20 completed, 4 terminated, 4 unknown, 3 recruiting. 35 Phase 2, 8 Phase 3, 7 Phase 1.
Follow Knee Injuries: new trials by email Literature Review of Knee Injuries trials Research Report on Knee Injuries
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Losartan to Improve Outcomes After Multi-ligament Knee Injury losartan 25 mg, Placebo capsule - Multi-ligament Knee Injury | Phase 2 | Recruiting | Brigham and Women's Hospital | 90 | 2025-10-01 | 2026-01-20 |
| Non-Narcotic Pain Control After ACL Reconstruction dispense of study drug, Ketorolac - ACL - Anterior Cruciate Ligament Rupture, ACL Injuries | Phase 2 | Active not recruiting | The Cleveland Clinic | 30 | 2025-07-15 | 2026-08-24 |
| Vitamin D to Improve Quadricep Muscle Strength Vitamin D3, Placebo - Anterior Cruciate Ligament Injuries, Quadriceps Muscle Atrophy | Phase 2 | Recruiting | Chinese University of Hong Kong | 60 | 2025-03-17 | 2025-03-18 |
| Preventing Injured Knees From osteoArthritis: Severity Outcomes Metformin, Placebo - Osteoarthritis, Knee, Post-traumatic Osteoarthritis | Phase 2 | Recruiting | Brigham and Women's Hospital | 512 | 2024-05-06 | 2026-10-15 |
| Platelet-Rich Plasma and the Effects of NSAIDs on Pain and Functional Scores in Knee Osteoarthritis Ibuprofen and PRP, Acetaminophen and PRP, Placebo and PRP - Osteoarthritis of the Knee, Degenerative Osteoarthritis | Phase 1 / Phase 2 | Withdrawn | QC Kinetix LLC | 2023-11-01 | 2024-10-09 | |
| Effectiveness Comparison Between Continuous Cryotherapy and Ice Pack Therapy After Anterior Cruciate Ligament Reconstruction Surgery Continuous compression cryotherapy, Conventional ice treatment - Postoperative Pain, Acute, Anterior Cruciate Ligament Injuries | Phase 2 / Phase 3 | Completed | University Medical Center Ho Chi Minh City (UMC) | 72 | 2023-06-01 | 2024-10-08 |
| Effect of Palmitoylethanolamide on Reducing Opioid Consumption for Below Knee Fracture Fixation Palmitoylethanolamide, Placebo - Tibial Fractures, Fibula Fracture | Phase 2 | Withdrawn | University of California, Irvine | 2023-05-01 | 2023-05-09 | |
| Synovial Tissue and Fat Pad Stromal Vascular Fraction Bioengineering in Patients With Knee Articular Cartilage Injury Synovial Tissue and Fat Pad Stromal Vascular Fraction - Cell- and Tissue-Based Therapy, Cartilage Injury | Phase 1 / Phase 2 | Unknown | University of Sao Paulo General Hospital | 10 | 2022-04-01 | 2021-11-15 |
| Clinical Efficacy of Exosome in Degenerative Meniscal Injury SF-MSC-EX, SF-MSC - Knee; Injury, Meniscus (Lateral) (Medial), Meniscus Tear | Phase 2 | Unknown | Eskisehir Osmangazi University | 30 | 2022-03-01 | 2022-03-04 |
| Success of Long-acting Anti-inflammatories After Anterior Cruciate Ligament and Meniscal Injury Zilretta, Placebo - Tibial Meniscus Injuries, Tibial Meniscus Tears | Phase 2 | Terminated | Austin V Stone | 1 | 2020-08-21 | 2023-07-27 |
| Use of Testosterone to Prevent Post-Surgical Muscle Loss - Pilot Study Aveed 750 MG in 3 ML IM Injection, Normal Saline 3 ML IM Injection - Muscle Atrophy, Surgery | Phase 2 / Phase 3 | Unknown | The Stone Research Foundation for Sports Medicine and Arthritis | 15 | 2020-05-08 | 2021-08-31 |
| Effects of Platelet Rich Plasma Injections on Biomarkers After Anterior Cruciate Ligament Tears Experimental Group, Control Group - Anterior Cruciate Ligament Tear, Anterior Cruciate Ligament Rupture | Phase 2 | Completed | Andrews Research & Education Foundation | 24 | 2019-09-12 | 2025-02-17 |
| Ultrasound-Guided Injections for Meniscal Injuries in Active-Duty Military Lipogems, Normal Saline - Tibial Meniscus Injuries, Knee Injuries | Phase 2 | Completed | Kessler Foundation | 3 | 2019-07-01 | 2024-12-18 |
| IL-1RA Treatment in Patients With Acute ACL Tear and Painful Effusions anakinra (150mg), Saline intraarticularly - Anterior Cruciate Ligament Tear | Phase 2 | Terminated | Cale Jacobs, PhD | 6 | 2019-06-20 | 2021-11-24 |
