96 completed, 57 recruiting, 21 unknown, 18 active not recruiting. 59 Not applicable, 37 Phase 2, 28 Phase 1, 17 Phase 3, 13 Early Phase 1.
Follow Multiple System Atrophy: new trials by email Literature Review of Multiple System Atrophy trials Research Report on Multiple System Atrophy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Trial of ONO-2808 in Participants With the Parkinsonian Subtype of Multiple System Atrophy (MSA-P) ONO-2808, Placebo - Multiple System Atrophy, Parkinson Variant | Phase 3 | Not yet recruiting | Ono Pharmaceutical Co., Ltd. | 486 | 2027-01-01 | 2026-09-17 |
| Early Molecular Biomarkers for Differentiating Parkinsonian Syndromes PARKINSON DISEASE (Disorder), Atypical Parkinsonism | Enrolling by invitation | International Institute of Molecular and Cell Biology in Warsaw | 200 | 2026-10-30 | 2026-11-06 | |
| Open-Label Access to ATH434 for Patients Who Completed Study ATH434-201 in France ATH434 - Multiple System Atrophy | Phase 2 | Enrolling by invitation | Alterity Therapeutics | 7 | 2026-10-01 | 2026-10-09 |
| Tributyrin for Progressive Supranuclear Palsy (PSP): Virtual Trial Tributyrin, Placebo - Parkinson Disease, Multiple System Atrophy | Phase 1 / Phase 2 | Recruiting | Prabesh Kanel | 15 | 2026-10-01 | 2026-11-05 |
| A Prospective Exploratory Study of the Safety and Preliminary Efficacy of the α-Syn H21 Monoclonal Antibody in Patients With Multiple System Atrophy α-Syn H21 Monoclonal Antibody - Multiple System Atrophy | Phase 1 | Not yet recruiting | Ruijin Hospital | 3 | 2026-09-15 | 2026-08-19 |
| Autologous Stem Cell Therapy in Patients With Multiple System Atrophy MSCs, Placebo - MSA - Multiple System Atrophy, MSA | Phase 2 | Not yet recruiting | Biocells Medical | 50 | 2026-09-01 | 2026-03-11 |
| VisMemoPD Protocol: an Observational Pilot Study on Spatial and Topographical Memory in Patients With Parkinson's Disease and Parkinsonism Multimodal visuospatial and topographical memory assessment - Parkinson's Disease, Parkinsonism | Not yet recruiting | IRCCS San Raffaele Roma | 80 | 2026-09-01 | 2026-09-18 | |
| Remote Monitoring in Progressive Supranuclear Palsy (PSP) Progressive Supranuclear Palsy, Parkinson Disease | Not yet recruiting | Massachusetts General Hospital | 85 | 2026-09-01 | 2026-07-29 | |
| Efficacy and Safety of Butylphthalide in the Treatment of Multiple System Atrophy 3-N-butylphthalide - Multiple System Atrophy | Phase 2 / Phase 3 | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 150 | 2026-08-27 | 2026-10-16 |
| Test-retest Trial With [11C]MODAG-005 in PD or MSA and AMHC - Pilot Phase [11C]MODAG-005 - Parkinson Disease (PD), MSA - Multiple System Atrophy | Early Phase 1 | Recruiting | MODAG GmbH | 9 | 2026-07-29 | 2026-07-31 |
| Expansion Study of ALT001 in Patients With Multiple System Atrophy ALT001 - Multiple System Atrophy | Early Phase 1 | Recruiting | yilong Wang | 60 | 2026-06-15 | 2026-09-09 |
| A Study to Evaluate Satety, Tolerability, Biodistribution, Radiation Dosimetry, and Pharmacokinetics of SST001 in Healthy Volunteers, Patients With PD and Patients With MSA SST001 - Multiple System Atrophy (MSA), Parkinson's Disease (PD) | Phase 1 | Recruiting | Synusight Biotech (Shanghai) Co., Ltd. | 30 | 2026-06-15 | 2026-09-01 |
| High-Altitude Neurodegeneration Cohort (HANC) Study No Intervention: Observational Cohort - Multiple System Atrophy | Withdrawn | West China Hospital | 2026-06-13 | 2026-08-25 | ||
| The Study of Safety and Preliminary Efficacy of ALT001 in Patients With MultIple System Atrophy-Cerebellar Type ALT001 - Multiple System Atrophy - Cerebellar Subtype (MSA-C) | Early Phase 1 | Recruiting | yilong Wang | 20 | 2026-06-10 | 2026-09-09 |
| Evaluation of the Pharmacokinetics, Biodistribution and Radiation Dosimetry of [18F]MODAG-009 Positron Emission Tomography (PET) Radiotracers in Adult Healthy Volunteers [¹⁸F]MODAG-009 PET Imaging - Healthy Adult | Early Phase 1 | Recruiting | MODAG GmbH | 6 | 2026-05-27 | 2026-06-04 |
| Evaluation of [¹⁸F]MODAG-009 PET Imaging in Synucleinopathies [¹⁸F]MODAG-009 PET imaging - Multiple System Atrophy (MSA), Healthy Adult | Early Phase 1 | Recruiting | MODAG GmbH | 13 | 2026-05-13 | 2026-06-10 |
