212 completed, 43 unknown, 22 terminated, 13 withdrawn. 90 Phase 4, 80 Not applicable, 66 Phase 3, 51 Phase 2, 33 Phase 1.
Follow Diclofenac: new trials by email Literature Review of Diclofenac trials Research Report on Diclofenac
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cold Water Papillary Irrigation Plus Rectal NSAIDs vs Rectal NSAIDs Alone for Post-ERCP Pancreatitis (COLD) Cold water irrigation of the papilla, Rectal NSAID (diclofenac 100 mg) - Post ERCP Pancreatitis, Acute Pancreatitis (AP) | Not applicable | Not yet recruiting | University Hospital Virgen de las Nieves | 250 | 2026-11-01 | 2026-10-21 |
| Medication vs. Meditation for Chronic Knee Osteoarthritis Oral diclofenac potassium 50 mg, Mindfulness meditation - Knee Osteoarthristis | Early Phase 1 | Not yet recruiting | Florida State University | 30 | 2026-10-01 | 2026-09-23 |
| Effect of Preoperative Diclofenac Potassium Dose on Endodontic Pain Diclofenac potassium 100mg, Diclofenac potassium 50mg, Placebo - Symptomatic Irreversible Pulpitis (SIP) | Not applicable | Not yet recruiting | Cairo University | 90 | 2026-08-01 | 2026-08-03 |
| Efficacy of Chemically Distinct Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and Pain Phenotypes in Adhesive Capsulitis Propionic acid deriaves, acetic acid derivatives, oxicam derivatives - Frozen Shoulder, Adhesive Capsulitis | Not applicable | Recruiting | Konya Beyhekim Training and Research Hospital | 120 | 2026-04-01 | 2026-05-14 |
| Topical Dexamethasone/Diclofenac Hydrogel for Postoperative Pain and Swelling in Facial Soft Tissue Injuries Poloxmer F-127 Hydrogel with Dexamethasone/Diclofenac, Plain Pluronic F-127 Hydrogel Placebo - Facial Injuries, Pain | Phase 2 / Phase 3 | Recruiting | Thamar University | 52 | 2026-01-01 | 2026-10-02 |
| Diclofenac for Prevention of Post-ERC Pancreatitis Diclofenac - Common Bile Duct Diseases | Phase 2 / Phase 3 | Not yet recruiting | Karolinska Institutet | 1000 | 2026-01-01 | 2025-08-13 |
| Counterpain PXM Versus Diclofenac Versus Piroxicam Piroxicam plus Counterirritant (brand name Counterpain® PXM)., Diclofenac Sodium 10 mg (Brand Name Hotin® DCL), Piroxicam 0.5% (Brand name Pirofel® gel) - Ankle Sprain, Back Pain | Phase 3 | Completed | Taisho Pharmaceutical Indonesia | 180 | 2025-11-04 | 2026-03-16 |
| The Antimicrobial Potential of Diclofenac Sodium as an Intracanal Medicament Diclofenac Sodium, Calcium hydroxide - Endodontic Disease, Pulp Disease, Dental | Phase 2 / Phase 3 | Recruiting | British University In Egypt | 48 | 2025-11-01 | 2025-05-30 |
| Comparative Evaluation of Diclofenac Sodium and Ibuprofen for Post-Endodontic Pain Management Ibuprofen, Diclofenac sodium - Irreversible Pulpitis, Post-endodontic Pain | Phase 4 | Completed | Armed Forces Institute of Dentistry, Pakistan | 60 | 2025-10-01 | 2026-05-04 |
| The Effect of Different Intracanal Medicaments on Periapical Lesion Healing Diclofenac sodium - Periapical Lesion Healing, Apical Periodontitis | Not applicable | Recruiting | Mustafa Kemal University | 60 | 2025-09-15 | 2026-10-07 |
| Topical Capsaicin Versus Diclofenac for Chronic Temporomandibular Joint-Related Pain Capsaicin Topical Cream, Diclofenac 1% Topical - Temporomandibular Disorders (TMD), Temporomandibular Pain | Not applicable | Completed | Istanbul University | 50 | 2025-08-28 | 2026-07-01 |
| Comparing Efficacy of Bromfenac 0.09%, Nepafenac 0.3% and Diclofenac 0.1% in Patients After Cataract Surgery Bromfenac 0.09 % Ophthalmic Solution, Nepafenac 0.3% Oph Susp, diclofenac 0.1% ophthalmic susp. - Macular Oedema, Cataract Surgery | Not applicable | Recruiting | Nemocnice Kolín | 150 | 2025-08-01 | 2025-09-17 |
| Pain Control After Open Radical Nephrectomy: Thoracic Paravertebral Block Versus External Oblique Intercostal Block Bupivacaine, morphine, paracetamol - Nephrectomy, Pain Scores | Not applicable | Completed | Hacettepe University | 98 | 2025-08-01 | 2026-03-17 |
