136 completed, 60 unknown, 25 recruiting, 17 not yet recruiting. 189 Not applicable, 30 Phase 2, 20 Phase 4, 15 Phase 1, 13 Phase 3.
Follow Cryotherapy: new trials by email Literature Review of Cryotherapy trials Research Report on Cryotherapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cryotherapy vs Lidocaine Spray for Oral Mucositis Oral Cryotherapy, Topical Lidocaine Spray - Cancer | Not applicable | Not yet recruiting | Hanady Jabbar Mahmood | 60 | 2026-12-31 | 2026-07-27 |
| Necrosectomy With Cryotechnology for Accelerated Removal Cryotechnology Necrosectomy Procedure - Pancreatic Necrosis, Acute Pancreatitis | Not applicable | Recruiting | Christopher C. Thompson, MD, MSc | 20 | 2026-12-01 | 2026-06-25 |
| Efficacy and Safety of Cryotherapy Followed by Tirbanibulin Ointment for Actinic Keratosis on the Scalp and Forehead Cryotherapy + Tirbanibulin - Keratosis, Actinic Keratoses | Phase 3 | Not yet recruiting | University Hospital, Lille | 59 | 2026-11-30 | 2026-05-22 |
| Whole-body Cryotherapy in Those With Chronic Fatigue: A Feasibility Study Cryotherapy - ME/CFS, Fibromyalgia (FM) | Not applicable | Not yet recruiting | Oxford Brookes University | 40 | 2026-10-01 | 2026-10-14 |
| Holistic Healing for Knee Osteoarthritis Trayodashang Guggulu, Ashwagandha Churna, Janubasti - Knee Osteoarthritis (Knee OA) | Not applicable | Not yet recruiting | All India Institute of Medical Sciences, Jodhpur | 300 | 2026-09-01 | 2026-08-27 |
| Cryo Nerve Block Trial Cryotherapy, PAiN - multimodal analgesia - Intercostal Nerve Block, Cryo Analgesia | Not applicable | Recruiting | St. Antonius Hospital | 150 | 2026-09-01 | 2026-06-26 |
| Cryotherapy for Post-Hemorrhoidectomy Pain Milligan-Morgan Hemorrhoidectomy with Cryotherapy, Miligan-Morgan haemorroidectomy - Hemorrhoid, Hemorrhoidectomy | Not applicable | Not yet recruiting | Cairo University | 114 | 2026-08-04 | 2026-07-22 |
| Effect of Oral Ice Chips to Prevent Chemotherapy-Induced Oral Mucositis in Patient With Solid Tumor Treated With 5 Fluorouracil and Methotrexate Oral Cryotherapy (Ice Chips), Standard Oral Care (Mouthwash) - Chemotherapy Induced Oral Mucositis | Not applicable | Not yet recruiting | University of Health Sciences Lahore | 102 | 2026-07-15 | 2026-06-16 |
| Virtual Reality and Cryotherapy for Postoperative Pain and Anxiety After Cesarean Section Virtual Reality, Cryotherapy - Postoperative Pain, Anxiety | Not applicable | Not yet recruiting | Shahid Beheshti University of Medical Sciences | 120 | 2026-07-12 | 2026-07-14 |
| Topical Cryotherapy and Keloid/Hypertrophic Scars Cryotherapy with liquid nitrogen, Intralesional Triamcinolone 10 mg/ml - Keloid Scars, Hypertrophic Scars | Phase 3 | Recruiting | Sonal Choudhary | 30 | 2026-06-10 | 2026-06-12 |
| Effect of Intracanal Cryotherapy on Postoperative Endodontic Pain root canal treatment and cryotherapy - Periapical Periodontitis, Asymptomatic Irreversible Pulpitis | Not applicable | Completed | Recep Tayyip Erdogan University | 132 | 2026-05-11 | 2026-07-17 |
| Retinoblastoma Consolidation in Egyptians transpupillary thermotherapy, Cryotherapy, Brachytherapy - Retinoblastoma | Not yet recruiting | Assiut University | 150 | 2026-05-01 | 2026-04-15 | |
| Post-Market Registry of Transbronchial Cryo-assisted RFA During Routine Standard Bronchoscopic Tumor Stagng and Resection Cryotherapy - NSCLC, Cryotherapy | Not applicable | Not yet recruiting | Elisabethinen Hospital | 20 | 2026-05-01 | 2026-04-15 |
| CRYO-1: Cryoablation in Elderly Patients With Early-Stage Breast Cancer. Cryoablation / Cryotherapy - Breast Cancer Stage I, Breast Cancer Early Stage Breast Cancer (Stage 1-3) | Not applicable | Not yet recruiting | St. Antonius Hospital | 61 | 2026-04-01 | 2026-03-23 |
