25 completed, 5 unknown, 4 recruiting, 4 withdrawn. 14 Not applicable, 12 Phase 3, 11 Phase 2, 7 Phase 4, 2 Phase 1.
Follow Cytidine Diphosphate Choline: new trials by email Literature Review of Cytidine Diphosphate Choline trials Research Report on Cytidine Diphosphate Choline
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Citicoline on Neurological Severity Score and Cerebral Doppler Resistive Index in Neonatal Hypoxic Ischemic Encephalopathy Citicoline, Standard medical treatment - Hypoxic Ischaemic Encephalopathy (HIE) | Not applicable | Not yet recruiting | Khyber Girls Medical College | 86 | 2026-09-01 | 2026-08-24 |
| CITADEL: Effectiveness of CITicoline in Preventing Cognitive Decline After DELirium Citicoline - Cognitive Decline, Delirium | Phase 2 | Recruiting | University of Milano Bicocca | 122 | 2026-06-03 | 2026-09-09 |
| Unravelling the Effects of Nicotinamide/Pyrroloquinolone Quinone /Citicoline/Homotaurine Fixed Combination on Contrast Sensitivity, Quality of Life, and Reading Performance in Glaucoma Citicoline 500 MG (Optigen) for 4 months, citicoline 500 mg + nicotinamide 54 mg + PQQ 5 mg + Homotaurine 50 mg fixed combination tablet (Neuprozin mito) - Glaucoma | Not applicable | Completed | Università degli Studi 'G. d'Annunzio' Chieti e Pescara | 44 | 2025-11-01 | 2026-10-06 |
| Evaluate the Effects of Citicoline on Mood in Healthy Adults Citicoline, Placebo - Healthy | Not applicable | Recruiting | Kirin Holdings Company, Limited | 90 | 2025-07-31 | 2025-09-02 |
| Citicoline in Youth Alcohol Use Disorder Citicoline (cytidine diphosphate-choline), Placebo oral capsule - Alcohol Use Disorder | Phase 2 | Active not recruiting | Medical University of South Carolina | 56 | 2024-10-01 | 2026-06-12 |
| Effect of Fixed Combination Citicoline Homotaurine and Pyrroloquinoline Quinone on Pattern-electroretinogram in Glaucoma Citicoline 500 mg plus Homotaurine 50 mg plus Pyrroloquinoline quinone (Neuprozin Mito® ) - Glaucoma, Neuroprotection | Phase 3 | Completed | Fondazione IRCCS Policlinico San Matteo di Pavia | 40 | 2024-01-27 | 2025-05-01 |
| Improving Sleep and AD Biomarkers Citicoline Supplement, Placebo - Mild Cognitive Impairment, Alzheimer Disease | Not applicable | Completed | Emory University | 100 | 2023-12-15 | 2026-02-27 |
| Supplemental Citicoline Administration to Reduce Lung Injury Efficacy Trial (SCARLET) Citicoline, Saline/Placebo - COVID-19 | Phase 1 / Phase 2 | Active not recruiting | Ohio State University | 80 | 2023-06-06 | 2025-04-02 |
| Multimodal Morpho-functional Study in Glaucoma Patients-Citicoline Oral Solution Citicoline, Placebo - Primary Open Angle Glaucoma | Not applicable | Active not recruiting | Fondazione G.B. Bietti, IRCCS | 29 | 2022-01-25 | 2025-02-26 |
| Citicoline in Ischemic Stroke Citicoline 500 MG - Acute Ischemic Stroke | Phase 3 | Unknown | Ain Shams University | 200 | 2021-07-22 | 2022-02-17 |
| The Impact of Air Travel on Passenger Cognitive Functions Citicoline, Cytochrome C6, Sodium Chloride Oral Product - Air Travel | Phase 2 / Phase 3 | Unknown | Dinara Zhumanbayeva | 50 | 2021-06-01 | 2021-03-17 |
| Citicoline as Neuroprotector in Preterm Citicoline, Placebo oral tablet - Pre-Term | Phase 3 | Recruiting | Sherief Abd-Elsalam | 40 | 2019-05-01 | 2019-05-29 |
