36 completed, 14 recruiting, 5 unknown, 4 terminated. 15 Phase 4, 14 Phase 1, 13 Phase 2, 11 Phase 3, 9 Not applicable.
Follow this drug Literature Review of Trazodone trials Research Report on Trazodone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| RCT: Trazodone vs Quetiapine vs Placebo for Treating ICU Delirium (TraQ) Trazodone, Quetiapine, Placebo - Delirium, Morality | Phase 4 | Withdrawn | University of Southern California | 2028-03-01 | 2026-05-04 | |
| Central Apnea in Heart Failure: Physiological Mechanisms to Inform Treatment Trazodone + positive airway pressure (PAP) therapy, Oxygen + positive airway pressure (PAP) therapy - Sleep Disordered Breathing, Able Bodied | Phase 4 | Recruiting | VA Office of Research and Development | 200 | 2026-09-16 | 2026-10-13 |
| Efficacy of Psilocybin and Trazodone Combination in Treatment-resistant Depression: a Randomized Controlled Proof-of-concept Study (PSILOTRAZ) Psilocybin 25 mg per os, Trazodone 5mg, Trazodone 30 mg - Depression - Major Depressive Disorder, Treatment-resistant Depression (TRD) | Phase 2 | Recruiting | Centre Hospitalier St Anne | 112 | 2026-06-30 | 2026-09-21 |
| A SMART Approach to Evaluating the Benefits of Common Prescription and OTC Medications for Insomnia Sleep Hygiene Education, Melatonin IR, 3 mg, Melatonin IR, 5 mg - Insomnia, Insomnia Disorder | Phase 4 | Recruiting | University of Pennsylvania | 1200 | 2026-05-01 | 2026-09-16 |
| Comparing Digital Therapy, Trazodone, and Daridorexant for Menopause-Related Insomnia Symptoms Cognitive behavioral therapy for insomnia (CBT-i), Trazodone, Daridorexant - Menopausal Women, Insomnia | Phase 4 | Recruiting | Brigham and Women's Hospital | 1000 | 2026-02-13 | 2026-06-08 |
| Efficacy of Trazodone to Treat Insomnia in Older Adults (TRADITION Study) Trazodone 25 mg - Insomnia Chronic, Older People | Phase 2 | Recruiting | Centre hospitalier de l'Université de Montréal (CHUM) | 40 | 2025-11-10 | 2025-12-08 |
| Prevention of Postpartum Depression: A Pilot Placebo-controlled Trial of Trazodone Trazodone, Placebo - Postpartum Depression | Phase 1 | Withdrawn | Verinder Sharma | 2025-04-17 | 2025-04-04 | |
| Neurobiological and Genomic Predictors of Relapse in Depression Antidepressant Medications - Healthy, Major Depressive Disorder (MDD) | Recruiting | Mehmet Kemal Arikan | 204 | 2025-01-01 | 2026-01-09 | |
| Pharmacological Treatment Targeting Endotypic Traits of Obstructive Sleep Apnea Atomoxetine 80mg combined with oxybutynin 5mg, Venlafaxine 37.5mg, oxybutynin 5mg combined with trazodone 100mg - Obstructive Sleep Apnea of Adult | Phase 4 | Completed | China Medical University Hospital | 45 | 2024-11-05 | 2026-04-23 |
| Quetiapine Versus Trazadone in Women With Postpartum Depression Trazodone, Quetiapine - Postpartum Depression | Early Phase 1 | Unknown | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 50 | 2024-09-01 | 2024-08-09 |
| Trazodone vs. Quetiapine for the Treatment of ICU Delirium Trazodone, Quetiapine - Delirium, Delirium of Mixed Origin | Terminated | University of Southern California | 10 | 2024-06-01 | 2026-05-04 | |
| Bioavailability of Trazodone Hydrochloride (New Polymer) vs. Trazodone Hydrochloride Contramid® at Steady-state. 150 mg trazodone hydrochloride, 300 mg trazodone hydrochloride - Bioavailability Heathy Volunteers, Bioavailability Study | Phase 1 | Completed | Aziende Chimiche Riunite Angelini Francesco S.p.A | 64 | 2024-05-22 | 2025-09-03 |
| Cognitive Behavioral Therapy and Trazodone Effects on Sleep and Blood Pressure in Insomnia Cognitive Behavioral Treatment for Insomnia (CBT-I), Trazodone, Placebo - Insomnia, Insomnia Chronic | Early Phase 1 | Recruiting | Milton S. Hershey Medical Center | 600 | 2024-03-20 | 2025-11-10 |
| Trazodone on OSA Endotypes Placebo oral tablet, Trazodone Hydrochloride - Obstructive Sleep Apnea | Phase 1 / Phase 2 | Recruiting | Brigham and Women's Hospital | 18 | 2024-01-01 | 2025-02-06 |
