82 recruiting. 82 Phase 3, 21 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 82 | Recruiting 82 |
| Phase 2 | 21 | Recruiting 21 |
Follow Pain: new trials by email Literature Review of Pain trials Research Report on Pain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Morphine or Ketamine for Analgesia Ketamine hydrochloride, Morphine sulphate - Abdominal Pain, Isolated Extremity Fracture | Phase 3 | Recruiting | Columbia University | 1010 | 2026-10-17 | 2026-10-20 |
| Suzetrigine in TKA Placebo, Suzetrigine - Total Knee Arthroplasty (TKA), Total Knee Arthroplasty \(TKA\) | Phase 3 | Recruiting | Hospital for Special Surgery, New York | 148 | 2026-10-15 | 2026-10-13 |
| Phase 3, Open-Label Extension Study of AMBTX-01 (Neridronate) for Complex Regional Pain Syndrome Type 1 Neridronate - Complex Regional Pain Syndrome Type I | Phase 3 | Recruiting | Ambros Therapeutics, Inc. | 135 | 2026-10-13 | 2026-10-16 |
| An Open-Label, Safety and Efficacy Study of Cebranopadol in Participants With Acute Pain With Surgical or Non-Surgical Origin Cebranopadol 400 ug - Pain | Phase 3 | Recruiting | Adneuris Therapeutics, Inc. | 160 | 2026-09-22 | 2026-10-23 |
| A Study of Combogesic® IV (Intravenous) in Pediatric Patients With Acute Pain Combogesic® IV (fixed-dose combination containing acetaminophen 10 mg/ml + ibuprofen 3 mg/ml in 100 ml solution for infusion) - Acute Pain | Phase 3 | Recruiting | AFT Pharmaceuticals, Ltd. | 60 | 2026-09-14 | 2026-09-16 |
| Comparative Efficacy of IV Dexamethasone vs. Nebulized Terbutaline for Renal Colic Pain in the ED Terbutaline 2.5 mg, Dexamethasone, Placebo - Renal Colic | Phase 3 | Recruiting | University of Monastir | 500 | 2026-08-08 | 2026-11-03 |
| Liposomal Bupivacaine Plus Plain Bupivacaine Versus Dexamethasone Plus Plain Bupivacaine in the Supraclavicular Brachial Plexus Block in Patients With Risk Factors for Severe Acute Postoperative Pain 10ml 0.5% plain bupivacaine with 10ml 1.33% liposomal bupivacaine, 19ml 0.5% plain bupivacaine with 1ml (4mg) dexamethasone - Pain, Postoperative, Liposomal Bupivacaine | Phase 3 | Recruiting | The University of Hong Kong | 90 | 2026-08-04 | 2026-09-08 |
| Intravenous Lidocaine to Prevent Post-Fundal Pressure Headache During Cesarean Section Lidocaine IV, Saline 0.9% - Intravenous Lidocaine, Fundal Pressure | Phase 3 | Recruiting | Tanta University | 680 | 2026-07-01 | 2026-07-06 |
| Extended-release Pregabalin for the Treatment of Neuropathic Pain in Patients With Diabetic Peripheral Neuropathy and Postherpetic Neuralgia Experimental: Pregabalin XR, Comparator: Dorene Tabs, Comparator placebo - Diabetic Neuropathy, Neuropathic Pain | Phase 3 | Recruiting | Brainfarma Industria Química e Farmacêutica S/A | 348 | 2026-06-18 | 2026-07-20 |
| Evaluate the Safety and Efficacy of HL-1186 Tablet for Postoperative Analgesia in Abdominal Surgery HL-1186, HL-1186 placebo, Oxycodone-Acetaminophen - Postoperative Pain | Phase 2 / Phase 3 | Recruiting | Shanghai Huilun Pharmaceutical Co., Ltd. | 330 | 2026-05-11 | 2026-07-16 |
