134 completed, 56 recruiting, 33 unknown, 21 active not recruiting. 80 Not applicable, 50 Phase 2, 36 Phase 1, 9 Phase 3, 7 Early Phase 1.
Follow Frontotemporal Dementia: new trials by email Literature Review of Frontotemporal Dementia trials Research Report on Frontotemporal Dementia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Alzheimer's Tau Platform: Regimen A - AADvac1 AADvac1, Donanemab - Preclinical Alzheimer's Disease, Prodromal Alzheimer's Disease | Phase 2 | Enrolling by invitation | Paul S. Aisen | 450 | 2026-11-03 | 2026-09-08 |
| A Wearable Sensor Platform for Remote Monitoring of Individuals on the Frontotemporal Dementia Spectrum Frontotemporal Lobar Degeneration (FTLD), Frontotemporal Dementia (FTD) | Not yet recruiting | BioSensics | 60 | 2026-11-01 | 2026-10-13 | |
| Speech-Based Artificial Intelligence for Detection of Dementia in Danish Patients (DetectAI) Mini-mental State Examination, Addenbrooke's Cognitive Examination, Speech Task - Picture Description - Dementia (Diagnosis), Alzheimer Dementia (AD) | Not yet recruiting | Zealand University Hospital | 440 | 2026-11-01 | 2026-09-02 | |
| A Study to Evaluate the Safety, Tolerability and Pharmacodynamics of NIO752 in Primary Tauopathies NIO752, Placebo - Progressive Supranuclear Palsy, Corticobasal Degeneration | Phase 2 | Not yet recruiting | Novartis Pharmaceuticals | 48 | 2026-10-23 | 2026-10-09 |
| Digital Measurements of Motor and Voice Functions in FTD Frontotemporal Lobar Degeneration (FTLD), Frontotemporal Dementia (FTD) | Not yet recruiting | BioSensics | 20 | 2026-08-01 | 2026-04-28 | |
| The Progressive Supranuclear Palsy Clinical Trial Platform - Regimen B: LM11A-31 LM11A-31, Matching Placebo - PSP - Progressive Supranuclear Palsy | Phase 2 | Enrolling by invitation | Adam Boxer | 147 | 2026-07-29 | 2026-08-12 |
| The Progressive Supranuclear Palsy Clinical Trial Platform - Regimen A: AADvac1 AADvac1, Matching Placebo - PSP - Progressive Supranuclear Palsy | Phase 2 | Enrolling by invitation | Adam Boxer | 146 | 2026-07-29 | 2026-08-13 |
| Temporal Interference Stimulation Treatment in Patients With Cognitive Impairment Temporal Interference Stimulation, Sham Temporal Interference Stimulation, Targeted Cognitive Training - Amnestic Mild Cognitive Impairment - aMCI, AD-MCI | Not applicable | Recruiting | Tianjin Huanhu Hospital | 60 | 2026-07-01 | 2026-06-11 |
| Restoring Cervical Lymphatic Drainage in Alzheimer's Disease Cervical lymphovenous anastomosis (LVA) - Alzheimer, Alzheimer Dementia (AD) | Not applicable | Recruiting | University of Siena | 5 | 2026-07-01 | 2026-10-02 |
| MSC-Exosome Therapy for Frontotemporal Dementia Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes （Low-Dose）, Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes （High-Dose）, Placebo Comparator (0.9% NaCl) - Frontotemporal Dementia | Phase 1 / Phase 2 | Not yet recruiting | Ruijin Hospital | 33 | 2026-07-01 | 2026-07-13 |
| AV-1980R (Tau Vaccine) in Preclinical Alzheimer's Disease (TAURUS-1980) AV-1980R 20 µg, AV-1980R 60 µg, AV-1980R 180 µg - Alzheimer Disease, Preclinical Alzheimer's Disease | Phase 1 | Recruiting | Institute for Molecular Medicine | 48 | 2026-06-23 | 2026-08-21 |
| A Study to Evaluate the Efficacy of NIO752 in Participants With Progressive Supranuclear Palsy NIO752, Placebo - Progressive Supranuclear Palsy Richardson Syndrome (PSP-RS) | Phase 3 | Recruiting | Novartis Pharmaceuticals | 300 | 2026-06-03 | 2026-10-15 |
| Intervention for Communication Quality of Life in Primary Progressive Aphasia Multicomponent Lexical Retrieval Cascade Training, Multicomponent Video Implemented Script Training in Aphasia - Primary Progressive Aphasia(PPA), Semantic Dementia | Not applicable | Recruiting | Maya Henry | 30 | 2026-04-01 | 2026-04-21 |
| Links Between Self-awareness and Sociocognitive Processes in Neurodegenerative Diseases Computer-based facial expression recognition task, Computerized affective task, UCLA Structured Insight Interview - Frontotemporal Dementia, Behavioral Variant, Alzheimer Disease | Recruiting | Assistance Publique - Hôpitaux de Paris | 34 | 2026-04-01 | 2026-04-15 | |
| Retrospective Observational Study of Blood-based Biomarkers in the Diagnosis and Monitoring of Patients With a Neurodegenerative Disease or Mental Disorder Alzheimer Disease, Dementia With Lewy Bodies (DLB) | Enrolling by invitation | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 1799 | 2026-02-19 | 2026-02-23 | |
| Learning Amyloid and Tau Results Disclose amyloid, tau results, Follow-up Assessments - Alzheimer Disease | Enrolling by invitation | University of Wisconsin, Madison | 240 | 2026-02-17 | 2026-06-24 | |
| Transcranial Alternating Current Stimulation in Frontotemporal Dementia Transcranial Alternating Current Stimulation, Sham Transcranial Alternating Current Stimulation - Transcranial Alternating Current Stimulation, Frontotemporal Dementia (FTD) | Not applicable | Recruiting | IRCCS Centro San Giovanni di Dio Fatebenefratelli | 30 | 2026-02-03 | 2026-09-24 |
| Prospective Observational Study of the Relationship Between Sociodemographic Factors, Blood-based Biomarkers and Psychiatric Symptoms in Neurodegenerative Diseases and Mental Disorders Major Depressive Disorder (MDD), Schizophenia Disorder | Enrolling by invitation | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 1310 | 2026-02-01 | 2026-04-24 | |
| Research Study for Patients With Neurological Diseases Which Evaluates the Patient Experience of the MemorEM Device MemorEM - Alzheimer Disease, Parkinson Disease | Not applicable | Enrolling by invitation | eQ8Health Corporation d/b/a CareONE Concierge | 1000 | 2025-12-01 | 2026-02-05 |
| First-in-Human Study for the Safety and Evaluation of Two 4R Tau Ligands as Potential PET Radioligands for Imaging Tau Protein in the Brain [18F]ABBV-964i, [18F]ABBV-965i, Lead Candidate - Progressive Supranuclear Palsy (PSP), Healthy Participants | Early Phase 1 | Completed | Invicro | 11 | 2025-11-17 | 2026-07-10 |
Showing 20 of 290. Sign in to see all of them.