| Comparison Between Oral Gabapentin Versus Diclofenac Sodium in Post-operative Analgesia Laparoscopic Cholecystectomy Gabapentin, Diclofenac Sodium - Cholecystitis, Chronic | Not applicable | Completed | Sohag University | 60 | 2025-07-14 | 2026-07-09 |
| The Effect of Three Different Medications on Anesthetic Success and Postoperative Pain Trypsin, Bromelain and Rutoside, Diclofenac Potassium 50mg Tab, Prednisolone Oral Tablet - Symptomatic Irreversible Pulpitis | Not applicable | Completed | Cairo University | 124 | 2025-06-15 | 2026-07-22 |
| Indomethacin vs Diclofenac for Preventing PEP Indomethacin 100 MG, Diclofenac 100mg - ERCP, Pancreatitis | Not applicable | Recruiting | Air Force Military Medical University, China | 4050 | 2025-06-01 | 2026-06-15 |
| Comparative Evaluation of Intraligamentary Injection of Dexamethasone, Diclofenac Sodium, and Chymotrypsin for Enhancing the Success of 4% Articaine Buccal Infiltration in Mandibular Molars With Symptomatic Irreversible Pulpitis Dexamathsone 4mg/ml associated with experimental arm, Diclofenac Sodium (DCS), chymotrypsin - Irreversible Pulpitis (Toothache) | Phase 4 | Completed | Fayoum University | 105 | 2025-05-23 | 2026-04-06 |
| Multimodal Imaging and Biospecimen Collection for Low Back Pain (LBPB) Nerve Block, endoscopic spinal disecetomy, Medication - Chronic Low Back Pain (CLBP), Acute Low Back Pain | Not yet recruiting | Peking University Third Hospital | 360 | 2025-05-15 | 2025-05-13 | |
| Diclofenac for the Treatment of Patients With Metastatic Non-small Cell Lung Cancer on Single Agent Immunotherapy Atezolizumab, Biospecimen Collection, Cemiplimab - Advanced Lung Non-Small Cell Carcinoma, Metastatic Lung Non-Small Cell Carcinoma | Phase 2 | Recruiting | Emory University | 20 | 2025-04-09 | 2026-02-12 |
| Intra-nasal Ketorolac for Acute Ureteral Stent-associated Pain Following Ureteroscopy for Stone Disease intra-nasal ketorolac, oral diclofenac - Post Operative Pain, Urolithiasis | Phase 1 / Phase 2 | Recruiting | University of Texas Southwestern Medical Center | 80 | 2025-03-01 | 2026-05-27 |
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Pain (44) · Pain, Postoperative (24) · Osteoarthritis (19) · Osteoarthritis, Knee (14) · Acute Pain (12) · Keratosis, Actinic (12) · Low Back Pain (11) · Agnosia (9) · Ankle Injuries (7) · Inflammation (7) · Renal Colic (7) · Pancreatitis (5) · Arthritis (4) · Dysmenorrhea (4) · Migraine Disorders (4)
Cairo University (19) · Pfizer (8) · Assiut University (6) · Boehringer Ingelheim (6) · Ain Shams University (4) · Cerimon Pharmaceuticals (4) · GlaxoSmithKline (4) · Novartis (4) · Novartis Pharmaceuticals (4) · Baskent University (3) · Depomed (3) · Fidia Farmaceutici s.p.a. (3) · Hamad Medical Corporation (3) · Iroko Pharmaceuticals, LLC (3) · Javelin Pharmaceuticals (3)
United States (64) · Egypt (30) · Germany (21) · Turkey (Türkiye) (19) · United Kingdom (13) · India (12) · Mexico (10) · Brazil (8) · France (7) · Italy (7) · Pakistan (7) · Russia (7) · Sweden (7) · Thailand (7) · China (6)
Nicola Giordan (3) · Paul D. Larsen, M.D. (3) · Alan Kivitz, MD (2) · Antoinette A Pragalos, MD (2) · Bradley Swenson, MD (2) · Brandon Essink, MD (2) · Cindy Tuten, MD (2) · Curtis S Horn, MD (2) · Dan Levitt, MD (2)
PMID 22587481, PMID 26993881, PMID 10352050, PMID 10613619, PMID 10754963, PMID 11942868, PMID 12148679, PMID 12447291, PMID 12480861, PMID 12490869, PMID 12609956, PMID 12917995, PMID 15230906, PMID 15507941, PMID 15791113, PMID 15798411, PMID 16321158, PMID 16331769, PMID 16460291, PMID 17029531, PMID 17196714, PMID 17437870, PMID 17470884, PMID 18498882, PMID 18702754, PMID 19647342, PMID 19736332, PMID 19922878, PMID 19967620, PMID 20102362, PMID 20124229, PMID 20178593, PMID 20465801, PMID 20638563, PMID 2070995, PMID 20804444, PMID 20934829, PMID 21300243, PMID 21362724, PMID 21629146, PMID 21692235, PMID 22186009, PMID 22678319, PMID 22842475, PMID 22892729, PMID 23100216, PMID 23364320, PMID 23440827, PMID 23578606, PMID 23672109
2015 (2), 2005 (1), 2009 (1), 2014 (1), 2017 (1), 2018 (1), 2019 (1), 2023 (1), P01CA027502 (1), P30CA023074 (1), P30CA138292 (1), R01CA193885 (1)