109 completed, 38 unknown, 12 terminated, 8 withdrawn. 71 Phase 4, 52 Not applicable, 28 Phase 3, 24 Phase 2, 4 Phase 1.
Follow Levobupivacaine: new trials by email Literature Review of Levobupivacaine trials Research Report on Levobupivacaine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pain After Scheduled Cesarean Delivery: Spinal Morphine With or Without Levobupivacaine Wound Infiltration Levobupivacaine, Intrathecal Morphine - Pain Management, C Section | Not yet recruiting | Fundación Santa Fe de Bogota | 336 | 2026-10-14 | 2026-10-06 | |
| Plasma Kinetics of Levobupivacaine After Transversus Abdominis Plane (TAP) Block in Abdominal Surgery Ultrasound-Guided Transversus Abdominis Plane Block with Levobupivacaine - Abdominal Surgery Patients, Transversus Abdominis Plane (TAP) Block | Not yet recruiting | University of Liege | 26 | 2026-07-01 | 2026-05-12 | |
| Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy Levobupivacaine, Dexamethasone contained in the solution for thoracic paravertebral block, Adrenaline - Obese Patients, Bariatric Surgical Pain | Not applicable | Not yet recruiting | IVO JURISIC | 36 | 2025-07-30 | 2025-07-24 |
| Evaluation of Three Different Antalgic Blocks in Total Knee Prosthesis Levobupivacaine - Analgesia | Not applicable | Completed | I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio | 141 | 2025-02-06 | 2026-09-14 |
| Efficacy and Safety of Adding Dexmedetomidine to Levobupivacaine in Rectus Sheath Block Compared to Quadratus Lumborum Block in Patients Undergoing Lower Abdominal Cancer Surgery: A Randomized Clinical Trial Levobupivacaine, Levobupivacaine + Dexmedetomidine - Abdominal Cancer Surgery | Phase 4 | Not yet recruiting | Assiut University | 122 | 2024-12-01 | 2024-11-19 |
| Effect of a Transversus Abdominis Plane Block on Wound Healing, Stress, and Immune Response After a Cesarean Delivery Postoperative pain management with acetaminophen, Bilateral TAP Block with levobupivacaine, Bilateral TAP Block with levobupivacaine and dexmedetomidine - Postoperative Pain, Cesarean Section | Not applicable | Completed | University Hospital Sestre Milosrdnice | 105 | 2024-09-03 | 2025-11-17 |
| Interpectoral-pectoserratus Plane Block for Minimally Invasive Aortic Valve Replacement Via Right Anterior Minithoracotomy Levobupivacaine Hydrochloride 0.25 % Injectable Solution, Sodium chloride 0.9% - Analgesic Effect | Phase 4 | Recruiting | Algemeen Ziekenhuis Maria Middelares | 144 | 2024-09-01 | 2024-09-19 |
| Spinal Nalbuphine for Analgesia in Total Hip Arthroplasty Levobupivacaine, Levobupivacaine plus nalbuphine - Total Hip Arthroplasty, Analgesia | Phase 2 | Completed | Asklepieion Voulas General Hospital | 60 | 2024-08-29 | 2026-05-12 |
| Dexmeditomedine as an Adjuvant to Levobupivacaine in Transversus Thoracis Plane Block on the Management of Post-sternotomy Pain in Open-heart Surgeries transversus thoracis plane block, Dexmedetomidine, Levobupivacaine - Pain, Postoperative | Not applicable | Unknown | Assiut University | 60 | 2024-06-15 | 2024-05-30 |
| Subpectoral Plexus Block With Multi-level TPVB for Surgical Anesthesia During Primary Breast Cancer Surgery Subpectoral plexus block (low dose), Subpectoral plexus block (High dose) - Breast Cancer | Not applicable | Recruiting | Chinese University of Hong Kong | 100 | 2024-03-15 | 2025-04-11 |
| Programmed Intermittent Epidural Bolus (PIEB) Techniques for Labour Analgesia Levobupivacaine and Fentanyl - Labor Pain, Obstetric Pain | Phase 4 | Completed | Hamad Medical Corporation | 136 | 2024-02-21 | 2024-11-01 |
| The Role of Peripheral Afferents in Modulating Post-stroke Central Pain Lidocaine 20mg/ml, Levobupivacaine Hydrochloride 1.25 MG/ML, Sodium Chloride 0.9% Inj - Stroke | Phase 3 | Completed | Institut National de la Santé Et de la Recherche Médicale, France | 33 | 2024-02-09 | 2026-10-19 |
| Echo-guided Transverse Abdominal Plane Block (TAP) in Anterior Lumbar Arthrodesis (ALIF) Levobupivacaine, Placebo Tap block - Fusion of Spine, Lumbar Region | Not applicable | Completed | Clinique Saint Jean, France | 80 | 2024-02-05 | 2026-07-10 |
