3 completed, 2 recruiting, 2 terminated, 1 unknown. 6 Phase 3, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 6 | Completed 2, Recruiting 2, Terminated 2 |
| Phase 2 | 3 | Completed 2, Unknown 1 |
Follow 6-amino-1-hydroxyhexane-1,1-diphosphonate: new trials by email Literature Review of 6-amino-1-hydroxyhexane-1,1-diphosphonate trials Research Report on 6-amino-1-hydroxyhexane-1,1-diphosphonate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase 3, Open-Label Extension Study of AMBTX-01 (Neridronate) for Complex Regional Pain Syndrome Type 1 Neridronate - Complex Regional Pain Syndrome Type I | Phase 3 | Recruiting | Ambros Therapeutics, Inc. | 135 | 2026-10-13 | 2026-10-16 |
| Evaluation of IV AMBTX-01 (Neridronate) for Treatment of CRPS Type 1 (CRPS-RISE) Neridronate, Placebo - Complex Regional Pain Syndrome Type I | Phase 3 | Recruiting | Ambros Therapeutics, Inc. | 270 | 2026-04-14 | 2026-10-16 |
| Efficacy and Safety of Intravenous Neridronic Acid in Complex Regional Pain Syndrome (CRPS) Neridronic acid 100 mg, Placebo - Complex Regional Pain Syndrome (CRPS) | Phase 3 | Terminated | Grünenthal GmbH | 267 | 2018-05-31 | 2020-08-05 |
| Efficacy and Safety of Intravenous Neridronic Acid in CRPS Neridronic acid 100 mg, Placebo - Complex Regional Pain Syndrome (CRPS) | Phase 3 | Terminated | Grünenthal GmbH | 182 | 2018-05-30 | 2020-08-06 |
| Safety of Intravenous Neridronic Acid in CRPS Neridronic acid - Complex Regional Pain Syndrome | Phase 3 | Completed | Grünenthal GmbH | 580 | 2016-12-20 | 2019-11-21 |
| Efficacy and Safety of Intravenous Neridronic Acid in CRPS-I Placebo, Neridronic acid 62.5 mg - Complex Regional Pain Syndrome, Type I | Phase 2 / Phase 3 | Completed | Grünenthal GmbH | 459 | 2015-04-01 | 2018-05-09 |
| Efficacy Study of Neridronate to Treat Painful Osteoarthritis of the Knee With Bone Marrow Lesions. Neridronate - Osteoarthritis, Knee | Phase 2 | Unknown | ASST Gaetano Pini-CTO | 60 | 2013-03-01 | 2013-03-14 |
| Efficacy and Safety of Neridronate (Nerixia®)to Treat Osteoporosis in Patients With TM and TI Neridronate - Osteoporosis, Thalassemia Major | Phase 2 | Completed | Ente Ospedaliero Ospedali Galliera | 120 | 2004-01-01 | 2020-02-05 |
Complex Regional Pain Syndromes (5) · Reflex Sympathetic Dystrophy (4) · Edema (2) · Pain (2) · Bone Diseases, Metabolic (1) · Osteoarthritis, Knee (1) · Osteoporosis (1) · Thalassemia (1) · beta-Thalassemia (1)
Grünenthal GmbH (4) · Ambros Therapeutics, Inc. (2) · ASST Gaetano Pini-CTO (1) · Ente Ospedaliero Ospedali Galliera (1)
United States (6) · Germany (3) · Italy (2) · United Kingdom (2) · Australia (1) · Canada (1) · Czechia (1) · France (1) · New Zealand (1) · Poland (1) · Serbia (1) · Slovakia (1) · South Korea (1) · Spain (1)
Ernesto Palummeri, MD (1) · Gail Cawkwell, MD, PhD (1) · Gian Luca Forni, MD (1)
2016 (2), 2014 (1), 2017 (1)