43 completed, 7 unknown, 2 not yet recruiting, 2 recruiting. 25 Phase 1, 9 Phase 4, 8 Not applicable, 6 Phase 2, 3 Early Phase 1.
Follow Flurbiprofen: new trials by email Literature Review of Flurbiprofen trials Research Report on Flurbiprofen
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Multiple-dose Study Investigating the Drug-drug Interaction Potential and QTc Effects of Fosmanogepix in Healthy Adult Subjects Fosmanogepix, Placebo, The medicine cocktail (caffeine, bupropion, flurbiprofen, omeprazole, dextromethorphan and midazolam) - Healthy Adult Participants | Phase 1 | Recruiting | Basilea Pharmaceutica | 42 | 2026-10-01 | 2026-10-19 |
| Efficacy and Safety of Anrikefon Injection for the Treatment of Postoperative Pain in Patients Undergoing Laparoscopic Hepatectomy Anrikefon Injection, Flurbiprofen - Pain Management | Phase 2 | Not yet recruiting | Tianjin Medical University Cancer Institute and Hospital | 108 | 2026-09-01 | 2026-09-17 |
| Effects of Flurbiprofen Spray and Ice Cream for Pain and Voice Outcomes After Thyroidectomy Flurbiprofen, Food Effect cohort, Placebo Control - Thyroidectomy, Sore Throat | Phase 4 | Not yet recruiting | Izmir Katip Celebi University | 100 | 2026-04-01 | 2026-04-15 |
| Study to Evaluate the Effect of Repotrectinib on the Drug Levels of Transporter and CYP P450 Probe Substrates in Healthy Adult Participants Repotrectinib, Metformin, Digoxin - Healthy Volunteers | Phase 1 | Completed | Bristol-Myers Squibb | 30 | 2025-12-31 | 2026-03-27 |
| Drug-drug Interaction Study of Vorasidenib With Bupropion, Repaglinide, Flurbiprofen, Omeprazole, Midazolam, and Rosuvastatin in Healthy Adult Participants Vorasidenib, Bupropion, Flurbiprofen - Healthy Adult Participants | Phase 1 | Completed | Institut de Recherches Internationales Servier (I.R.I.S.) | 28 | 2025-10-07 | 2026-02-17 |
| Efficacy of Flurbiprofen Spray for Postoperative Sore Throat Following Double-Lumen Endobronchial Intubation Flurbiprofen 8.75 MG, Saline spray - Post Operative Sore Throat, Hoarseness | Not applicable | Active not recruiting | Kittitorn Supphapipat, MD | 58 | 2025-09-10 | 2026-03-24 |
| To Assess the Bioavailability of TK-254RX in Comparison with Oral Flurbiprofen Tablets and the Adhesion of TK-254RX in Healthy Subjects Esflurbiprofen Topical System, Flurbiprofen tablet - Healthy | Phase 1 | Completed | Teikoku Seiyaku Co., Ltd. | 26 | 2025-01-21 | 2025-03-11 |
| Electroencephalographic Characteristics of Chronic Pain in Patients With Spinal Cord Injury Esketamine(Continuous infusion), Remifentanil (Target-Controlled Infusion), Flurbiprofen (Single intravenous injection) - Chronic Pain | Not applicable | Unknown | Beijing Tiantan Hospital | 60 | 2024-08-25 | 2024-08-13 |
| KF2022#4-trial: Effects of a Beta Blocker and NSAID on CYP Mediated Drug Metabolism Caffeine Tablet, Bupropion Hydrochloride Capsels, Repaglinide Capsels - Drug Interaction | Not applicable | Completed | Helsinki University Central Hospital | 12 | 2024-08-22 | 2026-03-06 |
| Flurbiprofen Tablet vs Spray In Oral Soft Tissue Wounds Flurbiprofen - Oral Soft Tissue Conditions, Drug Effect | Phase 4 | Completed | Yuzuncu Yil University | 40 | 2023-10-26 | 2024-07-26 |
| Effect of Over-the-counter NSAIDS on Cough Reflex Sensitivity in Patients with Upper Respiratory Tract Infections Flurbiprofen Oral Lozenge, Difflam, Flurbiprofen 8.75 MG - Cough, Upper Respiratory Tract Infections | Early Phase 1 | Completed | University of Melbourne | 101 | 2023-07-01 | 2024-12-06 |
| A Study to Assess the Effect of BMS-986419 on the Single Dose Drug Levels of Probe Substrates in Healthy Participants BMS-986419, Caffeine, Bupropion - Healthy Volunteers | Phase 1 | Completed | Bristol-Myers Squibb | 22 | 2023-06-29 | 2023-10-30 |
