454 completed, 128 unknown, 85 recruiting, 42 terminated. 335 Not applicable, 92 Phase 4, 79 Phase 2, 66 Phase 3, 30 Phase 1.
Follow Hypotension: new trials by email Literature Review of Hypotension trials Research Report on Hypotension
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ceasing Alpha-blockers Early After Resection of the Prostate (The CLEAR Trial) Tamsulosin hydrochloride 0.2 mg, Placebo - Benign Prostatic Hyperplasia | Phase 4 | Not yet recruiting | Shanghai East Hospital | 400 | 2026-12-01 | 2026-09-29 |
| Dopamine vs. Norepinephrine for Hypotension in Neonates With Pulmonary Hypertension (DONE) Dopamine administration, Norepinephrine - Hypotension and Shock, Pulmonary Hypertension of the Newborn (PPHN) | Phase 4 | Recruiting | University of California, Davis | 30 | 2026-10-30 | 2026-08-18 |
| Granisetron Use, Blood Pressure, and Nausea and Vomiting During Cesarean Delivery Under Spinal Anesthesia Granisetron - Hypotension, Nausea | Not yet recruiting | Kayseri City Hospital | 80 | 2026-10-15 | 2026-10-06 | |
| Pre-induction Norepinephrine in Septic Patients Undergoing Surgery Norepinephrine, Standard Care - Sepsis, Hypotension | Not applicable | Not yet recruiting | Assiut University | 90 | 2026-10-10 | 2026-10-15 |
| Cardiovascular Autonomic Function After Resistance Training Upper-Limb Resistance Training - Spinal Cord Injury | Not applicable | Not yet recruiting | Pusan National University Yangsan Hospital | 20 | 2026-10-01 | 2026-09-03 |
| Carotid Artery Blood Flow, Blood Pressure, and Cardiac Output During Anesthesia in Children Aged 0-5 Years Hypotension (MeSH: D007022) | Not yet recruiting | Karolinska Institutet | 100 | 2026-10-01 | 2026-10-07 | |
| ED50/ED90 of Phenylephrine Infusion for Preventing Spinal Anesthesia-Induced Hypotension: Supine vs Left-Tilt 15° Phenylephrine hydrochloride infusion - Hypotension After Spinal Anesthesia | Phase 4 | Not yet recruiting | Peking University People's Hospital | 200 | 2026-09-20 | 2026-09-17 |
| Ultrasound Versus Palpation for Determining Spinal Puncture Level in Cesarean Section Preprocedural ultrasound level identification, Landmark palpation level identification - Cesarean Section (MeSH: D002585), Anesthesia, Spinal (MeSH: D000775) | Not applicable | Not yet recruiting | Kahramanmaras Sutcu Imam University | 66 | 2026-09-01 | 2026-08-27 |
| Autologous Stem Cell Therapy in Patients With Multiple System Atrophy MSCs, Placebo - MSA - Multiple System Atrophy, MSA | Phase 2 | Not yet recruiting | Biocells Medical | 50 | 2026-09-01 | 2026-03-11 |
| Remote Monitoring in Progressive Supranuclear Palsy (PSP) Progressive Supranuclear Palsy, Parkinson Disease | Not yet recruiting | Massachusetts General Hospital | 85 | 2026-09-01 | 2026-07-29 | |
| Blood'up Device Versus Manual Palpation for Arterial Puncture in Healthy Volunteers: A Pilot Randomized Study Under Normal and Simulated Hypotension Arterial blood gas, Simulated hypotension, Arterial Puncture using Blood'Up device - Arterial Puncture, Radial Artery Injury | Not applicable | Not yet recruiting | Centre Hospitalier Régional d'Orléans | 32 | 2026-09-01 | 2026-08-14 |
| Effect of Oxytocin Bolus Versus Slow Infusion on Haemodynamic Stability During Caesarean Section Under Spinal Anaesthesia Oxytocin - Cesarean Section, Hypotension | Not applicable | Not yet recruiting | Khyber Girls Medical College | 60 | 2026-09-01 | 2026-08-25 |
| Impact of Transcutaneous Spinal Stimulation on Blood Pressure and Orthostasis in Spinal Cord Injury Tilt test with stimulation (real-time effects): Intervention 1, 20 sessions of stimulation (Intervention 2) - Spinal Cord Injuries, Hypotension | Not applicable | Not yet recruiting | Kessler Foundation | 10 | 2026-09-01 | 2026-06-29 |
| Internal Jugular Vein Collapsibility Index for Predicting Post-Induction Hypotension IJV-CI Measurement - Hypotension, Anesthesia, General | Not yet recruiting | University of Gaziantep | 42 | 2026-08-15 | 2026-08-03 | |
| NORTHERA (DROXIDOPA) for Dysautonomia in Pediatric Survivors of Menkes Disease Droxidopa Oral Product, Placebo Control - Menkes Disease | Phase 1 / Phase 2 | Recruiting | Stephen G. Kaler | 6 | 2026-08-10 | 2026-10-05 |
| Midodrine in Heart Failure With Reduced Ejection Fraction With Hypotension Midodrine Oral Tablet - Heart Failure With Reduced Ejection Fraction, Hypotension | Phase 2 / Phase 3 | Recruiting | Ottawa Heart Institute Research Corporation | 56 | 2026-08-07 | 2026-09-08 |