| Invasive Home Ventilation in Denmark Neuromuscular Diseases (NMD), ALS (Amyotrophic Lateral Sclerosis) | Recruiting | Copenhagen University Hospital, Rigshospitalet | 450 | 2026-04-13 | 2026-04-20 | |
| Ultra-High Resolution PET in Aging, Neurodegeneration and Psychotic Disorders UHR PET/CT scan of the brain with ¹⁸F-FDG, UHR PET/CT scan of the brain with ¹⁸F-PE2I, UHR PET/CT scan of the brain with ¹⁸F-SynVesT-1 - Alzheimer Dementia (AD), ALS - Amyotrophic Lateral Sclerosis | Not applicable | Recruiting | Universitaire Ziekenhuizen KU Leuven | 300 | 2026-02-13 | 2026-04-03 |
| MSA-01 in Multiple System Atrophy MSA-01, Placebo - Multiple System Atrophy (MSA) | Phase 3 | Recruiting | Tokyo University | 140 | 2026-02-09 | 2026-03-04 |
| Individualized Transcranial Magnetic Stimulation in Parkinsonian Disorders TMS - Parkinson's Disease, Multiple System Atrophy | Not applicable | Recruiting | Peking University First Hospital | 50 | 2025-12-22 | 2026-06-29 |
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Parkinson Disease (108) · Supranuclear Palsy, Progressive (58) · Pure Autonomic Failure (36) · Lewy Body Disease (35) · Shy-Drager Syndrome (33) · Parkinsonian Disorders (27) · Corticobasal Degeneration (23) · Hypotension, Orthostatic (22) · Neurodegenerative Diseases (20) · Alzheimer Disease (15) · Synucleinopathies (11) · Hypertension (10) · Parkinson Disease 4, Autosomal Dominant Lewy Body (10) · Amyotrophic Lateral Sclerosis (9)
Basal Ganglia Diseases (226) · Central Nervous System Diseases (226) · Brain Diseases (225) · Nervous System Diseases (225) · Autonomic Nervous System Diseases (223) · Primary Dysautonomias (222) · Movement Disorders (218) · Synucleinopathies (204) · Neurodegenerative Diseases (196) · Parkinsonian Disorders (87) · Pathological Conditions, Signs and Symptoms (85) · Signs and Symptoms (79) · Neurologic Manifestations (75) · Cardiovascular Diseases (61) · Vascular Diseases (61)
Droxidopa (9) · Midodrine (5) · 3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole (4) · Deep Brain Stimulation (4) · 8-hydroxyquinazolin-4(3H)-one (3) · ATH434 (3) · Blood Specimen Collection (3) · Carbidopa (3) · Saline Solution (3) · Sodium Chloride (3) · Sugars (3) · ampreloxetine (3) · entacapone (3) · Captopril (2) · Fluoxetine (2)
Vanderbilt University (10) · Vanderbilt University Medical Center (10) · University Hospital, Bordeaux (9) · MODAG GmbH (6) · University Hospital, Toulouse (6) · NYU Langone Health (5) · Alterity Therapeutics (4) · H. Lundbeck A/S (4) · National Institute of Neurological Disorders and Stroke (NINDS) (4) · Ruijin Hospital (4) · Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (3) · Beijing Tiantan Hospital (3) · Chelsea Therapeutics (3) · Massachusetts General Hospital (3) · Theravance Biopharma (3)
United States (103) · France (34) · China (25) · Italy (22) · United Kingdom (22) · Germany (15) · Canada (12) · Spain (12) · Austria (11) · South Korea (11) · Israel (9) · Japan (9) · Australia (7) · Poland (7) · Portugal (6)
Italo Biaggioni, MD (15) · Alberto Benussi, MD (3) · Barbara Borroni, MD (3) · Horacio Kaufmann, MD (3) · David Robertson, MD (2) · David S Goldstein, M.D. (2) · Florin Gandor, MD (2) · Horacio C Kaufmann, MD (2) · Italo Biaggioni, M.D. (2) · Luis E Okamoto, MD (2) · Nand Singh, BSc, MD, DPM, MFPM (2) · Olivier Rascol, MD (2)
PMID 27538531, PMID 28494751, PMID 33739123, PMID 10851208, PMID 11927799, PMID 12119802, PMID 12885750, PMID 12923400, PMID 15666063, PMID 15738343, PMID 16391172, PMID 16533484, PMID 17116758, PMID 17784944, PMID 18426998, PMID 19029129, PMID 19047577, PMID 19738158, PMID 19771175, PMID 21386111, PMID 21829612, PMID 22145021, PMID 22469621, PMID 22801444, PMID 23017648, PMID 23116538, PMID 23266540, PMID 23550093, PMID 24507091, PMID 24656908, PMID 25350981, PMID 25498732, PMID 26881179, PMID 27153166, PMID 27231659, PMID 28011164, PMID 28800338, PMID 29254664, PMID 29405350, PMID 29451447, PMID 30135258, PMID 31022213, PMID 31278067, PMID 32882100, PMID 32956556, PMID 33554315, PMID 33649343, PMID 33782836, PMID 33894193, PMID 34000076
2023 (4), R01HL144568 (3), 2018 (2), 2019 (2), 2025 (2), U54NS065736 (2), 2008 (1), 2009 (1), 2014 (1), P01HL056693 (1), P01NS044233 (1), R01AG059417 (1), R01HL161095 (1), R01NR016037 (1), R34AG056639 (1)