1675 completed, 518 unknown, 363 recruiting, 176 not yet recruiting. 1718 Not applicable, 202 Phase 2, 152 Phase 3, 116 Phase 4, 88 Phase 1.
Follow Neuromuscular Manifestations: new trials by email Literature Review of Neuromuscular Manifestations trials Research Report on Neuromuscular Manifestations
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Mixed Exercise Training and Novel Multi-Nutrient Supplementation in Young Adults Multi-nutrient supplement, Exercise - Sarcopenia | Not applicable | Withdrawn | McMaster University | 2030-01-20 | 2024-01-30 | |
| The FORCE Trial Pilot: Fish Oil-enriched Nutrition for Radiotherapy in Cancer of the hEad and Neck Nutrition counseling, Fresubin Supportan - Head &Amp;Amp; Neck Squamous Cell Carcinoma | Phase 1 / Phase 2 | Not yet recruiting | Anna Arthur, PhD | 15 | 2027-06-01 | 2026-08-07 |
| Lateral Cord Stimulation as a New Treatment for Refractory Spastic Cerebral Palsy Lateral spinal cord surgical implant of electrodes - Cerebral Palsy, Spasticity | Not applicable | Not yet recruiting | Juan Carlos M. Andreani MD | 40 | 2027-06-01 | 2026-04-28 |
| Evaluate the Efficacy and Safety of EN001 in Patients With Sarcopenia EN001, EN001 Placebo - Sarcopenia | Phase 1 / Phase 2 | Not yet recruiting | ENCell | 132 | 2027-03-01 | 2026-09-11 |
| Effect of Protein, Mobility Therapy and Electric Stimulation on Recovery in Older ICU Survivors MRP and High Protein Supplement (HPRO) and Neuromuscular Electric Stimulation (NMES) - Critical Illness, Sarcopenia | Early Phase 1 | Not yet recruiting | University of Maryland, Baltimore | 78 | 2027-03-01 | 2026-05-06 |
| The Simplified Total-body Resistance Exercise for Muscular Hypertrophy for Diabetic Population (D-STORM) D-STORM Resistance Training Programme, usual care - Type 2 Diabetes Mellitus (T2DM), Sarcopenia | Not applicable | Not yet recruiting | Universiti Teknologi Mara | 56 | 2027-01-01 | 2026-06-25 |
| Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD) Endothelial cell collection - Obesity and Obesity-related Medical Conditions, Diabetes | Recruiting | Bettina Mittendorfer | 100 | 2027-01-01 | 2026-05-07 | |
| A Study to Investigate Arbaclofen ER Tablets for the Treatment of Spasticity in Patients With Multiple Sclerosis Arbaclofen, Placebo - Spasticity | Phase 3 | Not yet recruiting | RVL Pharmaceuticals, Inc. | 442 | 2027-01-01 | 2025-12-03 |
| Management of Postoperative Complications After Mandibular Third Molar Extraction Using Submucosal Triamcinolone Injection, Kinesiology Taping, and Standard Care Triamcinolone Acetonide 10mg, Kinesiology Taping, Standard Postoperative Care - Trismus, Edema | Not applicable | Not yet recruiting | Allama Iqbal Medical College | 60 | 2027-01-01 | 2026-07-22 |
| Yijinjing Exercise for Musculoskeletal Health in Adults With Sarcopenia Modified Yijinjing Exercise, Progressive Resistance Training, Dietary Counseling and Health Education - Sarcopenia | Not applicable | Not yet recruiting | Beijing Hospital of Traditional Chinese Medicine | 240 | 2027-01-01 | 2026-10-21 |
| A Phase IIb Study of Nabiximols for Spasticity Due to Neuromyelitis Optica Spectrum Disorders Nabiximols, Placebo - NMO Spectrum Disorder, Spasticity, Muscle | Phase 2 | Withdrawn | Michael, Levy M.D.,Ph.D. | 2026-12-31 | 2025-07-16 | |
| Exercise and Nutritional Intervention in Patients With Melanoma Receiving Immunotherapy Structured Resistance Exercise, Individualized Nutritional Support - Melanoma | Not applicable | Not yet recruiting | Institute of Oncology Ljubljana | 40 | 2026-12-01 | 2026-10-07 |
| Feasibility of a Novel Resistance Exercise in Individuals With Osteoporosis Exercise training - Osteopenia, Osteoporosis | Not applicable | Withdrawn | University of Alabama at Birmingham | 2026-12-01 | 2026-07-01 | |
| HMB Plus Vitamin D to Preserve Muscle in Older Adults Starting Semaglutide Calcium-HMB Plus Vitamin D3, Matching placebo - Type 2 Diabetes Mellitus (T2DM), Sarcopenia | Phase 2 | Not yet recruiting | Vanderbilt University Medical Center | 90 | 2026-12-01 | 2026-08-28 |
| Targeted Nutritional Intervention (HMB, Arginine, Glutamine) in Patients With Pancreatic Cancer HMB / L-Arginine / L-Glutamine oral nutritional mixture, Standard Dietary Counseling - PDAC, Pancreas Adenocarcinoma (MSI-H) | Not applicable | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 24 | 2026-12-01 | 2026-10-20 |