| Citicoline as Neuroprotector in Neonates Exposed to Hypoxia Citicoline, Placebo - Neonatal Hypoxia | Phase 3 | Recruiting | Sherief Abd-Elsalam | 40 | 2019-02-01 | 2019-05-29 |
| The Combination Effect of Citicoline and Omega-3 Placebo supplement, Citicoline and Omega-3 supplement, Omega-3 supplement - Healthy | Not applicable | Completed | Kyowa Hakko Bio Co., Ltd. | 70 | 2018-06-12 | 2019-09-10 |
| Citicoline Concentration in Human Vitreous Citicoline - Neurodegenerative Diseases | Not applicable | Completed | Istituto di Ricerca Neuroftalmologia S.r.l. | 26 | 2018-03-21 | 2019-07-01 |
| Effect of Citicoline/Homotaurine on PERG in Primary Open Angle Glaucoma Citicoline 500 mg plus Homotaurine 50 mg - Glaucoma | Not applicable | Terminated | Fondazione IRCCS Policlinico San Matteo di Pavia | 63 | 2018-01-25 | 2025-05-01 |
| Citicholine-Amantadine Trial in Traumatic Brain Injury Citicholine, Amantadine - Intensive Care Unit | Phase 4 | Completed | Ain Shams University | 45 | 2017-12-07 | 2024-05-24 |
| Role of Citicoline in Treatment of Newborns With Hypoxic Ischemic Encephalopathy citicoline - Hypoxic-Ischemic Encephalopathy | Phase 3 | Unknown | Armed Forces Hospital, Pakistan | 50 | 2017-06-15 | 2017-06-09 |
| Citicoline in Non-Arteritic Ischemic Optic Neuropathy Citicoline - Non-arteritic Ischemic Optic Neuropathy | Not applicable | Completed | Fondazione G.B. Bietti, IRCCS | 40 | 2017-02-20 | 2023-11-24 |
| Superselective Citicoline and Verapamil for Ischemic Neuroprotection and Greater Effective Response Verapamil and Citicoline, Placebo - Ischemic Stroke | Phase 1 | Withdrawn | Justin Fraser | 2016-08-01 | 2016-09-23 |
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Glaucoma (6) · Brain Injuries, Traumatic (4) · Ischemic Stroke (4) · Alcoholism (3) · Bipolar Disorder (3) · Substance-Related Disorders (3) · Cerebral Infarction (2) · Cocaine-Related Disorders (2) · Cognitive Dysfunction (2) · Delirium (2) · Hypoxia-Ischemia, Brain (2) · Stroke (2) · Alzheimer Disease (1) · Amphetamine-Related Disorders (1) · Asphyxia Neonatorum (1)
University of Texas Southwestern Medical Center (5) · Deborah Yurgelun-Todd (3) · Fondazione G.B. Bietti, IRCCS (3) · Ain Shams University (2) · Fondazione IRCCS Policlinico San Matteo di Pavia (2) · Mclean Hospital (2) · Sherief Abd-Elsalam (2) · Armed Forces Hospital, Pakistan (1) · Centre Hospitalier Universitaire de Nice (1) · Clinical Institute of the Brain, Russia (1) · Dinara Zhumanbayeva (1) · Emory University (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · Ewha Womans University Mokdong Hospital (1) · Fengtian Hospital (1)
United States (21) · Italy (8) · Egypt (4) · Pakistan (2) · South Korea (2) · Spain (2) · Canada (1) · France (1) · Germany (1) · Portugal (1) · Russia (1)
Sherwood Brown, M.D., Ph.D. (2) · Abeer Salamah, Lecturer (1) · Abeer Salamah, MD (1) · Alfonso Anton, MD, PhD (1) · Beth Ansel, PhD (1) · Ciro Costagliola, MD (1) · Deborah A Hall, MD PhD (1) · Deborah Yurgelun-Todd, PhD (1) · E. Sherwood Brown, MD, PhD (1) · E. Sherwood Brown, PH.D., M.D. (1) · Francesco Oddone, MD, PHD (1) · Giuseppe Bellelli, Medical doctor, full professor (1) · Howard Eisenberg, MD (1) · Jack Jallo, MD, PhD (1)
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