Acute Kidney Injury: Clinical Trials

814 completed, 296 unknown, 182 recruiting, 115 not yet recruiting. 451 Not applicable, 156 Phase 2, 107 Phase 4, 102 Phase 3, 43 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	451	Completed 221, Recruiting 66, Unknown 66, Not yet recruiting 37, Terminated 33, Withdrawn 13, Active not recruiting 12, Enrolling by invitation 2, Suspended 1
Phase 2	156	Completed 65, Recruiting 24, Unknown 23, Terminated 19, Not yet recruiting 10, Withdrawn 10, Active not recruiting 4, Suspended 1
Phase 4	107	Completed 43, Unknown 22, Recruiting 14, Terminated 14, Not yet recruiting 7, Withdrawn 3, Active not recruiting 2, Suspended 2
Phase 3	102	Completed 40, Unknown 22, Terminated 16, Recruiting 9, Not yet recruiting 5, Withdrawn 5, Active not recruiting 4, Suspended 1
Phase 1	43	Completed 22, Unknown 8, Withdrawn 4, Recruiting 3, Terminated 3, Not yet recruiting 2, Active not recruiting 1
Early Phase 1	9	Completed 3, Not yet recruiting 2, Unknown 2, Active not recruiting 1, Terminated 1

Follow Acute Kidney Injury: new trials by email Literature Review of Acute Kidney Injury trials Research Report on Acute Kidney Injury

