615 completed, 155 recruiting, 128 terminated, 98 unknown. 296 Phase 2, 276 Not applicable, 183 Phase 1, 113 Phase 3, 42 Phase 4.
Follow this condition Literature Review of Anemia, Sickle Cell trials Research Report on Anemia, Sickle Cell
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Self-administered Acupressure in Patients With Sickle Cell Disease Verum Acupressure (using AcuWand), Sham Acupressure (using AcuWand) - Sickle Cell Disease (SCD) | Not applicable | Not yet recruiting | University of Cincinnati | 300 | 2027-10-01 | 2026-10-15 |
| Development of a Provider-Focused Intervention to Improve Health Outcomes in Pediatric Sickle Cell Disease Individuation and Perspective-Taking (IPT), pediatric SCD pain management education session - Sickle Cell Disease, Sickle Cell Anemia in Children | Not applicable | Not yet recruiting | Connecticut Children's Medical Center | 30 | 2027-09-01 | 2026-04-29 |
| Evaluation of Efficacy and Safety of a Single Dose of Exa-cel in Participants With Severe Sickle Cell Disease, βS/ βC Genotype Exa-cel - Sickle Cell Disease | Phase 3 | Withdrawn | Vertex Pharmaceuticals Incorporated | 2027-07-31 | 2026-03-25 | |
| MBI for Pain and Sleep in Adolescents and Young Adults With Sickle Cell Disease Mindfulness-based intervention - Chronic Pain, Sickle Cell Disease | Not applicable | Not yet recruiting | University of Illinois at Chicago | 48 | 2027-02-01 | 2026-09-21 |
| Omega-3-Fatty Acids in Children With Sickle Cell Disease Flaxseed - Sickle Cell Disease (SCD) | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 20 | 2026-12-01 | 2026-08-21 |
| Minocycline In Neurocognitive Outcomes - Sickle Cell Disease Minocycline, Placebo - Sickle Cell Disease, Cognitive Impairment | Phase 1 | Not yet recruiting | University of Cincinnati | 30 | 2026-12-01 | 2026-05-14 |
| Virtual Reality for SCD VOC Sham 2D Headset Control, Passive Immersive 3D Virtual Reality, Active Immersive Interactive 3D Virtual Reality - Sickle Cell Disease | Not applicable | Recruiting | University of Maryland, Baltimore | 50 | 2026-11-01 | 2026-10-16 |
| Feasibility and Acceptability of Amani Amani - Sickle Cell Disease | Phase 1 / Phase 2 | Not yet recruiting | Massachusetts General Hospital | 40 | 2026-11-01 | 2026-08-07 |
| Inflammatory Markers and Pain in Sickle Cell Disease Sickle Cell Disease | Not yet recruiting | Assiut University | 75 | 2026-11-01 | 2026-10-08 | |
| Transcranial Photobiomodulation Treatment in Patients With Sickle Cell Disease Active Transcranial Photobiomodulation (TPBM), Sham Transcranial photobiomodulation (TPBM) - Sickle Cell Disease | Not applicable | Not yet recruiting | St. Jude Children's Research Hospital | 60 | 2026-11-01 | 2026-09-10 |
| Comparison of Thrombin Generation, Platelet Activation and Aggregation Profiles in Patients With Sickle Cell Disease Depending on Their SS or SC Genotype (DrepAgreg) Sickle Cell Disease, Venous Thromboembolism | Not yet recruiting | Centre Hospitalier Universitaire de la Guadeloupe | 60 | 2026-10-15 | 2026-10-01 | |
| Buprenorphine for the Management of Pain in Children With Sickle Cell Disease Buprenorphine Buccal Film [Belbuca] - Sickle Cell Disease (SCD), Sickle Cell Disease Vaso-occlusive Crisis | Phase 1 | Not yet recruiting | Natasha Archer | 25 | 2026-10-01 | 2026-09-02 |
| Adaptive Platform Trial for Pain Management in Sickle Cell Vaso-Occlusive Crisis Group 02 Paracetamol + Morphine + Ketamine, Group 01 Control: Paracetamol + Morphine, Group 03 : Paracetamol + Morphine + Nefopam - Sickle Cell Disease, Vaso-occlusive Crisis | Phase 4 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 400 | 2026-10-01 | 2026-09-18 |
| CS-206 in Patients With Sickle Cell Disease CS-206 - Sickle Cell Disease | Early Phase 1 | Not yet recruiting | Children's Hospital of Fudan University | 5 | 2026-09-30 | 2026-05-15 |
| Sub-dissociative Dose Ketamine in Treatment of Vaso-occlusive Pain Event in Children and Young Adults Sub-dissociative Ketamine Infusion, Normal Saline Placebo Infusion - Sickle Cell Disease, Vaso-Occlusive Pain Episode in Sickle Cell Disease | Phase 2 | Recruiting | Mohsen Saidinejad | 120 | 2026-09-10 | 2026-09-02 |
| CPAP for Hypoxemic Acute Chest Syndrome in Sickle Cell Disease O2+CPAP group - Sickle Cell Disease (SCD), Acute Chest Syndrome (ACS) | Not applicable | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 140 | 2026-09-01 | 2026-07-23 |
