2605 completed, 496 unknown, 363 recruiting, 276 terminated. 1640 Not applicable, 515 Phase 3, 497 Phase 2, 485 Phase 4, 383 Phase 1.
Follow Schizophrenia Spectrum and Other Psychotic Disorders: new trials by email Literature Review of Schizophrenia Spectrum and Other Psychotic Disorders trials Research Report on Schizophrenia Spectrum and Other Psychotic Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Cannabidiol on Psychiatric Symptoms, Cognition, and Cannabis Consumption in Cannabis Users With Recent-Onset Psychosis Cannabidiol (CBD), Placebo - Schizophrenia Spectrum Disorders, Cannabis Use | Phase 2 | Withdrawn | University of Maryland, Baltimore | 2050-01-01 | 2021-04-19 | |
| Efficacy of Mindfulness in PREventing Progression to Psychosis in Individuals With an Ultra High Risk for Psychosis MBTP : Mindflulness based training for psychosis - Clinical High Risk for Psychosis (CHR) | Not applicable | Not yet recruiting | Centre Psychothérapique de Nancy | 270 | 2029-04-01 | 2026-03-25 |
| Personalized Pharmaco-Lifestyle Interventions for Severe Mental Illnesses (LIFETRAIN) Semaglutide (SEMA), Exercise module, Anti-inflammatory diet module - Severe Mental Illness, Depression / Major Depressive Disorder | Not applicable | Not yet recruiting | Ludwig-Maximilians - University of Munich | 140 | 2028-10-01 | 2026-05-14 |
| Cognitive Neurocomputational Task Reliability and Clinical Applications Consortium: Study 2 Motion Perception Task, Sine Wave Speech Task, Volatility Task - SCHIZOPHRENIA 1 (Disorder), Schizo Affective Disorder | Not applicable | Not yet recruiting | Washington University School of Medicine | 325 | 2028-04-01 | 2026-10-15 |
| Developing a Virtual Reality-assisted Intervention for Emotion Regulation Difficulties in Psychosis MANOEUVRE therapy - Psychosis, SCHIZOPHRENIA 1 (Disorder) | Not applicable | Not yet recruiting | King's College London | 15 | 2027-09-01 | 2026-06-03 |
| Improving Quality of Informal Care for People With Schizophrenia Dyadic Multicomponent Intervention (DMI), Dyadic Benefit-Finding Intervention (DBFI) - Schizophrenia | Not applicable | Not yet recruiting | Chinese University of Hong Kong | 228 | 2027-07-01 | 2026-08-25 |
| Low-Intensity Focused Ultrasound Neuromodulation of the Mediodorsal Thalamus for Treatment-Resistant Schizophrenia Insightec Exablate Neuro MR-guided focused ultrasound transducer - Treatment-resistant Schizophrenia | Not applicable | Suspended | NYU Langone Health | 3 | 2027-06-01 | 2026-04-02 |
| Feasibility and Acceptability of Mobile Mental Health App for SZ and SZA Intervention via mobile application - Schizophrenia, Schizo Affective Disorder | Not applicable | Not yet recruiting | University of Pittsburgh | 44 | 2027-06-01 | 2026-09-16 |
| Prucalopride for Cognitive Functioning in Schizophrenia Prucalopride 1 MG - Schizophrenia | Not applicable | Not yet recruiting | University of Pittsburgh | 34 | 2027-05-31 | 2026-09-17 |
| Feasibility Trial of a Parent Peer-Co-Led Caregiver Group for Pediatric Early Onset Schizophrenia Spectrum Disorders Group Therapy, Treatment as Usual (TAU) - Schizophrenia; Psychosis | Not applicable | Not yet recruiting | Boston Children's Hospital | 20 | 2027-05-01 | 2026-10-09 |
| Testing a Peer-Support Group for Veterans Who Hear Voices Veteran Voices and Visions (VVV), Wellness Recovery Action Planning (WRAP) - Psychotic Disorders, Hallucinations, Auditory | Not applicable | Not yet recruiting | VA Office of Research and Development | 160 | 2027-04-01 | 2026-04-29 |
| Frontal Gamma Coherence Neurofeedback for Patients With Schizophrenia Frontal gamma coherence neurofeedback, Placebo Neurofeedback - Schizophrenia, Schizoaffective | Not applicable | Not yet recruiting | BioSignal Solutions LLC | 30 | 2027-04-01 | 2026-09-24 |
| NST-SPARK Open-Label Phase 1 STTR (IGNITE) NST-SPARK - Schizophrenia / Schizoaffective Disorder | Not applicable | Not yet recruiting | North Shore Therapeutics, Inc. | 30 | 2027-03-01 | 2026-05-18 |
| LIFU Effects & Outcomes: Mechanisms Evaluating Striatal Systems Imaging (LEO MESSI) LIFU - Schizophrenia, Auditory Hallucinations | Not applicable | Not yet recruiting | University of California, San Francisco | 12 | 2027-02-01 | 2026-08-05 |
| Pilot Study of Sensor-Informed Smartphone-based Mental Health Interventions for Mood in Early Psychosis Smartphone-based Mindfulness Exercise, Smartphone-based Psychoeducation, Neutral Control Message - Psychosis, Anxiety | Not applicable | Not yet recruiting | Mclean Hospital | 10 | 2027-01-15 | 2026-10-05 |