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Maastricht Investigation of Renal Function in Absence of- and Post- Contrast in Patients With eGFR LEss Than 30 serum creatinine assay - Acute Kidney Injury (Nontraumatic), Contrast-induced Nephropathy		Withdrawn	Maastricht University Medical Center		2097-11-01	2023-10-19
Time to Excretion of Contrast, a Maastricht Prospective Observational Study Contrast concentration in urine - Renal Insufficiency, Acute Kidney Injury		Withdrawn	Maastricht University Medical Center		2097-11-01	2023-10-19
Efficacy of Point-Of-Care Creatinine Assays in Patients With eGFR <30 Receiving Intravascular Contrast serum creatinine assay - Renal Insufficiency, Acute Kidney Injury		Withdrawn	Maastricht University Medical Center		2097-05-01	2023-10-19
Precision-Medicine Diagnostic Support in Hospitalized Veterans With Acute Kidney Injury PRECISE-AKI Clinical Decision Support Tool - Acute Kidney Injury (AKI)	Not applicable	Not yet recruiting	VA Office of Research and Development	60	2028-01-01	2025-10-16
Amino Acid Therapy Evaluating the Incidence of New-Onset AKI Amino Acid infusion, Lactated Ringer Solution - Acute Kidney Injury	Phase 2	Not yet recruiting	Children's Hospital Medical Center, Cincinnati	270	2027-10-01	2026-10-21
Insights Into the Continuous Renal Replacement Therapy to Critical Ill Patients continuous renal replacement therapy - Continuous Renal Replacement Therapy (CRRT), Acute Kidney Injury		Not yet recruiting	University of Alberta	100000	2027-03-31	2026-09-09
SWedish Intensive Care Biobank Any Condition Underlying Critical Illness		Not yet recruiting	Uppsala University	25000	2027-01-01	2026-05-13
Finerenone for AKI: a Multicenter, Randomized, Placebo-Controlled Feasibility Pilot Trial Finerenone (BAY94-8862 ) 10 mg, Placebo - Acute Kidney Injury, Renal Insufficiency,Chronic	Not applicable	Not yet recruiting	Jean-Maxime Côté	72	2027-01-01	2026-08-20
Doppler Evaluation for Congestive Acute Kidney Injury in Critical Illness Fluid Management, No intervention - Acute Kidney Injury, VExUS	Not applicable	Not yet recruiting	University of Alabama at Birmingham	100	2026-12-01	2026-07-16
Vancomycin Exposure and Biomarker Tracking Using Real-time Monitoring of Interstitial Fluid Biomarkers, Acute Kidney Injury		Not yet recruiting	Nutromics	200	2026-12-01	2026-10-23
Cumulative Intra-Abdominal Pressure Burden and Acute Kidney Injury After Emergency Abdominal Surgery Serial Intra-Abdominal Pressure Measurement - Acute Kidney Injury, Intra-Abdominal Hypertension		Not yet recruiting	Ugur Duman	300	2026-12-01	2026-10-23
Analysis of Continuous Kidney Replacement Therapy (CKRT) Treatments With multiFlux Hemofilters Using Regional Citrate Anticoagulation (RCA) or Systemic Heparin Anticoagulation multiFlux 160 hemofilter with regional heparin anticoagulation, multiFlux 160 hemofilter with RCA with regional citrate anticoagulation, multiFlux 130 hemofilter with regional heparin anticoagulation - Acute Kidney Injury, Renal Failure		Not yet recruiting	Fresenius Medical Care Deutschland GmbH	62	2026-11-01	2026-09-04
Uric Acid to Albumin Ratio for Predicting Contrast Associated Acute Kidney Injury After Cardiac and Non Cardiac Procedures Contrast-Induced Nephropathy, Acute Kidney Injury		Not yet recruiting	Assiut University	100	2026-11-01	2026-10-02
Continuous Renal Replacement Therapy, Impact on Intensive Care Unit Length of Stay continuous renal replacement therapy - AKI - Acute Kidney Injury, Critical Illness		Not yet recruiting	Karolinska Institutet	500000	2026-11-01	2026-09-18
Frailty and Outcomes in Critically Ill Patients Receiving CRRT Acute Kidney Injury		Not yet recruiting	Karolinska Institutet	22000	2026-11-01	2026-09-28
Renal Angina Index for Predicting Acute Kidney Injury in Adult ICU Patients Renal Angina Index Assessment - Acute Kidney Injury		Not yet recruiting	Izmir Katip Celebi University	324	2026-11-01	2026-10-07
Safety and Efficacy of Ultrasound-Guided Percutaneous Nephrostomy in Oncology Patients Ultrasound-guided percutaneous nephrostomy - Obstructive Uropathy, Hydronephrosis	Not applicable	Not yet recruiting	Assiut University	40	2026-11-01	2026-10-02
Clinical Decision Support for SGLT2i After AKI in Type 2 Diabetes Clinical Decision Support Message - Type 2 Diabetes Mellitus, Acute Kidney Injury	Not applicable	Not yet recruiting	University of Minnesota	250	2026-10-20	2026-10-09
Real-Time Acute Kidney Injury Perioperative Prediction Clinical Trial EHR-Embedded AKI Risk Score, EHR-Embedded AKI Risk Score with Best Practice Advisory - Acute Kidney Injury, Surgery Complications	Not applicable	Not yet recruiting	University of California, San Francisco	25518	2026-10-15	2026-05-22
A Study to Evaluate the Safety and Feasibility of Continuous Renal Replacement Therapy With Regional Citrate Anticoagulation in a Cohort Critical Ill Patients With Acute Kidney Injury and Presumed Absent Citrate Metabolism continuous renal replacement therapy with regional citrate anticoagulation - Acute Kidney Injury		Not yet recruiting	University Hospital, Antwerp	50	2026-10-15	2026-09-21

Showing 20 of 1620. Sign in to see all of them.

Narrower conditions

Sepsis (101)  ·  Renal Insufficiency, Chronic (94)  ·  Critical Illness (91)  ·  Renal Insufficiency (77)  ·  Shock, Septic (54)  ·  Kidney Failure, Chronic (40)  ·  COVID-19 (33)  ·  Heart Failure (31)  ·  Kidney Diseases (31)  ·  Shock (27)  ·  Postoperative Complications (25)  ·  Edema (23)  ·  Coronary Artery Disease (19)  ·  Fibrosis (19)

Broader conditions

Female Urogenital Diseases (1620)  ·  Female Urogenital Diseases and Pregnancy Complications (1620)  ·  Male Urogenital Diseases (1620)  ·  Urogenital Diseases (1619)  ·  Urologic Diseases (1618)  ·  Kidney Diseases (1589)  ·  Renal Insufficiency (1543)  ·  Pathological Conditions, Signs and Symptoms (552)  ·  Pathologic Processes (503)  ·  Disease Attributes (229)  ·  Cardiovascular Diseases (215)  ·  Infections (193)  ·  Vascular Diseases (147)  ·  Inflammation (143)  ·  Systemic Inflammatory Response Syndrome (132)