| Rescue Pharmacotherapy for OSA Placebo, Acetazolamide, Trazodone - Obstructive Sleep Apnea | Phase 1 / Phase 2 | Recruiting | Brigham and Women's Hospital | 70 | 2023-07-01 | 2026-07-15 |
| Targeting Cognition in Early Alzheimer's Disease by Improving Sleep With Trazodone Trazodone, Placebo - AMCI - Amnestic Mild Cognitive Impairment, Sleep Disturbance | Phase 2 | Recruiting | Johns Hopkins University | 100 | 2023-02-02 | 2026-06-17 |
| Evaluation of Trazodone in OSA-MCI Trazodone, Placebo - Mild Cognitive Impairment, Obstructive Sleep Apnea | Phase 4 | Active not recruiting | Chinese University of Hong Kong | 134 | 2022-05-10 | 2026-01-06 |
| CBT-I or Zolpidem/Trazodone for Insomnia Zolpidem, Internet Cognitive Behavioral Therapy for Insomnia (CBT-I), Trazodone - Chronic Insomnia | Phase 4 | Completed | California Pacific Medical Center Research Institute | 155 | 2022-02-25 | 2025-02-24 |
| Investigating the Effectiveness of E-CBTi Compared to Pharmaceutical Interventions in Treating Insomnia e-CBTi, Trazodone - Insomnia | Not applicable | Recruiting | Dr. Nazanin Alavi | 60 | 2021-11-01 | 2024-10-18 |
| Obstructive Sleep Apnea and Arousal Threshold in Patients With Post-traumatic Stress Disorder Trazodone, Placebo, Epiglottic catheter - Sleep Apnea, Obstructive; Post-Traumatic Stress Disorders | Early Phase 1 | Withdrawn | University of California, San Diego | 2021-10-01 | 2019-07-10 |
Showing 20 of 65. Sign in to see all of them.
Sleep Initiation and Maintenance Disorders (13) · Depression (6) · Depressive Disorder, Major (6) · Sleep Apnea Syndromes (5) · Sleep Apnea, Obstructive (5) · Sleep Wake Disorders (4) · Delirium (3) · Substance-Related Disorders (3) · Alzheimer Disease (2) · Cognitive Dysfunction (2) · Depression, Postpartum (2) · Depressive Disorder, Treatment-Resistant (2) · Diabetic Neuropathies (2) · Neuralgia (2) · Parasomnias (2)
Aziende Chimiche Riunite Angelini Francesco S.p.A (7) · Labopharm Inc. (5) · Brigham and Women's Hospital (4) · VA Office of Research and Development (3) · Centre hospitalier de l'Université de Montréal (CHUM) (2) · Lee's Pharmaceutical Limited (2) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (2) · Milton S. Hershey Medical Center (2) · University of Southern California (2) · University of Washington (2) · BeerYaakov Mental Health Center (1) · Beitou Armed Forces Hospital, Taipei, Taiwan (1) · Brasilia University Hospital (1) · Butler Hospital (1) · California Pacific Medical Center Research Institute (1)
United States (30) · Canada (12) · Czechia (3) · Switzerland (3) · Taiwan (3) · Brazil (2) · China (2) · France (2) · Germany (2) · Hong Kong (2) · Poland (2) · Spain (2) · United Kingdom (2) · Austria (1) · Bulgaria (1)
Abdulghani Sankari, MD PhD (1) · Albert J Arias, MD, MS (1) · Alexandros N Vgontzas, MD (1) · Alexandros Vgontzas, MD (1) · Barry Greenberg, PhD (1) · Benjamin LI, Ph.D. (1) · Catherine Kuza, MD, FASA (1) · Catherine M Kuza, MD, FASA (1) · Charles Morin, PhD (1) · Daniel J. Buysse, MD (1) · David A Wellman, MD, PhD (1) · Doh Kwan Kim, M.D.,Ph.D. (1) · Douglas Zatzick, MD (1) · Einstein F Camargos, MD, MsC (1) · Elena P Calandre, MD (1)
PMID 11087767, PMID 12075033, PMID 15082703, PMID 15817019, PMID 1593914, PMID 18616688, PMID 18978492, PMID 19347026, PMID 19687169, PMID 19724732, PMID 19865006, PMID 20155590, PMID 20831796, PMID 21575194, PMID 21926597, PMID 22301509, PMID 23182527, PMID 23506796, PMID 24495406, PMID 25348864, PMID 25719754, PMID 26077062, PMID 26118922, PMID 26799332, PMID 26940892, PMID 27130272, PMID 30646197, PMID 32488885, PMID 32639561, PMID 32780015, PMID 32936427, PMID 33081705, PMID 33189083, PMID 33625584, PMID 33675113, PMID 33688908, PMID 34225296, PMID 34416369, PMID 34792177, PMID 34932440, PMID 35076931, PMID 35798516, PMID 35979039, PMID 36647114, PMID 36725099, PMID 37085877, PMID 37192176, PMID 37920522, PMID 38153735, PMID 38224591
1IK2CX000547 (1), 1UG3HL161342-01A1 (1), 2016 (1), 2018 (1), 2025 (1), I01RD001576 (1), P01HL095491 (1), R01AA013243 (1), R01AG071522 (1), R01DA020479 (1), R01DK115468 (1), R01MH091075 (1), U01AG010483 (1), UH3MH106338 (1)