| Ropivacaine and Midazolam by Intraarticular vs Epidural Administration in Arthroscopic ACL ropivacaine and midazolam intraarticular administration, ropivacaine and midazolam epidural administration - Anterior Cruciate Ligament Injuries, Anesthesia Injection Site | Phase 2 | Completed | Universidad Autonoma de Nuevo Leon | 108 | 2019-01-31 | 2021-10-14 |
| Nonopioid Analgesia After Anterior Cruciate Ligament Reconstruction Celecoxib, Hydrocodone-Acetaminophen, Ketorolac - Anterior Cruciate Ligament Injury | Phase 2 / Phase 3 | Completed | Henry Ford Health System | 90 | 2019-01-22 | 2026-03-19 |
| Can PRP Reduce Pro-Inflammatory Biomarkers Following ACL Injury Platelet Rich Plasma, Saline Placebo - ACL - Anterior Cruciate Ligament Rupture, ACL Injury | Phase 2 | Withdrawn | NYU Langone Health | 2018-09-09 | 2024-04-15 | |
| Objective Results of Anterior Cruciate Ligament Reconstruction With and Without Internal Suture Augmentation Technique all- inside anterior cruciate ligament reconstruction - Anterior Cruciate Ligament Injuries | Phase 2 / Phase 3 | Completed | Ain Shams University | 38 | 2018-09-01 | 2021-06-02 |
| Does Gabapentin Reduce Quadriceps Muscle Weakness After Anterior Cruciate Ligament Reconstruction? Gabapentin, Tramadol, Panadol - Muscle Weakness, Anterior Cruciate Ligament Rupture | Phase 2 / Phase 3 | Unknown | Hospital Authority, Hong Kong | 30 | 2018-07-01 | 2018-04-12 |
| Intra-articular Dexmedetomidine Versus Neostigmine After Knee Arthroscopy (a Comparative Study) dexamedetomidine, neostigmine - Knee Injuries | Phase 2 / Phase 3 | Completed | Assiut University | 100 | 2017-08-01 | 2018-01-11 |
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Anterior Cruciate Ligament Injuries (21) · Osteoarthritis (3) · Osteoarthritis, Knee (3) · Tibial Meniscus Injuries (3) · Wounds and Injuries (3) · Disease (2) · Joint Diseases (2) · Muscular Atrophy (2) · Pain, Postoperative (2) · Agnosia (1) · Arthralgia (1) · Cartilage Diseases (1) · Fibula Fractures (1) · Inflammation (1)
Leg Injuries (35) · Wounds and Injuries (32) · Musculoskeletal Diseases (8) · Pathological Conditions, Signs and Symptoms (8) · Neurologic Manifestations (7) · Signs and Symptoms (7) · Joint Diseases (5) · Pathologic Processes (5) · Arthritis (4) · Nervous System Diseases (4) · Neuromuscular Manifestations (3) · Pain (3) · Rheumatic Diseases (3) · Atrophy (2)
Sodium Chloride (4) · Acetaminophen (3) · Anterior Cruciate Ligament Reconstruction (2) · Gabapentin (2) · Interleukin 1 Receptor Antagonist Protein (2) · Ketorolac (2) · Ketorolac Tromethamine (2) · Saline Solution (2) · Celecoxib (1) · Cholecalciferol (1) · Control Groups (1) · Dexmedetomidine (1) · Diazepam (1) · Human Growth Hormone (1) · Hyaluronic Acid (1)
Brigham and Women's Hospital (2) · Isfahan University of Medical Sciences (2) · Ain Shams University (1) · AlgoRx Pharmaceuticals (1) · Andrews Research & Education Foundation (1) · Assiut University (1) · Austin V Stone (1) · Banc de Sang i Teixits (1) · Cale Jacobs, PhD (1) · Centers for Disease Control and Prevention (1) · Chinese University of Hong Kong (1) · Duke University (1) · Eskisehir Osmangazi University (1) · Hadassah Medical Organization (1) · Henry Ford Health System (1)
United States (16) · Egypt (2) · Iran (2) · Israel (2) · Australia (1) · Canada (1) · Hong Kong (1) · Mexico (1) · Netherlands (1) · Spain (1) · Turkey (Türkiye) (1) · Vietnam (1)
Adam W Anz, MD (1) · Adi Fridman, Dr. (1) · Ahmed A Khater, MD (1) · Andri MT Lubis, MD, PhD (1) · Ariana Nelson, MD (1) · Austin Stone, MD (1) · Austin Stone, MD, PhD (1) · Cale A Jacobs, PhD (1) · Cale Jacobs, PhD (1) · Christopher L Mendias, PhD, ATC (1) · Donna Skerrett, MD (1) · Eric Strauss, MD (1) · Freddie H Fu, MD (1)
PMID 11090729, PMID 12492792, PMID 15329580, PMID 16835255, PMID 17244900, PMID 18567675, PMID 21194441, PMID 22273632, PMID 25769789, PMID 26049805, PMID 26787787, PMID 27140500, PMID 27687059, PMID 28173788, PMID 28271084, PMID 28768528, PMID 29511256, PMID 30807886, PMID 31195095, PMID 32452208, PMID 32641270, PMID 38605374, PMID 39032093, PMID 39867299, PMID 40052182, PMID 40234828, PMID 40540943, PMID 41981668
R01AR056630 (1)