49 completed, 11 unknown, 10 terminated, 6 recruiting. 27 Not applicable, 27 Phase 4, 13 Phase 3, 7 Phase 2, 6 Phase 1.
Follow Isoflurane: new trials by email Literature Review of Isoflurane trials Research Report on Isoflurane
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cost-Effectiveness of Inhaled Sedation Versus Intravenous Propofol in Mechanically Ventilated Critically Ill Adults Isoflurane, Propofol (Astra-Zeneca) - Critical Illness, Mechanical Ventilation | Not yet recruiting | Hospital H+ Queretaro | 400 | 2026-07-29 | 2026-07-29 | |
| Comparison of Two Sedative Agents in Terms of Controlled Hypotension Propofol, Isoflurane - Controlled Hypotension for Nasal Surgeries | Not applicable | Not yet recruiting | Hayatabad Medical Complex | 136 | 2026-03-01 | 2026-03-10 |
| Inhaled Sedation in Critically Ill Patients Isoflurane, Propofol - Sedation, Airway Extubation | Phase 4 | Recruiting | Instituto de Investigación Hospital Universitario La Paz | 620 | 2025-12-15 | 2026-06-29 |
| Total Intravenous and Balanced Anesthesia in Diabetic Patients Undergoing Video-Assisted Thoracoscopy Propofol + fentanyl + Atracurium, Isoflurane and Atracurium - Diabete Mellitus, VATS | Phase 4 | Active not recruiting | Ain Shams University | 60 | 2025-12-01 | 2026-03-27 |
| Impact of Isoflurane and Sevoflurane on Oxidative Stress in Patients Undergoing Laparoscopic Cholecystectomy Isoflurane, Sevoflurane - Isoflurane, Sevoflurane | Not applicable | Recruiting | Ain Shams University | 80 | 2025-09-04 | 2025-09-05 |
| Sevoflurane/Dexmedetomidine vs. Isoflurane for Pediatric Emergence Delirium Sevoflurane, Isoflurane - Delirium on Emergence | Phase 3 | Recruiting | Mayo Clinic | 400 | 2024-12-20 | 2025-12-16 |
| Anesthesia and Non-small Cell Lung Cancer Recurrence Propofol, Inhaled anesthetics - Non-small Cell Lung Cancer, Surgery | Phase 4 | Recruiting | Samsung Medical Center | 5384 | 2024-08-05 | 2026-04-20 |
| Multicenter Retrospective Study of Isoflurane in Refractory and Super-Refractory Status Epilepticus Isoflurane - Refractory Status Epilepticus | Completed | Hopital of Melun | 66 | 2024-06-30 | 2025-09-26 | |
| Evaluation of the Safety of Inhaled Sedation With Isoflurane in Head Trauma Patients Isoflurane - Traumatic Brain Injury | Not applicable | Recruiting | University Hospital, Grenoble | 30 | 2024-06-20 | 2024-07-03 |
| Desflurane Versus Isoflurane for Speeding Postanesthetic Recovery and Hospital Discharge Desflurane, Isoflurane - Surgery | Not applicable | Withdrawn | The Cleveland Clinic | 2023-12-08 | 2026-03-05 | |
| Volatile Sedation for Patients With the Acute Respiratory Distress Syndrome Propofol, Isoflurane - Acute Respiratory Distress Syndrome, Mechanical Ventilation Complication | Phase 2 / Phase 3 | Recruiting | Guy's and St Thomas' NHS Foundation Trust | 20 | 2023-11-01 | 2026-06-04 |
| Intranasal Versus Intravenous Dexmedetomidine for Hypotensive Anesthesia in FESS Intranasal dexmedetomidine, Intravenous dexmedetomidine - Functional Endoscopic Sinus Surgery, Premedication | Phase 4 | Completed | Al-Azhar University | 60 | 2022-11-10 | 2023-03-14 |
| Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensive Care Unit Adult Patients (INSPiRE-ICU2) Isoflurane, Propofol - Sedation | Phase 3 | Completed | Sedana Medical | 282 | 2022-06-30 | 2026-03-24 |
| Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensive Care Unit Adult Patients (INSPiRE-ICU1) Isoflurane, Propofol, Isoflurane (run-ins) - Sedation | Phase 3 | Completed | Sedana Medical | 277 | 2022-04-28 | 2026-03-24 |