| Rotator Cuff Repair Under Isolated Loco-regional Anesthesia Arthroscopic rotator cuff repair, naropeine or chirocaine (Arthroscopic rotator cuff repair under LRA associated to GA), naropeine or chirocaine (Arthroscopic rotator cuff repair under LRA) - Shoulder Cuff Surgical Repair | Not applicable | Unknown | Elsan | 80 | 2023-11-13 | 2024-06-13 |
| Prospective RCT Lidocaine & Levobupivacaine on Block Dynamics After Subparaneural Popliteal Sciatic Nerve Block 0.5% Levobupivacaine, 2% Xylocaine with adrenaline 1:200,000 - Musculoskeletal Diseases or Conditions | Phase 4 | Recruiting | Chinese University of Hong Kong | 40 | 2023-09-20 | 2025-04-13 |
| Adding Ketamine to Levobupivacaine in Paravertebral Block in Thoracotomy Ketamine + Levobupivacaine, Levobupivacaine - Ketamine, Levobupivacaine | Phase 4 | Completed | Tanta University | 60 | 2023-08-30 | 2024-02-13 |
| Evaluate Efficacy Levobupivacaine 0.125% Versuss Ropivacaine 0.2% in Hemodynamic Alterations in Labor and Fetal Repercussions Levobupivacaine, Ropivacaine - Hemodynamic Instability, Epidural | Phase 4 | Unknown | Althaia Xarxa Assistencial Universitària de Manresa | 40 | 2023-06-01 | 2023-05-26 |
| Minimum Effective Local Anesthetic Volume for Ultrasound Guided Superior Trunk Block 0.5% levobupivacaine - Musculoskeletal Diseases or Conditions | Not applicable | Unknown | Chinese University of Hong Kong | 25 | 2023-01-19 | 2025-04-13 |
| Comparison of Zero- and Two-centimeter Distance From Sapheno-femoral Junction in Laser Ablation of Varicose Vein Saphenous Ablation, Endogenous Laser Ablation (EVLA), mixture of 20 mL 2% lidocaine, 1: 200,000 adrenaline and 20 mL 0.5% levobupivacaine in 1 L of 0.9% saline - Varicose Veins, Venous Reflux | Not applicable | Unknown | Mansoura University | 800 | 2023-01-04 | 2023-01-31 |
| Selective Trunk Block vs Hybrid Interscalene Supraclavicular BPB for Anaesthesia of the Entire Upper Extremity Selective Trunk Block, Interscalene-Supraclavicular Brachial Plexus Block (IS-SC BPB) - Musculoskeletal Diseases or Conditions | Not applicable | Withdrawn | Chinese University of Hong Kong | 2022-12-01 | 2023-04-20 |
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Pain, Postoperative (39) · Agnosia (18) · Pain (18) · Breast Neoplasms (7) · Hip Fractures (5) · Musculoskeletal Diseases (5) · Hypotension (4) · Labor Pain (4) · Hernia, Inguinal (3) · Postoperative Nausea and Vomiting (3) · Acute Pain (2) · Bites and Stings (2) · Bradycardia (2) · Cholecystolithiasis (2) · Cleft Palate (2)
Assiut University (13) · Chinese University of Hong Kong (6) · Mahidol University (4) · Pontificia Universidad Catolica de Chile (4) · University Hospital, Antwerp (4) · Algemeen Ziekenhuis Maria Middelares (3) · Brugmann University Hospital (3) · Cork University Hospital (3) · Mansoura University (3) · San Salvatore Hospital of L'Aquila (3) · TC Erciyes University (3) · University Hospital Dubrava (3) · University of Patras (3) · Ain Shams University (2) · Ankara University (2)
Egypt (28) · France (14) · Turkey (Türkiye) (14) · Belgium (13) · Spain (11) · Croatia (9) · Italy (8) · Greece (6) · Hong Kong (6) · Ireland (6) · United Kingdom (6) · Thailand (5) · Chile (4) · Netherlands (4) · South Korea (3)
Manoj K Karmakar, MD (5) · Fernando R Altermatt, MD (2) · Maria Teresa Fernandez (2) · Pierfrancesco Fusco, MD (2) · Resul Altuntas, MD (2) · Salwa MS Hayes, MD (2) · Abeer Salem, MD (1) · Alaa Wageeh, Dr (1) · Alessandro De Cassai, MD (1) · Andrea Araneda, MD (1)
PMID 33238043, PMID 23389068, PMID 10070549, PMID 1015603, PMID 10776835, PMID 1130742, PMID 11331167, PMID 11331334, PMID 11374619, PMID 11472277, PMID 12098173, PMID 12411815, PMID 12548273, PMID 12560416, PMID 12640407, PMID 14622770, PMID 15448529, PMID 15488058, PMID 15534532, PMID 15992136, PMID 16152868, PMID 16288617, PMID 16651569, PMID 17138203, PMID 1718720, PMID 17413915, PMID 17464603, PMID 17464604, PMID 17464605, PMID 17823012, PMID 18310746, PMID 18686750, PMID 18762870, PMID 18853583, PMID 19157368, PMID 19174373, PMID 19214642, PMID 19253247, PMID 19299145, PMID 19404806, PMID 19690943, PMID 19781964, PMID 19908166, PMID 20299988, PMID 20712261, PMID 2102683, PMID 21412996, PMID 21484501, PMID 21486711, PMID 21804697
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