402 completed, 201 unknown, 127 recruiting, 51 not yet recruiting. 586 Not applicable, 35 Phase 2, 34 Phase 4, 29 Phase 3, 15 Phase 1.
Follow Knee Injuries: new trials by email Literature Review of Knee Injuries trials Research Report on Knee Injuries
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Reducing Disparities in Knee Arthroscopy for Adolescents Educational program and patient navigator - Knee Injury, ACL Injury | Not applicable | Not yet recruiting | Ann & Robert H Lurie Children's Hospital of Chicago | 80 | 2027-10-01 | 2026-06-18 |
| Intraoperative Analysis of Knee Kinematics During ACL Reconstruction - an Exploratory Study Knee Cinematics - ACL - Anterior Cruciate Ligament Rupture | Not applicable | Not yet recruiting | GCS Ramsay Santé pour l'Enseignement et la Recherche | 30 | 2027-07-01 | 2026-06-18 |
| Exercise Program for ITB Syndrome Individualized Exercise Program, Standard Physical Therapy - Iliotibial Band Syndrome | Not applicable | Not yet recruiting | NYU Langone Health | 100 | 2027-03-01 | 2026-08-07 |
| Personalized Weight-Bearing With Smart Crutch Tips After Surgery for Tibial Plateau Fractures Crutch Tip Biofeedback System, Individualized FEA-Guided Postoperative Weight-Bearing, Usual-Care Postoperative Weight-Bearing - Tibial Plateau Fracture | Not applicable | Not yet recruiting | Comeback Mobility Inc | 86 | 2026-11-15 | 2026-10-27 |
| SharkScrew ACL RCT ACL Reconstruction with a Biocomposite Screw, ACL Reconstruction using a PEEK Screw, ACL Reconstruction using an Allograft Screw - ACL - Anterior Cruciate Ligament Rupture | Not applicable | Not yet recruiting | Austrian Workers Compensation Board Styria | 33 | 2026-11-01 | 2026-10-05 |
| Enhancing Wound Perfusion in High-Risk Lower Extremity Orthopaedic Surgery: A Study on Nitropaste Using Intraoperative SPY Imaging. Nitroglycerin Ointment 2% - Achilles Tendon Repairs/Reconstructions, Pilon Fracture of Tibia | Phase 1 | Not yet recruiting | Johns Hopkins University | 15 | 2026-11-01 | 2026-03-31 |
| Extended Post-Operative Oral Tranexamic Acid Dosing After ACL Reconstruction Tranexamic Acid, Placebo - Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture | Phase 3 | Not yet recruiting | Dave Bernholt | 100 | 2026-11-01 | 2026-10-26 |
| Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Postoperative Recovery Quality in Patients Undergoing Anterior Cruciate Ligament Reconstruction Experimental-Active taVNS, Sham transcutaneous auricular vagus nerve stimulation - Anterior Cruciate Ligament Injuries, Recovery Quality | Not applicable | Not yet recruiting | Peking University Third Hospital | 144 | 2026-10-28 | 2026-10-29 |
| Description of Return to Sport in Amateur Athletes Who Underwent Several Functional Tests (K-STARTS, Vertical Jumps and Soleus Muscle Strength) After Initial ACL Reconstruction Physical tests - ACL - Anterior Cruciate Ligament Rupture | Not applicable | Not yet recruiting | GCS Ramsay Santé pour l'Enseignement et la Recherche | 230 | 2026-10-01 | 2026-08-20 |
| Supporting Athletes' Return to Sports After ACL Reconstruction: A Study of a Psychological Readiness Program Unbroken Comeback - Anterior Cruciate Ligament Reconstruction, Anterior Cruciate Ligament Injuries | Not applicable | Not yet recruiting | Inova Health Care Services | 30 | 2026-10-01 | 2026-10-15 |
| Correlation Study Between the Classification of Arthrogenic Motor Inhibition (AMI) and Clinical Assessment After ACL Rupture Clinical testing - ACL - Anterior Cruciate Ligament Rupture | Not applicable | Not yet recruiting | GCS Ramsay Santé pour l'Enseignement et la Recherche | 90 | 2026-10-01 | 2026-08-20 |
| Therapeutic Benefits of a Motor Imaging Protocol Following Anterior Cruciate Ligament Reconstruction Surgery Reconstructive surgery after anterior cruciate ligament rupture, sessions from a physical therapist - Anterior Cruciate Ligament Tear | Not applicable | Not yet recruiting | GCS Ramsay Santé pour l'Enseignement et la Recherche | 70 | 2026-10-01 | 2026-09-21 |
| A Paradigm Shift in Musculoskeletal Rehabilitation Assessment After ACL Reconstruction Using Near-Infrared Spectroscopy Incremental Interval Test on a Cycle Ergometer - ACL Injury, Hemodynamics | Not yet recruiting | Universitat de Lleida | 129 | 2026-10-01 | 2026-09-10 | |