| Brain Network Mechanisms of Cognitive Impairments in Major Psychiatric Disorders and Their Clinical Applications repetitive transcranial magnetic stimulation (rTMS) - Schizophrenia, Bipolar Disorder | Not applicable | Not yet recruiting | Central South University | 400 | 2027-01-01 | 2026-03-04 |
| Shared Decision Making for Antipsychotic Medications The Antipsychotic Medication Decision Aid (APM-DA) - Schizophrenia, Schizoaffective Disorder | Not applicable | Not yet recruiting | New York State Psychiatric Institute | 120 | 2027-01-01 | 2026-03-30 |
| Stratification and Treatment in Early Psychosis Study -ASSIST CBD 100 mg/mL Oral Solution, Placeb - Treatment Resistant Psychosis, Psychosis | Phase 3 | Not yet recruiting | University of Oxford | 250 | 2027-01-01 | 2026-10-08 |
| Brain Imaging of DSP-2342 DSP-2342 - SCHIZOPHRENIA 1 (Disorder) | Phase 2 | Not yet recruiting | Johns Hopkins University | 20 | 2027-01-01 | 2026-09-30 |
| A Study Evaluating the Efficacy of Xanomeline/Trospium (XT) on Cognitive Impairment After 24 and 52 Weeks of Treatment in Adult Participants With Schizophrenia Xanomeline/trospium - Schizophrenia; Psychosis, Cognitive Impairment | Phase 3 | Not yet recruiting | European Group for Research In Schizophrenia | 171 | 2027-01-01 | 2026-05-13 |
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Schizophrenia (3471) · Psychotic Disorders (1582) · Bipolar Disorder (405) · Mental Disorders (252) · Depression (140) · Depressive Disorder, Major (140) · Hallucinations (97) · Cognitive Dysfunction (85) · Mood Disorders (81) · Anxiety Disorders (77) · Metabolic Syndrome (70) · Substance-Related Disorders (66) · Motor Activity (56) · Obesity (56)
Mental Disorders (3815) · Behavior (538) · Pathological Conditions, Signs and Symptoms (464) · Mood Disorders (446) · Bipolar and Related Disorders (403) · Signs and Symptoms (384) · Nervous System Diseases (354) · Neurologic Manifestations (266) · Behavioral Symptoms (240) · Neurobehavioral Manifestations (213) · Nutritional and Metabolic Diseases (186) · Chemically-Induced Disorders (173) · Neurocognitive Disorders (166) · Metabolic Diseases (147)
Risperidone (277) · Olanzapine (186) · Aripiprazole (177) · Paliperidone Palmitate (129) · Quetiapine Fumarate (114) · Therapeutics (104) · ziprasidone (78) · Transcranial Direct Current Stimulation (70) · Transcranial Magnetic Stimulation (59) · Clozapine (57) · Cognitive Behavioral Therapy (52) · Lurasidone Hydrochloride (47) · Haloperidol (44) · Cognitive Remediation (41) · Exercise (39)
Otsuka Pharmaceutical Development & Commercialization, Inc. (89) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (81) · AstraZeneca (80) · Yale University (66) · VA Office of Research and Development (65) · Centre for Addiction and Mental Health (64) · University of Maryland, Baltimore (64) · Shanghai Mental Health Center (59) · Massachusetts General Hospital (43) · National Institute of Mental Health (NIMH) (40) · King's College London (37) · National Taiwan University Hospital (35) · Hôpital le Vinatier (34) · New York State Psychiatric Institute (34) · Central South University (33)
United States (1651) · France (266) · China (250) · Canada (245) · Germany (200) · Taiwan (183) · Spain (181) · United Kingdom (157) · Israel (124) · South Korea (117) · Russia (112) · Turkey (Türkiye) (102) · Ukraine (94) · Romania (91) · Denmark (90)
Sophia Vinogradov, MD (14) · Benedicto Crespo-Facorro, Professor (13) · Hai-Gwo Hwu, Professor (12)
PMID 28433500, PMID 33539561, PMID 33854317, PMID 34091867, PMID 38958149, PMID 37142273, PMID 20537128, PMID 20537130, PMID 24423017, PMID 25890643, PMID 22198451, PMID 24955752, PMID 28350572, PMID 29523415, PMID 32476658, PMID 34689733, PMID 34751928, PMID 36369028, PMID 38085556, PMID 39144777, PMID 41130742, PMID 42393474, PMID 18466043, PMID 20840778, PMID 21155708, PMID 22935168, PMID 26493637, PMID 26934062, PMID 27188270, PMID 27743205, PMID 27816567, PMID 28117049, PMID 28318835, PMID 28640988, PMID 28692485, PMID 30420252, PMID 30470662, PMID 32336984, PMID 32606705, PMID 32840872, PMID 34004383, PMID 34901863, PMID 35235720, PMID 36772948, PMID 36883881, PMID 37230961, PMID 37756123, PMID 37777515, PMID 38244179, PMID 39730881
2019 (12), 2009 (10), 2016 (10), 2017 (10), 2025 (10), 2018 (9), 2015 (8), 2008 (6), 2023 (6), N01MH090001 (5), P50MH119569 (5), N01MH90001 (4), P50MH082999 (4), 2004 (3), 2005 (3)