| Comparison of Sarcopenia Index, Diaphragm Ultrasonography, and Traditional Weaning Parameters in Predicting Successful Weaning From Mechanical Ventilation sarcopenia index, diaphragma ultrasound, parameters of mechanical ventilation (MV) - Ventilator Weaning, Sarcopenia | Not yet recruiting | Kocaeli City Hospital | 80 | 2026-11-15 | 2026-09-28 | |
| Vicia Faba Peptides and Resistance Training in the Elderly Vicia faba L.-derived peptides, Placebo, Supervised Resistance Training - Healthy Aging | Not applicable | Enrolling by invitation | Universidade Cesumar (UNICESUMAR) | 77 | 2026-11-01 | 2026-10-07 |
| Effectiveness of Combined GLP-1/GIP Dual Agonist Therapy and Structured Exercise on Skeletal Muscle Morphology, Quality, and Physical Function in Overweight and Obese Individuals Resistance exercise, Lifestyle recommendations - Obesity, Sarcopenia | Not applicable | Not yet recruiting | Acibadem University | 108 | 2026-11-01 | 2026-06-04 |
| Sarcopenia Screening in Advanced Coxarthrosis: The SARCO-COX Study Intensive Physical Rehabilitation, Preoperative Sarcopenia Screening - Sarcopenia, Coxarthrosis | Not applicable | Not yet recruiting | Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud | 150 | 2026-11-01 | 2026-09-15 |
| Metformin and ACLR Muscle Recovery Metformin, Placebo - Atrophy, Inflammation | Early Phase 1 | Not yet recruiting | University of Utah | 40 | 2026-11-01 | 2026-07-13 |
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Sarcopenia (1290) · Muscle Spasticity (619) · Muscle Weakness (442) · Muscular Atrophy (404) · Stroke (256) · Motor Activity (194) · Frailty (175) · Cerebral Palsy (156) · Spasm (112) · Trismus (105) · Pain (96) · Obesity (95) · Malnutrition (89) · Multiple Sclerosis (85) · Spinal Cord Injuries (79)
Pathological Conditions, Signs and Symptoms (3053) · Signs and Symptoms (3044) · Neurologic Manifestations (3041) · Nervous System Diseases (3034) · Pathological Conditions, Anatomical (1643) · Atrophy (1614) · Musculoskeletal Diseases (1317) · Muscular Atrophy (1230) · Muscular Diseases (1159) · Pathologic Processes (870) · Muscle Hypertonia (626) · Central Nervous System Diseases (578) · Brain Diseases (480) · Nutritional and Metabolic Diseases (402)
Exercise (107) · Resistance Training (99) · Botulinum Toxins, Type A (81) · Control Groups (23) · Physical Therapy Modalities (23) · Dietary Supplements (18) · Dry Needling (18) · Saline Solution (18) · nabiximols (18) · Absorptiometry, Photon (16) · Creatine (16) · Proteins (16) · Ultrasonography (16) · Whey Proteins (16) · Baclofen (15)
National Taiwan University Hospital (31) · Riphah International University (31) · Chang Gung Memorial Hospital (28) · Maastricht University Medical Center (24) · Hacettepe University (23) · University of Nottingham (22) · McMaster University (19) · Cairo University (18) · Allergan (17) · Assistance Publique - Hôpitaux de Paris (16) · Ipsen (16) · University Hospital, Clermont-Ferrand (16) · Istanbul Physical Medicine Rehabilitation Training and Research Hospital (15) · Novartis Pharmaceuticals (15) · University of Saskatchewan (15)
United States (681) · Turkey (Türkiye) (294) · France (187) · Spain (187) · United Kingdom (162) · Taiwan (151) · Canada (129) · Italy (126) · China (105) · Brazil (98) · Germany (93) · Belgium (89) · South Korea (73) · Denmark (71) · Netherlands (69)
Luc JC van Loon, PhD (7) · Stuart M Phillips, PhD (7) · Bess Dawson-Hughes, MD (5) · David Charles, M.D. (5) · Galip Can Uyar, MD (5) · Sang Yeoup Lee, MD, PhD (5) · Stefan J Schaller, MD (5) · Charlotte Suetta, Professor (4) · Elena Volpi, MD, PhD (4)
PMID 30312372, PMID 20392703, PMID 32069356, PMID 24737557, PMID 32033882, PMID 12472328, PMID 28095426, PMID 18511703, PMID 19446324, PMID 27149465, PMID 31081853, PMID 32941253, PMID 12028177, PMID 16030064, PMID 16614412, PMID 16896165, PMID 17351147, PMID 17370477, PMID 17912368, PMID 18323467, PMID 18342407, PMID 18713956, PMID 18787087, PMID 20046132, PMID 20358216, PMID 20406506, PMID 20876843, PMID 21093718, PMID 21448087, PMID 22018588, PMID 22277759, PMID 22338078, PMID 24374288, PMID 24737560, PMID 25229260, PMID 25243821, PMID 25296344, PMID 25475413, PMID 25475435, PMID 26882087, PMID 26922142, PMID 27077744, PMID 27138015, PMID 27507236, PMID 27935521, PMID 28159728, PMID 28473464, PMID 29024353, PMID 29349935, PMID 30513782
2019 (7), 2018 (6), 2023 (6), P30AG028740 (5), 2025 (4), 2016 (3), 2017 (3), 2009 (2), 2015 (2), P30AG028747 (2), R01HD075813 (2), R61HL151952 (2), U54NS115054 (2), 1IK2RD000462 (1), 2005 (1)