-15
Cardiovascular Pre-participation Screening in Children and Adolescents Pre-participation clinical evaluation, Diagnostic Test: Resting 12-lead electrocardiogram, Diagnostic Test: Step test (Harvard step test) - Sudden Cardiac Death, Cardiac Arrhythmias		Not yet recruiting	University of Sao Paulo	334	2027-02-01	2026-10-15
AlEX-DHF: Ablation and Exercise in Diastolic Heart Failure Exercise training - HFpEF - Heart Failure With Preserved Ejection Fraction, Atrial Fibrillation	Not applicable	Recruiting	Technical University of Munich	40	2027-02-01	2026-09-18
Alert-HF: Early Detection and Intervention on Atrial Fibrillation in Heart Failure Patients Implantable loop recorder, Patient-driven portable ECG monitoring, Usual Care - Heart Failure	Phase 4	Not yet recruiting	Medisch Spectrum Twente	258	2027-01-01	2026-09-11
VT Cryoablation System Post-Market Clinical Follow-up (PMCF) Study VT Cryoablation System - Ventricular Tachycardia	Not applicable	Not yet recruiting	Adagio Medical	130	2027-01-01	2026-10-13
Relaxin Therapy for Atrial Fibrillation Relaxin, Placebo - Atrial Fibrillation (AF), Arrhythmia	Phase 1 / Phase 2	Not yet recruiting	Deeptankar DeMazumder	208	2027-01-01	2026-01-22
Comparing Two Heart Medicines for Fast, Irregular Heartbeat (Atrial Fibrillation) Verapamil Hydrochloride, Metoprolol tartrate - Atrial Fibrillation (AF), Atrial Fibrillation With Rapid Ventricular Response	Phase 4	Not yet recruiting	Muhammad Ali Javed	120	2027-01-01	2026-08-03
Stellate Ganglion Neuromodulation for the Treatment of Electrical Storm Stellate Ganglion Block Injection with Bupivicaine, Sham procedure control - Ventricular Tachycardia (V-Tach) Storm	Not applicable	Not yet recruiting	Population Health Research Institute	300	2027-01-01	2026-10-08
Catheter Ablation Using a Novel Navigation and Imaging System VERAFEYE System - Paroxysmal Atrial Fibrillation		Not yet recruiting	LUMA Vision Ltd.	100	2027-01-01	2026-09-15
An AI-ECG-Based Approach for Dynamic Assessment of Heart Failure Risk and Myocardial Recovery Following Atrial Fibrillation Ablation Atrial Fibrillation (AF), Heart Failure With Mildly Reduced Ejection Fraction (HFmrEF)		Not yet recruiting	Ewha Womans University Mokdong Hospital	1000	2027-01-01	2026-07-20
Pragmatic Amiodarone Trial to Reduce Postoperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery Amiodarone - Surgery, Cardiac, Atrial Fibrillation	Phase 4	Not yet recruiting	Massachusetts General Hospital	242	2027-01-01	2026-06-30
Randomized Interventional Clinical Trial on the Prevention of Atrial Fibrillation Using Colchicine, Amiodarone And a Posterior Pericardiotomy. Colchicine, Amiodarone, Posterior pericardiotomy - Atrial Fibrillation (AF)	Phase 3	Not yet recruiting	Elsan	636	2027-01-01	2026-10-21
Predicting Severe Cardiac Arrhythmias in the Perioperative Period Using AI-ECG digital single-channel ECG recording - Atrial Fibrillation, Atrioventricular Block, Second and Third Degree		Not yet recruiting	I.M. Sechenov First Moscow State Medical University	300	2026-12-31	2026-02-10

Showing 20 of 5756. Sign in to see all of them.

