278 completed, 69 unknown, 38 recruiting, 21 terminated. 277 Not applicable, 25 Phase 2, 19 Phase 4, 11 Phase 3, 10 Phase 1.
Follow Muscle Weakness: new trials by email Literature Review of Muscle Weakness trials Research Report on Muscle Weakness
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Metformin and ACLR Muscle Recovery Metformin, Placebo - Atrophy, Inflammation | Early Phase 1 | Not yet recruiting | University of Utah | 40 | 2026-11-01 | 2026-07-13 |
| Low-Volume Pericapsular Nerve Group (PENG) Block With Dexamethasone vs Standard-Volume PENG Block After Total Hip Arthroplasty Pericapsular nerve group (PENG) block, Bupivacaine, Dexamethasone - Pain, Postoperative, Muscle Weakness | Phase 4 | Recruiting | Ain Shams University | 60 | 2026-10-15 | 2026-10-16 |
| Muscle Aging Phenotypes in Childhood Cancer Survivors Multimodal Muscle Imaging and Functional Assessment, Multimodal Muscle Imaging and Neuromuscular Assessment, Comprehensive Muscle Phenotyping - Muscle Weakness, Low Muscle Mass | Recruiting | St. Jude Children's Research Hospital | 533 | 2026-09-14 | 2026-09-16 | |
| Clinical Investigation to Validate the Safety and Performance of the ABLE Kids Device in Pediatric Patients With Neurological Gait Disorders in a Clinical Setting ABLE Kids - Gait Impairment, Cerebral Palsy (CP) | Not applicable | Recruiting | ABLE Human Motion S.L. | 15 | 2026-09-01 | 2026-09-08 |
| STRIDE: Strength of The Calf Muscles and Their Role In Declining Effectiveness of Movement With Aging No intervention (observational study) - Sarcopenia, Aging | Not yet recruiting | University of Leicester | 200 | 2026-08-01 | 2026-07-24 | |
| Eccentric vs Low-Load Blood Flow Restriction Training in Knee Osteoarthritis in Knee Osteoarthritis Eccentric Gastrocnemius Strengthening Exercises, Low-Load Blood Flow Restriction Training - Knee Arthritis, Osteoarthritis | Not applicable | Recruiting | Riphah International University | 48 | 2026-07-21 | 2026-08-07 |
| Toward Ubiquitous Lower Limb Exoskeleton Use in Children and Young Adults Extension assist knee ankle foot orthosis (EA-KAFO) - Muscle Weakness, Problems Moving Their Arms and Legs | Recruiting | National Institutes of Health Clinical Center (CC) | 23 | 2026-06-23 | 2026-07-23 | |
| Comparative Effects of Different Inspiratory Muscle Training Modalities in Patients With Heart Failure. Mechanical Pressure-Threshold IMT Device, PowerBreathe KH2 Electronic IMT Device, Sub-therapeutic Mechanical IMT Device (Sham) - Heart Failure, Heart Failure and Reduced Ejection Fraction | Not applicable | Enrolling by invitation | Universidad Nacional Andres Bello | 60 | 2026-06-17 | 2026-07-07 |
| CALM-AF-AI: Counteracting Age-related Loss of Muscle With AAV-Follistatin Combined With Angiogenesis-Inducing VEGF Plasmid Gene Therapy AAV9-Follistatin gene therapy, VEGF Plasmid - Age-related Muscle Decline | Phase 1 / Phase 2 | Recruiting | Unlimited Biotechnology LLC | 12 | 2026-06-01 | 2026-07-13 |
| Mitigating Neural Hypoexcitability and Weakness During Disuse in Women Wrist immobilization, Resistance training, Resistance training rehabilitation - Muscle Weakness | Not applicable | Recruiting | Kansas State University | 20 | 2026-05-01 | 2026-06-10 |
| Perianchor Cyst Formation, Tendon Healing, and Clinical Outcomes Following Arthroscopic Rotator Cuff Repair MRI - Rotator Cuff Tears, Tendon Thickening | Active not recruiting | Fatih Sultan Mehmet Training and Research Hospital | 70 | 2026-05-01 | 2026-09-09 | |
| Reduction of Muscle Catabolism Through Brain Activation in Burn Patients Burn-Bundle Extended Rehabilitation Program, Isoflurane Inhalational Sedation, Functional Proprioceptive Stimulation - Burns - Multiple, Critical Illness | Not applicable | Not yet recruiting | Charles University, Czech Republic | 30 | 2026-05-01 | 2026-02-27 |
| Comparison of Frailty, Physical Fitness Parameters, and Irisin Levels Between Patients With Multiple Sclerosis and Healthy Volunteers MULTIPL SCLEROSİS | Not yet recruiting | Baskent University | 782 | 2026-04-01 | 2026-04-13 | |
| Comparative Effects of Kendall and Feldenkrais Exercise in Upper Crossed Syndrome Kendall Exercise Method (KM), Feldenkrais Exercise Method (FM) - Upper Crossed Syndrome | Not applicable | Recruiting | Riphah International University | 72 | 2026-01-15 | 2026-05-11 |
