599 completed, 174 unknown, 77 recruiting, 68 terminated. 1052 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 1052 | Completed 599, Unknown 174, Recruiting 77, Terminated 68, Not yet recruiting 57, Withdrawn 48, Active not recruiting 19, Enrolling by invitation 8, Suspended 2 |
Follow Pain, Postoperative: new trials by email Literature Review of Pain, Postoperative trials Research Report on Pain, Postoperative
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Perioperative Esketamine Safety and Efficacy in Reducing Postoperative ENDometriosis PAIN (the ENDPAIN Trial): a Randomized Controlled Trial. Esketamine, Placebo - Endometriosis | Phase 4 | Not yet recruiting | Region Skane | 1000 | 2028-01-01 | 2026-10-19 |
| Suzetrigine Versus Standard Analgesia After Skin Cancer Surgery Suzetrigine, Acetaminophen Plus Ibuprofen - Postoperative Pain, Acute Pain | Phase 4 | Not yet recruiting | University of Minnesota | 230 | 2027-04-01 | 2026-09-25 |
| Suzetrigine (Journavx) as Multimodal Therapy for Pain Management in Adults Undergoing Surgery for Hip Fracture Suzetrigine (Journavx) - Hip Fractures (ICD-10 72.01-72.2), Post Operative Analgesia | Phase 4 | Not yet recruiting | Beth Israel Deaconess Medical Center | 79 | 2027-01-05 | 2026-10-29 |
| Evaluation of the Efficacy of Sublingual Sufentanil (Prescribed as Rescue Analgesia for Acute Postoperative Pain) on the Quality of Health Recovery After Surgery: a Randomized, Controlled, Multicenter, Open-label Trial Against an Active Comparator (SUBLIME) Sublingual sufentanil 30 µg (one dose per hour, as needed), Morphine sulfate (10 mg every 4 hours as needed) - Postoperative Pain | Phase 4 | Not yet recruiting | University Hospital, Strasbourg, France | 1150 | 2027-01-01 | 2026-06-03 |
| Study of QL Analgesic Response and Extent Quadratus Lumborum with 1.5% Lidocaine - Acute Pain, Postoperative Pain | Phase 4 | Not yet recruiting | Duke University | 25 | 2027-01-01 | 2026-07-08 |
| Oral Tranexamic Acid After Total Knee Arthroplasty tranexamic acid Oral-Short Arm, tranexamic acid Oral-Long Arm, Control group placebo - Total Knee Arthroplasty | Phase 4 | Not yet recruiting | Rush University Medical Center | 351 | 2026-12-20 | 2026-10-22 |
| Perioperative Colchicine for TKA Colchicine 1.8 mg (loading dose) + Dextrose Oral Placebo, Colchicine 1.8 mg + 0.6 mg, Dextrose Oral Placebo - Osteoarthritis of Knee, Recovery Following Primary Total Knee Arthroplasty | Phase 4 | Not yet recruiting | Geisinger Clinic | 75 | 2026-12-01 | 2026-09-03 |
| Effect of Low-Dose Esketamine Combined With Dexmedetomidine on the Incidence of Chronic Postsurgical Pain in Patients Undergoing Pancreatic Surgery Esketamine combined with dexmedetomidine, saline placebo - Chronic Pain, Postoperative | Phase 4 | Not yet recruiting | Tianjin Medical University Cancer Institute and Hospital | 450 | 2026-12-01 | 2026-10-22 |
| Exparel and Dexamethasone Liposomal Bupivacaine with Bupivacaine, Dexamethasone - Postoperative Pain, Shoulder Arthroscopic Surgeries | Phase 4 | Not yet recruiting | Duke University | 80 | 2026-11-01 | 2026-10-19 |
