30 completed, 16 unknown, 10 not yet recruiting, 7 terminated. 71 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 71 | Completed 30, Unknown 16, Not yet recruiting 10, Terminated 7, Recruiting 6, Withdrawn 2 |
Follow Sedation: new trials by email Literature Review of Sedation trials Research Report on Sedation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Impact of Long-term High-risk Drinking on the Effective Dose of Osselidin long-term high-risk drinking, non-drinking - Sedation | Not applicable | Not yet recruiting | Affiliated Hospital of Jiaxing University | 110 | 2026-10-15 | 2026-10-19 |
| Efficacy and Safety of Nasopharyngeal Tube During Sedation nasopharyngeal tube, regular cannula - Sedation in Non-intubated Diagnostic and Therapeutic Procedures, Sedation | Not applicable | Not yet recruiting | International Peace Maternity and Child Health Hospital | 160 | 2026-10-08 | 2026-10-19 |
| Dexametedomidine Ketamine Infusion Versus Dexametedomidine Propofol Infusion in Non-compliant Agitated Patients on Continuous Positive Airway Pressure (CPAP) Mask Ventilation in the Intensive Care Unit Group DK will receive dexmedetomidine (0.2-1.4 μg/kg/hour) and ketamine (0.5 mg/kg/hr)., Group KP will receive dexmedetomidine (0.2-1.4 μg/kg/hour) and propofol (2-4 mg/kg/hr).( - CPAP Ventilation, Sedation | Not applicable | Not yet recruiting | Ain Shams University | 100 | 2026-10-01 | 2026-10-22 |
| Effects of Low-Dose Ketamine Added to Propofol Sedation During Colonoscopy Propofol group, Propofol + Ketamine - Colonoscopy Procedures, Sedation | Not applicable | Not yet recruiting | Ankara Etlik City Hospital | 100 | 2026-09-14 | 2026-09-09 |
| Effect of Maternal Voice on Pain, Sedation, and Physiological Parameters in Mechanically Ventilated Children Recorded Maternal Voice - Pain, Sedation | Not applicable | Not yet recruiting | TC Erciyes University | 28 | 2026-08-15 | 2026-08-10 |
| The Use of Remimazolam Versus Dexmedetomidine for Patients Receiving Drug-Induced Sleep Endoscopy Remimazolam, Dexmedetomidine - OSAS (Obstructive Sleep Apneas Syndrome), DISE | Not applicable | Not yet recruiting | Fu Jen Catholic University Hospital | 60 | 2026-08-05 | 2026-08-12 |
| Remimazolam Combined With Oliceridine for Sedation in Elderly Patients Undergoing Gastrointestinal Endoscopy Remimazolam Tosilate for Injection, Oliceridine Fumarate - Sedation, Gastrointestinal Endoscopy | Not applicable | Completed | Baoshan Branch, Renji Hospital, Shanghai Jiao Tong University School of Medicine | 240 | 2026-07-17 | 2026-11-03 |
| Opioid-Free Versus Opioid-Based Sedation for Endoscopic Procedures Dexmedetomidine, Remifentanil - Sedation, Endoscopy | Not applicable | Not yet recruiting | Bakirkoy Dr. Sadi Konuk Research and Training Hospital | 80 | 2026-06-01 | 2026-06-16 |
| End-of-life Care in Mechanically Ventilated Patients: Impact of a Comprehensive Palliative Care Protocol in the Intensive Care Setting Protocol for palliative care and life-support withdrawal - Palliative Care, Withdrawal of Life Support | Not applicable | Not yet recruiting | Nantes University Hospital | 720 | 2026-01-10 | 2026-01-26 |
| Dexmedetomidine and Propofol for Sedation in Cataract Surgery. Dexmedetomidine (DEX), Propofol (PRO), Fentanyl (FEN) - Sedation, Cataract | Not applicable | Recruiting | Saint-Joseph University | 1000 | 2025-11-09 | 2026-04-29 |
| Bispectral Monitoring on Mechanically Ventilated Patients BIS group, Non-BIS group - Sedation | Not applicable | Recruiting | The University of Texas Health Science Center, Houston | 30 | 2025-11-01 | 2026-06-25 |
| Preparing Kids for MRI Using VR Virtual Reality Orientation (Home+Booster), Virtual Reality Orientation (Pre-Scan Only), Usual Care (No VR) - Anxiety, Sedation | Not applicable | Not yet recruiting | Haseki Training and Research Hospital | 150 | 2025-10-06 | 2025-10-02 |
| Light and Anesthesia eye mask - Light, Anesthesia | Not applicable | Recruiting | Peking University People's Hospital | 66 | 2025-10-03 | 2026-05-29 |
| Study Comparing Atomizerd Midazolam & Fentanyl and Dexmedomidine for Procedural Sedation in Adult and Pediatric Patient (2 to 60 Years Old) atomizer, rescue medication, Midazolam - Sedation, Analgesia Assessment | Not applicable | Not yet recruiting | Oman Medical Speciality Board | 128 | 2025-09-01 | 2025-09-10 |
