248 completed, 150 unknown, 94 recruiting, 39 not yet recruiting. 405 Not applicable, 23 Phase 4, 21 Phase 2, 14 Phase 3, 8 Phase 1.
Follow Anterior Cruciate Ligament Injuries: new trials by email Literature Review of Anterior Cruciate Ligament Injuries trials Research Report on Anterior Cruciate Ligament Injuries
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Reducing Disparities in Knee Arthroscopy for Adolescents Educational program and patient navigator - Knee Injury, ACL Injury | Not applicable | Not yet recruiting | Ann & Robert H Lurie Children's Hospital of Chicago | 80 | 2027-10-01 | 2026-06-18 |
| Intraoperative Analysis of Knee Kinematics During ACL Reconstruction - an Exploratory Study Knee Cinematics - ACL - Anterior Cruciate Ligament Rupture | Not applicable | Not yet recruiting | GCS Ramsay Santé pour l'Enseignement et la Recherche | 30 | 2027-07-01 | 2026-06-18 |
| SharkScrew ACL RCT ACL Reconstruction with a Biocomposite Screw, ACL Reconstruction using a PEEK Screw, ACL Reconstruction using an Allograft Screw - ACL - Anterior Cruciate Ligament Rupture | Not applicable | Not yet recruiting | Austrian Workers Compensation Board Styria | 33 | 2026-11-01 | 2026-10-05 |
| Extended Post-Operative Oral Tranexamic Acid Dosing After ACL Reconstruction Tranexamic Acid, Placebo - Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture | Phase 3 | Not yet recruiting | Dave Bernholt | 100 | 2026-11-01 | 2026-10-19 |
| Description of Return to Sport in Amateur Athletes Who Underwent Several Functional Tests (K-STARTS, Vertical Jumps and Soleus Muscle Strength) After Initial ACL Reconstruction Physical tests - ACL - Anterior Cruciate Ligament Rupture | Not applicable | Not yet recruiting | GCS Ramsay Santé pour l'Enseignement et la Recherche | 230 | 2026-10-01 | 2026-08-20 |
| Supporting Athletes' Return to Sports After ACL Reconstruction: A Study of a Psychological Readiness Program Unbroken Comeback - Anterior Cruciate Ligament Reconstruction, Anterior Cruciate Ligament Injuries | Not applicable | Not yet recruiting | Inova Health Care Services | 30 | 2026-10-01 | 2026-10-15 |
| Correlation Study Between the Classification of Arthrogenic Motor Inhibition (AMI) and Clinical Assessment After ACL Rupture Clinical testing - ACL - Anterior Cruciate Ligament Rupture | Not applicable | Not yet recruiting | GCS Ramsay Santé pour l'Enseignement et la Recherche | 90 | 2026-10-01 | 2026-08-20 |
| Therapeutic Benefits of a Motor Imaging Protocol Following Anterior Cruciate Ligament Reconstruction Surgery Reconstructive surgery after anterior cruciate ligament rupture, sessions from a physical therapist - Anterior Cruciate Ligament Tear | Not applicable | Not yet recruiting | GCS Ramsay Santé pour l'Enseignement et la Recherche | 70 | 2026-10-01 | 2026-09-21 |
| A Paradigm Shift in Musculoskeletal Rehabilitation Assessment After ACL Reconstruction Using Near-Infrared Spectroscopy Incremental Interval Test on a Cycle Ergometer - ACL Injury, Hemodynamics | Not yet recruiting | Universitat de Lleida | 129 | 2026-10-01 | 2026-09-10 | |
| Quadriceps Strengthening ACL Reconstruction NMES and BFR, Standard physical therapy - ACL Tear | Not applicable | Recruiting | Stanford University | 20 | 2026-09-29 | 2026-10-15 |
| Effect of Tourniquet Use on the Pivot Shift Test Thigh Tourniquet Inflation - Anterior Cruciate Ligament Injury | Not applicable | Not yet recruiting | Umraniye Education and Research Hospital | 34 | 2026-09-16 | 2026-09-22 |
| Effectiveness of a Digital Prehabilitation Programme Before ACL Reconstruction Digital Prehabilitation Programme, Usual Care - Anterior Cruciate Ligament Injury | Not applicable | Not yet recruiting | Alejandro Caña Pino | 60 | 2026-09-15 | 2026-06-11 |
| Assessment of Electromyographic Activity in the Quadriceps and Hamstrings of the Operated Limb Versus the Unaffected Limb in Patients Who Have Undergone ACL Surgery, With and Without Post-operative AMI - an Exploratory Study Electromyography - ACL - Anterior Cruciate Ligament Rupture | Not applicable | Not yet recruiting | GCS Ramsay Santé pour l'Enseignement et la Recherche | 40 | 2026-09-01 | 2026-06-22 |
| Anterior Cruciate Ligament (ACL) Reconstruction With Bone Tendon Bone Autograft With Versus Without Internal Bracing ACL reconstruction with BTB autograft with internal brace augmentation (suture tape), ACL reconstruction with BTB autograft without internal brace augmentation (suture tape), Standardized Rehabilitation Protocol - ACL Tear | Not applicable | Withdrawn | Columbia University | 2026-09-01 | 2026-09-21 | |
