1345 completed, 571 unknown, 326 recruiting, 155 terminated. 1593 Not applicable, 171 Phase 4, 112 Phase 3, 99 Phase 2, 32 Phase 1.
Follow Leg Injuries: new trials by email Literature Review of Leg Injuries trials Research Report on Leg Injuries
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Reducing Disparities in Knee Arthroscopy for Adolescents Educational program and patient navigator - Knee Injury, ACL Injury | Not applicable | Not yet recruiting | Ann & Robert H Lurie Children's Hospital of Chicago | 80 | 2027-10-01 | 2026-06-18 |
| Intraoperative Analysis of Knee Kinematics During ACL Reconstruction - an Exploratory Study Knee Cinematics - ACL - Anterior Cruciate Ligament Rupture | Not applicable | Not yet recruiting | GCS Ramsay Santé pour l'Enseignement et la Recherche | 30 | 2027-07-01 | 2026-06-18 |
| Mortality and Predictors of In-hospital Mortality Among Geriatric Patients With Hip Fracture Hip Fractures, In-hospital Mortality | Not yet recruiting | Assiut University | 141 | 2027-03-01 | 2026-10-14 | |
| Exercise Program for ITB Syndrome Individualized Exercise Program, Standard Physical Therapy - Iliotibial Band Syndrome | Not applicable | Not yet recruiting | NYU Langone Health | 100 | 2027-03-01 | 2026-08-07 |
| Relationship Between Anesthetic Regimen and Bone Cement Implantation Syndrome (BCIS) Administration of general anaesthesia, Neuraxial Analgesia - Bone Cement Implantation Syndrome | Not applicable | Enrolling by invitation | Johns Hopkins University | 24 | 2027-01-10 | 2026-07-21 |
| Suzetrigine (Journavx) as Multimodal Therapy for Pain Management in Adults Undergoing Surgery for Hip Fracture Suzetrigine (Journavx) - Hip Fractures (ICD-10 72.01-72.2), Post Operative Analgesia | Phase 4 | Not yet recruiting | Beth Israel Deaconess Medical Center | 79 | 2027-01-05 | 2026-10-29 |
| Study of the AxisBoard Single-Leg Balance Board in Adults With Lateral Ankle Sprain AxisBoard Single-Leg Balance Board - Ankle Sprains, Lateral Ankle Sprain | Not applicable | Not yet recruiting | DITU Inc. | 80 | 2027-01-04 | 2026-10-06 |
| Accelerated Flap Coverage Versus Standard Timing in the Treatment of Severe Lower Extremity Musculoskeletal Injuries Accelerated Flap Coverage Surgery, Standard of Care Flap Timing - Open Tibia Fracture, Open Dislocation of Ankle | Not applicable | Not yet recruiting | Johns Hopkins University | 356 | 2027-01-01 | 2026-09-18 |
| Low-cost Negative Pressure Wound Therapy vs Standard Dressings for Gustilo IIIb Tibial Fractures (Bukavu Pilot RCT) intervention2: standard wound dressing, Intervention1: Low-cost NPWT - Open Tibia Fracture | Not applicable | Not yet recruiting | Université Catholique de Bukavu | 66 | 2027-01-01 | 2026-08-27 |
| Outpatient Floor Pedal Bike Utilization Floor Pedal Bike with Guided Instructions for Home - Femur Fracture, Tibia Fracture | Not applicable | Not yet recruiting | Wake Forest University Health Sciences | 20 | 2027-01-01 | 2026-10-26 |
| Personalized Weight-Bearing With Smart Crutch Tips After Surgery for Tibial Plateau Fractures Crutch Tip Biofeedback System, Individualized FEA-Guided Postoperative Weight-Bearing, Usual-Care Postoperative Weight-Bearing - Tibial Plateau Fracture | Not applicable | Not yet recruiting | Comeback Mobility Inc | 86 | 2026-11-15 | 2026-10-27 |
| SharkScrew ACL RCT ACL Reconstruction with a Biocomposite Screw, ACL Reconstruction using a PEEK Screw, ACL Reconstruction using an Allograft Screw - ACL - Anterior Cruciate Ligament Rupture | Not applicable | Not yet recruiting | Austrian Workers Compensation Board Styria | 33 | 2026-11-01 | 2026-10-05 |
| Enhancing Wound Perfusion in High-Risk Lower Extremity Orthopaedic Surgery: A Study on Nitropaste Using Intraoperative SPY Imaging. Nitroglycerin Ointment 2% - Achilles Tendon Repairs/Reconstructions, Pilon Fracture of Tibia | Phase 1 | Not yet recruiting | Johns Hopkins University | 15 | 2026-11-01 | 2026-03-31 |
| Effects of PNB Timing on Postoperative Delirium for Hip Fracture Peripheral Nerve Block for Hip Fracture - Delirium - Postoperative | Not yet recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 120 | 2026-11-01 | 2026-10-02 | |
| Extended Post-Operative Oral Tranexamic Acid Dosing After ACL Reconstruction Tranexamic Acid, Placebo - Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture | Phase 3 | Not yet recruiting | Dave Bernholt | 100 | 2026-11-01 | 2026-10-26 |
| Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Postoperative Recovery Quality in Patients Undergoing Anterior Cruciate Ligament Reconstruction Experimental-Active taVNS, Sham transcutaneous auricular vagus nerve stimulation - Anterior Cruciate Ligament Injuries, Recovery Quality | Not applicable | Not yet recruiting | Peking University Third Hospital | 144 | 2026-10-28 | 2026-10-29 |
| Monitored Anesthesia Care and Soft Tissue Infiltration With Local Anesthesia Feasibility Trial Monitored Anesthesia Care (MAC), Soft Tissue Infiltration with Local Anesthetic (STILA), General Anesthesia - Hip Fracture Surgeries, Intertrochanteric Fracture | Not applicable | Recruiting | NYU Langone Health | 140 | 2026-10-27 | 2026-10-29 |
| Trochanteric Bursa Repair and Lateral Hip Pain After Hemiarthroplasty for Femoral Neck Fracture Trochanteric Bursa Repair, Trochanteric Bursa Left Unrepaired - Femoral Neck Fracture | Not applicable | Not yet recruiting | Osman Sarıyar | 102 | 2026-10-12 | 2026-10-16 |
| Description of Return to Sport in Amateur Athletes Who Underwent Several Functional Tests (K-STARTS, Vertical Jumps and Soleus Muscle Strength) After Initial ACL Reconstruction Physical tests - ACL - Anterior Cruciate Ligament Rupture | Not applicable | Not yet recruiting | GCS Ramsay Santé pour l'Enseignement et la Recherche | 230 | 2026-10-01 | 2026-08-20 |
| Efficacy of Oral Nutritional Supplement in Femoral Neck Fracture Patients Undergoing Hip Arthroplasty Oral nutritional supplementation - Femoral Neck Fractures, Geriatric Hip Fracture | Not applicable | Not yet recruiting | Thammasat University | 60 | 2026-10-01 | 2026-08-21 |
Showing 20 of 2760. Sign in to see all of them.
