13 completed, 7 terminated, 4 unknown, 2 recruiting. 29 Phase 3, 8 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 29 | Completed 13, Terminated 7, Unknown 4, Recruiting 2, Active not recruiting 1, Enrolling by invitation 1, Not yet recruiting 1 |
| Phase 2 | 8 | Completed 5, Unknown 2, Terminated 1 |
Follow Knee Injuries: new trials by email Literature Review of Knee Injuries trials Research Report on Knee Injuries
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Extended Post-Operative Oral Tranexamic Acid Dosing After ACL Reconstruction Tranexamic Acid, Placebo - Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture | Phase 3 | Not yet recruiting | Dave Bernholt | 100 | 2026-11-01 | 2026-10-26 |
| Topical Diclofenac vs.Oral Ibuprofen for MSK Pain in Children Voltaren Topical Gel, Ibuprofen Oral Suspension 100 mg/5mL, ORA-Blend Oral Suspension - Musculoskeletal Injury, Pediatrics | Phase 3 | Recruiting | University of Calgary | 60 | 2026-04-02 | 2026-04-13 |
| Reduce Opiate Exposure With ACL Surgery Opiate Sparing, Opiate Based - Anterior Cruciate Ligament Injuries | Phase 3 | Enrolling by invitation | Campbell Clinic | 56 | 2024-09-01 | 2026-09-15 |
| Effectiveness Comparison Between Continuous Cryotherapy and Ice Pack Therapy After Anterior Cruciate Ligament Reconstruction Surgery Continuous compression cryotherapy, Conventional ice treatment - Postoperative Pain, Acute, Anterior Cruciate Ligament Injuries | Phase 2 / Phase 3 | Completed | University Medical Center Ho Chi Minh City (UMC) | 72 | 2023-06-01 | 2024-10-08 |
| Dronabinol After Arthroscopic Surgery Dronabinol, Placebo - Knee Osteoarthritis, Knee Injuries | Phase 3 | Active not recruiting | Northwestern University | 30 | 2022-06-28 | 2026-09-25 |
| PRP in ACLR to Prevent PTOA platelet rich plasma (PRP) injection, placebo saline injection - Anterior Cruciate Ligament Injuries, Post-traumatic Osteoarthritis | Phase 3 | Recruiting | Hospital for Special Surgery, New York | 56 | 2022-06-27 | 2026-02-13 |
| Evaluation of Exparel Adductor Canal Field Block for Pain Control After ACL Reconstruction Liposomal bupivacaine, Bupivacaine Hydrochloride - Anterior Cruciate Ligament Tear, Pain, Postoperative | Phase 3 | Unknown | Carilion Clinic | 60 | 2021-02-16 | 2021-02-21 |
| Feasibility of a RCT That Compares Immediate Versus Optional Delayed Surgical Repair After ACL Injury Immediate anterior cruciate ligament reconstruction, Rehabilitation, Optional delayed anterior cruciate ligament reconstruction - Anterior Cruciate Ligament Injuries | Phase 3 | Completed | Universitaire Ziekenhuizen KU Leuven | 29 | 2020-09-15 | 2023-11-15 |
| Use of Testosterone to Prevent Post-Surgical Muscle Loss - Pilot Study Aveed 750 MG in 3 ML IM Injection, Normal Saline 3 ML IM Injection - Muscle Atrophy, Surgery | Phase 2 / Phase 3 | Unknown | The Stone Research Foundation for Sports Medicine and Arthritis | 15 | 2020-05-08 | 2021-08-31 |
| IPACK Versus Popliteal Sciatic Nerve Block in ACL Reconstruction Ropivacaine injection - Anterior Cruciate Ligament Tear | Phase 3 | Terminated | Sujana Dontukurthy | 7 | 2019-08-30 | 2021-09-16 |
| Ketorolac as an Adjuvant Agent for Postoperative Pain Control Following Arthroscopic ACL Surgery Ketorolac, Oxycodone-Acetaminophen - ACL Injury, Postoperative Pain | Phase 3 | Completed | University Hospitals Cleveland Medical Center | 49 | 2019-05-21 | 2021-12-21 |
| Nonopioid Analgesia After Anterior Cruciate Ligament Reconstruction Celecoxib, Hydrocodone-Acetaminophen, Ketorolac - Anterior Cruciate Ligament Injury | Phase 2 / Phase 3 | Completed | Henry Ford Health System | 90 | 2019-01-22 | 2026-03-19 |
| Objective Results of Anterior Cruciate Ligament Reconstruction With and Without Internal Suture Augmentation Technique all- inside anterior cruciate ligament reconstruction - Anterior Cruciate Ligament Injuries | Phase 2 / Phase 3 | Completed | Ain Shams University | 38 | 2018-09-01 | 2021-06-02 |
