322 completed, 145 recruiting, 93 unknown, 55 active not recruiting. 300 Not applicable, 94 Phase 2, 49 Phase 1, 42 Phase 3, 29 Phase 4.
Follow Primary Dysautonomias: new trials by email Literature Review of Primary Dysautonomias trials Research Report on Primary Dysautonomias
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Impact of Improved Vagal Function on Periaqueductal Gray Connectivity breathing exercise training - Postural Tachycardia Syndrome | Not applicable | Not yet recruiting | Virginia Commonwealth University | 12 | 2028-01-01 | 2026-09-16 |
| A Trial of ONO-2808 in Participants With the Parkinsonian Subtype of Multiple System Atrophy (MSA-P) ONO-2808, Placebo - Multiple System Atrophy, Parkinson Variant | Phase 3 | Not yet recruiting | Ono Pharmaceutical Co., Ltd. | 486 | 2027-01-01 | 2026-09-17 |
| Ceasing Alpha-blockers Early After Resection of the Prostate (The CLEAR Trial) Tamsulosin hydrochloride 0.2 mg, Placebo - Benign Prostatic Hyperplasia | Phase 4 | Not yet recruiting | Shanghai East Hospital | 400 | 2026-12-01 | 2026-09-29 |
| Guanfacine and Cromolyn Sodium for POTS: The DBPOTS Trial Guanfacine (GFC), Cromolyn Sodium, Placebo - Postural Orthostatic Tachycardia Syndrome (POTS), Dysautonomia | Early Phase 1 | Not yet recruiting | Johns Hopkins University | 25 | 2026-11-15 | 2026-10-09 |
| Continuous and Non-invasive Measurements by Task Force® CORE/CARDIO in Autonomic Function Testing (AFT) Autonomic Function Testing - Autonomic Dysfunction, Orthostatic Intolerance | Not yet recruiting | CNSystems Medizintechnik GmbH | 75 | 2026-11-01 | 2026-03-18 | |
| The Precision Mito- Mito Map COMPASS Study Mito Map Energy Score and Home Functional Assessments - Mitochondrial Diseases, Myalgic Encephalomyelitis Chronic Fatigue Syndrome | Not yet recruiting | AI Agent Vault, Inc. d/b/a Precision Mito | 400 | 2026-11-01 | 2026-10-02 | |
| Cardiovascular Autonomic Function After Resistance Training Upper-Limb Resistance Training - Spinal Cord Injury | Not applicable | Not yet recruiting | Pusan National University Yangsan Hospital | 20 | 2026-10-01 | 2026-09-03 |
| RESET-POTS: Multimodal Phenotyping and Stellate Ganglion Block in Postural Orthostatic Tachycardia Syndrome Bilateral Sequential Stellate Ganglion Block - POTS - Postural Orthostatic Tachycardia Syndrome | Not applicable | Not yet recruiting | University Medical Centre Ljubljana | 30 | 2026-10-01 | 2026-09-24 |
| Time-Domain Heart Rate Variability and QT Interval in Children With Epilepsy Epilepsy, Pediatric Epilepsy | Not yet recruiting | Assiut University | 60 | 2026-10-01 | 2026-09-22 | |
| Open-Label Access to ATH434 for Patients Who Completed Study ATH434-201 in France ATH434 - Multiple System Atrophy | Phase 2 | Enrolling by invitation | Alterity Therapeutics | 7 | 2026-10-01 | 2026-10-09 |
| Presentation of Young Adults With and Without Joint Hypermobility Hypermobile Ehlers-Danlos Syndrome, Postural Orthostatic Tachycardia Syndrome (POTS) | Enrolling by invitation | Clarkson University | 100 | 2026-09-23 | 2026-10-22 | |
| Adverse Events During Physical Therapy in Neurocritical ICU Patients Physical Therapy Intervention - Critical Illness, Brain Injury | Active not recruiting | Hospital H+ Queretaro | 47 | 2026-09-23 | 2026-10-28 | |
| A Prospective Exploratory Study of the Safety and Preliminary Efficacy of the α-Syn H21 Monoclonal Antibody in Patients With Multiple System Atrophy α-Syn H21 Monoclonal Antibody - Multiple System Atrophy | Phase 1 | Not yet recruiting | Ruijin Hospital | 3 | 2026-09-15 | 2026-08-19 |
| aVNT in POTS - Pilot active aVNT vs. Sham - Postural Orthostatic Tachycardia Syndrome (POTS) | Not applicable | Not yet recruiting | University of Calgary | 30 | 2026-09-01 | 2026-05-01 |
| Autologous Stem Cell Therapy in Patients With Multiple System Atrophy MSCs, Placebo - MSA - Multiple System Atrophy, MSA | Phase 2 | Not yet recruiting | Biocells Medical | 50 | 2026-09-01 | 2026-03-11 |
| Tributyrin for Progressive Supranuclear Palsy (PSP): Virtual Trial Tributyrin, Placebo - Parkinson Disease, Multiple System Atrophy | Phase 1 / Phase 2 | Recruiting | Prabesh Kanel | 15 | 2026-09-01 | 2026-10-07 |
| VisMemoPD Protocol: an Observational Pilot Study on Spatial and Topographical Memory in Patients With Parkinson's Disease and Parkinsonism Multimodal visuospatial and topographical memory assessment - Parkinson's Disease, Parkinsonism | Not yet recruiting | IRCCS San Raffaele Roma | 80 | 2026-09-01 | 2026-09-18 | |
| Remote Monitoring in Progressive Supranuclear Palsy (PSP) Progressive Supranuclear Palsy, Parkinson Disease | Not yet recruiting | Massachusetts General Hospital | 85 | 2026-09-01 | 2026-07-29 | |
| Impact of Transcutaneous Spinal Stimulation on Blood Pressure and Orthostasis in Spinal Cord Injury Tilt test with stimulation (real-time effects): Intervention 1, 20 sessions of stimulation (Intervention 2) - Spinal Cord Injuries, Hypotension | Not applicable | Not yet recruiting | Kessler Foundation | 10 | 2026-09-01 | 2026-06-29 |
| Efficacy and Safety of Butylphthalide in the Treatment of Multiple System Atrophy 3-N-butylphthalide - Multiple System Atrophy | Phase 2 / Phase 3 | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 150 | 2026-08-27 | 2026-10-16 |
Showing 20 of 732. Sign in to see all of them.