| Quadriceps Strengthening ACL Reconstruction NMES and BFR, Standard physical therapy - ACL Tear | Not applicable | Recruiting | Stanford University | 20 | 2026-09-29 | 2026-10-15 |
| Knee Cartilage Repair Registry Marketed Product - MP01, Other Surgical Treatments - Knee Injuries, Joint Surface Knee Lesions | Recruiting | Smith & Nephew, Inc. | 1000 | 2026-09-23 | 2026-10-08 | |
| Effect of Tourniquet Use on the Pivot Shift Test Thigh Tourniquet Inflation - Anterior Cruciate Ligament Injury | Not applicable | Not yet recruiting | Umraniye Education and Research Hospital | 34 | 2026-09-16 | 2026-09-22 |
| Identification of Kinematic Variables Specific of Patellar Tendinopathy in Athletes at Risk The intervention consists of a series of vertical jump tests captured using high-resolution cameras with markerless motion capture technology., The intervention consists of a series of vertical jump tests captured using high-resolution cameras with markerless motion capture technology at 6 months and 12 months - Patellar Tendinitis, Jumper's Knee | Not applicable | Recruiting | University Hospital, Montpellier | 60 | 2026-09-15 | 2026-09-21 |
| Effectiveness of a Digital Prehabilitation Programme Before ACL Reconstruction Digital Prehabilitation Programme, Usual Care - Anterior Cruciate Ligament Injury | Not applicable | Not yet recruiting | Alejandro Caña Pino | 60 | 2026-09-15 | 2026-06-11 |
| Exploring Factors Linked to Worsening Over Time in People With Early-stage Knee Osteoarthritis and Those With Prior Proven Acute Knee Injury. Knee Osteoarthritis | Not yet recruiting | Imperial College London | 200 | 2026-09-01 | 2026-09-28 | |
| Conservative Versus Operative - First Time Patella Dislocations medial patellofemoral reconstruction, Non-operative group - Patella Dislocation | Not applicable | Withdrawn | Columbia University | 2026-09-01 | 2026-09-21 |
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Anterior Cruciate Ligament Injuries (618) · Osteoarthritis, Knee (47) · Patellar Dislocation (39) · Wounds and Injuries (32) · Tibial Plateau Fractures (29) · Pain, Postoperative (26) · Athletic Injuries (24) · Osteoarthritis (23) · Disease (20) · Iliotibial Band Syndrome (19) · Pain (17) · Ankle Injuries (14) · Muscle Weakness (11) · Knee Fractures (9)
Leg Injuries (916) · Wounds and Injuries (889) · Musculoskeletal Diseases (136) · Joint Diseases (117) · Pathological Conditions, Signs and Symptoms (97) · Neurologic Manifestations (71) · Signs and Symptoms (71) · Pathologic Processes (66) · Arthritis (59) · Rheumatic Diseases (59) · Fractures, Bone (49) · Joint Dislocations (43) · Osteoarthritis (39) · Knee Fractures (38)
Anterior Cruciate Ligament Reconstruction (25) · Blood Flow Restriction Therapy (18) · Bupivacaine (14) · Sodium Chloride (14) · Physical Therapy Modalities (13) · Ropivacaine (12) · Exercise (9) · Rehabilitation (7) · Magnetic Resonance Imaging (6) · Surgical Procedures, Operative (6) · Surveys and Questionnaires (6) · Acetaminophen (5) · Control Groups (5) · Dexamethasone (5) · Ketorolac (5)
Peking University Third Hospital (38) · GCS Ramsay Santé pour l'Enseignement et la Recherche (13) · Assiut University (12) · Cairo University (11) · Riphah International University (11) · University of Michigan (11) · Chinese University of Hong Kong (10) · Istituto Ortopedico Rizzoli (10) · Hospital for Special Surgery, New York (8) · Mayo Clinic (8) · Stanford University (8) · Chang Gung Memorial Hospital (7) · Hacettepe University (7) · Universitas Indonesia (7) · University Hospital, Caen (7)
United States (270) · Turkey (Türkiye) (63) · France (58) · China (51) · Canada (32) · Egypt (31) · Italy (29) · Spain (26) · Pakistan (25) · United Kingdom (23) · Denmark (21) · Norway (21) · Poland (21) · Belgium (19) · Switzerland (19)
Hongshi Huang, Doctor (5) · Adam Anz, MD (4) · Gregory D Myer, PhD (4) · Konrad Malinowski, MD PhD (4) · Kurt P Spindler, MD (3) · Lin Lin (3) · Robert F LaPrade, MD, PhD (3) · Simo Saarakkala, Ph.D. (3) · Adam Weaver, PT, DPT (2) · Austin Stone, MD, PhD (2) · Brian Pietrosimone, PhD (2) · Chandramouli Krishnan, PT, PhD (2) · Chandramouli Krishnan, PhD (2)
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R01AR053684 (2), R01AR055563 (2), R21AR082643 (2), 2004 (1), 2019 (1), 2023 (1), 2025 (1), DP5OD031833 (1), K01AR082421 (1), K08AR053152 (1), K23AR047631 (1), K23AR079056 (1), K23AR084596 (1), P20GM109090 (1), P2CHD086844 (1)