54 completed, 21 unknown, 10 recruiting, 8 not yet recruiting. 65 Not applicable, 9 Phase 4, 6 Phase 3, 4 Phase 2, 2 Phase 1.
Follow Hypospadias: new trials by email Literature Review of Hypospadias trials Research Report on Hypospadias
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Emerging Indications for Hyperbaric Oxygen Treatment Hyperbaric oxygen treatment (HBOT), 100% Oxygen - Post-COVID-19 Condition, Ulcerative Colitis | Phase 4 | Not yet recruiting | Jay C. Buckey Jr. | 100 | 2026-11-01 | 2026-09-09 |
| Efficacy of PRF in Hypospadias Repair Tubularized Incised Plate urethroplasty with intraoperative placement of autologous PRF onto the urethral plate., standard Tubularized Incised Plate urethroplasty - Hypospadias | Not applicable | Not yet recruiting | Ain Shams University | 80 | 2026-08-01 | 2026-08-11 |
| Urethral Plate Flap vs. Tunica Vaginalis Flap for Residual Severe Ventral Curvature in Hypospadias Urethral Plate Flap Corporoplasty, Tunica Vaginalis Flap Corporoplasty - Residual Severe Ventral Curvature, Transection of the Urethral Plate | Not applicable | Not yet recruiting | The Children's Hospital of Zhejiang University School of Medicine | 90 | 2026-02-23 | 2026-02-11 |
| Comparison of Sacral ESP Block and Dorsal Penile Nerve Block in Pediatric Hypospadias Surgery Sacral ESP Block Group, Dorsal Penile Nerve Block Group - Postoperative Pain, Hypospadias | Not applicable | Completed | Medipol University | 70 | 2026-02-20 | 2026-08-24 |
| Fibrin-Enhanced TIP Versus Grafted TIP Urethroplasty in Distal Hypospadias Fibrin-Enhanced TIP Urethroplasty, Grafted TIP Urethroplasty - Distal Hypospadias, Hypospadias | Not applicable | Recruiting | National Children's Medical Center, Uzbekistan | 100 | 2026-01-05 | 2026-01-30 |
| Comparison of Sacral ESP Block and Caudal Block in Pediatric Hypospadias Surgery Sacral ESP Block, Caudal Epidural Block - Hypospadias, Postoperative Pain | Not applicable | Recruiting | TC Erciyes University | 60 | 2026-01-05 | 2026-06-25 |
| Virtual Reality Intervention in Children After Hypospadias Surgery Virtual reality headset, routine clinical practice - Pain, Comfort | Not applicable | Completed | Istanbul Medipol University Hospital | 62 | 2025-12-05 | 2026-08-07 |
| Effect of Caudal Block on Urethrocutaneous Fistula After Distal Hypospadias Repair Caudal Block, General Anesthesia without Caudal Block - Hypospadias, Caudal Block | Not applicable | Recruiting | Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital | 80 | 2025-12-01 | 2026-06-30 |
| Breaking Silence Through Story: A Narrative Medicine Intervention for Parents of Children With Urogenital Conditions Narrative Medicine Journaling Intervention - DSD, Hypospadias | Not applicable | Recruiting | Sarah Schlegel | 20 | 2025-10-10 | 2026-05-18 |
| Comparison of Caudal Block and Sacral Erector Spinae Plane Block With Dexmedetomidine in Pediatric Penile Hypospadias Repair Sacral ESP Block, Caudal epidural block - Hypospadias | Phase 3 | Not yet recruiting | Assiut University | 66 | 2025-10-01 | 2025-09-29 |
| Worldwide Yearly Screening for Hypospadias WYSH Web Application - Hypospadias | Not applicable | Recruiting | University of Wisconsin, Madison | 20 | 2025-07-23 | 2026-10-01 |
| A Multicenter Randomized Controlled Trial Comparing Platelet-Rich Fibrin and Ventral Dartos Flap as Intermediate Layers in Tabularized Incised Plate (TIP) Urethroplasty for Distal Hypospadias With Mild Penile Curvature - Group A: Platelet-rich fibrin membrane prepared intraoperatively and applied over neourethra, Group B: Ventral dartos flap rotated over neourethra - PRF, Hypospadias | Not applicable | Enrolling by invitation | National Children's Medical Center, Uzbekistan | 5 | 2025-06-05 | 2025-07-01 |
| PREDICT-H Study: Prospective Research on Essential Determinants Influencing Complication Trends in Hypospadias - a Landmark Prospective Multicenter Cohort Study Aimed at Improving Outcome Prediction in Hypospadias Surgery Hypospadias | Recruiting | Sidra Medicine | 1300 | 2025-06-04 | 2025-06-12 | |
| Randomized Trial Of Urethroplasty With Stent Versus Without Stent For Hypospadias Stent urethroplasty, Stentless urethroplasty - Hypospadias | Not applicable | Completed | Children's Hospital and Institute of Child Health, Multan | 110 | 2025-05-25 | 2025-11-21 |
| Improving Parental Support in Hypospadias Care Educational Website Developed by Study Team, Basic Educational Website - Hypospadias | Not applicable | Recruiting | University of North Carolina, Chapel Hill | 324 | 2025-05-07 | 2026-06-30 |
