26 completed, 3 unknown, 3 withdrawn, 1 recruiting. 10 Phase 4, 6 Phase 2, 4 Phase 3, 3 Not applicable, 3 Phase 1.
Follow Benzodiazepines: new trials by email Literature Review of Benzodiazepines trials Research Report on Benzodiazepines
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Measuring Acute Drug Demand in Humans II Blinded Study Medication - Condition 1, Blinded Study Medication - Condition 2, Blinded Study Medication - Condition 3 - Healthy Volunteers | Early Phase 1 | Withdrawn | Johns Hopkins University | 2025-11-15 | 2025-11-12 | |
| Maternal And Infant Antipsychotic Study Antipsychotics, Non-antipsychotic medication, No Medication - Antipsychotics, Pregnancy | Recruiting | Icahn School of Medicine at Mount Sinai | 74 | 2023-09-29 | 2026-06-22 | |
| Side Effects of Psychiatric Medications - a Nested Case Control Cohort Historical Prospective Study Psychiatric Drugs - Psychotic Disorders | Unknown | Mark Weiser, MD, Principal Investigator | 22777 | 2023-03-26 | 2024-03-04 | |
| Benzodiazepines in Opiate Replacement Therapy Benzodiazepine - Substance-Related Disorders | Completed | University of Stirling | 46899 | 2021-08-01 | 2023-03-09 | |
| Pilot RECAP Study in Healthy Volunteers Psilocybin and Midazolam - Psychedelic Experiences, Amnesia | Phase 1 | Completed | University of Wisconsin, Madison | 8 | 2021-05-21 | 2023-05-19 |
| Benzodiazepine Discontinuation in Opioid Agonist Therapy Distress Tolerance - Benzodiazepine Discontinuation (DT-BD), BZD discontinuation protocol - Substance Use Disorders | Phase 2 | Completed | Boston Medical Center | 4 | 2021-03-18 | 2022-02-11 |
| Maternal and Neonatal Outcomes Following Exposure to Benzodiazepines During Pregnancy Benzodiazepine - Pregnancy Related, Benzodiazepines Causing Adverse Effects in Therapeutic Use | Completed | Sungkyunkwan University | 3094227 | 2020-12-01 | 2022-03-07 | |
| Effects of Experimental Sleep Disturbances on Receptor Function of Study Drug Sleep Fragmentation, Within-Subject test of blinded study medication (stimulant, benzodiazepine, opioid, cannabinoid, over-the-counter pain medication, or placebo), Sleep Continuity Disruption - Sleep Disorder, Healthy | Phase 2 | Completed | Johns Hopkins University | 148 | 2020-11-11 | 2025-09-24 |
| Comparison of Postoperative Delirium in Elders Anaesthetised With Midazolam and Without Midazolam Midazolam - Postoperative Delirium | Completed | Chinese PLA General Hospital | 11927 | 2020-04-01 | 2022-07-18 | |
| Efficacy of Electroencephalography (EEG) Neurofeedback (NF) for the Treatment of Anxiety Disorder SSRI or SNRI or benzodiazepines or tricyclic antidepressants or other antidepressants or antipsychotics or other sedative-hypnotics, Neurofeedback system - Anxiety Disorder, Healthy | Not applicable | Unknown | Tianjin Anding Hospital | 60 | 2019-09-10 | 2021-10-19 |
| Consequences of Doing What Should Not be Done in Primary Care Benzodiazepines, Non-steroidal anti-inflammatory drugs, paracetamol - Overdose, Adverse Event | Completed | Universidad Miguel Hernandez de Elche | 750000 | 2018-10-14 | 2020-04-03 | |
| Maximizing Analgesia to Reduce Pain in Knee Osteoarthritis Blinded study medication - Knee Osteoarthritis | Phase 2 | Completed | Johns Hopkins University | 58 | 2017-11-01 | 2024-12-11 |
| Decreasing the Incidence of Delirium After Cardiac Surgery Benzodiazepine, Fentanyl, Propofol - C.Surgical Procedure; Cardiac, Delirium | Phase 4 | Withdrawn | University of California, Los Angeles | 2017-08-01 | 2018-06-12 | |
| Efficacy of Ketamine Infusion Compared With Traditional Anti-epileptic Agents in Refractory Status Epilepticus Traditional Treatment (Group T), Ketamine Infusion (Group K) - Refractory Epilepsy | Phase 2 / Phase 3 | Withdrawn | University of Alabama at Birmingham | 2017-05-04 | 2021-05-21 | |