Narrower conditions

Atrial Fibrillation (3820)  ·  Heart Failure (449)  ·  Tachycardia, Ventricular (436)  ·  Stroke (362)  ·  Bradycardia (300)  ·  Atrial Flutter (207)  ·  Cardiovascular Diseases (185)  ·  Ventricular Fibrillation (185)  ·  Tachycardia (174)  ·  Heart Diseases (163)  ·  Death, Sudden, Cardiac (153)  ·  Ischemic Stroke (121)  ·  Hypertension (113)  ·  Atrioventricular Block (112)

Broader conditions

Pathological Conditions, Signs and Symptoms (5721)  ·  Pathologic Processes (5701)  ·  Heart Diseases (5593)  ·  Cardiovascular Diseases (5571)  ·  Cardiac Conduction System Disease (1163)  ·  Vascular Diseases (966)  ·  Nervous System Diseases (679)  ·  Tachycardia (516)  ·  Central Nervous System Diseases (507)  ·  Brain Diseases (506)  ·  Cerebrovascular Disorders (471)  ·  Signs and Symptoms (272)  ·  Congenital, Hereditary, and Neonatal Diseases and Abnormalities (268)  ·  Heart Block (252)

Interventions

Catheter Ablation (193)  ·  Rivaroxaban (115)  ·  Warfarin (110)  ·  Amiodarone (92)  ·  apixaban (83)  ·  Dabigatran (82)  ·  Radiofrequency Ablation (74)  ·  edoxaban (57)  ·  Electrocardiography (43)  ·  Sotalol (40)  ·  Defibrillators, Implantable (39)  ·  Flecainide (37)  ·  Left Atrial Appendage Closure (37)  ·  Aspirin (36)  ·  Electrocardiography, Ambulatory (36)

Sponsors

Abbott Medical Devices (125)  ·  Boston Scientific Corporation (119)  ·  Medtronic Cardiac Rhythm and Heart Failure (102)  ·  Bayer (59)  ·  Biosense Webster, Inc. (59)  ·  Yonsei University (57)  ·  Biotronik SE & Co. KG (51)  ·  Boehringer Ingelheim (45)  ·  Mayo Clinic (43)  ·  Beijing Anzhen Hospital (38)  ·  Medtronic Cardiac Ablation Solutions (36)  ·  Meshalkin Research Institute of Pathology of Circulation (32)  ·  National Heart, Lung, and Blood Institute (NHLBI) (32)  ·  Population Health Research Institute (32)  ·  Assiut University (31)

Countries

United States (1525)  ·  Germany (593)  ·  France (478)  ·  Canada (467)  ·  China (461)  ·  United Kingdom (431)  ·  Italy (410)  ·  Netherlands (364)  ·  Spain (361)  ·  Belgium (295)  ·  South Korea (253)  ·  Denmark (248)  ·  Czechia (242)  ·  Poland (205)  ·  Switzerland (178)

Top investigators

Vivek Reddy, MD (34)  ·  Andrea Natale, MD (31)  ·  Dhanunjaya Lakkireddy, MD (21)  ·  Atul Verma, MD (14)  ·  Biosense Webster, Inc. Clinical Trial (14)  ·  Dhanunjaya Lakkireddy (9)  ·  Khaldoun Tarakji, MD (9)  ·  Kristin Ruffner, PhD (9)  ·  Stephan Willems, MD (9)

Results publications

PMID 32860505, PMID 36700520, PMID 31698933, PMID 34022170, PMID 22236222, PMID 27042964, PMID 12968085, PMID 19717844, PMID 21712276, PMID 24345399, PMID 25946280, PMID 28506916, PMID 33933412, PMID 40014354, PMID 11343485, PMID 15313941, PMID 15670960, PMID 17577005, PMID 18294562, PMID 18946063, PMID 20876603, PMID 21403098, PMID 21830957, PMID 22700854, PMID 23273528, PMID 23325525, PMID 23583249, PMID 24576516, PMID 24682347, PMID 24685669, PMID 25172965, PMID 25399274, PMID 26095867, PMID 28851729, PMID 29653649, PMID 29976287, PMID 30874766, PMID 31085321, PMID 31431051, PMID 31961420, PMID 32720823, PMID 32865375, PMID 33107945, PMID 33197159, PMID 33338644, PMID 33769555, PMID 33892489, PMID 35488127, PMID 35717354, PMID 35876418

NIH funding

2025 (15), 2023 (14), 2018 (13), 2016 (12), 2019 (11), 2014 (10), 2009 (8), 2017 (6), 2015 (5), 2008 (4), 2004 (3), 2005 (3), R01AA022222 (3), U01HL088942 (3), K23MH119047 (2)