| Remimazolam Besylate in Sedation of Postcardioperative Patients Remimazolam, Propofol - Remimazolam, Propofol | Not applicable | Recruiting | First Affiliated Hospital of Zhejiang University | 120 | 2025-02-10 | 2025-02-18 |
| Effects of Different Sedation Techniques on Early Cognitive Recovery After Ambulatory Gynecologic Surgery Propofol-Fentanyl, Ketamine-Fentanyl, Propofol + Ketamine + Fentanyl (Ketofol) - Cognitive Recovery, Sedation | Not applicable | Completed | Sait Fatih Öner | 120 | 2024-12-15 | 2025-12-16 |
| Sedation With Dexmedetomidine or Midazolam in Combination With Propofol for Removal of Double-J Ureteral Stent Propofol, Propofol and Dexmedetomidine, Propofol and Midazolam - Sedation, Dexmedetomidine | Not applicable | Completed | Tanta University | 60 | 2024-11-01 | 2026-05-12 |
| Sevoflurane Sedation as an Alternative for Awake Fiberoptic Intubation in Difficult Airway Patients Sevoflurane, 2% Xylocaine (2 ml ) - Sevoflurane, Sedation | Not applicable | Unknown | Tanta University | 70 | 2024-09-17 | 2024-09-19 |
| Additive Effects of Clonidine Used in Propofol Sedation in Colonoscopy Propofol, Propofol combined with clonidine - Clonidine, Propofol | Not applicable | Unknown | Tanta University | 62 | 2024-07-20 | 2024-07-23 |
| Evaluation of the Impact of Virtual Reality on Sedation Use in Patients Undergoing Regional Anesthesia for Scheduled Orthopedic Surgery Virtual reality headset, Standard Care (in control arm) - Orthopedic Procedure, Anesthesia | Not applicable | Recruiting | Centre Hospitalier Eure-Seine | 164 | 2024-07-18 | 2025-06-10 |
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Anxiety Disorders (4) · Pain (4) · Agnosia (3) · Cataract (2) · Delirium (2) · Hypoxia (2) · Bradycardia (1) · Critical Illness (1) · Death (1) · Depression (1) · Genital Diseases, Female (1) · Inflammation (1) · Lung Injury (1) · Microcephaly, Primary Autosomal Recessive, 6 (1) · Nausea (1)
Pathological Conditions, Signs and Symptoms (14) · Signs and Symptoms (11) · Neurologic Manifestations (7) · Mental Disorders (6) · Nervous System Diseases (6) · Respiratory Tract Diseases (6) · Neurobehavioral Manifestations (5) · Behavior (4) · Pathologic Processes (4) · Respiration Disorders (4) · Behavioral Symptoms (3) · Lung Diseases (3) · Perceptual Disorders (3) · Signs and Symptoms, Respiratory (3) · Confusion (2)
Dexmedetomidine (19) · Propofol (16) · Midazolam (11) · Ketamine (9) · Fentanyl (7) · Remifentanil (6) · remimazolam (4) · Chloral Hydrate (2) · Laryngeal Masks (2) · Lidocaine (2) · Music Therapy (2) · Sevoflurane (2) · Sodium Chloride (2) · ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine (1) · Acupuncture Therapy (1)
Changhai Hospital (5) · Seoul National University Hospital (3) · Tanta University (3) · Ondokuz Mayıs University (2) · Affiliated Hospital of Jiaxing University (1) · Ain Shams University (1) · Ankara City Hospital Bilkent (1) · Ankara Etlik City Hospital (1) · Assiut University (1) · Bakirkoy Dr. Sadi Konuk Research and Training Hospital (1) · Baoshan Branch, Renji Hospital, Shanghai Jiao Tong University School of Medicine (1) · Beijing Tiantan Hospital (1) · Bezmialem Vakif University (1) · CMC Ambroise Paré (1) · Cairo University (1)
China (12) · United States (10) · Turkey (Türkiye) (9) · Egypt (5) · France (5) · South Korea (5) · Canada (3) · Israel (2) · Spain (2) · Taiwan (2) · Thailand (2) · Belgium (1) · Germany (1) · Indonesia (1) · Italy (1)
Amr Gaber (1) · Anas Sawas, MS MPH (1) · Andrew Nugent, MD (1) · Annop Piriyapatsom, MD (1) · Antonius H. Pudjiadi, MD, PhD (1) · Brett Faine, Pharm.D. (1) · Christina Maratta (1) · Christopher Hogrefe, MD (1) · Conall Francoeur (1) · Daniel Bourdeaux (1) · Dina Kao, MD (1)
PMID 11719318, PMID 12421743, PMID 16387935, PMID 16573781, PMID 16694380, PMID 18492267, PMID 19003534, PMID 19869306, PMID 20225074, PMID 2105779, PMID 21233500, PMID 21304242, PMID 23223772, PMID 23263584, PMID 24199628, PMID 2689263, PMID 27210780, PMID 27626706, PMID 28159539, PMID 28854538, PMID 28854543, PMID 28930478, PMID 3057957, PMID 31694692, PMID 31915621, PMID 32075842, PMID 32204729, PMID 3230208, PMID 33933271, PMID 34115638, PMID 36597163, PMID 40119601, PMID 40319232, PMID 41200122, PMID 41707239
2019 (1), K23GM068842 (1)