| Remifentanil Effect-site Prediction by Algometry Remifentanil 1 MG Injection [Ultiva], Midazolam 1 MG/ML Prefilled Syringe, Saline solution - Conscious Sedation Failure During Procedure | Completed | Hospital Universitari Vall d'Hebron Research Institute | 100 | 2017-03-01 | 2021-11-10 | |
| Gabapentin for Alcohol Withdrawal Syndrome Gabapentin, Benzodiazepines, Divalproex Sodium - Alcohol Withdrawal Syndrome | Phase 4 | Completed | Mayo Clinic | 88 | 2017-02-01 | 2022-03-24 |
| The Assessment of POCD After TURBT Under Spinal Anesthesia benzodiazepines, opioid, spinal anesthesia - Bladder Tumor, Postoperative Cognitive Dysfunction | Phase 4 | Unknown | Medical University of Warsaw | 200 | 2017-01-01 | 2017-01-24 |
| Comparative Effectiveness of Adaptive Treatment Strategies for Schizophrenia Antipsychotic, Antidepressant, Benzodiazepine - Schizophrenia, Schizoaffective Disorder | Completed | New York State Psychiatric Institute | 81921 | 2015-07-01 | 2024-05-01 | |
| Effects of PQ912 on the Pharmacokinetics of Midazolam and Omeprazole PQ912, Midazolam, Omeprazole - Healthy Volunteers, Pharmacologic Action | Phase 1 | Completed | Vivoryon Therapeutics N.V. | 18 | 2014-06-01 | 2015-10-21 |
| Pregabalin for Opiate Withdrawal Syndrome Pregabalin, Clonidine, Doxylamin - Opioid Withdrawal | Phase 4 | Completed | St. Petersburg Bekhterev Research Psychoneurological Institute | 100 | 2014-01-01 | 2020-04-07 |
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Anxiety Disorders (3) · Psychotic Disorders (3) · Substance-Related Disorders (3) · Drug Overdose (2) · Seizures (2) · Acute Disease (1) · Aggression (1) · Agnosia (1) · Amnesia (1) · Breast Neoplasms (1) · Congenital Abnormalities (1) · Delirium (1) · Drug Resistant Epilepsy (1) · Emergence Delirium (1) · Forearm Injuries (1)
Johns Hopkins University (3) · Assistance Publique - Hôpitaux de Paris (1) · AstraZeneca (1) · Boston Medical Center (1) · Chinese PLA General Hospital (1) · Ethicon Endo-Surgery (1) · GlaxoSmithKline (1) · Hospital Universitari Vall d'Hebron Research Institute (1) · Hospital Universitari de Bellvitge (1) · Icahn School of Medicine at Mount Sinai (1) · Janssen Cilag N.V./S.A. (1) · Mark Weiser, MD, Principal Investigator (1) · Mayo Clinic (1) · Medical University of Warsaw (1) · Minamihanno Hospital (1)
United States (14) · Spain (4) · China (2) · Japan (2) · United Kingdom (2) · Belgium (1) · Israel (1) · Italy (1) · Poland (1) · Russia (1) · South Korea (1) · Thailand (1)
Alexandra Kearson, BA (1) · Alice P Chen, M.D. (1) · Ana Abad-Torrent, M.D (1) · Apinya Vutikullird, DO (1) · Cathy D. Sherbourne, PhD (1) · Christopher R Nicholas, MD,PHD (1) · Claudia Campbell, PhD (1) · Claudia M Campbell, Ph.D. (1) · Eric C Strain, MD (1) · Faris Murad, M.D. (1) · Giorgio Danelli, MD (1) · Greer Sullivan, MD, MSPH (1) · Guido Fanelli, MD (1) · Hiroto Kuwabara, MD (1)
PMID 19212970, PMID 19829198, PMID 20146834, PMID 20483968, PMID 21168841, PMID 21367351, PMID 21464362, PMID 21762829, PMID 22152230, PMID 22304968, PMID 22404963, PMID 23184657, PMID 23225338, PMID 23290323, PMID 23332608, PMID 23370069, PMID 23377641, PMID 23407203, PMID 23580378, PMID 23608160, PMID 23729989, PMID 23750465, PMID 23801589, PMID 23886736, PMID 24338947, PMID 24619599, PMID 24660674, PMID 25272965, PMID 25562579, PMID 26563229, PMID 26994459, PMID 27775823, PMID 30232735, PMID 30837247, PMID 34009877, PMID 35235572, PMID 36302173, PMID 37469099, PMID 38485490, PMID 41481837
2009 (1), 2014 (1), K23DA044321 (1), R01DA042751 (1), R01HD111117 (1), U01HL150568 (1), U01MH057858 (1)