Multiple System Atrophy (204) · Hypotension, Orthostatic (149) · Postural Orthostatic Tachycardia Syndrome (134) · Parkinson Disease (133) · Syncope, Vasovagal (88) · Orthostatic Intolerance (63) · Supranuclear Palsy, Progressive (58) · Pure Autonomic Failure (56) · Syncope (51) · Autonomic Nervous System Diseases (42) · Spinal Cord Injuries (38) · Lewy Body Disease (35) · Hypertension (34) · Shy-Drager Syndrome (33)
Nervous System Diseases (724) · Autonomic Nervous System Diseases (690) · Pathological Conditions, Signs and Symptoms (335) · Orthostatic Intolerance (331) · Central Nervous System Diseases (307) · Signs and Symptoms (284) · Brain Diseases (277) · Cardiovascular Diseases (264) · Neurologic Manifestations (264) · Basal Ganglia Diseases (253) · Vascular Diseases (246) · Movement Disorders (245) · Neurodegenerative Diseases (241) · Synucleinopathies (229)
Midodrine (24) · Droxidopa (20) · Exercise (15) · Saline Solution (13) · Sodium Chloride (11) · Pyridostigmine Bromide (8) · Atomoxetine Hydrochloride (7) · Carbidopa (7) · Propranolol (7) · Blood Specimen Collection (6) · Tilt-Table Test (6) · Insulin (5) · Ivabradine (5) · Metoprolol (5) · Phenylephrine (5)
Vanderbilt University Medical Center (31) · Vanderbilt University (28) · University of Calgary (19) · NYU Langone Health (17) · National Institute of Neurological Disorders and Stroke (NINDS) (15) · Wake Forest University Health Sciences (11) · Mayo Clinic (10) · University Hospital, Bordeaux (10) · University of Colorado, Denver (9) · James J. Peters Veterans Affairs Medical Center (8) · University Hospital, Toulouse (7) · University of British Columbia (7) · Chelsea Therapeutics (6) · Istituto Auxologico Italiano (6) · MODAG GmbH (6)
United States (352) · Canada (58) · France (49) · Italy (43) · United Kingdom (34) · China (32) · Germany (29) · Spain (27) · Denmark (21) · Poland (21) · Israel (17) · South Korea (17) · Austria (16) · Netherlands (15) · Brazil (14)
Italo Biaggioni, MD (24) · Satish R Raj, MD MSCI (16) · Horacio Kaufmann, MD (8) · Alfredo J Gamboa, MD (4) · Charles Tegeler, MD (4) · Cyndya Shibao, M.D (4) · David Robertson, MD (4) · David S Goldstein, M.D. (4) · Horacio C Kaufmann, MD (4) · Italo Biaggioni, M.D. (4) · Jill Wecht, EdD (4) · Satish R Raj, MD, MSCI (4)
PMID 15670960, PMID 21712276, PMID 36114133, PMID 38036236, PMID 21762873, PMID 22565936, PMID 27538531, PMID 28494751, PMID 30354289, PMID 11927799, PMID 12119802, PMID 15710782, PMID 15738343, PMID 18426998, PMID 19797151, PMID 22275485, PMID 26411271, PMID 27402231, PMID 29562304, PMID 30338504, PMID 31330187, PMID 31439288, PMID 33279955, PMID 33739123, PMID 34339231, PMID 42475649, PMID 10037110, PMID 10214756, PMID 10406987, PMID 10527042, PMID 10662747, PMID 10851208, PMID 10853813, PMID 10979878, PMID 11018167, PMID 11076832, PMID 11146266, PMID 11210997, PMID 11231036, PMID 11400186, PMID 11724917, PMID 11904109, PMID 12239256, PMID 12498954, PMID 12832331, PMID 12885750, PMID 12904089, PMID 12923400, PMID 15066944, PMID 15175402
2023 (4), R01HL102387 (4), 2018 (3), 2019 (3), 2025 (3), P01HL056693 (3), P01NS044233 (3), R01HL144568 (3), U54NS065736 (3), K23RR020783 (2), UL1RR024975 (2), UL1TR000445 (2), 2008 (1), 2009 (1), 2014 (1)