| A Study to Evaluate the Drug-drug Interaction Potential of BMS-986196 in Healthy Participants BMS-986196, Caffeine, Montelukast - Healthy Volunteers | Phase 1 | Completed | Bristol-Myers Squibb | 18 | 2023-05-31 | 2023-09-26 |
| Voxelotor CYP and Transporter Cocktail Interaction Study Voxelotor, Bupropion, Repaglinide - Sickle Cell Disease | Phase 1 | Completed | Pfizer | 44 | 2023-04-17 | 2024-11-22 |
| Flurbiprofen Versus Aloe Vera Gel in the Treatment of Chronic Periodontitis in Smoking Patients. 2.5% flurbiprofen, 98% aloe vera, Placebo - Periodontitis Chronic Generalized Severe | Phase 4 | Completed | Beirut Arab University | 60 | 2022-09-30 | 2023-09-18 |
| A Study to Investigate the Effect of Single and Repeated Oral Doses of ACT-539313 on What the Body Does to Flurbiprofen, Omeprazole, Midazolam in Healthy Subjects ACT-539313, Flurbiprofen, Omeprazole - Healthy | Phase 1 | Completed | Idorsia Pharmaceuticals Ltd. | 22 | 2022-02-18 | 2022-05-04 |
| The Effects of NSAIDs on Bone Metabolism Following Exercise Ibuprofen 800 mg, Celecoxib 200mg, Flurbiprofen 100 mg - Bone Resorption, Stress Fracture | Phase 1 | Completed | United States Army Research Institute of Environmental Medicine | 12 | 2022-02-15 | 2023-11-29 |
| The Comparison of the Analgesic Effects of Dezocine and Sufentanil in Patient-controlled Analgesia After Laryngectomy Dezocine, Sufentanil injection, Flurbiprofen - Patient-controlled Analgesia | Not applicable | Completed | Eye & ENT Hospital of Fudan University | 129 | 2022-02-10 | 2023-08-21 |
| Remimazolam Tosilate Sedation and Midazolam Sedation in Dental Patients Fentanyl, Flurbiprofen, Midazolam - Sedation Complication, Midazolam | Phase 4 | Completed | Peking University | 81 | 2021-04-01 | 2022-03-15 |
| Oro-tracheal Intubation: Flurbiprofen Subglottic Instillation to Prevent Laryngeal Inflammation Flurbiprofen, saline solution - D010612 | Phase 2 | Unknown | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 70 | 2021-01-01 | 2021-01-14 |
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Pharyngitis (5) · Arthritis, Rheumatoid (3) · Pain (3) · Acquired Immunodeficiency Syndrome (2) · Agnosia (2) · Infections (2) · Respiratory Tract Infections (2) · Anemia (1) · Anemia, Sickle Cell (1) · Arthritis (1) · Bone Resorption (1) · Chronic Pain (1) · Cough (1) · Deglutition Disorders (1) · Depression (1)
Bristol-Myers Squibb (7) · GlaxoSmithKline (4) · Reckitt Benckiser LLC (3) · Chinese Medical Association (2) · Jules Desmeules (2) · University Hospital, Geneva (2) · Abliva AB (1) · Basilea Pharmaceutica (1) · Beijing Tiantan Hospital (1) · Beirut Arab University (1) · Changhai Hospital (1) · Dexcel Pharma Technologies Ltd. (1) · Express Specialty Pharmacy (1) · Eye & ENT Hospital of Fudan University (1) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1)
United States (16) · China (9) · Germany (4) · Switzerland (4) · United Kingdom (4) · Israel (3) · Turkey (Türkiye) (3) · Australia (2) · Finland (1) · France (1) · Jordan (1) · Lebanon (1) · Netherlands (1) · South Korea (1) · Thailand (1)
Timothy J Shea, BS (2) · Abdullah AlAlwani, DDS (1) · Celia Lloret-Linares, MD, PhD (1) · Cennet N Eroglu, DDS,PhD (1) · David Polak, DMD PhD (1) · Dr. Rana T. Bustami, Ph.D. of Pharmacy (1) · Emanuel DeNoia, MD (1) · Frank Donath, MD (1) · Jie Li (1) · Joseph Chiesa, MD (1) · Jules A Desmeules, Pr (1) · Kate McLellan, PhD (1)
PMID 25296661, PMID 22288567, PMID 24018772, PMID 24722393, PMID 24988909, PMID 26547293, PMID 27146963, PMID 27878474, PMID 29381110, PMID 29570971, PMID 30007054, PMID 37800597
2019 (1), 2023 (1), R01GM069753 (1)