| Cardioprotective Effect of Ketamine-dexmeditomidine Versus Fentanyl-midazolam in Open Heart Surgery in Pediatrics Ketamine- dexmedetomidine, Fentanyl- midazolam, Isoflurane - Anesthesia | Phase 1 | Completed | Cairo University | 81 | 2022-04-15 | 2024-02-07 |
| Influence of Anesthetics on Clinical Outcome During Cardiac Surgery in Adults Propofol, Isoflurane, Sevoflurane - CHD - Coronary Heart Disease | Not applicable | Completed | Astana Medical University | 90 | 2022-01-22 | 2023-01-23 |
| Effect of Anesthetics on Troponin I and С-reactive Protein Propofol, Isoflurane, Sevoflurane - Mitral Valve Insufficiency, Aortic Valve Insufficiency | Phase 1 | Completed | Astana Medical University | 255 | 2021-11-30 | 2023-06-05 |
| Neurotoxicity of Anesthesia in Middle Aged Patients Anesthesia Agent - Anesthesia; Adverse Effect | Unknown | Tanta University | 600 | 2021-03-01 | 2022-03-15 | |
| The Effects of Sevoflurane, Isoflurane and Propofol During Cardiac Surgery Propofol, Isoflurane, Sevoflurane - Coronary Artery Disease, Mitral Valve Insufficiency | Phase 1 | Completed | Astana Medical University | 89 | 2021-01-22 | 2023-01-25 |
| Effect & Safety of Inhaled Isoflurane vs IV Midazolam for Sedation in Mechanically Ventilated Children 3-17 Years Old Midazolam, Isoflurane - Sedation | Phase 3 | Completed | Sedana Medical | 94 | 2021-01-14 | 2025-05-25 |
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Delirium (5) · Emergence Delirium (4) · Alzheimer Disease (3) · Aortic Valve Insufficiency (3) · Cognitive Dysfunction (3) · Mitral Valve Insufficiency (3) · Aneurysm (2) · Breast Neoplasms (2) · Colonic Neoplasms (2) · Coronary Artery Disease (2) · Heart Defects, Congenital (2) · Heart Diseases (2) · Hypotension (2) · Lung Neoplasms (2) · Opioid-Related Disorders (2)
Astana Medical University (4) · Sedana Medical (4) · Ain Shams University (3) · Duke University (3) · University Health Network, Toronto (3) · Nanjing Medical University (2) · Ruhr University of Bochum (2) · Samsung Medical Center (2) · Tanta University (2) · The Cleveland Clinic (2) · UPECLIN HC FM Botucatu Unesp (2) · University Hospital, Basel, Switzerland (2) · University of Chicago (2) · Aga Khan University (1) · Air Force Military Medical University, China (1)
United States (21) · Egypt (9) · China (7) · Brazil (5) · France (5) · Germany (5) · Kazakhstan (4) · United Kingdom (4) · Canada (3) · Australia (2) · Croatia (2) · India (2) · Israel (2) · Italy (2) · Pakistan (2)
Alibek Kh Mustafin, Professor (4) · James Zacny, Ph.D. (2) · Jonathan P Wanderer, MD, MPhil (2) · Miles Berger, MD, PhD (2) · Thomas Weber, PhD (2) · XiaoFeng Shen, MD (2) · Abdelrady S Ibrahim, M.D. (1) · Alexander Albert, MD (1) · Allen Keebler, D.O. (1) · Amany H Saleh, MD (1) · Angela Jerath, MD (1) · Ante Crncevic, MD, MSc. (1) · Artur Lichtenberg, MD (1) · Astrid Fahlenkamp, Dr. med. (1)
PMID 10366002, PMID 10400452, PMID 15277925, PMID 15502041, PMID 16369168, PMID 17761724, PMID 17959952, PMID 18946287, PMID 19602953, PMID 20495811, PMID 20962652, PMID 22103808, PMID 22116817, PMID 22824929, PMID 23132045, PMID 23246491, PMID 23440355, PMID 23465551, PMID 23535829, PMID 23793449, PMID 23953384, PMID 23994303, PMID 24548338, PMID 26052727, PMID 26646404, PMID 27079717, PMID 27833669, PMID 28719609, PMID 29181002, PMID 29610659, PMID 29913033, PMID 29979837, PMID 30116207, PMID 30166653, PMID 30548252, PMID 30888743, PMID 31288740, PMID 31620921, PMID 31664468, PMID 33608400, PMID 33849618, PMID 34286464, PMID 34454654, PMID 35104057, PMID 37271721, PMID 38193018, PMID 38724266, PMID 39039548, PMID 39076624, PMID 39461861
R01DA008391 (2), 2009 (1), 2019 (1), 5KL2RR025006 (1)