| Suzetrigine for Opioid-Sparing Postoperative Analgesia Following Transvaginal Pelvic Reconstructive Surgery Suzetrigine, Opioid Analgesics (Tramadol or Oxycodone), Scheduled Acetaminophen and Ibuprofen - Pelvic Organ Prolapse (POP), Stress Urinary Incontinence (SUI) | Phase 4 | Not yet recruiting | University of California, Los Angeles | 120 | 2026-11-01 | 2026-09-15 |
| Suzetrigine Added to Multimodal Analgesia for Women Undergoing Minimally Invasive Hysterectomy Suzetrigine - Postoperative Pain | Phase 4 | Not yet recruiting | Duke University | 123 | 2026-11-01 | 2026-09-23 |
| Suzetrigine Following Urogynecologic Surgery: Investigation of Postoperative Pain Management Suzetrigine, Placebo - Pelvic Organ Prolapse (POP), Postoperative Pain | Phase 4 | Not yet recruiting | Aditi Talkad | 48 | 2026-11-01 | 2026-10-02 |
| Effect of Labetalol, Magnesium Sulfate, or Lidocaine on Opioid Consumption During Laparoscopic Cholecystectomy Labetalol, Magnesium Sulfate, Lidocaine - Postoperative Pain, Cholelithiasis | Phase 4 | Not yet recruiting | Assiut University | 90 | 2026-11-01 | 2026-10-08 |
| Suzetrigine in Tonsillectomy for Opioid-sparing Pain Management Suzetrigine, Acetaminophen, oxycodone - Tonsillectomy, Pharyngoplasty | Phase 4 | Not yet recruiting | Stanford University | 58 | 2026-11-01 | 2026-09-16 |
| Effect of Oxybutynin on Opioid Use After Urologic Surgery in Children Oxybutynin, Placebo - Ureteropelvic Junction Obstruction, Hypospadias | Phase 4 | Not yet recruiting | University of Calgary | 200 | 2026-11-01 | 2026-11-02 |
| Low-Volume Pericapsular Nerve Group (PENG) Block With Dexamethasone vs Standard-Volume PENG Block After Total Hip Arthroplasty Pericapsular nerve group (PENG) block, Bupivacaine, Dexamethasone - Pain, Postoperative, Muscle Weakness | Phase 4 | Recruiting | Ain Shams University | 60 | 2026-10-15 | 2026-10-16 |
| A Randomized, Double-Blind, Placebo-Controlled Trial of Anrikefon for Postoperative Analgesia After Percutaneous Nephrolithotomy 0.9% Sodium Chloride Injection as Placebo, Anrikefon - Postoperative Pain, Nephrolithiasis | Phase 4 | Not yet recruiting | Beijing Tsinghua Chang Gung Hospital | 160 | 2026-10-12 | 2026-09-17 |
| Ultrasound-Guided Ilioinguinal-Iliohypogastric Nerve Block Following Spinal Anesthesia Comparing Dexmedetomidine Versus Nalbuphine as Adjuvants to Bupivacaine in Unilateral Inguinal Hernia Repair Bupivacaine, Nalbuphine, Dexmedetomidine - Inguinal Hernia, Postoperative Pain | Phase 4 | Not yet recruiting | Assiut University | 102 | 2026-10-01 | 2026-09-23 |
| Suzetrigine for Postoperative Pain After Total Ankle Replacement Suzetrigine - Ankle Osteoarthritis, Postoperative Pain | Phase 4 | Not yet recruiting | Soheil Ashkani Esfahani | 28 | 2026-10-01 | 2026-09-30 |
| Dexmedetomidine Versus Ketamine in TAP Block for Postoperative Analgesia After Total Abdominal Hysterectomy TAP block using Dexmedetomidine & Bupivacaine, TAP block using Ketamine Hydrochloride and Bupivacaine - Postoperative Pain, Total Abdominal Hysterectomy | Phase 4 | Not yet recruiting | Bangladesh Medical University | 64 | 2026-10-01 | 2026-10-01 |
Showing 20 of 1052. Sign in to see all of them.
