Fractures, Bone: Clinical Trials

1712 completed, 705 unknown, 352 recruiting, 222 terminated. 1783 Not applicable, 264 Phase 4, 163 Phase 2, 151 Phase 3, 63 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	1783	Completed 833, Unknown 391, Recruiting 197, Terminated 110, Not yet recruiting 94, Active not recruiting 79, Withdrawn 52, Enrolling by invitation 17, Suspended 10
Phase 4	264	Completed 130, Unknown 48, Terminated 32, Recruiting 20, Withdrawn 14, Not yet recruiting 10, Active not recruiting 7, Enrolling by invitation 3
Phase 2	163	Completed 87, Unknown 29, Terminated 17, Recruiting 12, Withdrawn 9, Not yet recruiting 5, Active not recruiting 2, Suspended 2
Phase 3	151	Completed 85, Unknown 22, Terminated 17, Recruiting 14, Withdrawn 6, Not yet recruiting 3, Active not recruiting 2, Enrolling by invitation 1, Suspended 1
Phase 1	63	Completed 25, Unknown 16, Recruiting 8, Terminated 7, Active not recruiting 3, Withdrawn 3, Not yet recruiting 1
Early Phase 1	26	Completed 12, Unknown 5, Active not recruiting 4, Withdrawn 3, Recruiting 1, Terminated 1

Follow Fractures, Bone: new trials by email Literature Review of Fractures, Bone trials Research Report on Fractures, Bone