Alzheimer Disease (139) · Pick Disease of the Brain (103) · Dementia (83) · Cognitive Dysfunction (48) · Lewy Body Disease (44) · Amyotrophic Lateral Sclerosis (31) · Aphasia, Primary Progressive (31) · Dementia, Vascular (30) · Supranuclear Palsy, Progressive (28) · Parkinson Disease (27) · Frontotemporal Lobar Degeneration (26) · Corticobasal Degeneration (24) · Neurodegenerative Diseases (24) · Plaque, Amyloid (20)
Central Nervous System Diseases (286) · Brain Diseases (284) · Nervous System Diseases (284) · Neurocognitive Disorders (281) · Mental Disorders (280) · Frontotemporal Lobar Degeneration (264) · Neurodegenerative Diseases (246) · Nutritional and Metabolic Diseases (213) · Metabolic Diseases (212) · Proteostasis Deficiencies (210) · Dementia (207) · TDP-43 Proteinopathies (207) · Tauopathies (149) · Pathological Conditions, Signs and Symptoms (123)
7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (9) · Transcranial Direct Current Stimulation (7) · florbetapir (7) · AADvac1 (6) · Blood Specimen Collection (5) · Memantine (5) · Spinal Puncture (5) · 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole (4) · Oxytocin (4) · Transcranial Magnetic Stimulation (4) · 4-(N-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbene (3) · Fluorodeoxyglucose F18 (3) · Genetic Testing (3) · Magnetic Resonance Imaging (3) · Observation (3)
University of California, San Francisco (11) · Assistance Publique - Hôpitaux de Paris (8) · Mayo Clinic (8) · National Institute of Neurological Disorders and Stroke (NINDS) (7) · University of Pennsylvania (7) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (6) · Chang Gung Memorial Hospital (5) · University of Southern California (5) · Alector Inc. (4) · Axon Neuroscience SE (4) · Columbia University (4) · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (4) · Johns Hopkins University (4) · Massachusetts General Hospital (4) · University Health Network, Toronto (4)
United States (144) · Canada (46) · France (33) · United Kingdom (26) · Italy (23) · Spain (21) · Netherlands (16) · Germany (15) · Australia (11) · Belgium (11) · China (9) · Sweden (8) · South Korea (7) · Taiwan (7) · Finland (6)
Adam Boxer, MD, PhD (7) · Edward Huey, MD (4) · Bradley Boeve, MD (3) · Maya L Henry, PhD (3) · Michael W. Weiner, MD (3) · Paul Aisen, MD (3) · Adam L Boxer, MD, PhD (2) · Adam L. Boxer, M.D., Ph.D. (2) · Anne-Marie Wills, MD (2) · Elizabeth C Finger, MD (2) · Elizabeth Finger, MD (2) · Emily Roglaski, PhD (2) · Howie Rosen, MD (2) · Irene Litvan, MD (2)
PMID 35790423, PMID 27955995, PMID 30355322, PMID 33441454, PMID 33827960, PMID 34187867, PMID 34349004, PMID 35492244, PMID 38853879, PMID 39219209, PMID 39324520, PMID 42862762, PMID 10720283, PMID 11976975, PMID 12092785, PMID 12566600, PMID 12921793, PMID 15034582, PMID 15753425, PMID 1580810, PMID 16199218, PMID 16317258, PMID 16419137, PMID 16783167, PMID 16799555, PMID 16984901, PMID 17071924, PMID 17224685, PMID 17345602, PMID 17436289, PMID 17664410, PMID 17909133, PMID 17935506, PMID 18245784, PMID 18260132, PMID 19251627, PMID 19380227, PMID 19734901, PMID 19828315, PMID 20104022, PMID 20301649, PMID 20582942, PMID 20633386, PMID 20685689, PMID 20801717, PMID 21157021, PMID 21325651, PMID 21396882, PMID 21412659, PMID 21438137
2023 (4), 2016 (3), R01AG055425 (3), 2017 (2), R01AG085029 (2), R44AG065088 (2), U01AG024904 (2), U54NS092091 (2), 1RF1AG058067-01A1 (1), 2014 (1), 2015 (1), 2RF1AG038465-06 (1), I01CX000736 (1), K23AG088248 (1), K76AG060005 (1)