Agnosia (97) · Pain (97) · Postoperative Nausea and Vomiting (38) · Acute Pain (31) · Postoperative Complications (19) · Chronic Pain (15) · Osteoarthritis, Knee (15) · Breast Neoplasms (14) · Patient Satisfaction (13) · Hernia, Inguinal (9) · Hyperalgesia (8) · Osteoarthritis (8) · Phantom Limb (8) · Emergence Delirium (7)
Neurologic Manifestations (1052) · Pathologic Processes (1052) · Pathological Conditions, Signs and Symptoms (1052) · Signs and Symptoms (1052) · Postoperative Complications (1033) · Pain (955) · Nervous System Diseases (145) · Neurobehavioral Manifestations (115) · Perceptual Disorders (105) · Musculoskeletal Diseases (58) · Signs and Symptoms, Digestive (51) · Wounds and Injuries (43) · Joint Diseases (38) · Nausea (37) · Vomiting (37)
Bupivacaine (148) · Ropivacaine (105) · Sodium Chloride (105) · Acetaminophen (98) · Dexamethasone (79) · Saline Solution (68) · Morphine (66) · Dexmedetomidine (52) · Ketamine (50) · Lidocaine (47) · Fentanyl (43) · Ibuprofen (42) · Oxycodone (40) · Ketorolac (29) · Epinephrine (27)
University of California, San Diego (24) · Cairo University (15) · Hvidovre University Hospital (15) · Ain Shams University (13) · Beijing Tiantan Hospital (13) · Cukurova University (13) · The University of Texas Health Science Center, Houston (13) · Duke University (11) · Mahidol University (11) · Mayo Clinic (11) · University of Aarhus (10) · Assiut University (9) · The Cleveland Clinic (8) · Zealand University Hospital (8) · B.P. Koirala Institute of Health Sciences (7)
United States (353) · Denmark (78) · China (64) · Turkey (Türkiye) (59) · Egypt (49) · Canada (38) · Finland (23) · Thailand (22) · Brazil (20) · South Korea (20) · Pakistan (19) · Belgium (17) · Poland (16) · Taiwan (15) · Spain (14)
Brian M Ilfeld, M.D., M.S. (9) · Fang Luo, M.D. (7) · Brian M Ilfeld, MD, MS (5) · Sirilak Suksompong, MD (5) · XiaoFeng Shen, MD (5) · Dong-Xin Wang, MD, PhD (4) · Ebru Biricik (3) · Fang Luo (3) · Glenn S Murphy, MD (3) · Kareem MA Nawwar, M.D. (3) · Nicolai Bang Foss, Dr.med. (3) · Ole Mathiesen, MD (3)
PMID 11020772, PMID 15041597, PMID 19478674, PMID 20418301, PMID 23121612, PMID 23850410, PMID 24216403, PMID 26184397, PMID 31663286, PMID 32175985, PMID 33990439, PMID 10702460, PMID 10927999, PMID 11020770, PMID 11034732, PMID 11098714, PMID 11589257, PMID 11737181, PMID 11808971, PMID 12067003, PMID 12351295, PMID 12453928, PMID 12538372, PMID 12680529, PMID 12760985, PMID 12873949, PMID 14612482, PMID 14616431, PMID 14693611, PMID 14971669, PMID 15082974, PMID 15114210, PMID 15157685, PMID 15495014, PMID 15505441, PMID 15779842, PMID 15795144, PMID 15907646, PMID 15923838, PMID 16568327, PMID 16580905, PMID 16632328, PMID 16691088, PMID 16856074, PMID 17042843, PMID 17179249, PMID 17299013, PMID 17435557, PMID 17513656, PMID 17519263
2017 (8), 2014 (7), 2009 (4), 2008 (3), 2015 (3), 2016 (2), 2019 (2), 2004 (1), 2005 (1), 2018 (1), 2025 (1), P01HD033988 (1), R01AG085287 (1), R01DA042985 (1), R01HD114678 (1)