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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Study on Outcomes of Proximal Humerus Fractures open reduction internal fixation, intramedullary nail, reverse total shoulder arthroplasty - Proximal Humerus Fracture	Not applicable	Not yet recruiting	University of Massachusetts, Worcester	100	2027-09-01	2026-10-19
Real-time Ultrasound Guidance for Thoracic Epidural Blocks Real-time ultrasound guidance for thoracic epidural catheter placement. - Analgesia, Thoracic Tumors		Withdrawn	University of Chile		2027-07-01	2026-05-19
Evaluation of Serratus Plane Block on the Respiratory Pattern in Patients With Multiple Rib Fractures Serratus plane block (continuous or single-shot) - Rib Fractures, Spirometry	Not applicable	Not yet recruiting	Niguarda Hospital	72	2027-06-01	2026-11-12
Biodegradable Magnesium Screws for Unstable Ankle Fracture Surgery RemeOs Magnesium-Based Biodegradable Screw - Ankle Fractures, Syndesmotic Injury	Not applicable	Not yet recruiting	Massachusetts General Hospital	28	2027-04-01	2026-11-06
Mortality and Predictors of In-hospital Mortality Among Geriatric Patients With Hip Fracture Hip Fractures, In-hospital Mortality		Not yet recruiting	Assiut University	141	2027-03-01	2026-10-14
Relationship Between Anesthetic Regimen and Bone Cement Implantation Syndrome (BCIS) Administration of general anaesthesia, Neuraxial Analgesia - Bone Cement Implantation Syndrome	Not applicable	Enrolling by invitation	Johns Hopkins University	24	2027-01-10	2026-07-21
Suzetrigine (Journavx) as Multimodal Therapy for Pain Management in Adults Undergoing Surgery for Hip Fracture Suzetrigine (Journavx) - Hip Fractures (ICD-10 72.01-72.2), Post Operative Analgesia	Phase 4	Not yet recruiting	Beth Israel Deaconess Medical Center	79	2027-01-05	2026-10-29
Allograft vs. Autograft Nonunion Autograft, Allograft - Nonunion Fracture	Not applicable	Not yet recruiting	Wake Forest University Health Sciences	156	2027-01-01	2026-10-26
Outpatient Floor Pedal Bike Utilization Floor Pedal Bike with Guided Instructions for Home - Femur Fracture, Tibia Fracture	Not applicable	Not yet recruiting	Wake Forest University Health Sciences	20	2027-01-01	2026-10-26
Use of a Vibration Tool for Postoperative Pain Control in Distal Radius Fractures Vibration tool - Distal Radius Fracture, Radius Fracture Distal	Not applicable	Not yet recruiting	Northwestern University	100	2027-01-01	2026-07-10
Accelerated Flap Coverage Versus Standard Timing in the Treatment of Severe Lower Extremity Musculoskeletal Injuries Accelerated Flap Coverage Surgery, Standard of Care Flap Timing - Open Tibia Fracture, Open Dislocation of Ankle	Not applicable	Not yet recruiting	Johns Hopkins University	356	2027-01-01	2026-09-18
Sacroplasty for Sacral Insufficiency Fractures. Percutaneous Sacroplasty, Standard conservative management - Sacral Fracture, Osteoporotic Fracture	Not applicable	Not yet recruiting	Hull University Teaching Hospitals NHS Trust	110	2027-01-01	2026-09-10
Low-cost Negative Pressure Wound Therapy vs Standard Dressings for Gustilo IIIb Tibial Fractures (Bukavu Pilot RCT) intervention2: standard wound dressing, Intervention1: Low-cost NPWT - Open Tibia Fracture	Not applicable	Not yet recruiting	Université Catholique de Bukavu	66	2027-01-01	2026-08-27
Local Iloprost Therapy to Promote Bone Healing in High Risk Fractures Ilomedin, Normal saline placebo - Nonunion Bone Fracture, Fractures Ununited	Phase 2	Not yet recruiting	Charite University, Berlin, Germany	60	2027-01-01	2026-11-09
Local Antibiotic Delivery From an Intramedullary Nail After Surgical Treatment of Tibial Fractures at High Risk of Infection Reselution V Tibial Intramedullary Fixation System, Reselution VT Tibial Intramedullary Fixation System - Tibial Fractures, Fractures, Open	Not applicable	Not yet recruiting	Reselute, Inc.	317	2027-01-01	2026-11-10
Repair of Extra-articular Fractures of the Metacarpals and First Phalanges of the Long Fingers Percutaneous pinning, Locked plate, Intramedullary screw - Hand Fractures	Not applicable	Not yet recruiting	University Hospital, Montpellier	111	2026-12-15	2026-10-26
Functional Outcomes in Older Adults With Fragility Fractures of the Pelvis: The FFP-France Study Observational Assessment of Fragility Fractures of the Pelvis - Fragility Fractures of the Pelvis (FFP), Osteoporotic Fractures		Not yet recruiting	Centre Hospitalier Universitaire de Nice	200	2026-12-01	2026-10-13
Comparison of GMI, PNF, and Standard Care for Post-Traumatic Elbow Stiffness Rehabilitation in Adults Standard Multidisciplinary Rehabilitation, Graded Motor Imagery (GMI), Proprioceptive Neuromuscular Facilitation (PNF) - Hold-Relax - Elbow Stiffess, Rehabilitation Treatment	Not applicable	Not yet recruiting	Centre Hospitalier de Valenciennes	75	2026-12-01	2026-10-30
Post-osteoporotic Fracture Exercise Program Exercise Program - Osteoporosis, Osteoporotic Fracture	Not applicable	Recruiting	Western University, Canada	100	2026-12-01	2026-11-10
Magnesium-Enhanced ESPB for Respiratory Recovery and Analgesia in Unilateral Rib Fractures Bupivacaine 0.25%, Magnesium sulfate 500 mg - Unilateral Rib Fracture, ESPB	Not applicable	Not yet recruiting	Assiut University	36	2026-11-30	2026-11-10

Showing 20 of 3468. Sign in to see all of them.