| Evaluate the Safety and Efficacy of HL-1186 Tablet for Postoperative Analgesia in Orthopedic Surgery HL-1186, HL-1186 placebo, Oxycodone-Acetaminophen - Postoperative Pain | Phase 2 / Phase 3 | Recruiting | Shanghai Huilun Pharmaceutical Co., Ltd. | 330 | 2026-05-09 | 2026-07-13 |
| Suzetrigine-enhanced MultimOdal Opioid-sparing THerapy in Cardiac and Bariatric SURGery Suzetrigine, Placebo - Bariatric Surgery, Cardiac Surgery With Sternotomy | Phase 3 | Recruiting | Icahn School of Medicine at Mount Sinai | 235 | 2026-05-01 | 2026-05-14 |
| Safinamide vs Placebo for Pain in Patients With Parkinson's Disease and Motor Fluctuations Safinamide, Placebo - PARKINSON DISEASE (Disorder), Pain | Phase 3 | Recruiting | Universita di Verona | 60 | 2026-04-28 | 2026-08-13 |
| Virtual Menstrual Pain Approaches in Females Virtual Auricular Acupressure, Virtual Baduanjin Qigong Exercise, Self Education - Pain (Visceral, Somatic, or Neuropathic), Women of Reproductive Age | Phase 2 / Phase 3 | Recruiting | Nanyang Technological University | 145 | 2026-04-15 | 2026-06-23 |
| Evaluation of IV AMBTX-01 (Neridronate) for Treatment of CRPS Type 1 (CRPS-RISE) Neridronate, Placebo - Complex Regional Pain Syndrome Type I | Phase 3 | Recruiting | Ambros Therapeutics, Inc. | 270 | 2026-04-14 | 2026-10-29 |
| Suzetrigine for Treatment and Reduction of Intense Discomfort After knEe Replacement PAIN Suzetrigine, Placebo - Total Knee Replacement Surgery, Post-operative Pain | Phase 3 | Recruiting | Icahn School of Medicine at Mount Sinai | 235 | 2026-04-01 | 2026-04-23 |
| Comparative Efficacy Of 4 mg VS. 8 mg Submucosal Dexamethasone In Postoperative Pain Management After Dental Implant Surgery: A Randomized Double-Blind Controlled Clinical Trial Dexamethasone 4 Mg/mL Injectable Solution, Dexamethasone 8Mg Solution for Injection, Saline (NaCl 0,9 %) (placebo) - Postoperative Pain | Phase 3 | Recruiting | Oman Ministry of Health | 138 | 2026-03-25 | 2026-03-30 |
| Anesthetic Block of the Erector Muscles of the Lumbar Spine to Relieve Acute Lumbar Pain: Pilot Study Ropivacaine and dexamethasone injection solution, Sodium Chloride 0.9% Injection Solution - Lumbago | Phase 3 | Recruiting | Elsan | 40 | 2026-03-24 | 2026-06-10 |
| Clinical Trial to Evaluate the Efficacy and Safety of Platelet-rich Plasma Infiltration in Chronic Omalgia Platelet-rich Plasma Local injection, betamethasone and Ropivacaine - Chronic Pain | Phase 3 | Recruiting | Biobizkaia Health Research Institute | 86 | 2026-02-24 | 2026-03-04 |
| Clinical Trial Exploring the Outpatient Treatment of Phantom Limb Pain With Ketamine Administration in a Six Month Study With a Minimum Remission Period of 7 Days Between Treatment Session. 25-30 Subjects With an Ongoing History of Significant PLP.--FDA and IRB Approved. IM ketamine in dose finding and then continuation - Phantom Limb Syndrome With Pain | Phase 2 / Phase 3 | Recruiting | The Ketamine Research Foundation | 30 | 2026-01-15 | 2026-03-18 |