| Fainting Detection And Early Warning In Syncope Evaluation Study (ARISE) Wearable holter monitor - Orthostatic Hypotension, Reflex Syncope | Recruiting | Boston Scientific Corporation | 40 | 2026-08-06 | 2026-10-14 | |
| Perfusion Index and Spinal Hypotension in Day-Case Knee Arthroscopy Hypotension, Spinal Anesthesia Induced Hypotension | Recruiting | Ankara Etlik City Hospital | 150 | 2026-08-06 | 2026-08-10 | |
| 5 Versus 10 mcg Norepinephrine Bolus in Treatment of Postinduction and Early Intraoperative Hypotension in Emergency Abdominal Surgery Norepinephrine 10 mcg, Norepinephrine 5 mcg - Hypotension on Induction, Emergency Surgery | Not applicable | Recruiting | Cairo University | 136 | 2026-08-04 | 2026-08-05 |
| Effects of Dexmedetomidine on Sublingual Microcirculation and Vascular Waterfall Phenomenon in Patients With Septic Shock Dexmedetomidine Intravenous Infusion - Septic Shock, Sepsis | Not applicable | Not yet recruiting | First Affiliated Hospital of Wannan Medical College | 20 | 2026-08-01 | 2026-06-18 |
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Hypotension, Orthostatic (149) · Hypertension (53) · Shock (40) · Parkinson Disease (34) · Spinal Cord Injuries (34) · Shy-Drager Syndrome (33) · Multiple System Atrophy (29) · Pure Autonomic Failure (27) · Post-Exercise Hypotension (22) · Sepsis (21) · Bradycardia (20) · Acute Kidney Injury (19) · Syncope (15) · Shock, Septic (14)
Vascular Diseases (812) · Cardiovascular Diseases (801) · Pathological Conditions, Signs and Symptoms (241) · Nervous System Diseases (232) · Autonomic Nervous System Diseases (195) · Primary Dysautonomias (194) · Pathologic Processes (173) · Orthostatic Intolerance (163) · Central Nervous System Diseases (116) · Signs and Symptoms (100) · Brain Diseases (90) · Urogenital Diseases (70) · Basal Ganglia Diseases (67) · Female Urogenital Diseases and Pregnancy Complications (66)
Norepinephrine (50) · Phenylephrine (45) · Ephedrine (26) · Midodrine (25) · Saline Solution (22) · Bupivacaine (17) · Sodium Chloride (17) · Droxidopa (16) · Ondansetron (13) · Propofol (13) · Anesthesia, Spinal (10) · Epinephrine (10) · Ringer's Lactate (10) · Vasoconstrictor Agents (9) · Vasopressins (8)
Seoul National University Hospital (13) · Vanderbilt University Medical Center (13) · Assiut University (11) · University of British Columbia (11) · Mayo Clinic (10) · Vanderbilt University (10) · Cairo University (9) · James J. Peters Veterans Affairs Medical Center (9) · Samuel Lunenfeld Research Institute, Mount Sinai Hospital (7) · Ain Shams University (6) · Ankara City Hospital Bilkent (6) · Assistance Publique - Hôpitaux de Paris (6) · Brigham and Women's Hospital (6) · Chelsea Therapeutics (5) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (5)
United States (235) · Turkey (Türkiye) (67) · Canada (62) · France (52) · Egypt (43) · China (35) · South Korea (33) · Italy (30) · United Kingdom (27) · Germany (21) · Brazil (20) · Netherlands (20) · Denmark (18) · Poland (17) · Taiwan (16)
Italo Biaggioni, MD (13) · Jill Wecht, EdD (5) · Adeel Riaz, MD (4) · Jill M Wecht, EdD (3) · Satish R Raj, MD MSCI (3) · Abhik Das, PhD (2) · Adrian E Stephan, MD (2) · Ahmed M Shaat, MD (2) · Alain F Kalmar, MD, PhD (2) · Albert Moore, MD (2) · Christina I. Olofsson, MD, PhD (2) · Emmanouil Stamatakis, PhD (2)
PMID 21762873, PMID 27538531, PMID 28494751, PMID 32619039, PMID 39498822, PMID 11927799, PMID 12119802, PMID 15738343, PMID 17667564, PMID 17959591, PMID 19859776, PMID 20495139, PMID 23835589, PMID 25635593, PMID 28327122, PMID 29090733, PMID 29916861, PMID 30335625, PMID 31989416, PMID 33739123, PMID 40676549, PMID 42475649, PMID 10365009, PMID 10662747, PMID 10851208, PMID 11094595, PMID 11132738, PMID 11227314, PMID 11573596, PMID 11904109, PMID 11916798, PMID 12032019, PMID 12145072, PMID 12832331, PMID 12885750, PMID 12923400, PMID 12960536, PMID 14693603, PMID 14980943, PMID 15066944, PMID 15093843, PMID 15105213, PMID 15220175, PMID 15321207, PMID 15376771, PMID 1539892, PMID 15554749, PMID 15559738, PMID 15666063, PMID 15680647
2023 (5), 2018 (3), 2025 (2), P01HL056693 (2), R01HL144568 (2), U10HD021364 (2), U10HD021373 (2), U10HD021385 (2), U10HD027851 (2), U10HD027853 (2), U10HD027856 (2), U10HD027871 (2), U10HD027880 (2), U10HD027904 (2), U10HD034216 (2)