Narrower conditions

Hip Fractures (817)  ·  Wrist Fractures (321)  ·  Osteoporosis (248)  ·  Femoral Neck Fractures (207)  ·  Fractures, Stress (194)  ·  Ankle Fractures (183)  ·  Femoral Fractures (183)  ·  Spinal Fractures (143)  ·  Tibial Fractures (132)  ·  Rib Fractures (110)  ·  Shoulder Fractures (110)  ·  Wounds and Injuries (102)  ·  Pain, Postoperative (100)  ·  Pain (95)

Broader conditions

Wounds and Injuries (3366)  ·  Leg Injuries (1490)  ·  Hip Injuries (982)  ·  Femoral Fractures (980)  ·  Pathological Conditions, Signs and Symptoms (695)  ·  Musculoskeletal Diseases (591)  ·  Arm Injuries (503)  ·  Signs and Symptoms (434)  ·  Pathologic Processes (413)  ·  Nervous System Diseases (398)  ·  Neurologic Manifestations (396)  ·  Bone Diseases (390)  ·  Nutritional and Metabolic Diseases (325)  ·  Wrist Injuries (311)

Interventions

Fracture Fixation, Internal (81)  ·  Bupivacaine (55)  ·  Open Fracture Reduction (45)  ·  Surgical Procedures, Operative (45)  ·  Ropivacaine (42)  ·  Sodium Chloride (42)  ·  Tranexamic Acid (34)  ·  Standard of Care (31)  ·  Saline Solution (30)  ·  Arthroplasty, Replacement, Hip (26)  ·  Control Groups (26)  ·  Acetaminophen (24)  ·  Exercise (24)  ·  Dexmedetomidine (23)  ·  Morphine (23)

Sponsors

Assiut University (58)  ·  Zimmer Biomet (56)  ·  Cairo University (37)  ·  AO Clinical Investigation and Publishing Documentation (29)  ·  University of Aarhus (24)  ·  National Taiwan University Hospital (23)  ·  Ain Shams University (22)  ·  Assistance Publique - Hôpitaux de Paris (22)  ·  University of British Columbia (22)  ·  Oslo University Hospital (20)  ·  McMaster University (19)  ·  Sahlgrenska University Hospital (19)  ·  London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (17)  ·  Peking University Third Hospital (17)  ·  Sohag University (17)

Countries

United States (782)  ·  Canada (233)  ·  Turkey (Türkiye) (196)  ·  France (195)  ·  Egypt (170)  ·  China (168)  ·  United Kingdom (144)  ·  Germany (143)  ·  Spain (143)  ·  Denmark (138)  ·  Sweden (119)  ·  Switzerland (114)  ·  Italy (105)  ·  Norway (101)  ·  Netherlands (83)

Top investigators

Hassan Achakri (9)  ·  Sheila Sprague, PhD (9)  ·  Rebecca Gibson (8)  ·  Emilie Rohmer (5)  ·  Gerard Slobogean, MD (5)  ·  Mohit Bhandari, MD (5)  ·  Paola Vivoda (5)  ·  Brett D Crist, MD (4)  ·  Ding-Cheng Chan (4)  ·  Ding-Cheng Chan, MD, PhD (4)  ·  Erin Osborn (4)  ·  Hillary Overholser (4)

Results publications

PMID 35727196, PMID 33238043, PMID 36070134, PMID 34766330, PMID 36197809, PMID 19926634, PMID 30063657, PMID 34932836, PMID 41114449, PMID 12548273, PMID 12560416, PMID 12795371, PMID 16394745, PMID 16632842, PMID 17413915, PMID 18762870, PMID 19594305, PMID 20236640, PMID 20701962, PMID 21062463, PMID 21401544, PMID 21464735, PMID 22035956, PMID 22353604, PMID 22975218, PMID 23803880, PMID 23975226, PMID 24048551, PMID 25030780, PMID 25068412, PMID 25265109, PMID 25349008, PMID 25527752, PMID 2589650, PMID 26069709, PMID 26093811, PMID 26330019, PMID 26335402, PMID 26869384, PMID 26940645, PMID 27072861, PMID 27195774, PMID 27385761, PMID 27557655, PMID 27680993, PMID 27702779, PMID 27787895, PMID 28972994, PMID 29256945, PMID 29605469

NIH funding

2017 (9), 2019 (9), 2018 (6), 2023 (5), 2025 (5), 2009 (4), 2015 (3), 2016 (3), U01AR079113 (2), 1UG3AR085896 (1), K23HL148310 (1), K25AG058804 (1), K76AG057020 (1), M01RR000036 (1), N01CM00039 (1)