| Assessment of NEURO-K-STARTS Following Primary Anterior Cruciate Ligament (ACL) Reconstruction NEURO-K-STARTS - ACL - Anterior Cruciate Ligament Rupture | Not applicable | Not yet recruiting | GCS Ramsay Santé pour l'Enseignement et la Recherche | 144 | 2026-09-01 | 2026-06-22 |
| Donor Ankle Sensorimotor Recovery After ACL Reconstruction With a Peroneus Longus Tendon Autograft Anterior Cruciate Ligament Reconstruction Using a Peroneus Longus Tendon Autograft - Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Reconstruction | Recruiting | Gazi University | 20 | 2026-08-22 | 2026-10-09 | |
| Neuromuscular Profiles After Anterior Cruciate Ligament Reconstruction Neuromuscular and Patient-Reported Assessmen - Anterior Cruciate Ligament Injury | Recruiting | Hopitaux de Saint-Maurice | 30 | 2026-08-21 | 2026-09-29 | |
| Clinical and Functional Outcomes After ACL Reconstruction Versus Primary Repair Anterior Cruciate Ligament (ACL) Tear, Anterior Cruciate Ligament Reconstruction | Recruiting | Gazi University | 45 | 2026-08-04 | 2026-08-25 | |
| Graft Type and Outcomes After ACL Reconstruction in Female Athletes Hamstring tendon autograft ACL reconstruction, Quadriceps tendon autograft ACL reconstruction - Anterior Cruciate Ligament Injuries, Knee Injuries | Not yet recruiting | Universidad Católica San Antonio de Murcia | 82 | 2026-08-01 | 2026-07-23 | |
| A Study Of Focused Shockwave For Anterior Knee Pain Following Anterior Cruciate Ligament Reconstruction Focused Shockwave, Sham Focused Shockwave - Anterior Cruciate Ligament Injuries | Not applicable | Enrolling by invitation | Mayo Clinic | 20 | 2026-08-01 | 2026-08-07 |
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Knee Injuries (52) · Pain, Postoperative (18) · Osteoarthritis, Knee (15) · Athletic Injuries (14) · Osteoarthritis (14) · Wounds and Injuries (12) · Muscle Weakness (10) · Rupture (8) · Pain (7) · Kinesiophobia (6) · Motor Activity (5) · Musculoskeletal Diseases (5) · Arthritis (4) · Lacerations (4)
Leg Injuries (617) · Wounds and Injuries (605) · Knee Injuries (565) · Musculoskeletal Diseases (46) · Pathological Conditions, Signs and Symptoms (44) · Neurologic Manifestations (40) · Signs and Symptoms (40) · Joint Diseases (35) · Pathologic Processes (30) · Rheumatic Diseases (25) · Arthritis (23) · Postoperative Complications (19) · Nervous System Diseases (18) · Pain (17) · Neuromuscular Manifestations (13)
Anterior Cruciate Ligament Reconstruction (24) · Blood Flow Restriction Therapy (15) · Bupivacaine (10) · Ropivacaine (10) · Sodium Chloride (8) · Rehabilitation (6) · Magnetic Resonance Imaging (5) · Physical Therapy Modalities (5) · Resistance Training (5) · Control Groups (4) · Dexamethasone (4) · Oxycodone (4) · Plastic Surgery Procedures (4) · Plyometric Exercise (4) · Acetaminophen (3)
Peking University Third Hospital (32) · University of Michigan (11) · Chinese University of Hong Kong (10) · GCS Ramsay Santé pour l'Enseignement et la Recherche (9) · Assiut University (7) · Chang Gung Memorial Hospital (7) · Hospital for Special Surgery, New York (7) · Universitas Indonesia (7) · University Hospital, Caen (7) · University of North Carolina, Chapel Hill (7) · Istituto Ortopedico Rizzoli (6) · Riphah International University (6) · Vanderbilt University Medical Center (6) · Aarhus University Hospital (5) · Andrews Research & Education Foundation (5)
United States (175) · France (45) · Turkey (Türkiye) (43) · China (35) · Italy (19) · Canada (18) · Egypt (17) · Switzerland (17) · Denmark (16) · Belgium (14) · Pakistan (13) · United Kingdom (13) · Poland (12) · Spain (12) · Sweden (12)
Hongshi Huang, Doctor (5) · Adam Anz, MD (4) · Gregory D Myer, PhD (3) · Konrad Malinowski, MD PhD (3) · Kurt P Spindler, MD (3) · Adam Weaver, PT, DPT (2) · Austin Stone, MD, PhD (2) · Brian Pietrosimone, PhD (2) · Chandramouli Krishnan, PT, PhD (2) · Chandramouli Krishnan, PhD (2) · Cheng Wang, M.D. (2) · Eva Ageberg, PhD (2) · Joanna Kvist, Professor (2) · John Xerogeanes, MD (2)
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R01AR053684 (2), R21AR082643 (2), 2004 (1), 2019 (1), 2023 (1), 2025 (1), K01AR082421 (1), K08AR053152 (1), K23AR047631 (1), K23AR079056 (1), K23AR084596 (1), P20GM109090 (1), P2CHD086844 (1), P30AR072572 (1), R01AR047910 (1)