11 completed, 9 not yet recruiting, 7 recruiting, 2 active not recruiting. 33 Phase 2, 8 Phase 3, 6 Phase 1.
Follow Pain Management: new trials by email Literature Review of Pain Management trials Research Report on Pain Management
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Clinical Trial of MK-6916 in Participants With Pain After Bunion Removal Surgery (MK-6916-007) MK-6916, Hydrocodone/acetaminophen (HB/APAP), MK-6916 Placebo - Pain Management | Phase 2 | Not yet recruiting | Merck Sharp & Dohme LLC | 380 | 2026-11-23 | 2026-11-06 |
| Genistein for the Reduction of Adverse Cardiovascular Events (GRACE) Genistein (Unconjugated Isoflavones 100), Placebo - HIV, Vascular Disease | Phase 1 / Phase 2 | Not yet recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 60 | 2026-09-30 | 2026-08-25 |
| Sub-dissociative Dose Ketamine in Treatment of Vaso-occlusive Pain Event in Children and Young Adults Sub-dissociative Ketamine Infusion, Normal Saline Placebo Infusion - Sickle Cell Disease, Vaso-Occlusive Pain Episode in Sickle Cell Disease | Phase 2 | Recruiting | Mohsen Saidinejad | 120 | 2026-09-10 | 2026-09-02 |
| Fentanyl Intranasal for Retinopathy of Prematurity Screening in Preterm Infants Fentanyl Citrate (Intranasal), Normal Saline (Placebo, Intranasal) - Neonatal Pain, Retinopathy of Prematurity (ROP) | Phase 1 / Phase 2 | Not yet recruiting | Marsha Campbell-Yeo | 58 | 2026-09-09 | 2026-06-30 |
| Efficacy and Safety of Anrikefon Injection for the Treatment of Postoperative Pain in Patients Undergoing Laparoscopic Hepatectomy Anrikefon Injection, Flurbiprofen - Pain Management | Phase 2 | Not yet recruiting | Tianjin Medical University Cancer Institute and Hospital | 108 | 2026-09-01 | 2026-09-17 |
| Effect of Opioid-Sparing Anesthesia on Postoperative Opioid Consumption and Pain in Elderly Patients Undergoing Spine Surgery Opioid-Sparing Protocol, Routine anesthesia protocol - Opoid Managment, Pain Management | Phase 2 | Not yet recruiting | Massachusetts General Hospital | 120 | 2026-09-01 | 2026-09-08 |
| The Use of Photobiomodulation for Pain and Healing in Cesarean Section Photobiomodulation (PBM), Placebo PBM, Standard Hospital Treatment - Post Partum, Cesarean Birth | Phase 2 | Not yet recruiting | University of Nove de Julho | 30 | 2026-09-01 | 2026-09-08 |
| Paracervical Block With Combined Ketorolac and Lidocaine for Osmotic Dilator Placement Ketorolac, oral ibuprofen, Placebo - Pain Management, Abortion | Phase 2 | Recruiting | Rush University Medical Center | 76 | 2026-06-29 | 2026-07-06 |
| Pilot Randomized Control Trial Comparing Oral Ketamine and Oral Oxycodone for Pain Control in Emergency Department Patients oral ketamine, oxycodone - Pain Management | Phase 2 / Phase 3 | Not yet recruiting | Albany Medical College | 60 | 2026-06-24 | 2026-06-26 |
| Evaluation of the Efficacy and Onset of Action of a Topical Anesthetic Marker Cutaneous marker (Transcutol P+ 20%, Tetracaine 7%, Lidocaine 23%, and dye q.s.), - Pain Management | Phase 2 | Not yet recruiting | Hexsel Dermatology Clinic | 20 | 2026-03-01 | 2025-12-10 |
| Sufentanil Versus Ketamine Intranasally in the Management of Severe Acute Trauma-related Pain in Children. Intranasal Sufentanil, Intranasal Ketamine (IN) - Traumatology, Wounds and Injury | Phase 2 | Not yet recruiting | Fondation Lenval | 116 | 2026-02-05 | 2026-01-28 |
| Comparison of Submucosal Dexamethasone and Methylprednisolone in Postoperative Sequelae of Parasymphsis Fractures Dexamethasone, Methylprednisolone (Corticosteroid) - Mandible Fracture, Edema Face | Phase 2 | Recruiting | Nishtar Medical University | 72 | 2026-01-03 | 2026-04-06 |
| Analgesic Efficacy and Safety of Topical VMD-3866 Gel in Management of Pain Induced by Chemotherapy (CIPN) VMD-3866 Gel, Placebo Gel - Chemotherapy-induced Peripheral Neuropathy, Chemotherapy-induced Neuropathic Pain | Phase 2 | Recruiting | VM Therapeutics LLC | 16 | 2025-12-12 | 2026-10-21 |
