257 completed, 40 terminated, 36 unknown, 11 withdrawn. 132 Phase 4, 109 Phase 3, 40 Phase 2, 39 Not applicable, 33 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Post-acute Infectious Syndrome - Aripiprazole Symptom Evaluation (PAIS-AriSE) Aripiprazole (low-dose, 1mg), Placebo - Post-acute Infectious Syndrome (PAIS), Post-COVID-19 Condition (PCC or Long COVID) | Phase 2 | Not yet recruiting | Christiana Franke | 138 | 2026-10-01 | 2026-07-20 |
| The BAARD Study : Evaluating a Computerized Approach to Treatment Selection in Older Adults With Treatment Resistant Depression. Aripiprazole Augmentation, Bupropion Augmentation - Late Life Treatment Resistant Depression, Depression - Major Depressive Disorder | Phase 2 | Not yet recruiting | Washington University School of Medicine | 300 | 2026-10-01 | 2026-10-16 |
| Evaluating Safety and Efficacy of VV119 in Acute Schizophrenia Adults VV119 2mg, VV119 4mg, VV119 6mg - Schizophrenia | Phase 2 | Not yet recruiting | Vigonvita Life Sciences | 500 | 2026-07-31 | 2026-07-15 |
| Aripiprazole in Body Focused Repetitive Behaviors Placebo, Aripiprazole - Trichotillomania (Hair-Pulling Disorder), Dermatillomania | Phase 2 | Not yet recruiting | University of Chicago | 100 | 2026-06-01 | 2025-10-02 |
| Study to Evaluate Efficacy and Safety of Roluperidone in Adult Subjects With Negative Symptoms and Stable Positive Symptoms of Schizophrenia and to Evaluate the Relapse Rate of Roluperidone and Antipsychotic Medications Roluperidone, risperidone, aripiprazole - Negative Symptoms of Schizophrenia | Phase 3 | Recruiting | Minerva Neurosciences | 380 | 2026-04-23 | 2026-07-28 |
| Steady-state Bioequivalence Study of Aripiprazole for Injection in Patients With Schizophrenia. Aripiprazole for Injection - Schizophrenia | Not applicable | Not yet recruiting | CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd. | 116 | 2026-04-05 | 2026-04-23 |
| Cerebellum-based Imaging Neural Markers for Antipsychotic Response risperidone, aripiprazole - Psychosis; Acute | Phase 4 | Recruiting | Northwell Health | 120 | 2025-11-01 | 2026-05-26 |
| Quality of Life, Safety and Compliance of Patients Using Monotherapy or Combinatorial Therapy With Quetiapine for Treatment of Schizophrenia or Bipolar Affective Disorder Quetiapine (drug), quetiapine + aripiprazole, quetiapine + haloperidol - Schizophrenia, Bipolar Affective Disorder | Recruiting | Bosnalijek D.D | 500 | 2025-10-30 | 2026-10-15 | |
| Dopamine and Sensorimotor Function in Stuttering Aripiprazole 10 MG, Placebo - Stuttering, Adult | Phase 1 | Recruiting | University of California, San Francisco | 25 | 2025-09-30 | 2026-08-19 |
| Switching Medication and Augmentation Strategies for SSRI-Resistant Adolescent Depression（SMART-I) Sertraline, Agomelatine, Aripiprazole - Major Depressive Disorder (MDD) | Phase 4 | Not yet recruiting | Xinyu Zhou | 400 | 2025-06-20 | 2025-06-10 |
| Τhe Combination of Pharmacotherapy With RECOVERYTRSGR and RECOVERYTRSBDGR. Group A: (Clozapine, quietiapine, olanzapine, aripiprazole, zyprasidone, risperidone, asenapine, paliperidone, clopixol,anxiolytics: clonazepam, stedon, tavor antidepressants: seropram),, Group B (Pharmacotherapy and TAU) (Clozapine, quietiapine, olanzapine, aripiprazole, zyprasidone, risperidone, asenapine, paliperidone, clopixol, clonazepam, stedon, tavor, antidepressants,, Group C (Pharmacotherapy and Psychotherapy) Clozapine, quietiapine, olanzapine, aripiprazole, zyprasidone, risperidone, asenapine, paliperidone, clopixol, clonazepam, stedon, tavor, lithium, depakine - Treatment Resistant Schizophrenia, Treatment Resistant Bipolar Disorder | Phase 4 | Active not recruiting | Dr. Stavroula Rakitzi | 84 | 2025-06-04 | 2026-05-01 |
| Neurobiological Mechanisms of Pathological Rumination and Effects of Aripiprazole Escitalopram, Aripiprazole 5mg - Major Depressive Disorder (MDD), Rumination | Not applicable | Active not recruiting | Central South University | 108 | 2025-05-08 | 2026-06-12 |
