7 completed, 3 terminated, 2 unknown, 1 active not recruiting. 7 Phase 4, 3 Phase 2, 2 Phase 3, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 7 | Completed 3, Recruiting 1, Terminated 1, Unknown 1, Withdrawn 1 |
| Phase 2 | 3 | Active not recruiting 1, Completed 1, Terminated 1 |
| Phase 3 | 2 | Completed 2 |
| Early Phase 1 | 1 | Unknown 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cerebrolysin as an Add-On Therapy to Standard Treatment of Basilar Artery Occlusion Cerebrolysin - Basilar Artery Occlusion, Posterior Circulation Brain Infarction | Early Phase 1 | Unknown | University Hospital Sestre Milosrdnice | 20 | 2024-07-01 | 2024-07-09 |
| CERebrolysin In CADASIL Cerebrolysin, 0.9 % NaCl - Cadasil | Phase 2 | Active not recruiting | Ever Neuro Pharma GmbH | 30 | 2023-11-29 | 2025-02-25 |
| Efficacy and Safety of Cerebrolysin on Prolonged Disorders of Consciousness Cerebrolysin, Control - Disorder of Consciousness, Hemorrhagic Stroke | Phase 4 | Recruiting | Konkuk University Medical Center | 12 | 2023-06-01 | 2026-05-11 |
| Effect of Cerebrolysin on the Blood Brain Barrier in Patients With Diabetes and Ischemic Stroke Cerebrolysin, Brain-MRI with contrast after 10-14 days of cerebrolysin - Ischemic Stroke, Acute, Diabetes Mellitus, Type 2 | Phase 4 | Unknown | Hospital Universitario Dr. Jose E. Gonzalez | 60 | 2022-11-17 | 2024-02-22 |
| IMPULSE - StIMulation of Brain Plasticity to Improve Upper Limb Recovery After StrokE Cerebrolysin, non-invasive brain stimulation, Placebo - Chronic Stroke, Subacute Stroke | Phase 2 | Terminated | Ever Neuro Pharma GmbH | 4 | 2021-06-25 | 2022-07-28 |
| Cerebrolysin REGistry Study in Stroke - a High-quality Observational Study of Comparative Effectiveness Cerebrolysin - Acute Ischemic Stroke | Completed | Ever Neuro Pharma GmbH | 1851 | 2018-04-24 | 2025-02-25 | |
| Effects of Cerebrolysin Combined With Rehabilitation on Motor Recovery in Stroke Cerebrolysin, Placebo - Stroke | Phase 4 | Completed | Samsung Medical Center | 80 | 2016-03-14 | 2019-09-20 |
| Cerebrolysin REGistry Study in Stroke Cerebrolysin - Ischemic Stroke | Terminated | Ever Neuro Pharma GmbH | 1823 | 2014-05-01 | 2022-04-06 | |
| The CAPTAIN Trial: Cerebrolysin Asian Pacific Trial in Acute Brain Injury and Neurorecovery Cerebrolysin, 0.9% NaCl, saline - Traumatic Brain Injury | Phase 4 | Terminated | Ever Neuro Pharma GmbH | 46 | 2013-09-01 | 2020-02-25 |
| Navigation Brain Stimulation for Evaluation of the Neuroprotective Drug Efficiency in Patients After Ischemic Stroke. citicoline, L-Alpha glycerylphosphorylcholine, cerebrolysin - Stroke | Phase 3 | Completed | Clinical Institute of the Brain, Russia | 30 | 2011-01-01 | 2011-12-23 |
| A Clinical Trial to Evaluate the Safety and Efficacy of 20 ml Cerebrolysin in Patients With Vascular Dementia Cerebrolysin, 0.9% Saline Solution - Vascular Dementia | Phase 4 | Completed | Ever Neuro Pharma GmbH | 242 | 2006-10-01 | 2024-02-21 |
| The Safety and Efficacy of Cerebrolysin in Patients With Acute Ischemic Stroke Cerebrolysin, 0.9% Saline Solution - Ischemic Stroke | Phase 4 | Completed | Ever Neuro Pharma GmbH | 1071 | 2006-09-01 | 2023-12-15 |
| Combined Treatment With Alteplase (Rt-PA) and Cerebrolysin® in Acute Ischemic Hemispheric Stroke Cerebrolysin, 0.9% Saline Solution - Stroke | Phase 3 | Completed | Ever Neuro Pharma GmbH | 119 | 2005-10-01 | 2010-12-28 |
| Comparative Study to Test Safety and Efficacy of Neurotrophic and Cholinergic Treatment of Alzheimer's Disease Cerebrolysin + donepezil, Cerebrolysin + placebo, Donepezil + placebo - Alzheimer Disease | Phase 2 | Completed | Ever Neuro Pharma GmbH | 217 | 2004-10-01 | 2009-06-10 |
| Cerebrolysin Compared to Donepezil in Patients With Mild to Moderate Dementia of Alzheimer's Type (DAT) Cerebrolysin, Donepezil - Alzheimer Disease | Phase 4 | Withdrawn | Ever Neuro Pharma GmbH | 2015-10-26 |
Ischemic Stroke (6) · Stroke (4) · Alzheimer Disease (2) · Brain Infarction (1) · Brain Injuries, Traumatic (1) · CADASIL (1) · Consciousness Disorders (1) · Dementia, Vascular (1) · Diabetes Mellitus, Type 2 (1) · Hemorrhagic Stroke (1)
cerebrolysin (15) · Saline Solution (3) · Sodium Chloride (3) · Donepezil (2) · Cytidine Diphosphate Choline (1) · Glycerylphosphorylcholine (1) · brain natriuretic peptide, porcine (1)
Austria (5) · South Korea (3) · Czechia (2) · Hong Kong (2) · Russia (2) · China (1) · Croatia (1) · Mexico (1) · Slovakia (1) · Slovenia (1) · Spain (1)
Philipp Novak, PhD (2) · Andreas Winkler, MD, MSc (1) · Dieter Meier, MD (1) · Herbert Moessler, PhD (1) · Kennedy Lees, MD (1) · Manfred Windisch, PhD (1) · Michael Brainin, Univ.-Prof. Dr. (1) · Wai S Poon, Prof. (1) · Wilfried Lang, MD (1) · Yun-Hee Kim, MD, PhD (1) · Zhen Hong, MD (1)
PMID 20656516, PMID 21679156, PMID 22282884, PMID 23009193, PMID 29248999, PMID 31494820, PMID 40851188