21 withdrawn. 21 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 21 | Withdrawn 21 |
Follow Neurocognitive Disorders: new trials by email Literature Review of Neurocognitive Disorders trials Research Report on Neurocognitive Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| RCT: Trazodone vs Quetiapine vs Placebo for Treating ICU Delirium (TraQ) Trazodone, Quetiapine, Placebo - Delirium, Morality | Phase 4 | Withdrawn | University of Southern California | 2028-03-01 | 2026-05-04 | |
| Histidine Oral Supplementation as a Therapeutic Modality for Alzheimer's Disease l-Histidine, Control - Alzheimer Disease | Phase 4 | Withdrawn | Wake Forest University Health Sciences | 2025-04-01 | 2025-04-27 | |
| Suvorexant for Insomnia to Prevent Delirium in Hospitalized Cancer Patients Best Practice, Electronic Health Record Review, Interview - Advanced Malignant Solid Neoplasm, Delirium | Phase 4 | Withdrawn | Mayo Clinic | 2025-02-26 | 2025-05-01 | |
| Dexmedetomidine Cycling and Sleep in the Pediatric ICU Dexmedetomidine Hydrochloride - Cycling, Fentanyl - PICU Standard, Dexmedetomidine Hydrochloride - PICU Standard - Critical Illness, Sedation Complication | Phase 4 | Withdrawn | Vanderbilt University Medical Center | 2023-02-20 | 2022-05-10 | |
| Ramelteon vs Placebo for Prevention of Delirium and Improvement of Sleep in Hospitalized Older Adults Ramelteon, Placebo - Delirium in Old Age | Phase 4 | Withdrawn | Brigham and Women's Hospital | 2019-12-01 | 2020-01-22 | |
| Effect of Sevoflurane, Propofol and Dexmedetomidine on Delirium & Neuroinflammation in Mechanically Ventilated Patients Sevoflurane, Propofol, Dexmedetomidine - Delirium | Phase 4 | Withdrawn | Moscow Regional Research and Clinical Institute (MONIKI) | 2017-09-01 | 2019-08-15 | |
| Decreasing the Incidence of Delirium After Cardiac Surgery Benzodiazepine, Fentanyl, Propofol - C.Surgical Procedure; Cardiac, Delirium | Phase 4 | Withdrawn | University of California, Los Angeles | 2017-08-01 | 2018-06-12 | |
| Efficacy and Safety of 1612 Capsules in aMnestic Mild Cognitive Impairment 1612 capsule, Placebos - Mild Cognitive Impairment | Phase 4 | Withdrawn | Dongzhimen Hospital, Beijing | 2017-01-01 | 2021-03-04 | |
| Ramelteon and Citicoline for Delirium Ramelteon, Citicoline - Delirium | Phase 4 | Withdrawn | University of Texas Southwestern Medical Center | 2016-07-01 | 2017-11-09 | |
| Melatonin for Delirium Prophylaxis Melatonin, Placebo - Delirium | Phase 4 | Withdrawn | University of British Columbia | 2016-02-01 | 2021-10-07 | |
| Melatonin for Prevention of Post- Operative Delirium Pilot Study Protocol Melatonin, Placebo - Delirium | Phase 4 | Withdrawn | Loyola University | 2015-06-01 | 2016-09-16 | |
| Comparison of Dexmedetomidine and Propofol on the Delirium and Neuroinflammation in Patients With SIRS. Dexmedetomidine, Propofol - Delirium | Phase 4 | Withdrawn | Moscow Regional Research and Clinical Institute (MONIKI) | 2015-02-01 | 2019-08-14 | |
| Use of Dexmedetomidine in Children Undergoing Oral Maxillofacial Surgery to Decrease Emergence Delirium dexmedetomidine - Delirium | Phase 4 | Withdrawn | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University | 2011-06-01 | 2017-05-05 | |
| Efficacy and Safety of Risperidone and Trazodone Monotherapy and Combination Therapy in Critically Ill Patients With Delirium Risperidone, Trazodone, Placebo - Delirium, Agitation | Phase 4 | Withdrawn | Rochester General Hospital | 2011-03-01 | 2019-09-10 | |
| Once Weekly D-cycloserine for Schizophrenia D-cycloserine, Placebo - Schizophrenia | Phase 4 | Withdrawn | Massachusetts General Hospital | 2009-07-01 | 2013-11-20 | |
