12 completed, 3 unknown, 3 withdrawn, 1 not yet recruiting. 20 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 20 | Completed 12, Unknown 3, Withdrawn 3, Not yet recruiting 1, Terminated 1 |
| Phase 2 | 3 | Completed 1, Not yet recruiting 1, Unknown 1 |
Follow Sedation: new trials by email Literature Review of Sedation trials Research Report on Sedation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Children of Age 2-6years Undergoing Elective Surgery Will be Divided Into Two Groups Randomly. This Study Aims to Evaluate if Intranasal Dexmedetomidine is Better Than Intranasal Ketamine in Producing Sedation and Reducing Parent Separation Anxiety Before Surgery. Intranasal dexmedetomidine, Intranasal ketamine - Sedation, Preoperative Anxiety Experienced by the Pediatric Patient | Phase 1 / Phase 2 | Not yet recruiting | Liaquat National Hospital & Medical College | 60 | 2026-01-01 | 2025-09-18 |
| The Dreamy Jet Study Ketamine - Sedation, Blood Drawing Procedure | Phase 1 | Withdrawn | University of Wisconsin, Madison | 2025-09-01 | 2025-08-12 | |
| Lidocaine Infusion for Propofol Dose Reduction in ERCP Procedure Placebo, Lidocaine - Sedation | Phase 1 | Unknown | Iuliu Hatieganu University of Medicine and Pharmacy | 100 | 2022-01-03 | 2022-03-11 |
| Pre-emptive Pregabalin on Attenuating Maternal Anxiety And Stress Response To Intubation During Caesarean Section Pregabalin 150mg, multivitamin - Anxiety State, Sedation | Phase 1 / Phase 2 | Unknown | Zagazig University | 74 | 2020-11-15 | 2021-02-04 |
| A Study Evaluating the Mass Balance of Micro-dose[14C]HSK3486 Emulsion Injection in Healthy Adults HSK3486 - Anesthesia, Sedation | Phase 1 | Withdrawn | Sichuan Haisco Pharmaceutical Group Co., Ltd | 2020-03-30 | 2022-06-02 | |
| A Study Evaluating Drug-Drug Interaction (DDI) Between HSK3486 Injectable Emulsion and Voriconazole Tablets HSK3486, voriconazole +HSK3486 - Anesthesia, Sedation | Phase 1 | Completed | Sichuan Haisco Pharmaceutical Group Co., Ltd | 16 | 2019-12-14 | 2020-12-19 |
| A Study Evaluating the Safety and Pharmacokinetics/Pharmacodynamics of HSK3486 HSK3486, Propofol - Anesthesia, Sedation | Phase 1 | Completed | Sichuan Haisco Pharmaceutical Group Co., Ltd | 16 | 2019-01-09 | 2020-01-09 |
| A Study Evaluating the Mass Balance of [14C]HSK3486 Emulsion Injection in Healthy Adults. HSK3486 - Anesthesia, Sedation | Phase 1 | Completed | Sichuan Haisco Pharmaceutical Group Co., Ltd | 6 | 2019-01-06 | 2019-10-28 |
| A Study Evaluating Drug-Drug Interaction (DDI) Between HSK3486 Injectable Emulsion and Rifampin Capsules HSK3486, rifampin , HSK3486 - Anesthesia, Sedation | Phase 1 | Completed | Sichuan Haisco Pharmaceutical Group Co., Ltd | 16 | 2018-12-14 | 2019-08-20 |
| Safety, Pharmacokinetics and Pharmacodynamics of Intranasal Dexmedetomidine in Healthy Subjects Intranasal Dexmedetomidine, Intravenous Dexmedetomidine, Intranasal Placebo - Sedation | Phase 1 | Unknown | Jiangsu HengRui Medicine Co., Ltd. | 48 | 2017-07-26 | 2018-01-23 |
| A Study Evaluating Safety, Pharmacodynamics and Pharmacokinetics of HSK3486 and Etomidate for Induction of Anesthesia in Healthy Male Subjects HSK3486+ etomidate - General Anesthetic, Sedation | Phase 1 | Completed | Sichuan Haisco Pharmaceutical Group Co., Ltd | 25 | 2016-11-30 | 2019-08-13 |
