5 completed, 2 recruiting, 2 withdrawn, 1 not yet recruiting. 5 Phase 2, 4 Not applicable, 1 Early Phase 1, 1 Phase 1, 1 Phase 3.
Follow Histidine: new trials by email Literature Review of Histidine trials Research Report on Histidine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Monosodium Glutamate on Microbiome-Derived Imidazole Propionate Production in Healthy Volunteers L-histidine, Monosodium glutamate (MSG), Sodium chloride (NaCl) - Healthy Adult | Not applicable | Not yet recruiting | University of Chicago | 18 | 2026-07-15 | 2026-07-14 |
| Histidine Supplementation for Antitumor Immunity in Colorectal Cancer Histidine - Colorectal Cancer | Not applicable | Recruiting | Jing-yuan Fang, MD, Ph. D | 20 | 2026-05-06 | 2026-08-20 |
| Histidine Oral Supplementation as a Therapeutic Modality for Alzheimer's Disease l-Histidine, Control - Alzheimer Disease | Phase 4 | Withdrawn | Wake Forest University Health Sciences | 2025-04-01 | 2025-04-27 | |
| Histaminergic Basis of Fatigue in Multiple Sclerosis L-Histidine, Placebo, Lodosyn - Multiple Sclerosis | Phase 2 | Withdrawn | University of Miami | 2022-01-01 | 2021-07-29 | |
| Biomarkers of Diet-microbiota Interactions in Irritable Bowel Syndrome L-Histidine, High-FODMAP beverage, Low-FODMAP beverage - Irritable Bowel Syndrome | Early Phase 1 | Completed | McMaster University | 30 | 2021-07-15 | 2026-04-13 |
| Histidine Therapy: A Project to Treat HARS Deficiency L-Histidine - HARS Syndrome | Phase 2 / Phase 3 | Unknown | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 14 | 2018-08-01 | 2022-06-10 |
| Histaminergic Basis of Central Fatigue in Multiple Sclerosis - A Novel Approach Carbidopa, L-Histidine - Multiple Sclerosis | Phase 1 | Completed | University of Miami | 18 | 2018-03-23 | 2020-10-08 |
| Safety of Graded-Dose of Histidine in Humans Histidine - Healthy | Not applicable | Completed | Cornell University | 40 | 2017-09-21 | 2022-02-07 |
| Phase 2 Trial of Seribantumab Plus Fulvestrant in Postmenopausal Women With Metastatic Breast Cancer Seribantumab, Fulvestrant, Placebo - Metastatic Breast Cancer | Phase 2 | Terminated | Elevation Oncology | 22 | 2017-08-15 | 2020-09-02 |
| Neurovascular Transduction During Exercise in Chronic Kidney Disease 6R-BH4, 6R-BH4 placebo, Folic acid - Renal Insufficiency, Chronic | Phase 2 | Recruiting | Emory University | 150 | 2016-10-01 | 2026-05-18 |
| Mechanistic Approach to Preventing Atrophy and Restoring Function in Older Adults Essential Amino Acids (EAA), Placebo (Alanine) - Muscle Atrophy, Quality of Life | Phase 2 | Completed | University of Oregon | 80 | 2014-12-01 | 2024-07-23 |
| Muscle Regrowth During Physical Rehabilitation and Amino Acid Supplementation Essential amino acids, Alanine - Osteoarthritis | Not applicable | Completed | University of Oregon | 60 | 2008-06-01 | 2014-12-04 |
Fatigue (2) · Multiple Sclerosis (2) · Alzheimer Disease (1) · Breast Neoplasms (1) · Colorectal Neoplasms (1) · Hypertension (1) · Irritable Bowel Syndrome (1) · Kidney Diseases (1) · Muscular Atrophy (1) · Osteoarthritis (1) · Renal Insufficiency, Chronic (1)
University of Miami (2) · University of Oregon (2) · Cornell University (1) · Elevation Oncology (1) · Emory University (1) · Jing-yuan Fang, MD, Ph. D (1) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (1) · McMaster University (1) · University of Chicago (1) · Wake Forest University Health Sciences (1)
United States (9) · Canada (3) · Austria (1) · Belgium (1) · China (1) · Germany (1) · Spain (1)
Kottil Rammohan, MD (2) · Hans C Dreyer, PT, PhD (1) · Jing-Yuan Fang, M.D. (1) · Joe Nocera, PhD (1) · Marc Pipas, MD (1) · Premysl Bercik, MD (1) · Stephen Vanner, MD (1) · Wells Reynolds, MD (1)
PMID 22204954, PMID 24135139, PMID 26733251, PMID 26829246, PMID 30280129, PMID 31343947, PMID 32766885, PMID 36810250
2017 (1), K01HD057332 (1), R01AG046401 (1), R01HL135183 (1)