| High Intensity Focused Ultrasound vs. Cryotherapy in the Treatment of Basal Cell Carcinomas and Bowen's Disease in Adults High Intensity Focused Ultrasound, Cryotherapy - Superficial Basal Cell Carcinoma, Nodular Basal Cell Carcinoma | Not applicable | Not yet recruiting | Jussi Salonen | 294 | 2026-04-01 | 2026-02-03 |
| Evaluatation of a Microcurrent + Cold Therapy Device Acute Microcurrent Treatment, Acute Microcurrent + cold therapy, 8-week Chronic Use of Microcurrent + Cold Therapy - Skin Health | Not applicable | Completed | Therabody, Inc. | 112 | 2026-03-30 | 2026-10-01 |
| Comparing Pre-Anesthetic Approaches in Dentistry 10% lidocaine spray, Ice Pen (Cryotherapy) - Injection Site Pain, Pain | Not applicable | Completed | Harran University | 192 | 2026-02-23 | 2026-09-10 |
| Effect of Cryotherapy on Anesthetic Success and Pain in Irreversible Pulpitis infiltration anesthesia alone, mandibular anesthesia alone, infiltration anesthesia combined with cryotherapy - Irreversible Pulpitis, Cryotherapy | Not applicable | Not yet recruiting | TC Erciyes University | 100 | 2026-01-30 | 2026-02-11 |
| Effect of Cryotherapy on Postoperative Pain for Pulpotomy Cryotherapy - Pulpitis - Irreversible | Early Phase 1 | Active not recruiting | Sirawut Hiran-us | 82 | 2026-01-21 | 2026-02-02 |
| Effects of Muscle Cooling on Motor Unit Firing of the Quadriceps Cryotherapy - Healthy | Not applicable | Suspended | Wake Forest University | 24 | 2026-01-20 | 2026-08-21 |
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Pain, Postoperative (22) · Pain (18) · Breast Neoplasms (13) · Keratosis, Actinic (12) · Warts (12) · Prostatic Neoplasms (11) · Peripheral Nervous System Diseases (7) · Retinoblastoma (7) · Uterine Cervical Dysplasia (7) · Lung Neoplasms (6) · Neoplasm Metastasis (6) · Neoplasms (6) · Osteoarthritis, Knee (6) · Stomatitis (6) · Agnosia (4)
Cairo University (10) · Assiut University (8) · Fuda Cancer Hospital, Guangzhou (8) · Boston Scientific Corporation (5) · CSA Medical, Inc. (4) · Combined Military Hospital Abbottabad (4) · Cukurova University (4) · Ain Shams University (3) · Centre Leon Berard (3) · Mayo Clinic (3) · Minia University (3) · National Taiwan University Hospital (3) · The 306 Hospital of People's Liberation Army (3) · Universidade Federal de Sao Carlos (3) · Assistance Publique - Hôpitaux de Paris (2)
United States (71) · Egypt (25) · Turkey (Türkiye) (20) · France (18) · China (16) · Brazil (14) · Pakistan (12) · Canada (10) · Taiwan (9) · India (5) · Spain (5) · Italy (4) · United Kingdom (4) · Netherlands (3) · Singapore (3)
Jibing Chen, Doctor (7) · Shichao Lu, MD (3) · Carlos M Pastre, PhD (2) · Cynthia S Firnhaber, MD (2) · Gary Goldenberg, MD (2) · Jerry Matteo, MD (2) · Maram F Obeid, Professor (2) · Rajeev Muni, FRSCS (2) · Abbas Ardehali, MD (1) · Abdussalam Abdussalam, PhD (1) · Adam Burgoyne, MD, PhD (1) · Adeel Dr Siddiqui, FCPS (1) · AeRang Kim, MD, PhD (1)
PMID 15168956, PMID 11049150, PMID 11238198, PMID 11708692, PMID 11966728, PMID 12533168, PMID 12665987, PMID 12673142, PMID 12776983, PMID 12807939, PMID 1443317, PMID 15897380, PMID 16973081, PMID 18032894, PMID 18067627, PMID 19180223, PMID 19768644, PMID 19892345, PMID 20185615, PMID 20231500, PMID 20438389, PMID 20602109, PMID 20725550, PMID 22261815, PMID 22892729, PMID 22901424, PMID 22972052, PMID 22972114, PMID 23336207, PMID 23390069, PMID 23997389, PMID 24149681, PMID 24440471, PMID 24509965, PMID 24672213, PMID 24819349, PMID 24918567, PMID 24942380, PMID 25257941, PMID 25273231, PMID 25415413, PMID 25516991, PMID 25607709, PMID 25987340, PMID 26051846, PMID 26112148, PMID 26398750, PMID 26708360, PMID 27064168, PMID 27215155
2017 (1), 2018 (1), P30CA015083 (1), P30CA015704 (1), P30CA022453 (1), P30CA033572 (1)