Interventions

Saline Solution (47)  ·  Sodium Chloride (41)  ·  Continuous Renal Replacement Therapy (31)  ·  Standard of Care (27)  ·  Sodium Bicarbonate (19)  ·  Blood Specimen Collection (18)  ·  Renal Replacement Therapy (18)  ·  Cardiac Surgical Procedures (14)  ·  Acetylcysteine (13)  ·  Dexmedetomidine (13)  ·  Furosemide (13)  ·  Norepinephrine (12)  ·  Heparin (11)  ·  Terlipressin (11)  ·  Observation (10)

Sponsors

Assiut University (34)  ·  Assistance Publique - Hôpitaux de Paris (19)  ·  Yonsei University (18)  ·  Hospices Civils de Lyon (17)  ·  Seoul National University Hospital (17)  ·  Children's Hospital Medical Center, Cincinnati (15)  ·  National Taiwan University Hospital (14)  ·  Peking University First Hospital (14)  ·  Ain Shams University (12)  ·  University Hospital, Ghent (12)  ·  Chulalongkorn University (11)  ·  Guy's and St Thomas' NHS Foundation Trust (11)  ·  Mayo Clinic (11)  ·  University of Alabama at Birmingham (11)  ·  University of California, San Francisco (11)

Countries

United States (364)  ·  China (155)  ·  France (148)  ·  Germany (104)  ·  Canada (81)  ·  Turkey (Türkiye) (81)  ·  United Kingdom (72)  ·  Italy (70)  ·  South Korea (62)  ·  Egypt (56)  ·  Spain (46)  ·  Belgium (43)  ·  Brazil (40)  ·  Sweden (36)  ·  Netherlands (31)

Top investigators

Alexander Zarbock, MD (10)  ·  Claudio Ronco, MD (6)  ·  Dong-Xin Wang, MD, PhD (5)  ·  Marlies Ostermann, PhD (5)  ·  Marie-Carmelle Elie, MD (4)  ·  Max Bell, MD, PhD (4)  ·  Stuart Goldstein, MD (4)  ·  Stuart L Goldstein, MD (4)  ·  Azra Bihorac, MD (3)  ·  Chi-yuan Hsu, MD, MSc (3)  ·  Detlef Kindgen-Milles, Prof. (3)  ·  Eric Hoste, MD, PhD (3)  ·  Francis P Wilson, MD MSCE (3)  ·  James A Tumlin, MD (3)

Results publications

PMID 36416787, PMID 34519356, PMID 33314078, PMID 39607014, PMID 39878152, PMID 39301879, PMID 15312219, PMID 21336114, PMID 32270297, PMID 40232884, PMID 11979336, PMID 16363316, PMID 16374442, PMID 17331245, PMID 18492867, PMID 19114912, PMID 19809295, PMID 21178824, PMID 21345279, PMID 21382993, PMID 22206744, PMID 22839577, PMID 23149172, PMID 23394211, PMID 24053972, PMID 24523666, PMID 24993448, PMID 25128022, PMID 25237065, PMID 25326742, PMID 25638527, PMID 25881975, PMID 26162677, PMID 26169430, PMID 27181456, PMID 27285313, PMID 27458386, PMID 28219057, PMID 28302179, PMID 29130810, PMID 29382510, PMID 29485925, PMID 29673370, PMID 29732396, PMID 30053231, PMID 30135570, PMID 30304656, PMID 30484934, PMID 32668114, PMID 32791973

NIH funding

2025 (6), 2014 (4), 2023 (3), R01DK113191 (3), 2008 (2), 2015 (2), 2016 (2), 2017 (2), K23HL151882 (2), 2018 (1), 2019 (1), 3UH3DK114920-04S2 (1), 5U2CDK114886 (1), F32DK115030 (1), I01CX002045 (1)