| Ultrasound-Guided Pudendal vs Dorsal Penile Nerve Block for Pediatric Hypospadias Surgery Ultrasound-Guided Pudendal Nerve Block, Ultrasound-Guided Dorsal Penile Nerve Block - Hypospadias, Pudendal Nerve Block | Not applicable | Completed | Bangladesh Medical University | 60 | 2025-05-01 | 2026-05-12 |
| Postoperative Pain Relief in Children: Comparing Caudal Bupivacaine Alone Versus Bupivacaine With Dexmedetomidine for Infra-Umbilical Surgeries Under General Anesthesia Bupivacaine %0.25 (isobaric), Dexmedetomidine & Bupivacaine. - Hernia Repair, Orchiopexy | Phase 4 | Completed | Allama Iqbal Teaching Hospital | 60 | 2025-04-27 | 2025-08-13 |
| Evaluation of the Method and Duration of Urinary Diversion in the Management of Distal Penile Hypospadias Following Surgical Repair. Application of urethral catheter alone for 1 week., Application of urethral catheter alone for 2 weeks., Application of urethral stent and suprapubic catheter for 1 week - Hypospadias, Urinary Diversion | Not applicable | Completed | Ain Shams University | 86 | 2025-04-10 | 2026-02-19 |
| Ultrasound Guided Sacral Erector Spinae Plane Block Versus Ultrasound Guided Caudal Block in Pediatric Undergoing Hypospadias Surgery Ultrasound-guided sacral erector spinae plane block (sESPB), Ultrasound-guided caudal epidural block - Hypospadias, Caudal Block | Not applicable | Recruiting | Tanta University | 70 | 2025-04-01 | 2025-09-09 |
| Pearls and Pitfalls in Usage of Plasma-Rich Platelet Graft Versus Dartos Flap in Distal Penile Hypospadias Repair Plasma-Rich Platelet Graft, Dartos Flap - Penile Hypospadias | Not applicable | Not yet recruiting | Assiut University | 70 | 2025-03-01 | 2025-02-05 |
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Pain, Postoperative (10) · Cryptorchidism (5) · Testicular Hydrocele (5) · Disorders of Sex Development (4) · Pain (4) · Agnosia (3) · Congenital Abnormalities (3) · Fistula (3) · Phimosis (3) · Anxiety Disorders (2) · Bladder Exstrophy (2) · Epispadias (2) · Hernia, Inguinal (2) · Ovotesticular Disorders of Sex Development (2)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (108) · Female Urogenital Diseases and Pregnancy Complications (108) · Female Urogenital Diseases (107) · Genital Diseases (107) · Genital Diseases, Male (107) · Male Urogenital Diseases (107) · Penile Diseases (107) · Urogenital Abnormalities (106) · Urogenital Diseases (106) · Congenital Abnormalities (105) · Pathological Conditions, Signs and Symptoms (23) · Signs and Symptoms (16) · Neurologic Manifestations (15) · Pathologic Processes (13) · Postoperative Complications (11)
Bupivacaine (6) · Dexmedetomidine (5) · Ropivacaine (4) · Anesthesia, General (2) · Lysine Acetyltransferase 5 (2) · Trimethoprim, Sulfamethoxazole Drug Combination (2) · Acetaminophen (1) · Anesthesia, Caudal (1) · Anesthesia, Local (1) · Atropine (1) · Bucrylate (1) · Dexamethasone (1) · Epinephrine (1) · Esketamine (1) · Evaluation Studies as Topic (1)
Assiut University (7) · Ain Shams University (5) · Yonsei University (4) · Al-Azhar University (3) · Hospices Civils de Lyon (3) · Mansoura University (3) · Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization (3) · Cairo University (2) · Isfahan University of Medical Sciences (2) · Johns Hopkins University (2) · National Children's Medical Center, Uzbekistan (2) · Sohag University (2) · Tanta University (2) · University Hospital, Montpellier (2) · University of North Carolina, Chapel Hill (2)
Egypt (27) · United States (20) · Turkey (Türkiye) (12) · France (7) · China (5) · Pakistan (5) · South Korea (5) · Canada (2) · United Kingdom (2) · Uzbekistan (2) · Bangladesh (1) · Colombia (1) · Indonesia (1) · Iran (1) · Israel (1)
Volkan Ozen, MD (2) · Ahmed Elrouby, MD (1) · Asad Munir, FCPS (1) · Aysel Kokcu Dogan (1) · Barry Kogan, MD (1) · Bhalaajee Meenakshi-Sundaram, MD (1) · Boris Chertin, MD, Prof. (1) · Craig Peters, MD (1) · David E Sandberg, PhD (1) · Diansan Su, M.D., Ph.D (1) · Dincer Avlan, Profesor, MD (1) · Earl Y Cheng, MD (1)
PMID 32507565, PMID 35031224, PMID 35644790, PMID 10631746, PMID 10799234, PMID 10893631, PMID 10971284, PMID 11488741, PMID 11713004, PMID 16516617, PMID 17572214, PMID 20634140, PMID 20713233, PMID 21527191, PMID 21957982, PMID 22568526, PMID 23116700, PMID 24325905, PMID 24360521, PMID 24528990, PMID 25048468, PMID 25444989, PMID 25850928, PMID 27267992, PMID 27501015, PMID 27623810, PMID 2873259, PMID 29780414, PMID 29929047, PMID 31203111, PMID 31233129, PMID 31630465, PMID 32386308, PMID 33178502, PMID 33585088, PMID 35144885, PMID 36283712, PMID 37470555, PMID 37740425, PMID 37871332, PMID 38071112, PMID 38627668, PMID 39461004, PMID 41588344, PMID 42265792, PMID 42727983, PMID 7855949, PMID 8126792, PMID 8283561, PMID 836989
K12DK100022 (1), K23DK111987 (1), R01DK140178 (1)