| Does Gabapentin Reduce Quadriceps Muscle Weakness After Anterior Cruciate Ligament Reconstruction? Gabapentin, Tramadol, Panadol - Muscle Weakness, Anterior Cruciate Ligament Rupture | Phase 2 / Phase 3 | Unknown | Hospital Authority, Hong Kong | 30 | 2018-07-01 | 2018-04-12 |
| Intra-articular Dexmedetomidine Versus Neostigmine After Knee Arthroscopy (a Comparative Study) dexamedetomidine, neostigmine - Knee Injuries | Phase 2 / Phase 3 | Completed | Assiut University | 100 | 2017-08-01 | 2018-01-11 |
| Clinical Outcomes of ACL Reconstruction Augmented by an Injectable Osteoconductive/Osteoinductive Compound OOC - ACL Injury | Phase 3 | Completed | University of Miami | 26 | 2016-10-24 | 2021-09-05 |
| L-C Ligament Versus Hamstring Autograft for Primary ACL Reconstruction L-C Ligament, Hamstring Autograft - Acute Ruptures of the Anterior Cruciate Ligament | Phase 2 / Phase 3 | Terminated | Soft Tissue Regeneration, Inc. | 60 | 2015-09-01 | 2021-11-22 |
| Decadron as Adjuvant in Femoral Nerve Blocks in Knee Arthroscopy Dexamethasone, Ropivacaine - Knee Injury | Phase 3 | Completed | Nationwide Children's Hospital | 77 | 2014-07-01 | 2018-12-11 |
| Opioid Use in Single Shot Nerve Block vs Continuous Peripheral Nerve Infusion in Anterior Cruciate Ligament (ACL) Repair bupivacaine, continuous perineural infusion catheter - Injury of Anterior Cruciate Ligament | Phase 3 | Terminated | Children's Hospital of Philadelphia | 1 | 2014-03-01 | 2016-05-18 |
| Treatment of Knee Pain With Topical Diclofenac Cream 8% or Diclofenac Gel 1% Diclofenac Cream 8%, Diclofenac Gel 1% - Knee Pain Chronic, Knee Injuries | Phase 3 | Unknown | FPR Specialty Pharmacy | 106 | 2014-01-01 | 2014-02-21 |
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Anterior Cruciate Ligament Injuries (14) · Pain, Postoperative (4) · Pain (3) · Disease (1) · Hemarthrosis (1) · Muscle Weakness (1) · Muscular Atrophy (1) · Osteoarthritis, Knee (1) · Patellar Dislocation (1) · Patellofemoral Pain Syndrome (1) · Sprains and Strains (1) · Tibial Plateau Fractures (1) · Wounds and Injuries (1)
Leg Injuries (29) · Wounds and Injuries (28) · Neurologic Manifestations (7) · Pathological Conditions, Signs and Symptoms (7) · Signs and Symptoms (7) · Pathologic Processes (6) · Musculoskeletal Diseases (5) · Joint Diseases (4) · Postoperative Complications (4) · Nervous System Diseases (2) · Neuromuscular Manifestations (2) · Pain (2) · Arthritis (1) · Atrophy (1)
Acetaminophen (2) · Bupivacaine (2) · Celecoxib (2) · Gabapentin (2) · Ketorolac (2) · OMS 103HP (2) · Ropivacaine (2) · oxycodone-acetaminophen (2) · Analgesia (1) · Botulinum Toxins, Type A (1) · Cryotherapy (1) · Dexamethasone (1) · Dexmedetomidine (1) · Diazepam (1) · Dronabinol (1)
RTI Surgical (3) · Omeros Corporation (2) · Ain Shams University (1) · Assiut University (1) · Campbell Clinic (1) · Carilion Clinic (1) · Children's Hospital of Philadelphia (1) · Dave Bernholt (1) · FPR Specialty Pharmacy (1) · Henry Ford Health System (1) · Hospital Authority, Hong Kong (1) · Hospital for Special Surgery, New York (1) · Meir Medical Center (1) · Nationwide Children's Hospital (1) · Northwestern University (1)
United States (19) · Canada (4) · Egypt (2) · Belgium (1) · Israel (1) · Netherlands (1) · Thailand (1) · Vietnam (1)
Scott Houston (2) · Ahmed A Khater, MD (1) · Akbar Nawab, MD (1) · Boonsin Tangtrakulwanich, MD.,Ph.D (1) · David Flanigan, MD (1) · Francesco Travascio (1) · Frederick Azar, MD (1) · Giorgio Veneziano, MD (1) · Harshad Gurnaney, MBBS, MPH (1) · Jack Farr, MD, PhD (1) · Jeffrey Dugas, MD (1) · Jesse A Shantz, MD, MBA (1) · Kees van Egmond, MD (1) · Koen Peers, MD, PhD (1) · Mani Vessal, Ph.D. (1)
PMID 15329580, PMID 16835255, PMID 18567675, PMID 20973952, PMID 21467282, PMID 28711636, PMID 29377866, PMID 35277406, PMID 35803549, PMID 36194219, PMID 36476466, PMID 36794826, PMID 40340976, PMID 40540943