| A Double-Blind, Randomized Comparative Study of Carliprazine and Aripiprazole in Patients with Acute Schizophrenia Hydrochloride Carliprazine capsules, Aripiprazole tablets - Acute Schizophrenia | Phase 3 | Not yet recruiting | Chengdu Kanghong Pharmaceutical Group Co., Ltd. | 376 | 2024-10-01 | 2024-09-19 |
| Sequential Multiple Assignment Randomized Trial for Bipolar Depression Cariprazine, Aripiprazole/Escitalopram combination, Quetiapine - Bipolar I Disorder, Depression | Phase 4 | Active not recruiting | Massachusetts General Hospital | 2726 | 2024-10-01 | 2025-12-16 |
| Biomarkers to Enhance Early Schizophrenia Treatment aripiprazole, risperidone, clozapine - Schizophenia Disorder | Phase 4 | Recruiting | Northwell Health | 180 | 2024-09-04 | 2026-07-31 |
| Magnetic Seizure Therapy for Psychotic Disorders Magnetic seizure therapy by Magnetic stimulator, Antipsychotic medications (such as olanzpine, risperidone, aripiprazole, quetiapine, amisulpride, etc) - Psychotic Disorders | Not applicable | Recruiting | Shanghai Jiao Tong University School of Medicine | 50 | 2024-09-01 | 2025-11-25 |
| Maintenance Electroconvulsive Therapy (ECT) Versus Aripiprazole in Clozapine-resistant Schizophrenia maintenance ECT, Aripiprazole tablet - Clozapine Resistant Schizophrenia | Phase 4 | Unknown | All India Institute of Medical Sciences, Bhubaneswar | 40 | 2024-08-10 | 2024-07-16 |
| Lumateperone for the Improvement of Apathy in Patients With Psychotic Symptoms. Lumateperone 42 mg, Risperidone 2 mg - Apathy, Schizophrenia | Phase 3 | Recruiting | Louisiana State University Health Sciences Center Shreveport | 80 | 2024-06-01 | 2024-07-01 |
| A Study Assessing the Efficacy and Safety of HS-10380 in Hospitalized Adults With Acute Schizophrenia HS-10380 Low Dose, HS-10380 Medium dose, HS-10380 High Dose - SCHIZOPHRENIA 1 (Disorder) | Phase 2 | Completed | Jiangsu Hansoh Pharmaceutical Co., Ltd. | 363 | 2024-05-23 | 2026-04-24 |
| Atypical Antipsychotic-induced Mitochondrial Dysfunction in Patients With Schizophrenia Aripiprazole, Risperidone - Schizophrenia | Phase 4 | Completed | All India Institute of Medical Sciences, Bhubaneswar | 60 | 2024-04-05 | 2025-11-25 |
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Schizophrenia (163) · Psychotic Disorders (59) · Bipolar Disorder (44) · Depressive Disorder, Major (33) · Depression (20) · Autistic Disorder (14) · Metabolic Syndrome (12) · Tourette Syndrome (10) · Mental Disorders (8) · Tic Disorders (8) · Depressive Disorder, Treatment-Resistant (7) · Diabetes Mellitus (7) · Alcoholism (6) · Alzheimer Disease (6) · Attention Deficit Disorder with Hyperactivity (6)
Otsuka Pharmaceutical Development & Commercialization, Inc. (85) · Otsuka Pharmaceutical Co., Ltd. (13) · Massachusetts General Hospital (8) · Northwell Health (8) · Otsuka Beijing Research Institute (7) · Fundación Marques de Valdecilla (6) · Indiana University (5) · Janssen Research & Development, LLC (5) · Korea Otsuka Pharmaceutical Co., Ltd. (5) · Washington University School of Medicine (5) · All India Institute of Medical Sciences, Bhubaneswar (4) · Bristol-Myers Squibb (4) · Denovo Biopharma LLC (4) · Medical University of South Carolina (4) · New York State Psychiatric Institute (4)
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PMID 37811711, PMID 18832427, PMID 21731833, PMID 23106023, PMID 23585997, PMID 23585999, PMID 24766999, PMID 38958149, PMID 20816039, PMID 21731831, PMID 22697189, PMID 24138011, PMID 24925984, PMID 25711509, PMID 26232241, PMID 28204607, PMID 29856773, PMID 30097769, PMID 30420252, PMID 37756123, PMID 38085556, PMID 41034820, PMID 42138587, PMID 10686270, PMID 11691689, PMID 1308374, PMID 14661862, PMID 15685125, PMID 15800181, PMID 16801664, PMID 17074942, PMID 17229469, PMID 17284127, PMID 17284138, PMID 17287825, PMID 17502776, PMID 17592907, PMID 17620483, PMID 17805214, PMID 17909124, PMID 17960961, PMID 18204334, PMID 18312036, PMID 18370574, PMID 18373615, PMID 18425072, PMID 18605811, PMID 18626272, PMID 18759644, PMID 18765484
2009 (5), P50AA010761 (2), 1UG3MH137353-01 (1), 2017 (1), 2018 (1), K23MH081285 (1), N01MH090001 (1), N01MH90001 (1), P30MH071478 (1), R01DA020429 (1), R01DA022190 (1), R01DA023387 (1), R01MH059312 (1), R01MH060004 (1), R01MH071536 (1)