| Virtual Reality for Pain and Anxiety Relief During Peripheral Angioplasty Virtual Reality, dexketoprofen + midazolam - Peripheral Angioplasty, Pain Management | Phase 2 / Phase 3 | Completed | Kastamonu University | 52 | 2025-08-01 | 2025-11-19 |
| Opioid-Free Anesthesia in Colorectal Surgery, 2025 (OFA-CRC-2025) Opioid-Free Anesthesia (OFA), Opioid-Based Anesthesia (OBA) - Pain Management, Colorectal Surgery | Phase 1 / Phase 2 | Active not recruiting | Hospital Universitario La Fe | 200 | 2025-03-15 | 2026-08-18 |
| Psilocybin for Enhanced Analgesia in Chronic nEuropathic PAIN Psilocybin, Active Placebo - Chronic Neuropathic Pain, Pain Management | Phase 2 | Recruiting | Unity Health Toronto | 30 | 2025-03-05 | 2025-03-30 |
| Non-steroidal Anti-inflammatory Drugs in Pleurodesis pleurodesis procedures, KETOPROFEN(RP19583), Placebo - Non-steroidal Anti-inflammatory Drugs, Pleurodesis | Phase 2 | Recruiting | Centre Hospitalier Universitaire, Amiens | 358 | 2025-02-01 | 2025-03-19 |
| Dexmedetomidine in Sonographic Guided Erector Spinae Plane Block Dexmedetomidine - Pain Management | Phase 2 / Phase 3 | Completed | Assiut University | 90 | 2024-10-01 | 2026-10-30 |
| Psilocybin in Cancer Pain Study Psilocybin - Opioid-Related Disorders, Pain Management | Phase 2 | Active not recruiting | Yvan Beaussant, MD, MSci | 15 | 2024-09-23 | 2026-10-27 |
| Combination of Equisetum Arvense and Palmitoylethanolamide (PEA) for the Management of Patients With Chronic Pain in a Before-after Study Supplement - Chronic Pain, Chronic Pain (Back / Neck) | Phase 1 / Phase 2 | Completed | noiVita Srls | 50 | 2024-07-29 | 2025-08-07 |
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Agnosia (33) · Pain (9) · Chronic Pain (3) · Pain, Postoperative (3) · Neuralgia (2) · Wounds and Injuries (2) · Acute Pain (1) · Anemia, Sickle Cell (1) · Burns (1) · Cancer Pain (1) · Cardiovascular Diseases (1) · Dilatation, Pathologic (1) · Disease (1) · Edema (1) · Emergencies (1)
Nervous System Diseases (33) · Neurobehavioral Manifestations (33) · Neurologic Manifestations (33) · Pathological Conditions, Signs and Symptoms (33) · Perceptual Disorders (33) · Signs and Symptoms (33) · Pathologic Processes (7) · Pain (4) · Postoperative Complications (3) · Trauma, Nervous System (3) · Wounds and Injuries (3) · Central Nervous System Diseases (2) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Neuromuscular Diseases (2) · Peripheral Nervous System Diseases (2)
Acetaminophen (4) · Oxycodone (4) · Bupivacaine (3) · Dexmedetomidine (3) · Ketamine (3) · Ibuprofen (2) · Ketorolac (2) · Psilocybin (2) · Sodium Chloride (2) · Adrenal Cortex Hormones (1) · Dexamethasone (1) · Dietary Supplements (1) · Epinephrine (1) · Fentanyl (1) · Flurbiprofen (1)
Assiut University (3) · Antonios Likourezos (2) · Albany Medical College (1) · Azad University of Medical Sciences (1) · Centre Hospitalier Universitaire, Amiens (1) · Centre hospitalier de l'Université de Montréal (CHUM) (1) · Christian Fromm, MD (1) · Fondation Lenval (1) · Hexsel Dermatology Clinic (1) · Hospital Universitario La Fe (1) · Kastamonu University (1) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (1) · Marsha Campbell-Yeo (1) · Massachusetts General Hospital (1) · Merck Sharp & Dohme LLC (1)
United States (11) · Canada (4) · Egypt (4) · France (2) · Pakistan (2) · Italy (1) · Spain (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Sergey Motov, MD (2) · Ahmad M Abd El-Rahman, M.D. (1) · Ashok Hemal, MD (1) · Christian Fromm, MD (1) · Jay Piccirillo, MD (1) · Kathryn Crofton, MD (1) · Mark JK Chandy, MD PhD (1)
PMID 21674151, PMID 23241361, PMID 24550805, PMID 27578767, PMID 28704354, PMID 29577509, PMID 29764303, PMID 32371500, PMID 34867525, PMID 35001856, PMID 36044208, PMID 36532184, PMID 42161544, PMID 42458331
2025 (1), P30CA012197 (1)