| Improving Function, Quality of Life, Glycemia in Diabetics With Dementia Methylphenidate, Placebo - Diabetes Mellitus, Alzheimer's Disease | Phase 4 | Withdrawn | University of Nebraska | 2008-11-18 | 2024-09-23 | |
| Ziprasidone vs Standard Therapy for Agitated Patients in the ED ziprasidone, Standard therapy - Psychosis, Agitation | Phase 4 | Withdrawn | George Washington University | 2008-09-01 | 2017-09-25 | |
| Evaluating The Impact Of Donepezil Hydrochloride (Aricept) On Behavioral And Psychological Symptoms In Patients With Severe Alzheimer's Disease Donepezil Hydrochloride (Aricept) - Severe Alzheimer's Disease | Phase 4 | Withdrawn | Eisai Inc. | 2008-01-01 | 2012-12-10 | |
| Safety and Efficacy of Divalproex and Quetiapine in Elderly Alzheimer's Dementia Patients Divalproex ER, Quetiapine - Alzheimer's Disease, Dementia | Phase 4 | Withdrawn | University of Cincinnati | 2006-10-01 | 2015-05-27 | |
| Amantadine for the Treatment of Behavioral Disturbance in Frontotemporal Dementia (FTD) Amantadine, Placebo - Dementia | Phase 4 | Withdrawn | Johns Hopkins University | 2005-09-01 | 2017-08-14 |
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Delirium (13) · Alzheimer Disease (5) · Dementia (3) · Cognitive Dysfunction (2) · Mental Disorders (2) · Psychomotor Agitation (2) · Psychotic Disorders (2) · Sleep Initiation and Maintenance Disorders (2) · Behavioral Symptoms (1) · Critical Illness (1) · Diabetes Mellitus (1) · Emergence Delirium (1) · Frontotemporal Dementia (1) · Lethargy (1) · Lymphoma, Follicular (1)
Mental Disorders (19) · Nervous System Diseases (19) · Neurobehavioral Manifestations (14) · Neurologic Manifestations (14) · Pathological Conditions, Signs and Symptoms (14) · Signs and Symptoms (14) · Confusion (13) · Brain Diseases (6) · Central Nervous System Diseases (6) · Neurodegenerative Diseases (6) · Tauopathies (5) · Behavior (3) · Dementia (3) · Aberrant Motor Behavior in Dementia (2)
Dexmedetomidine (4) · Propofol (3) · Donepezil (2) · Melatonin (2) · Quetiapine Fumarate (2) · Standard of Care (2) · Trazodone (2) · ramelteon (2) · Amantadine (1) · Benzodiazepines (1) · Cycloserine (1) · Cytidine Diphosphate Choline (1) · Fentanyl (1) · Histidine (1) · Interviews as Topic (1)
Moscow Regional Research and Clinical Institute (MONIKI) (2) · Brigham and Women's Hospital (1) · Dongzhimen Hospital, Beijing (1) · Eisai Inc. (1) · Ever Neuro Pharma GmbH (1) · George Washington University (1) · Johns Hopkins University (1) · Loyola University (1) · Massachusetts General Hospital (1) · Mayo Clinic (1) · Rochester General Hospital (1) · Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University (1) · University of British Columbia (1) · University of California, Los Angeles (1) · University of Cincinnati (1)
United States (14) · China (2) · Austria (1) · Canada (1)
Catherine M Kuza, MD, FASA (1) · Chiara N Foster, MD (1) · David M Blass, M.D. (1) · Dieter Meier, MD (1) · Donald C Goff, M.D. (1) · E. Sherwood Brown, MD, PhD (1) · Elizabeth B Klerman, M.D.,PhD (1) · Hong Jiang, MD, PHD (1) · Jacques Neelankavil, M.D. (1) · Jinzhou Tian, M.D,PhD (1) · Mindee S Hite, Pharm.D. (1) · Muhammad Aslam, MD (1) · Muralidhara S Rao, MD (1) · Peter KY Chan, MD (1) · Prasad R Padala, M.D. (1)
PMID 12075033, PMID 15082703, PMID 15817019, PMID 1593914, PMID 19347026, PMID 19687169, PMID 19865006, PMID 21926597, PMID 22301509, PMID 23182527, PMID 23506796, PMID 25348864, PMID 26077062, PMID 26118922, PMID 6880820
P50MH060450 (1)