| Effects of Early Rehabilitation Using Blood Flow Restriction and/or Surface Electromyography Biofeedback on Quadriceps Activation and Strength After Anterior Cruciate Ligament Reconstruction: A Multicenter Randomized Controlled Trial Standard Rehabilitation, Blood Flow Restriction (BFR) Training, sEMG Biofeedback - Anterior Cruciate Ligament Injuries, Knee Injuries | Not applicable | Not yet recruiting | Haute Ecole ARC Sante | 200 | 2026-01-02 | 2025-08-28 |
| Otago Exercise Program in Chemotherapy Induced Peripheral Neuropathy Otago Exercise Program, Resistance Exercise - Chemotherapy-induced Peripheral Neuropathy (CIPN) | Not applicable | Completed | Cairo University | 48 | 2026-01-01 | 2026-08-19 |
| Effects of Exercises and Electrical Current Application Aiming to Strengthen Neck and Shoulder Blades Muscles on Symptoms of a Pinched Nerve in the Neck Exercise Therapy, Superimposition of electrical muscle stimulation on active movement - Cervical Radiculopathy, Cervical Radicular Pain | Not applicable | Completed | European University of Lefke | 50 | 2025-12-01 | 2026-03-24 |
| A Biomechanical Study of Collaborative FES on Lower Limb Motor Function in the Elderly Collaborative Functional Electrical Stimulation, Traditional functional electrical stimulation - Muscle Fatigue (C23.888.592.612.612), Muscle Weakness or Atrophy | Not applicable | Not yet recruiting | Chen Xuan | 30 | 2025-11-30 | 2025-11-24 |
| Reliability of Muscle Strength and Activation Assessment Tools and Effects of an Online Therapeutic Exercise Program in Patients With Chronic Kidney Disease Reliability Assessment, Online Therapeutic Exercise - Chronic Kidney Disease, Renal Insufficiency, Chronic | Not applicable | Active not recruiting | University of Extremadura | 50 | 2025-11-07 | 2025-12-18 |
| Early Assessment of Quadriceps Muscle Recovery by Dynamometry and 3D Ultrasound in Intensive Care Patients Under Invasive Mechanical Ventilation Early assessment of quadriceps muscle strength - Intensive Care Unit Acquired Weakness, Muscle Weakness | Recruiting | Nantes University Hospital | 100 | 2025-10-03 | 2026-09-01 |
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Muscular Atrophy (38) · Critical Illness (34) · Sarcopenia (31) · Motor Activity (26) · Fatigue (18) · Frailty (18) · Muscular Diseases (14) · Stroke (14) · Pain (13) · COVID-19 (12) · Pulmonary Disease, Chronic Obstructive (11) · Respiratory Insufficiency (11) · Anterior Cruciate Ligament Injuries (10) · Myalgia (9)
Pathological Conditions, Signs and Symptoms (443) · Pathologic Processes (442) · Neurologic Manifestations (441) · Signs and Symptoms (441) · Nervous System Diseases (440) · Neuromuscular Manifestations (440) · Musculoskeletal Diseases (439) · Muscular Diseases (429) · Pathological Conditions, Anatomical (71) · Atrophy (63) · Disease Attributes (57) · Neuromuscular Diseases (52) · Respiratory Tract Diseases (49) · Behavior (45) · Wounds and Injuries (36)
Resistance Training (17) · Exercise (15) · Blood Flow Restriction Therapy (7) · Physical Therapy Modalities (7) · Therapeutics (5) · Ultrasonography (5) · Vitamin D (5) · Absorptiometry, Photon (4) · Creatine (4) · Exercise Therapy (4) · Plyometric Exercise (4) · Deoxycytidine (3) · Early Ambulation (3) · Exercise Movement Techniques (3) · Respiratory Function Tests (3)
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PMID 12472328, PMID 19446324, PMID 20046132, PMID 20406506, PMID 28159728, PMID 36905161, PMID 1002644, PMID 10212115, PMID 10793162, PMID 10923010, PMID 11412159, PMID 11447547, PMID 11509512, PMID 11537577, PMID 11680441, PMID 12091180, PMID 12589633, PMID 12598483, PMID 12714344, PMID 1361207, PMID 1402772, PMID 1572864, PMID 16132895, PMID 16260965, PMID 16492857, PMID 16778570, PMID 17130281, PMID 17186299, PMID 18283429, PMID 18511703, PMID 18596631, PMID 18804003, PMID 18840842, PMID 1920064, PMID 19523207, PMID 19623052, PMID 19884353, PMID 20046133, PMID 20152747, PMID 20236839, PMID 20426834, PMID 21161177, PMID 21333948, PMID 21385346, PMID 21401544, PMID 21470008, PMID 21502865, PMID 21543538, PMID 22008401, PMID 22147819
2018 (3), 2023 (2), U54NS115054 (2), 2008 (1), 2017 (1), 2019 (1), I01RX000528 (1), K23AR055664 (1), K23AR079583 (1), K76AG054864 (1), P20GM113109 (1), P30AG028740 (1), P30CA016056 (1), P50CA090440 (1), R01AG018169 (1)