| Evaluation of the Efficacy of Iloprost in the Management of Vaso-occlusive Crises in Adult Patients With Sickle Cell Disease Iloprost, Placebo - Vaso-Occlusive Crises, Sickle Cell Disease | Phase 3 | Not yet recruiting | University Hospital, Rouen | 144 | 2026-09-01 | 2026-03-27 |
| Hypoxic Red Blood Cells in Sickle Cell Anemia Hemanext ONE System, Conventional RBCs - Sickle Cell Anaemia, Sickle Cell Anemia Crisis | Not applicable | Not yet recruiting | Hemanext | 48 | 2026-09-01 | 2026-08-17 |
| Assessing Molecular Mechanisms and Effects of Music Therapy in Youth With Sickle Cell Disease Using Single-cell RNA-sequencing Music Therapy, Standard of Care - Sickle Cell Disease | Not applicable | Recruiting | Emory University | 25 | 2026-09-01 | 2026-09-10 |
| Standard of Care Comparative Arm of Phase 1/2 Gene Therapy Trial DREPAMIR" in Severe Sickle Cell Disease Patients standard of care - Sickle Cell Disease (SCD), Vaso-occlusive Events | Not applicable | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 30 | 2026-09-01 | 2026-08-07 |
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Vaso-Occlusive Crises (103) · Thalassemia (78) · beta-Thalassemia (59) · Hematologic Diseases (57) · Hemoglobinopathies (54) · Pain (54) · Sickle Cell Trait (43) · Anemia (42) · Acute Chest Syndrome (40) · Hemoglobin SC Disease (32) · Hypertension, Pulmonary (28) · Anemia, Diamond-Blackfan (26) · Genetic Diseases, Inborn (25) · Stroke (25)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1157) · Hemic and Lymphatic Diseases (1157) · Anemia, Hemolytic, Congenital (1151) · Anemia, Hemolytic (1142) · Genetic Diseases, Inborn (1133) · Anemia (1116) · Hemoglobinopathies (1104) · Hematologic Diseases (1101) · Pathological Conditions, Signs and Symptoms (200) · Signs and Symptoms (116) · Respiratory Tract Diseases (105) · Neurologic Manifestations (102) · Cardiovascular Diseases (100) · Pathologic Processes (100) · Lung Diseases (99)
Hydroxyurea (76) · Alemtuzumab (34) · Cyclophosphamide (30) · fludarabine (28) · fludarabine phosphate (26) · Sirolimus (25) · voxelotor (23) · Whole-Body Irradiation (22) · Busulfan (21) · Blood Specimen Collection (19) · Mycophenolic Acid (16) · Saline Solution (14) · Standard of Care (14) · Ketamine (13) · Surveys and Questionnaires (13)
National Heart, Lung, and Blood Institute (NHLBI) (62) · Assistance Publique - Hôpitaux de Paris (51) · St. Jude Children's Research Hospital (45) · Children's Hospital Medical Center, Cincinnati (30) · Emory University (28) · Pfizer (27) · Duke University (26) · Novartis Pharmaceuticals (22) · UCSF Benioff Children's Hospital Oakland (14) · University of Illinois at Chicago (14) · HaEmek Medical Center, Israel (13) · Vanderbilt University Medical Center (13) · Washington University School of Medicine (13) · Hospices Civils de Lyon (11) · Centre Hospitalier Universitaire de la Guadeloupe (10)
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John F Tisdale, M.D. (16) · Swee Lay Thein, M.D. (12) · Lakshmanan Krishnamurti, MD (9) · Ariel Koren, MD (8) · Russell Ware, MD, PhD (7) · Michael R DeBaun, MD, MPH (6) · Nirmish Shah, MD (6) · Elliott Vichinsky, MD (5) · Kenneth I Ataga, MD (5) · Michael R. DeBaun, MD, MPH (5)
PMID 36240296, PMID 37254256, PMID 38775255, PMID 40569673, PMID 41026975, PMID 42133908, PMID 26589907, PMID 20175775, PMID 24916507, PMID 33661274, PMID 36860093, PMID 36975201, PMID 38866240, PMID 39382077, PMID 39428602, PMID 39659429, PMID 41809202, PMID 19721013, PMID 23416852, PMID 30655275, PMID 30952488, PMID 31799940, PMID 32384147, PMID 34000072, PMID 34175041, PMID 34922648, PMID 35019238, PMID 35075288, PMID 35120836, PMID 35981565, PMID 36123234, PMID 36355805, PMID 36529836, PMID 36890729, PMID 37975597, PMID 38249565, PMID 38361924, PMID 38538687, PMID 39615812, PMID 40010689, PMID 40800810, PMID 40857358, PMID 40891510, PMID 41701977, PMID 41871072, PMID 41954645, PMID 42224366, PMID 42233421, PMID 42549972, PMID 10100293
2019 (8), U54HL070587 (8), 2023 (6), 2017 (5), U01HL133996 (4), 2014 (3), 2018 (3), 2025 (3), K23HL094376 (2), K23HL148310 (2), K23HL150232 (2), K24AT009893 (2), N01HB07160 (2), R01DK057778 (2), R01HL098014 (2)