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Pain, Postoperative (28) · Agnosia (8) · Chronic Pain (8) · Neuralgia (7) · Arthralgia (3) · Back Pain (3) · Headache (3) · Low Back Pain (3) · Opioid-Related Disorders (3) · Pelvic Pain (3) · Abdominal Pain (2) · Acute Pain (2) · Angina Pectoris (2) · Anxiety Disorders (2)
Pathological Conditions, Signs and Symptoms (82) · Signs and Symptoms (82) · Neurologic Manifestations (81) · Pathologic Processes (35) · Postoperative Complications (29) · Nervous System Diseases (28) · Neurobehavioral Manifestations (11) · Neuromuscular Diseases (10) · Musculoskeletal Diseases (9) · Perceptual Disorders (9) · Peripheral Nervous System Diseases (9) · Mental Disorders (8) · Brain Diseases (6) · Cardiovascular Diseases (6)
Saline Solution (8) · Sodium Chloride (7) · Morphine (5) · Dexamethasone (4) · Dexmedetomidine (4) · Ketamine (4) · Methadone (3) · oxycodone-acetaminophen (3) · 6-amino-1-hydroxyhexane-1,1-diphosphonate (2) · Capsaicin (2) · Clonidine (2) · Diclofenac (2) · Fentanyl (2) · Ibuprofen (2) · Injections (2)
Assistance Publique - Hôpitaux de Paris (4) · Hospital for Special Surgery, New York (3) · Sahiwal medical college sahiwal (3) · Stanford University (3) · Ambros Therapeutics, Inc. (2) · Icahn School of Medicine at Mount Sinai (2) · Medical University of South Carolina (2) · Rutgers, The State University of New Jersey (2) · Shanghai Huilun Pharmaceutical Co., Ltd. (2) · The University of Hong Kong (2) · University Health Network, Toronto (2) · University of California, Davis (2) · University of Monastir (2) · University of Utah (2) · AFT Pharmaceuticals, Ltd. (1)
United States (33) · France (12) · China (5) · Canada (4) · Pakistan (4) · Brazil (3) · Egypt (3) · Hong Kong (3) · Spain (3) · Australia (2) · Denmark (2) · Israel (2) · Russia (2) · Singapore (2) · Tunisia (2)
Adeel Riaz, MD (3) · Alexandra Sideris, PhD (1) · Amy L Drendel, DO, MS (1) · Anatoly V Karalkin, MD, PhD (1) · Andrew Schrepf, PhD (1) · Anuj Bhatia, MD, PhD (1) · Arash Afshari, PhD (1) · Arash L Afshari, MD, PhD (1) · Bernardino Clavo, MD, PhD (1) · Christelle Nguyen, MD, PhD (1) · Christian Veillette, MD, MSc, FRCSC (1) · Christine Picinich, MS, AGACNP-BC, CCRN (1) · Christopher Fatora, MD (1) · Christopher Kim, HBSc, MSc, MD, FRCSC, PhD(c) (1)
PMID 16331769, PMID 16870080, PMID 17312203, PMID 18806027, PMID 19260079, PMID 20693179, PMID 21427067, PMID 21575276, PMID 22128754, PMID 23102757, PMID 23549581, PMID 24687190, PMID 24733808, PMID 25699252, PMID 26509324, PMID 27627711, PMID 28025837, PMID 28409480, PMID 29529620, PMID 29923953, PMID 30544393, PMID 30971284, PMID 31082965, PMID 31353997, PMID 31779159, PMID 32086778, PMID 32379556, PMID 32776794, PMID 33372949, PMID 33738491, PMID 34292820, PMID 34556382, PMID 35351553, PMID 35852550, PMID 36855160, PMID 37337269, PMID 38297390, PMID 38528704, PMID 38907675, PMID 39285437, PMID 39428602, PMID 40855727, PMID 42325096
2023 (3), 2019 (1), 2025 (1), R01DA056045 (1), R01DA056537 (1), R01HD108253 (1), U01HD116253 (1), U48DP006833 (1)