| A Study Evaluating Safety, Tolerability, and Pharmacokinetics/Pharmacodynamics of Single IV Dose of HSK3486 Injectable Emulsion in Healthy Subjects. HSK3486 - Anesthesia, Sedation | Phase 1 | Completed | Sichuan Haisco Pharmaceutical Group Co., Ltd | 24 | 2016-05-01 | 2020-03-03 |
| A Study Evaluating Pharmacodynamics, Pharmacokinetics, Safety and Tolerability of HSK3486 Single Bolus Dose Followed With a 30 Minute Constant Infusion in Healthy Male Subjects HSK3486 - Anesthesia, Sedation | Phase 1 | Completed | Sichuan Haisco Pharmaceutical Group Co., Ltd | 13 | 2015-11-10 | 2021-01-29 |
| Evaluating the Safety, Pharmacodynamics and Pharmacokinetics of HSK3486 in Healthy Female Subjects. HSK3486, Propofol - Anesthesia, Sedation | Phase 1 | Completed | Sichuan Haisco Pharmaceutical Group Co., Ltd | 25 | 2015-04-22 | 2019-07-31 |
| A Study Evaluating the Safety, Pharmacodynamics and Pharmacokinetics of HSK3486 in Healthy Subjects. HSK3486, Propofol, Placebo - Anesthesia, Sedation | Phase 1 | Completed | Sichuan Haisco Pharmaceutical Group Co., Ltd | 48 | 2014-04-13 | 2019-07-26 |
| Phase I, Single Centre, Study to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD3043 AZD3043 - Safety, Tolerability | Phase 1 | Withdrawn | AstraZeneca | 2010-03-01 | 2012-12-20 | |
| Bioavailability of Dexmedetomidine After Intranasal Administration Intravenous dexmedetomidine, Intranasal dexmedetomidine - Sedation | Phase 1 | Completed | University of Turku | 7 | 2009-03-01 | 2010-01-13 |
| Pharmacokinetics of Dexmedetomidine During Prolonged Infusion in ICU Dexmedetomidine - Pharmacokinetics, Sedation | Phase 1 | Completed | Orion Corporation, Orion Pharma | 13 | 2008-09-01 | 2009-04-21 |
| Pharmacokinetics of Low Dose Ketamine Infusion Ketamine - Sedation, Opioid Tolerance | Phase 1 | Terminated | University of Texas Southwestern Medical Center | 5 | 2006-06-01 | 2016-10-26 |
| Clonidine-Remifentanil. Effect of the Combination on Acute Pain and Respiration in Healthy Volunteers Remifentanil+clonidine - Acute Pain, Respiration | Phase 1 / Phase 2 | Completed | Oslo University Hospital | 12 | 2005-02-01 | 2011-07-06 |
Acute Pain (1) · Agnosia (1) · Anxiety Disorders (1) · Respiratory Aspiration (1)
Neurologic Manifestations (2) · Pathological Conditions, Signs and Symptoms (2) · Signs and Symptoms (2) · Mental Disorders (1) · Nervous System Diseases (1) · Neurobehavioral Manifestations (1) · Pain (1) · Pathologic Processes (1) · Perceptual Disorders (1) · Respiration Disorders (1) · Respiratory Tract Diseases (1)
HSK3486 (9) · Propofol (3) · Ketamine (2) · AZD-3043 (1) · Clonidine (1) · Dexmedetomidine (1) · Geritol (1) · Lidocaine (1) · Pregabalin (1) · Remifentanil (1) · Rifampin (1)
Sichuan Haisco Pharmaceutical Group Co., Ltd (10) · AstraZeneca (1) · Iuliu Hatieganu University of Medicine and Pharmacy (1) · Jiangsu HengRui Medicine Co., Ltd. (1) · Liaquat National Hospital & Medical College (1) · Orion Corporation, Orion Pharma (1) · Oslo University Hospital (1) · University of Texas Southwestern Medical Center (1) · University of Turku (1) · University of Wisconsin, Madison (1) · Zagazig University (1)
China (5) · Finland (2) · United States (2) · Egypt (1) · Norway (1) · Romania (1)
Brendan Smyth (1) · Cindy Darnell, MD (1) · Daniela Ionescu, MD PhD (1) · Darren Wilbraham (1) · Jon B Bergmann, Ass. Prof. (1) · Klaus T Olkkola, MD, PhD, Professor (1) · Liyan Miao, PhD (1) · Megan Peters, MD (1) · Sara Abdel Naby, M.D (1) · Stephen Kanes (1) · Timo Iirola (1) · Timo Iirola, MD (1)