6 completed, 5 enrolling by invitation, 2 unknown, 2 withdrawn. 7 Not applicable, 5 Phase 4, 2 Phase 3, 1 Phase 2.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Genicular Embolization Using Doxycycline Sclerotherapy Doxycycline Injection - Chronic Knee Pain, Osteoarthritis | Phase 2 | Withdrawn | Campbell Clinic | 2026-06-01 | 2026-02-27 | |
| Extended Oral Tranexamic Acid After Anterior Cruciate Ligament Reconstruction Tranexamic Acid (TXA), Placebo - ACL Injury, ACL Tears | Phase 4 | Withdrawn | Campbell Clinic | 2026-04-01 | 2026-03-03 | |
| Reverse Shoulder Arthroplasty vs Rotator Cuff Repair for 60+ Reverse Total Shoulder Arthroplasty, Rotator Cuff Repair - Shoulder Injuries, Shoulder Pain | Enrolling by invitation | Campbell Clinic | 74 | 2025-06-10 | 2026-08-05 | |
| Extended Oral Tranexamic Acid After Total Knee Arthroplasty Tranexamic acid, Placebo - Osteo Arthritis Knee, Pain, Postoperative | Phase 3 | Enrolling by invitation | Campbell Clinic | 120 | 2024-09-17 | 2026-08-13 |
| Reduce Opiate Exposure With ACL Surgery Opiate Sparing, Opiate Based - Anterior Cruciate Ligament Injuries | Phase 3 | Enrolling by invitation | Campbell Clinic | 56 | 2024-09-01 | 2026-09-15 |
| EXPAREL IPSA Block in Knee Arthroplasty Exparel - Pain, Postoperative, Osteo Arthritis Knee | Phase 4 | Unknown | Campbell Clinic | 10 | 2024-05-20 | 2024-10-01 |
| Study of Zimmer Biomet Mymobility Application on Reverse Total Shoulder Arthroplasty (RTSA) Outcomes mymobility Physical Therapy, Standard Office-based Physical Therapy - Reverse Total Shoulder Arthroplasty, Physical Therapy | Not applicable | Enrolling by invitation | Campbell Clinic | 100 | 2023-10-31 | 2026-01-05 |
| Opiate Sparing Protocol Randomized Controlled Trial in Open Distal Radius Fracture Repair Opiate Sparing, Opiate Based - Distal Radius Fracture | Not applicable | Completed | Campbell Clinic | 72 | 2022-03-01 | 2025-10-06 |
| Extended Postoperative Oral Tranexamic Acid in Knee Replacement Tranexamic Acid Pill, Placebo - Knee Osteoarthritis, Blood Loss | Phase 4 | Unknown | Campbell Clinic | 46 | 2021-12-07 | 2024-03-06 |
| Opioid Reduction Program for Total Knee Replacement Patients Opioid Reduction Program - Knee Injuries, Knee Injuries and Disorders | Not applicable | Completed | University of Tennessee | 85 | 2021-08-01 | 2022-11-08 |
| Periarticular Injection Versus Popliteal Block Exparel, Bupivicaine - Foot Surgery, Ankle Surgery | Phase 4 | Enrolling by invitation | Campbell Clinic | 100 | 2021-07-13 | 2025-12-24 |
| Safe Options for ACL Recovery ACL Opioid Exposure Reduction Program - Anterior Cruciate Ligament Injuries, Opioid Use | Not applicable | Completed | Karen Derefinko, PhD | 120 | 2020-02-12 | 2022-11-02 |
| Pain Increases After Shoulder Injection Methylprednisolone (MPA), Triamcinolone Acetonide (TA) - Shoulder Pain | Phase 4 | Completed | Campbell Clinic | 421 | 2020-01-01 | 2023-03-07 |
| Opiate Sparing Versus Opiate Based Following Shoulder Arthroplasty Cryotherapy - Shoulder Surgery | Not applicable | Completed | Campbell Clinic | 82 | 2019-08-01 | 2022-12-06 |
| Alpha-Defensin and Synovial Proteins to Improve Detection of Pediatric Septic Arthritis Synovial Alpha-defensin assay, Synovial Neutrophil elastase assay, Synovial lactate assay - Joint Infection, Infection of Hip Joint (Disorder) | Not applicable | Recruiting | Hospital for Special Surgery, New York | 442 | 2016-06-28 | 2026-07-29 |
| Multi-Center Adolescent Clavicle Fracture Trial: Operative vs. Non-Operative Treatment Surgery - Clavicle Fracture | Active not recruiting | Boston Children's Hospital | 250 | 2013-03-11 | 2025-06-15 | |
| Closed Reduction of Distal Forearm Fractures by Pediatric Emergency Medicine Physicians: A Prospective Study Distal Forearm Fracture Reduction - Pediatric Distal Forearm Fractures | Not applicable | Completed | InMotion Orthopaedic Research Center | 104 | 2008-04-01 | 2010-04-12 |
Anterior Cruciate Ligament Injuries (3) · Pain, Postoperative (3) · Shoulder Pain (2) · Wrist Fractures (2) · Arthritis, Infectious (1) · Disease (1) · Hemorrhage (1) · Knee Injuries (1) · Osteoarthritis (1) · Osteoarthritis, Knee (1) · Shoulder Injuries (1)
Tranexamic Acid (3) · Blood Cell Count (1) · Blood Culture (1) · Cryotherapy (1) · Doxycycline (1) · Methylprednisolone (1) · Surgical Procedures, Operative (1) · Triamcinolone Acetonide (1) · microcrystalline cellulose (1)
United States (16)
Tyler Brolin, MD (2) · Tyler J Brolin, MD (2) · Benton E Heyworth, MD (1) · Christopher Holland, MD, MS (1) · Emily R Dodwell, MD, MPH (1) · Frederick Azar, MD (1) · Garnett A Murphy, MD (1) · Jay Pershad, MD (1) · Joshua Brandon, MD (1) · Karen Derefinko, PhD (1) · Marcus C Ford, MD (1) · Shehma Khan, MD (1) · William J Weller, MD (1) · William Mihalko, MD, PhD (1)
PMID 16568327, PMID 21467282, PMID 23365029, PMID 25155203, PMID 28711636, PMID 28870300, PMID 29107495, PMID 29560399, PMID 30062946, PMID 30383292, PMID 30650169, PMID 31653221, PMID 32209286, PMID 32253548, PMID 32766393, PMID 32862267, PMID 32869124, PMID 35803549, PMID 35984091, PMID 36194219, PMID 38218405, PMID 38430972, PMID 38618461