Hip Fractures (814) · Anterior Cruciate Ligament Injuries (618) · Ankle Injuries (328) · Knee Injuries (259) · Femoral Neck Fractures (205) · Femoral Fractures (183) · Ankle Fractures (181) · Tibial Fractures (131) · Pain, Postoperative (94) · Fractures, Bone (89) · Pain (72) · Wounds and Injuries (65) · Foot Injuries (59) · Osteoporosis (54)
Wounds and Injuries (2695) · Fractures, Bone (1401) · Femoral Fractures (976) · Hip Injuries (976) · Knee Injuries (662) · Pathological Conditions, Signs and Symptoms (510) · Musculoskeletal Diseases (348) · Pathologic Processes (335) · Signs and Symptoms (324) · Neurologic Manifestations (307) · Joint Diseases (224) · Nervous System Diseases (186) · Hip Fractures (180) · Ankle Injuries (156)
Bupivacaine (53) · Ropivacaine (41) · Fracture Fixation, Internal (38) · Sodium Chloride (37) · Tranexamic Acid (30) · Physical Therapy Modalities (29) · Standard of Care (29) · Saline Solution (26) · Anterior Cruciate Ligament Reconstruction (25) · Arthroplasty, Replacement, Hip (25) · Control Groups (23) · Exercise (23) · Surgical Procedures, Operative (23) · Blood Flow Restriction Therapy (20) · Anesthesia, Spinal (19)
Peking University Third Hospital (46) · Assiut University (36) · Zimmer Biomet (26) · Riphah International University (24) · Cairo University (21) · AO Clinical Investigation and Publishing Documentation (17) · Hvidovre University Hospital (17) · University of British Columbia (17) · Chang Gung Memorial Hospital (16) · Istituto Ortopedico Rizzoli (16) · Ain Shams University (15) · University of Aarhus (15) · Chinese University of Hong Kong (14) · Mayo Clinic (14) · University of Utah (14)
United States (659) · Turkey (Türkiye) (211) · France (156) · China (149) · Canada (138) · Spain (112) · Denmark (104) · Egypt (101) · United Kingdom (87) · Italy (86) · Norway (77) · Sweden (75) · Germany (68) · Switzerland (68) · Pakistan (61)
Jason M Wilken, PT, PhD (6) · Hassan Achakri (5) · Hongshi Huang, Doctor (5) · Adam Anz, MD (4) · Gregory D Myer, PhD (4) · Konrad Malinowski, MD PhD (4) · Mohit Bhandari, MD (4) · Nicolai B Foss, MD (4) · Paola Vivoda (4) · Rebecca Gibson (4) · Sheila Sprague, PhD (4) · David A Volgas, MD (3) · Emilie Rohmer (3)
PMID 33238043, PMID 36070134, PMID 34766330, PMID 36197809, PMID 19926634, PMID 30063657, PMID 16309613, PMID 34932836, PMID 41114449, PMID 12548273, PMID 12560416, PMID 15902321, PMID 16632842, PMID 16935061, PMID 17413915, PMID 17414553, PMID 18345343, PMID 18762870, PMID 20236640, PMID 21303520, PMID 21401544, PMID 22035956, PMID 22353604, PMID 22610971, PMID 25043629, PMID 25068412, PMID 25265109, PMID 2589650, PMID 26330019, PMID 26920430, PMID 26940645, PMID 27195774, PMID 27496909, PMID 27787895, PMID 29789919, PMID 30053790, PMID 30241509, PMID 32298131, PMID 33289066, PMID 33913035, PMID 34145009, PMID 34988237, PMID 35988569, PMID 37715173, PMID 10037543, PMID 10053175, PMID 10093980, PMID 1015603, PMID 10201543, PMID 10333917
2019 (6), 2017 (5), 2018 (4), 2025 (4), 2016 (3), 2023 (3), 2009 (2), 2015 (2), R01AR053684 (2), R01AR055563 (2), R21AR082643 (2), 1UG3AR085896 (1), 2004 (1), 2008 (1), DP5OD031833 (1)